HK1255668A1 - 用於治療皮膚病症的包含二吲哚基甲烷和類視黃醇的組合物 - Google Patents
用於治療皮膚病症的包含二吲哚基甲烷和類視黃醇的組合物Info
- Publication number
- HK1255668A1 HK1255668A1 HK18114815.4A HK18114815A HK1255668A1 HK 1255668 A1 HK1255668 A1 HK 1255668A1 HK 18114815 A HK18114815 A HK 18114815A HK 1255668 A1 HK1255668 A1 HK 1255668A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- diindolylmethane
- retinoid
- treat
- composition
- skin condition
- Prior art date
Links
- VFTRKSBEFQDZKX-UHFFFAOYSA-N 3,3'-diindolylmethane Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4NC=3)=CNC2=C1 VFTRKSBEFQDZKX-UHFFFAOYSA-N 0.000 title 1
- TWJAXIHBWPVMIR-UHFFFAOYSA-N diindolylmethane Natural products C1=CC=C2NC(CC=3NC4=CC=CC=C4C=3)=CC2=C1 TWJAXIHBWPVMIR-UHFFFAOYSA-N 0.000 title 1
- 150000004492 retinoid derivatives Chemical class 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1105050.7A GB201105050D0 (en) | 2011-03-25 | 2011-03-25 | Pharmaceutical agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1255668A1 true HK1255668A1 (zh) | 2019-08-23 |
Family
ID=44067371
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16103720.3A HK1215788A1 (zh) | 2011-03-25 | 2016-03-31 | 用於治療皮膚病症的包含二吲哚基甲烷和類視黃醇的組合物 |
| HK18114815.4A HK1255668A1 (zh) | 2011-03-25 | 2018-11-20 | 用於治療皮膚病症的包含二吲哚基甲烷和類視黃醇的組合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16103720.3A HK1215788A1 (zh) | 2011-03-25 | 2016-03-31 | 用於治療皮膚病症的包含二吲哚基甲烷和類視黃醇的組合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US9180117B2 (zh) |
| EP (1) | EP2685970A1 (zh) |
| JP (3) | JP6132360B2 (zh) |
| CN (2) | CN108498803B (zh) |
| AU (2) | AU2012234462B2 (zh) |
| BR (1) | BR112013024606B1 (zh) |
| CA (2) | CA2831185C (zh) |
| GB (2) | GB201105050D0 (zh) |
| HK (2) | HK1215788A1 (zh) |
| RU (1) | RU2619851C2 (zh) |
| WO (1) | WO2012130698A1 (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201105050D0 (en) | 2011-03-25 | 2011-05-11 | Iiaa Ltd | Pharmaceutical agent |
| GB2528482A (en) * | 2014-07-23 | 2016-01-27 | Skintech Life Science Ltd | Pharmaceutical agent |
| US9918965B2 (en) | 2015-04-10 | 2018-03-20 | Bioresponse, L.L.C. | Self-emulsifying formulations of DIM-related indoles |
| WO2017006331A1 (en) * | 2015-07-07 | 2017-01-12 | Ariel Kushmaro | Quorum sensing inhibitors for biofilm inhibition |
| US11331303B2 (en) * | 2016-09-15 | 2022-05-17 | Skintech Life Science Limited | Sublingual or buccal administration of dim for treatment of skin diseases |
| EP3570889A1 (en) | 2017-01-20 | 2019-11-27 | Skintech Life Science Limited | Combination therapy for treatment of skin diseases |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU605772B2 (en) * | 1987-06-12 | 1991-01-24 | Molecular Design International, Inc. | Topical prodrugs for treatment of acne and skin diseases |
| US5962517A (en) * | 1997-01-31 | 1999-10-05 | Murad; Howard | Pharmaceutical compositions and methods for treating acne |
| US7348352B2 (en) | 2001-10-23 | 2008-03-25 | Bioresponse L.L.C. | Diindolylmethane for the treatment of HPV infection |
| WO2003055456A1 (en) * | 2001-12-21 | 2003-07-10 | Rhodia Inc. | Stable surfactant compositions for suspending components |
| CN1463636A (zh) * | 2002-06-27 | 2003-12-31 | 胡佐满 | 多功能蔬菜汁及其制备方法 |
| US20050058600A1 (en) * | 2003-09-16 | 2005-03-17 | Bjeldanes Leonard F. | 3,3'-Diindolylmethane antiandrogenic compositions |
| BRPI0508914A (pt) | 2004-03-17 | 2007-08-14 | Arnold C Takemoto | desintoxicação de tecidos e suplementos para a saúde e processos de obtenção e de utilização dos mesmos |
| WO2006047716A2 (en) | 2004-10-26 | 2006-05-04 | Bioresponse Llc | Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus associated disease |
| EP1838303B1 (en) | 2004-12-30 | 2011-02-09 | Bioresponse LLC | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions |
| IL173971A (en) | 2006-02-27 | 2012-07-31 | Lycored Ltd | Compositions for treating age-related macular degeneration |
| BRPI0717753B1 (pt) * | 2006-10-27 | 2022-04-12 | Bioresponse, Llc | Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição |
| JP4835411B2 (ja) * | 2006-12-01 | 2011-12-14 | 大正製薬株式会社 | アダパレン含有外用剤組成物 |
| US20090068190A1 (en) * | 2007-08-29 | 2009-03-12 | Drugtech Corporation | Anti-proliferative combinations |
| WO2009103754A2 (en) | 2008-02-19 | 2009-08-27 | Dsm Ip Assets B.V. | Novel use of 3,3'-diindolylmethane |
| US20100029765A1 (en) * | 2008-07-30 | 2010-02-04 | Ranbaxy Labortories Limited | Topical aqueous composition comprising tretinoin |
| US9387160B2 (en) * | 2008-12-22 | 2016-07-12 | Johnson & Johnson Consumer Holdings France | Composition and method of treating skin conditions |
| CN101428016B (zh) * | 2008-12-23 | 2011-06-15 | 南京大学 | 二吲哚甲烷及其衍生物在制备治疗类风湿关节炎的药物中的应用 |
| CN102438590B (zh) * | 2009-02-25 | 2013-07-10 | 施泰福研究澳大利亚有限公司 | 局部泡沫组合物 |
| JP5635090B2 (ja) * | 2009-07-16 | 2014-12-03 | スティーフェル ラボラトリーズ インコーポレイテッド | タザロテン誘導体 |
| RU2409363C9 (ru) * | 2009-09-18 | 2013-12-10 | Всеволод Иванович Киселев | Фармацевтические композиции для пероральной доставки дииндолилметана (dim) и способы применения этих композиций |
| RU2419426C1 (ru) | 2010-04-26 | 2011-05-27 | Всеволод Иванович Киселев | Лекарственное средство на основе дииндолилметана (dim) с повышенной биодоступностью и его использование в лечении гиперпластических и воспалительных заболеваний человека |
| CN101884642A (zh) | 2010-07-30 | 2010-11-17 | 哈尔滨乐泰药业有限公司 | 一种治疗痤疮的复方乳膏及其制备方法 |
| GB201105050D0 (en) * | 2011-03-25 | 2011-05-11 | Iiaa Ltd | Pharmaceutical agent |
-
2011
- 2011-03-25 GB GBGB1105050.7A patent/GB201105050D0/en not_active Ceased
-
2012
- 2012-03-21 WO PCT/EP2012/055032 patent/WO2012130698A1/en active Application Filing
- 2012-03-21 CA CA2831185A patent/CA2831185C/en active Active
- 2012-03-21 US US14/007,247 patent/US9180117B2/en active Active
- 2012-03-21 CN CN201810603413.7A patent/CN108498803B/zh active Active
- 2012-03-21 GB GB1316955.2A patent/GB2525835B/en active Active
- 2012-03-21 RU RU2013147651A patent/RU2619851C2/ru active
- 2012-03-21 CA CA3011732A patent/CA3011732C/en active Active
- 2012-03-21 JP JP2014500378A patent/JP6132360B2/ja active Active
- 2012-03-21 EP EP12710503.9A patent/EP2685970A1/en active Pending
- 2012-03-21 CN CN201280022059.XA patent/CN103501772B/zh active Active
- 2012-03-21 AU AU2012234462A patent/AU2012234462B2/en active Active
- 2012-03-21 BR BR112013024606-5A patent/BR112013024606B1/pt active IP Right Grant
-
2015
- 2015-09-24 US US14/864,632 patent/US9351958B2/en active Active
-
2016
- 2016-03-31 HK HK16103720.3A patent/HK1215788A1/zh unknown
- 2016-04-25 US US15/137,481 patent/US9907785B2/en active Active
- 2016-12-15 AU AU2016273929A patent/AU2016273929B2/en active Active
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2017
- 2017-04-12 JP JP2017079230A patent/JP6630310B2/ja active Active
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2018
- 2018-01-26 US US15/881,453 patent/US10500189B2/en active Active
- 2018-11-20 HK HK18114815.4A patent/HK1255668A1/zh unknown
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2019
- 2019-11-14 US US16/684,300 patent/US10966958B2/en active Active
- 2019-12-05 JP JP2019220640A patent/JP6994492B2/ja active Active
-
2021
- 2021-03-08 US US17/195,535 patent/US11911365B2/en active Active
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