HK1257616A1 - 新雙膦酸化合物 - Google Patents

新雙膦酸化合物

Info

Publication number
HK1257616A1
HK1257616A1 HK18116739.2A HK18116739A HK1257616A1 HK 1257616 A1 HK1257616 A1 HK 1257616A1 HK 18116739 A HK18116739 A HK 18116739A HK 1257616 A1 HK1257616 A1 HK 1257616A1
Authority
HK
Hong Kong
Prior art keywords
acid compound
bisphosphonic acid
novel bisphosphonic
novel
compound
Prior art date
Application number
HK18116739.2A
Other languages
English (en)
Inventor
小橋精一
青柳吉宣
加藤宏茂
德山竜光
蘆澤直樹
石田紘一
松本浩二
Original Assignee
株式會社富士藥品
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式會社富士藥品 filed Critical 株式會社富士藥品
Publication of HK1257616A1 publication Critical patent/HK1257616A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups
    • C07F9/3852—Cycloaliphatic derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK18116739.2A 2016-01-29 2018-12-28 新雙膦酸化合物 HK1257616A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016027405 2016-01-29
PCT/JP2017/002855 WO2017131127A1 (ja) 2016-01-29 2017-01-27 新規ビスホスホン酸化合物

Publications (1)

Publication Number Publication Date
HK1257616A1 true HK1257616A1 (zh) 2019-10-25

Family

ID=59398507

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18116739.2A HK1257616A1 (zh) 2016-01-29 2018-12-28 新雙膦酸化合物

Country Status (19)

Country Link
US (1) US10689408B2 (zh)
EP (1) EP3409679A4 (zh)
JP (1) JP6259957B2 (zh)
KR (1) KR20180111791A (zh)
CN (1) CN108473518B (zh)
AR (1) AR107472A1 (zh)
AU (1) AU2017211464B9 (zh)
BR (1) BR112018015552A2 (zh)
CA (1) CA3012957A1 (zh)
CO (1) CO2018007788A2 (zh)
HK (1) HK1257616A1 (zh)
MX (1) MX2018009231A (zh)
MY (1) MY195906A (zh)
PH (1) PH12018501586A1 (zh)
RU (1) RU2731615C2 (zh)
SG (1) SG11201806125UA (zh)
TW (1) TWI730039B (zh)
WO (1) WO2017131127A1 (zh)
ZA (1) ZA201804945B (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112839661A (zh) 2018-10-11 2021-05-25 萨尼菲特治疗有限公司 用于治疗异位钙化的肌醇磷酸酯类
EP4015494A1 (en) 2020-12-15 2022-06-22 Sanifit Therapeutics S.A. Processes for the preparation of soluble salts of inositol phosphates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3540150A1 (de) 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DD298267A5 (de) * 1989-01-27 1992-02-13 Zentralinstitut Fuer Molekularbiologie,De Verfahren zur immobilisierung von lipase, beta-galactosidase oder invertase
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89364C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
PL175475B1 (pl) 1992-05-29 1999-01-29 Procter & Gamble Pharma Nowe zawierające siarkę związki fosfonianowe
ATE161423T1 (de) 1992-06-30 1998-01-15 Procter & Gamble Pharma Verwendung von phosphinate zur behandlung der osteoporose
AU2756701A (en) 2000-01-04 2001-07-16 Regents Of The University Of California, The Use of low dosage bisphosphonates to inhibit cardiac and arterial calcification
WO2004035060A1 (en) * 2002-10-15 2004-04-29 Novartis Ag Bisphosphonates for the treatment of antheroscleorosis and devices comprising them
CN1705486A (zh) * 2002-10-15 2005-12-07 诺瓦提斯公司 用于治疗动脉粥样硬化的双膦酸类化合物和包含它们的装置
WO2008128056A1 (en) 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
AU2007226964B2 (en) * 2006-03-17 2012-03-22 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
FR2926080B1 (fr) * 2008-01-03 2010-04-02 Univ Nantes Procede de synthese de derives d'acide hydroxy-bisphosphonique

Also Published As

Publication number Publication date
US10689408B2 (en) 2020-06-23
CN108473518B (zh) 2021-07-06
BR112018015552A2 (pt) 2018-12-26
CA3012957A1 (en) 2017-08-03
EP3409679A4 (en) 2019-11-06
JPWO2017131127A1 (ja) 2018-02-01
RU2731615C2 (ru) 2020-09-07
US20190002482A1 (en) 2019-01-03
TWI730039B (zh) 2021-06-11
AU2017211464B2 (en) 2021-07-01
AU2017211464B9 (en) 2021-07-22
WO2017131127A1 (ja) 2017-08-03
ZA201804945B (en) 2019-09-25
MY195906A (en) 2023-02-27
SG11201806125UA (en) 2018-08-30
RU2018130994A (ru) 2020-03-03
CN108473518A (zh) 2018-08-31
EP3409679A1 (en) 2018-12-05
JP6259957B2 (ja) 2018-01-10
TW201728332A (zh) 2017-08-16
KR20180111791A (ko) 2018-10-11
PH12018501586A1 (en) 2019-04-08
CO2018007788A2 (es) 2018-08-10
AR107472A1 (es) 2018-05-02
MX2018009231A (es) 2018-11-09
RU2018130994A3 (zh) 2020-03-13
AU2017211464A1 (en) 2018-08-09

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