EA201992328A1 - Фармацевтическая композиция, содержащая ленватиниба мезилат - Google Patents
Фармацевтическая композиция, содержащая ленватиниба мезилатInfo
- Publication number
- EA201992328A1 EA201992328A1 EA201992328A EA201992328A EA201992328A1 EA 201992328 A1 EA201992328 A1 EA 201992328A1 EA 201992328 A EA201992328 A EA 201992328A EA 201992328 A EA201992328 A EA 201992328A EA 201992328 A1 EA201992328 A1 EA 201992328A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- composition containing
- lenvatiniba
- mesilate
- lenvatinib mesylate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
Настоящее изобретение относится к фармацевтической композиции, содержащей терапевтически эффективную дозу ленватиниба мезилата, содержащей натрий, где массовое соотношение ленватиниба мезилата к карбонатам натрия находится в диапазоне от 1:1,5 до 1:5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17164761.3A EP3384901A1 (en) | 2017-04-04 | 2017-04-04 | Pharmaceutical composition comprising lenvatinib mesylate |
PCT/EP2018/058629 WO2018185175A1 (en) | 2017-04-04 | 2018-04-04 | Pharmaceutical composition comprising lenvatinib mesylate |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201992328A1 true EA201992328A1 (ru) | 2020-02-14 |
Family
ID=58489241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201992328A EA201992328A1 (ru) | 2017-04-04 | 2018-04-04 | Фармацевтическая композиция, содержащая ленватиниба мезилат |
Country Status (6)
Country | Link |
---|---|
US (1) | US11911509B2 (ru) |
EP (2) | EP3384901A1 (ru) |
EA (1) | EA201992328A1 (ru) |
ES (1) | ES2923214T3 (ru) |
PT (1) | PT3606511T (ru) |
WO (1) | WO2018185175A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10583133B2 (en) | 2018-03-12 | 2020-03-10 | Shilpa Medicare Limited | Pharmaceutical compositions of lenvatinib |
PT3632436T (pt) * | 2018-10-04 | 2022-07-22 | Synthon Bv | Composição farmacêutica compreendendo sais de lenvatinib |
CN111053772A (zh) * | 2018-10-16 | 2020-04-24 | 四川科伦药物研究院有限公司 | 一种乐伐替尼的药物组合物及其用途 |
WO2021240281A1 (en) * | 2020-05-23 | 2021-12-02 | Shilpa Medicare Limited | Oral liquid formulations of lenvatinib |
EP4147689A1 (en) | 2021-09-13 | 2023-03-15 | Lotus Pharmaceutical Co., Ltd. | Lenvatinib formulation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1415987B1 (en) | 2000-10-20 | 2007-02-28 | Eisai R&D Management Co., Ltd. | Nitrogenous aromatic ring compounds as anti cancer agents |
BRPI0418200A (pt) | 2003-12-25 | 2007-04-17 | Eisai Co Ltd | forma cristalina do sal de 4-(3-cloro-4-(ciclopropilaminocarbonila) aminofenóxi)-7-metóxi-6-quinolinacarboxamida ou o solvato do sal e um processo para a sua preparação |
EP1797881B1 (en) | 2004-09-17 | 2009-04-15 | Eisai R&D Management Co., Ltd. | Medicinal composition with improved stability and reduced gelation properties |
WO2006084474A2 (en) | 2005-02-10 | 2006-08-17 | Lifecycle Pharma A/S | A stable pharmaceutical composition comprising a fixed dose combination of fenofibrate and an hmg-coa reductase inhibitor |
JP5209966B2 (ja) | 2005-09-01 | 2013-06-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 崩壊性の改善された医薬組成物の製造方法 |
MX344927B (es) | 2009-08-19 | 2017-01-11 | Eisai R&D Man Co Ltd | Composición farmacéutica que contiene derivado de quinolina. |
WO2017028660A1 (zh) * | 2015-08-17 | 2017-02-23 | 江苏恒瑞医药股份有限公司 | 一种含有喹啉衍生物或其盐的药物组合物 |
DE102015215604A1 (de) | 2015-08-17 | 2017-02-23 | Schaeffler Technologies AG & Co. KG | Stufenlos verstellbares Getriebe (CVT) mit elektronischem Drehmomentfühler, Antriebstrang und Verfahren zum Steuern / Regeln eines stufenlosen Getriebes |
-
2017
- 2017-04-04 EP EP17164761.3A patent/EP3384901A1/en active Pending
-
2018
- 2018-04-04 EA EA201992328A patent/EA201992328A1/ru unknown
- 2018-04-04 EP EP18713995.1A patent/EP3606511B1/en active Active
- 2018-04-04 PT PT187139951T patent/PT3606511T/pt unknown
- 2018-04-04 ES ES18713995T patent/ES2923214T3/es active Active
- 2018-04-04 US US16/603,031 patent/US11911509B2/en active Active
- 2018-04-04 WO PCT/EP2018/058629 patent/WO2018185175A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3606511A1 (en) | 2020-02-12 |
US11911509B2 (en) | 2024-02-27 |
EP3384901A1 (en) | 2018-10-10 |
EP3606511B1 (en) | 2022-04-20 |
PT3606511T (pt) | 2022-07-22 |
WO2018185175A1 (en) | 2018-10-11 |
US20200188380A1 (en) | 2020-06-18 |
ES2923214T3 (es) | 2022-09-26 |
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