MX394356B - Métodos y composiciones para tratar hiperhidrosis. - Google Patents

Métodos y composiciones para tratar hiperhidrosis.

Info

Publication number
MX394356B
MX394356B MX2018008694A MX2018008694A MX394356B MX 394356 B MX394356 B MX 394356B MX 2018008694 A MX2018008694 A MX 2018008694A MX 2018008694 A MX2018008694 A MX 2018008694A MX 394356 B MX394356 B MX 394356B
Authority
MX
Mexico
Prior art keywords
muscarinic antagonist
methods
compositions
subject
hyperhidrosis
Prior art date
Application number
MX2018008694A
Other languages
English (en)
Other versions
MX2018008694A (es
Inventor
Iii Benjamin F Mcgraw
Original Assignee
Theravida Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravida Inc filed Critical Theravida Inc
Publication of MX2018008694A publication Critical patent/MX2018008694A/es
Publication of MX394356B publication Critical patent/MX394356B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Los aspectos de la descripción incluyen métodos para tratar hiperhidrosis en un sujeto con una composición que incluye un antagonista muscarínico y un antagonista muscarínico. Al poner en práctica los métodos según ciertas realizaciones, una cantidad terapéuticamente eficaz de una composición que incluye un antagonista muscarínico, o una sal farmacéuticamente aceptable del mismo, y un antagonista muscarínico, o una sal farmacéuticamente aceptable del mismo, se administra a un sujeto, y es suficiente para reducir la hiperhidrosis en el sujeto y para reducir un efecto secundario de sequedad de boca del antagonista muscarínico. También se describen composiciones para poner en práctica los presentes métodos, así como unidades de dosis que contienen una o más de las presentes composiciones.
MX2018008694A 2016-01-20 2016-01-20 Métodos y composiciones para tratar hiperhidrosis. MX394356B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/014150 WO2017127073A1 (en) 2016-01-20 2016-01-20 Methods and compositions for treating hyperhidrosis

Publications (2)

Publication Number Publication Date
MX2018008694A MX2018008694A (es) 2019-05-15
MX394356B true MX394356B (es) 2025-03-24

Family

ID=59314209

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008694A MX394356B (es) 2016-01-20 2016-01-20 Métodos y composiciones para tratar hiperhidrosis.

Country Status (15)

Country Link
US (4) US10328057B2 (es)
EP (1) EP3405191B1 (es)
JP (1) JP6841834B2 (es)
KR (2) KR102495757B1 (es)
CN (1) CN108697688A (es)
AU (2) AU2016388308B2 (es)
BR (1) BR112018014661A2 (es)
CA (1) CA3011683C (es)
DK (1) DK3405191T3 (es)
HK (1) HK1258825A1 (es)
MX (1) MX394356B (es)
RU (1) RU2718906C2 (es)
TW (2) TWI810150B (es)
WO (1) WO2017127073A1 (es)
ZA (1) ZA201805490B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3061821B1 (en) 2009-07-22 2019-07-10 Puretech Health LLC Compositions for treatment of disorders ameliorated by muscarinic receptor activation
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
EP3405191B1 (en) 2016-01-20 2025-02-19 TheraVida, Inc. Compositions for use in treating hyperhidrosis
US10933020B2 (en) 2018-09-28 2021-03-02 Karuna Therapeutics, Inc. Compositions and methods for treating disorders ameliorated by muscarinic receptor activation
US11957165B2 (en) 2019-07-05 2024-04-16 Swedish Match North Europe Ab Oral pouched nicotine product including a filling material comprising nicotine-containing particles
US20220400735A1 (en) 2019-11-20 2022-12-22 Swedish Match North Europe Ab An oral pouched nicotine product including a filling material comprising nicotine particles
EP3967311A1 (en) * 2020-09-11 2022-03-16 Astellas Pharma Inc. Compounds for use in the treatment of dry mouth
EP4018848B1 (en) 2020-12-22 2024-09-18 Swedish Match North Europe AB A pouched product for oral use comprising a liquid permeable cover material and a filling material
EP4018847B1 (en) 2020-12-22 2024-09-18 Swedish Match North Europe AB A pouched product for oral use
EP4018849B1 (en) 2020-12-22 2024-10-23 Swedish Match North Europe AB A pouched product for oral use
JP2024534013A (ja) * 2021-08-11 2024-09-18 セラヴィダ，インコーポレイテッド． 多汗症を治療するための医薬組成物および方法
TR2023000985A2 (tr) * 2023-01-27 2023-02-21 Ardi Farma Ilac Pazarlama Ticaret Ltd Sirketi Kontrollü salim sağlayan propi̇veri̇n formülasyonu

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209505A (en) 1979-04-03 1980-06-24 Mikhail Adib R Pilocarpine mouthwash for dry mouth relief
US4302440B1 (en) * 1980-07-31 1986-08-05 Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof
SE450087B (sv) 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US6787156B1 (en) 1994-02-23 2004-09-07 Bm Research A/S Controlled release composition
US5674895A (en) 1995-05-22 1997-10-07 Alza Corporation Dosage form comprising oxybutynin
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
CA2277220A1 (en) 1997-01-10 1998-07-16 Abbott Laboratories Tablet for the controlled release of active agents
WO1998042318A1 (en) * 1997-03-26 1998-10-01 Janssen Pharmaceutica N.V. Pellets having a core coated with an antifungal and a polymer
BR9813826A (pt) 1997-12-22 2000-10-10 Euro Celtique Sa Potencial de uso abusivo de administração oral de opióide analgésico
EP2266564B1 (en) 1997-12-22 2013-03-13 Euro-Celtique S.A. Pharmaceutical oral dosage form comprising a combination of an opioid agonist and an opioid antagonist
US6482837B1 (en) 1998-04-24 2002-11-19 University Of Rochester Antimuscarinic compounds and methods for treatment of bladder diseases
US5997905A (en) 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
AU6228799A (en) 1998-10-26 2000-05-15 Tanabe Seiyaku Co., Ltd. Sustained-release particles
FR2795962B1 (fr) 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
CN100391438C (zh) 1999-09-14 2008-06-04 史密丝克莱恩比彻姆公司 制备水性包被小球粒的方法
MXPA02004574A (es) 1999-11-11 2004-09-10 Pharmacia Ab Formulacion farmaceutica que contiene tolterodina y su uso.
US20030018061A1 (en) 2000-01-28 2003-01-23 Kohei Ogawa Novel remedies with the use of beta 3 agonist
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
US6419954B1 (en) 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
CA2481236A1 (en) 2002-03-29 2003-10-09 Alza Corporation Volume efficient controlled release dosage form
FR2842735B1 (fr) 2002-07-26 2006-01-06 Flamel Tech Sa Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
FR2842736B1 (fr) 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
EP1635795A1 (en) 2003-05-30 2006-03-22 Ranbaxy Laboratories, Ltd. Controlled release pharmaceutical compositions of tolterodine and processes for their preparation
BRPI0413353A (pt) 2003-08-06 2006-10-10 Nirmal Mulye composição farmacêutica contendo droga solúvel em água
DE602004030931D1 (es) 2003-11-04 2011-02-17 Supernus Pharmaceuticals Inc
WO2006026556A2 (en) 2004-08-27 2006-03-09 Spherics, Inc. Bioadhesive rate-controlled oral dosage formulations
EP1787640A4 (en) 2004-04-30 2012-04-11 Astellas Pharma Inc GRAINED PHARMACEUTICAL COMPOSITION WITH TEMPORARY DELIVERY FOR ORAL ADMINISTRATION AND FAST-DECREASING INTRAORAL TABLET WITH THE COMPOSITION
US20080254115A1 (en) 2004-05-19 2008-10-16 Rubino Orapin P Micropellet Containing Pellets and Method of Preparing Such Pellets
US20070224269A1 (en) 2004-06-10 2007-09-27 Rubino Orapin P Controlled Release Pharmaceutical Formulation
EP1629834A1 (en) 2004-08-27 2006-03-01 KRKA, D.D., Novo Mesto Sustained release pharmaceutical composition of tolterodine
WO2006132196A1 (ja) 2005-06-08 2006-12-14 Asahi Kasei Pharma Corporation β３作動薬を含有する新規な医薬
NZ565840A (en) 2005-09-02 2011-07-29 Theravida Inc Therapy for the treatment of disease
WO2007029087A2 (en) 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Controlled release multiple unit formulations
US20070077300A1 (en) 2005-09-30 2007-04-05 Wynn David W Oral compositions containing a salivation inducing agent
WO2007046102A2 (en) * 2005-10-19 2007-04-26 Menni Menashe Zinger Methods for the treatment of hyperhidrosis
BRPI0809563A2 (pt) 2007-03-29 2014-09-16 Panacea Biotec Ltd Formas de dosagem modificadas de tacrolimus
US7563508B2 (en) 2007-05-30 2009-07-21 Chung Shan Institute Of Science And Technology, Armaments Bureau, M.N.D. Diffusion beads with core-shell structure
EP2173329A1 (en) 2007-07-03 2010-04-14 Synthon B.V. Tolterodine bead
US8110226B2 (en) 2007-07-20 2012-02-07 Mylan Pharmaceuticals Inc. Drug formulations having inert sealed cores
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine
US9561015B2 (en) * 2007-08-24 2017-02-07 General Electric Company Method and apparatus for voice recording with ultrasound imaging
PT2205279E (pt) 2007-09-28 2011-07-11 Novartis Ag Associação farmacêutica de aliscireno e valsartan
JP2011502140A (ja) 2007-10-29 2011-01-20 ルピン・リミテッド トルテロジンの制御放出型医薬組成物
US20090192228A1 (en) 2008-01-28 2009-07-30 Actavis Group Ptc Ehf Controlled-Release Tolterodine Compositions and Methods
US20090247628A1 (en) * 2008-03-25 2009-10-01 Auspex Pharmaceuticals, Inc. Substituted phenylcyclohexylglycolates
SG174658A1 (en) * 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
CA2795253A1 (en) 2010-04-01 2011-10-06 Theravida, Inc. Methods of improving quality of sleep
BR112013028755A2 (pt) 2011-05-10 2017-01-31 Theravida Inc combinações de solifenacina e estimulantes salivares para o tratamento de bexiga hiperativa
WO2012154770A1 (en) 2011-05-10 2012-11-15 Theravida, Inc. Combinations of tolterodine and salivary stimulants for the treatment of overactive bladder
US20140037713A1 (en) * 2012-08-03 2014-02-06 Antares Pharma Ipl, Ag Transdermal compositions for anti-cholinergic agents
JP2015533174A (ja) 2012-10-11 2015-11-19 セラヴィダ，インコーポレイテッド ピロカルピンの医薬製剤
EP3405191B1 (en) 2016-01-20 2025-02-19 TheraVida, Inc. Compositions for use in treating hyperhidrosis

Also Published As

Publication number Publication date
US20220047558A1 (en) 2022-02-17
EP3405191A4 (en) 2019-09-04
RU2018128047A (ru) 2020-02-20
TW202341976A (zh) 2023-11-01
KR102495757B1 (ko) 2023-02-06
US20170202778A1 (en) 2017-07-20
AU2016388308B2 (en) 2022-08-04
HK1258825A1 (zh) 2019-11-22
JP2019506401A (ja) 2019-03-07
CA3011683A1 (en) 2017-07-27
KR102600541B1 (ko) 2023-11-08
US20190307727A1 (en) 2019-10-10
KR20180102649A (ko) 2018-09-17
US10328057B2 (en) 2019-06-25
RU2018128047A3 (es) 2020-02-20
ZA201805490B (en) 2019-11-27
US11779569B2 (en) 2023-10-10
WO2017127073A1 (en) 2017-07-27
JP6841834B2 (ja) 2021-03-10
CA3011683C (en) 2023-09-26
US20200188360A1 (en) 2020-06-18
TW201737906A (zh) 2017-11-01
CN108697688A (zh) 2018-10-23
EP3405191A1 (en) 2018-11-28
RU2718906C2 (ru) 2020-04-15
EP3405191B1 (en) 2025-02-19
DK3405191T3 (da) 2025-05-19
TWI810150B (zh) 2023-08-01
KR20230021184A (ko) 2023-02-13
US11185533B2 (en) 2021-11-30
AU2016388308A1 (en) 2018-08-02
AU2022206709A1 (en) 2022-08-11
US10610519B2 (en) 2020-04-07
BR112018014661A2 (pt) 2018-12-11
MX2018008694A (es) 2019-05-15

Similar Documents

Publication Publication Date Title
MX394356B (es) Métodos y composiciones para tratar hiperhidrosis.
CL2019003542A1 (es) Métodos de tratamiento para la fibrosis quística.
AR121843A2 (es) Formulación oftálmica y método para mejorar la presbicia
MX394252B (es) Tratamiento del cancer usando combinaciones de inhibidores de erk y raf
MX2020003415A (es) Compuestos de benzoxacepina oxazolidinona y métodos de uso.
CO2018009561A2 (es) Métodos para tratar la depresión con antagonistas del receptor de orexina-2
CO2019000069A2 (es) Agentes antivirales contra la hepatitis b
CO2018010748A2 (es) Agentes antivirales contra la hepatitis b
AR090456A1 (es) Combinaciones farmaceuticas que comprenden un analogo de tionucleotidos
BR112015020389A8 (pt) compostos carbazol úteis como inibidores de bromodomínio, seu uso, bem como composição e produto farmacêuticos compreendendo os mesmos
MX2009006786A (es) Composiciones y metodos para el tratamiento de infecciones y tumores.
MX2019007587A (es) Composicion oftalmica para el tratamiento de la enfermedad del ojo seco.
PE20161218A1 (es) (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1
PE20171241A1 (es) Terapias de combinacion para el tratamiento de canceres
TR201904455T4 (tr) Nükleer taşıma modülatörleri olarak 1,2,4-triazoller ve bunların kullanımları.
PE20142314A1 (es) Composiciones intranasales de dexmedetomidina y metodos de uso de ellas
EA201592250A1 (ru) Пиразолопирролидиновые производные и их применение в лечение заболеваний
MX2018003893A (es) Moduladores del receptor p2x3 y p2x2/3 de diaminopirimidina para usarse en el tratamiento de la tos.
AR096892A1 (es) Una combinación farmacéutica para el tratamiento del melanoma
CU20160169A7 (es) Compuestos y composiciones para inducir condrogénesis
AR101674A1 (es) Uso de un compuesto tricíclico que contiene nitrógeno
EA201992328A1 (ru) Фармацевтическая композиция, содержащая ленватиниба мезилат
UY36257A (es) “compuestos de imidazopiridazina”.
CR20110648A (es) Compuestos heterocíclicos de fenoximetilo
EA201792264A1 (ru) Способы лечения воспалительных заболеваний