HK1258825A1 - 用於治疗多汗症的方法和组合物 - Google Patents

用於治疗多汗症的方法和组合物

Info

Publication number
HK1258825A1
HK1258825A1 HK19101228.1A HK19101228A HK1258825A1 HK 1258825 A1 HK1258825 A1 HK 1258825A1 HK 19101228 A HK19101228 A HK 19101228A HK 1258825 A1 HK1258825 A1 HK 1258825A1
Authority
HK
Hong Kong
Prior art keywords
subject
compositions
methods
muscarinic
hyperhidrosis
Prior art date
Application number
HK19101228.1A
Other languages
English (en)
Chinese (zh)
Inventor
Benjamin F. MCGRAW III
Original Assignee
Theravida, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravida, Inc. filed Critical Theravida, Inc.
Publication of HK1258825A1 publication Critical patent/HK1258825A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
HK19101228.1A 2016-01-20 2016-01-20 用於治疗多汗症的方法和组合物 HK1258825A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/014150 WO2017127073A1 (en) 2016-01-20 2016-01-20 Methods and compositions for treating hyperhidrosis

Publications (1)

Publication Number Publication Date
HK1258825A1 true HK1258825A1 (zh) 2019-11-22

Family

ID=59314209

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19101228.1A HK1258825A1 (zh) 2016-01-20 2016-01-20 用於治疗多汗症的方法和组合物

Country Status (15)

Country Link
US (4) US10328057B2 (enExample)
EP (1) EP3405191B1 (enExample)
JP (1) JP6841834B2 (enExample)
KR (2) KR102600541B1 (enExample)
CN (1) CN108697688A (enExample)
AU (2) AU2016388308B2 (enExample)
BR (1) BR112018014661A2 (enExample)
CA (1) CA3011683C (enExample)
DK (1) DK3405191T3 (enExample)
HK (1) HK1258825A1 (enExample)
MX (1) MX394356B (enExample)
RU (1) RU2718906C2 (enExample)
TW (2) TWI810150B (enExample)
WO (1) WO2017127073A1 (enExample)
ZA (1) ZA201805490B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
PL3061821T3 (pl) 2009-07-22 2020-01-31 PureTech Health LLC Kompozycje do leczenia zaburzeń łagodzonych przez aktywację receptora muskarynowego
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
WO2017127073A1 (en) 2016-01-20 2017-07-27 Theravida, Inc. Methods and compositions for treating hyperhidrosis
JP7096441B2 (ja) 2018-09-28 2022-07-05 カルナ セラピューティックス,インコーポレイテッド ムスカリン受容体活性化によって改善される障害を処置するための組成物及び方法
EP3993646B1 (en) 2019-07-05 2023-08-16 Swedish Match North Europe AB An oral pouched nicotine product including a filling material comprising nicotine-containing particles
HUE066565T2 (hu) 2019-11-20 2024-08-28 Swedish Match North Europe Ab Orálisan alkalmazható tasakos nikotintermék, beleértve egy nikotinrészecskéket tartalmazó töltõanyagot
EP3967311A1 (en) * 2020-09-11 2022-03-16 Astellas Pharma Inc. Compounds for use in the treatment of dry mouth
PL4018847T3 (pl) 2020-12-22 2024-11-18 Swedish Match North Europe Ab Produkt w saszetce do stosowania doustnego
PL4018848T3 (pl) 2020-12-22 2024-11-25 Swedish Match North Europe Ab Wyrób w saszetkach do użytku doustnego zawierający materiał pokrywający przepuszczalny dla cieczy oraz materiał wypełniający
PL4018849T3 (pl) 2020-12-22 2025-02-10 Swedish Match North Europe Ab Wyrób w saszetkach do użytku doustnego
US20240350420A1 (en) * 2021-08-11 2024-10-24 Wayne Stephen ANDREWS Pharmaceutical compositions and methods for treating hyperhidrosis
WO2024162929A1 (en) * 2023-01-27 2024-08-08 Ardi Farma Ilac Pazarlama Ticaret Limited Sirketi A controlled release formulation of propiverine

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209505A (en) 1979-04-03 1980-06-24 Mikhail Adib R Pilocarpine mouthwash for dry mouth relief
US4302440B1 (en) * 1980-07-31 1986-08-05 Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof
SE450087B (sv) 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
WO1995022962A1 (en) 1994-02-23 1995-08-31 Bm Research A/S Controlled release composition
US5674895A (en) 1995-05-22 1997-10-07 Alza Corporation Dosage form comprising oxybutynin
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
AU5609998A (en) 1997-01-10 1998-08-03 Abbott Laboratories Tablet for the controlled release of active agents
JP3608800B2 (ja) * 1997-03-26 2005-01-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗真菌剤およびポリマーでコートされたコアを有するペレット剤
ES2412409T3 (es) 1997-12-22 2013-07-11 Euro-Celtique S.A. Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo
CN1204890C (zh) 1997-12-22 2005-06-08 欧罗赛铁克股份有限公司 防止阿片样物质滥用的方法
US6482837B1 (en) 1998-04-24 2002-11-19 University Of Rochester Antimuscarinic compounds and methods for treatment of bladder diseases
US5997905A (en) 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
KR20010082251A (ko) 1998-10-26 2001-08-29 찌바따 이찌로, 다나까 도시오 서방성 입자
FR2795962B1 (fr) 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
HK1052297B (zh) 1999-09-14 2008-11-28 Glaxosmithkline Llc 制备水性包被小球粒的方法
PT1227806E (pt) 1999-11-11 2005-10-31 Pfizer Health Ab Formulacao farmaceutica contendo tolterodina e sua utilizacao
CA2398199A1 (en) 2000-01-28 2001-08-02 Asahi Kasei Kabushiki Kaisha Novel therapeutic agents that use a .beta.3 agonist
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
US6419954B1 (en) 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
CA2481236A1 (en) 2002-03-29 2003-10-09 Alza Corporation Volume efficient controlled release dosage form
FR2842735B1 (fr) 2002-07-26 2006-01-06 Flamel Tech Sa Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
FR2842736B1 (fr) 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
EP1635795A1 (en) 2003-05-30 2006-03-22 Ranbaxy Laboratories, Ltd. Controlled release pharmaceutical compositions of tolterodine and processes for their preparation
NZ545145A (en) 2003-08-06 2009-07-31 Nirmal Mulye Pharmaceutical composition containing water soluble drug
US7410978B2 (en) 2003-11-04 2008-08-12 Supernus Pharmaceuticals, Inc. Once daily dosage forms of trospium
WO2006026556A2 (en) 2004-08-27 2006-03-09 Spherics, Inc. Bioadhesive rate-controlled oral dosage formulations
US9050249B2 (en) 2004-04-30 2015-06-09 Astellas Pharma Inc. Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition
EP1755557A4 (en) 2004-05-19 2007-08-29 Glatt Air Tech Inc GRANULES CONTAINING MICROGRANULES AND PROCESS FOR THE PREPARATION THEREOF
WO2005123042A1 (en) 2004-06-10 2005-12-29 Glatt Air Techniques, Inc. Controlled release pharmaceutical formulation
EP1629834A1 (en) 2004-08-27 2006-03-01 KRKA, D.D., Novo Mesto Sustained release pharmaceutical composition of tolterodine
WO2006132196A1 (ja) 2005-06-08 2006-12-14 Asahi Kasei Pharma Corporation β3作動薬を含有する新規な医薬
BRPI0615432A2 (pt) * 2005-09-02 2011-05-17 Theravida Inc composição farmacêutica, e, uso de compostos
WO2007029087A2 (en) 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Controlled release multiple unit formulations
US20070077300A1 (en) 2005-09-30 2007-04-05 Wynn David W Oral compositions containing a salivation inducing agent
WO2007046102A2 (en) * 2005-10-19 2007-04-26 Menni Menashe Zinger Methods for the treatment of hyperhidrosis
NZ579811A (en) 2007-03-29 2012-02-24 Panacea Biotec Ltd Modified dosage forms of tacrolimus
US7563508B2 (en) 2007-05-30 2009-07-21 Chung Shan Institute Of Science And Technology, Armaments Bureau, M.N.D. Diffusion beads with core-shell structure
WO2009003724A1 (en) 2007-07-03 2009-01-08 Synthon B.V. Tolterodine bead
US8110226B2 (en) 2007-07-20 2012-02-07 Mylan Pharmaceuticals Inc. Drug formulations having inert sealed cores
EP2175843B1 (en) 2007-08-08 2014-10-08 Inventia Healthcare Private Limited Extended release compositions comprising tolterodine
US9561015B2 (en) * 2007-08-24 2017-02-07 General Electric Company Method and apparatus for voice recording with ultrasound imaging
JP2010540548A (ja) 2007-09-28 2010-12-24 ノバルティス アーゲー アリスキレンとバルサルタンの医薬組み合わせ剤
JP2011502140A (ja) 2007-10-29 2011-01-20 ルピン・リミテッド トルテロジンの制御放出型医薬組成物
US20090192228A1 (en) 2008-01-28 2009-07-30 Actavis Group Ptc Ehf Controlled-Release Tolterodine Compositions and Methods
WO2009151712A2 (en) * 2008-03-25 2009-12-17 Auspex Pharmaceuticals. Inc. Substituted phenylcyclohexylglycolates
WO2011123815A1 (en) 2010-04-01 2011-10-06 Theravida, Inc. Methods of improving quality of sleep
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
US20120289560A1 (en) 2011-05-10 2012-11-15 Theravida, Inc. Combinations of tolterodine and salivary stimulants for the treatment of overactive bladder
BR112013028755A2 (pt) 2011-05-10 2017-01-31 Theravida Inc combinações de solifenacina e estimulantes salivares para o tratamento de bexiga hiperativa
US20140037713A1 (en) * 2012-08-03 2014-02-06 Antares Pharma Ipl, Ag Transdermal compositions for anti-cholinergic agents
WO2014059309A1 (en) 2012-10-11 2014-04-17 Theravida, Inc. Pharmaceutical formulations of pilocarpine
WO2017127073A1 (en) 2016-01-20 2017-07-27 Theravida, Inc. Methods and compositions for treating hyperhidrosis

Also Published As

Publication number Publication date
JP2019506401A (ja) 2019-03-07
TWI810150B (zh) 2023-08-01
US20190307727A1 (en) 2019-10-10
AU2022206709A1 (en) 2022-08-11
KR102600541B1 (ko) 2023-11-08
WO2017127073A1 (en) 2017-07-27
EP3405191B1 (en) 2025-02-19
US20170202778A1 (en) 2017-07-20
EP3405191A4 (en) 2019-09-04
US11779569B2 (en) 2023-10-10
RU2718906C2 (ru) 2020-04-15
US20220047558A1 (en) 2022-02-17
RU2018128047A (ru) 2020-02-20
KR20230021184A (ko) 2023-02-13
MX2018008694A (es) 2019-05-15
JP6841834B2 (ja) 2021-03-10
US10610519B2 (en) 2020-04-07
MX394356B (es) 2025-03-24
TW201737906A (zh) 2017-11-01
KR102495757B1 (ko) 2023-02-06
ZA201805490B (en) 2019-11-27
US20200188360A1 (en) 2020-06-18
AU2016388308B2 (en) 2022-08-04
DK3405191T3 (da) 2025-05-19
BR112018014661A2 (pt) 2018-12-11
KR20180102649A (ko) 2018-09-17
AU2016388308A1 (en) 2018-08-02
CA3011683A1 (en) 2017-07-27
TW202341976A (zh) 2023-11-01
CN108697688A (zh) 2018-10-23
RU2018128047A3 (enExample) 2020-02-20
US10328057B2 (en) 2019-06-25
CA3011683C (en) 2023-09-26
EP3405191A1 (en) 2018-11-28
US11185533B2 (en) 2021-11-30

Similar Documents

Publication Publication Date Title
HK1258825A1 (zh) 用於治疗多汗症的方法和组合物
EA201690287A1 (ru) 1,4-дизамещенные аналоги пиридазин хинолина и способы лечения состояний, связанных с smn-дефицитом
NZ700881A (en) Compositions and methods comprising celecoxib or related compounds and dextromethorphan
WO2015157559A3 (en) 10',11'-modified saxitoxins useful for the treatment of pain
NZ732154A (en) Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
WO2014152029A3 (en) Oxazolo[5,4-c]quinolin-2-one compounds as bromodomain inhibitors
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
JO3784B1 (ar) الاستخدام المشترك للاجسمام المضادة pd-1 ومضادات m-csf في علاج السرطان
IN2013MU03583A (enExample)
EP4324454A3 (en) Cross-linking agents and associated methods
HRP20160646T1 (hr) Poboljšano liječenje multiplog mijeloma
TW201613578A (en) Pharmaceutical combinations
WO2015056094A3 (en) Pharmaceutical composition comprising a trpa1 antagonist and an analgesic agent
PH12016502352A1 (en) Pharmaceutical composition
IN2014MN02269A (enExample)
WO2015116856A3 (en) Farnesoid x receptor antagonists
MX2020006309A (es) Fórmulaciones de parasiticida de isoxazolina y métodos para el tratamiento de la blefaritis.
EA032271B9 (ru) Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний
AU2016216741A1 (en) Compositions and methods of use of an inappetance-controlling compound
RU2019139886A (ru) Терапевтическое средство против дисфункции мейбомиевых желез
MX2015000179A (es) Composiciones y formas de dosificacion de itraconazol y metodos de uso de las mismas.
WO2015035410A8 (en) Cancer therapy
HK1243704A1 (zh) 用於在未接触疟疾的受试者中预防疟疾的他非诺喹的新方案
BR112014004737A2 (pt) composto de composição de cloridrato de ambroxol e método de preparação do composto
MX348723B (es) Combinaciones de solifenacina y estimulantes salivales para el tratamiento de la vejiga hiperactiva.