HK1255476A1 - 合成奈比洛爾中間體的方法 - Google Patents
合成奈比洛爾中間體的方法Info
- Publication number
- HK1255476A1 HK1255476A1 HK18114650.2A HK18114650A HK1255476A1 HK 1255476 A1 HK1255476 A1 HK 1255476A1 HK 18114650 A HK18114650 A HK 18114650A HK 1255476 A1 HK1255476 A1 HK 1255476A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nebivolol
- intermediates
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUB2016A000227A ITUB20160227A1 (it) | 2016-01-21 | 2016-01-21 | Processo per la sintesi di intermedi di Nebivololo |
| PCT/IB2017/050332 WO2017125900A1 (en) | 2016-01-21 | 2017-01-23 | Process for the synthesis of intermediates of nebivolol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1255476A1 true HK1255476A1 (zh) | 2019-08-16 |
Family
ID=56507764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18114650.2A HK1255476A1 (zh) | 2016-01-21 | 2018-11-15 | 合成奈比洛爾中間體的方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10392361B2 (zh) |
| EP (1) | EP3405467B1 (zh) |
| KR (1) | KR20180101546A (zh) |
| CN (1) | CN108602808B (zh) |
| AR (1) | AR107402A1 (zh) |
| AU (1) | AU2017210249B2 (zh) |
| CY (1) | CY1124686T1 (zh) |
| DK (1) | DK3405467T3 (zh) |
| EA (1) | EA036157B1 (zh) |
| ES (1) | ES2891549T3 (zh) |
| HK (1) | HK1255476A1 (zh) |
| HR (1) | HRP20211636T1 (zh) |
| HU (1) | HUE056979T2 (zh) |
| IL (1) | IL260661B (zh) |
| IT (1) | ITUB20160227A1 (zh) |
| JO (1) | JOP20170012B1 (zh) |
| LT (1) | LT3405467T (zh) |
| PL (1) | PL3405467T3 (zh) |
| PT (1) | PT3405467T (zh) |
| RS (1) | RS62461B1 (zh) |
| SG (1) | SG11201806250QA (zh) |
| SI (1) | SI3405467T1 (zh) |
| TW (1) | TWI722099B (zh) |
| WO (1) | WO2017125900A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110082451B (zh) * | 2019-05-23 | 2021-12-24 | 南京趣酶生物科技有限公司 | 一种2-氯-1-(6-氟-色满-2-)乙醇手性醇中间体制备过程的sfc检测方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337432C (en) | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| JP3665343B2 (ja) * | 1995-02-03 | 2005-06-29 | 株式会社カネカ | α−ハロケトン、α−ハロヒドリン及びエポキシドの製造法 |
| CA2362070A1 (en) * | 1999-02-16 | 2000-08-24 | Masaru Mitsuda | Substituted acetylpyridine derivatives and process for the preparation of intermediates for optically active .beta.3 agonist by the use of the same |
| US7560575B2 (en) | 2005-12-28 | 2009-07-14 | Acino Pharma Ag | Process for preparation of racemic Nebivolol |
| ITMI20061889A1 (it) * | 2006-10-03 | 2008-04-04 | Zambon Spa | Processo di preparazione di nebivololo |
| SI2102196T1 (sl) | 2006-11-27 | 2012-12-31 | Zach System S.P.A. | Postopek za pripravo nebivolola |
| CN102164906A (zh) * | 2008-09-24 | 2011-08-24 | Zach系统股份公司 | 用于制备奈必洛尔的方法 |
| DE102010005953A1 (de) | 2010-01-27 | 2011-07-28 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Nebivolol |
| IT1397962B1 (it) * | 2010-02-11 | 2013-02-04 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
| CN102190647A (zh) * | 2010-03-12 | 2011-09-21 | 浙江海翔药业股份有限公司 | 一种奈比洛尔的中间体的制备方法 |
| IT1402974B1 (it) * | 2010-11-30 | 2013-09-27 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
-
2016
- 2016-01-21 IT ITUB2016A000227A patent/ITUB20160227A1/it unknown
-
2017
- 2017-01-19 JO JOP/2017/0012A patent/JOP20170012B1/ar active
- 2017-01-20 TW TW106102131A patent/TWI722099B/zh active
- 2017-01-20 AR ARP170100154A patent/AR107402A1/es unknown
- 2017-01-23 WO PCT/IB2017/050332 patent/WO2017125900A1/en active Application Filing
- 2017-01-23 RS RS20211165A patent/RS62461B1/sr unknown
- 2017-01-23 ES ES17702954T patent/ES2891549T3/es active Active
- 2017-01-23 CN CN201780007784.2A patent/CN108602808B/zh active Active
- 2017-01-23 EP EP17702954.3A patent/EP3405467B1/en active Active
- 2017-01-23 DK DK17702954.3T patent/DK3405467T3/da active
- 2017-01-23 US US16/071,741 patent/US10392361B2/en active Active
- 2017-01-23 PL PL17702954T patent/PL3405467T3/pl unknown
- 2017-01-23 HR HRP20211636TT patent/HRP20211636T1/hr unknown
- 2017-01-23 SG SG11201806250QA patent/SG11201806250QA/en unknown
- 2017-01-23 AU AU2017210249A patent/AU2017210249B2/en active Active
- 2017-01-23 KR KR1020187023497A patent/KR20180101546A/ko not_active Application Discontinuation
- 2017-01-23 PT PT17702954T patent/PT3405467T/pt unknown
- 2017-01-23 SI SI201730948T patent/SI3405467T1/sl unknown
- 2017-01-23 EA EA201891456A patent/EA036157B1/ru unknown
- 2017-01-23 HU HUE17702954A patent/HUE056979T2/hu unknown
- 2017-01-23 LT LTEPPCT/IB2017/050332T patent/LT3405467T/lt unknown
-
2018
- 2018-07-19 IL IL260661A patent/IL260661B/en active IP Right Grant
- 2018-11-15 HK HK18114650.2A patent/HK1255476A1/zh unknown
-
2021
- 2021-11-03 CY CY20211100946T patent/CY1124686T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017125900A1 (en) | 2017-07-27 |
| KR20180101546A (ko) | 2018-09-12 |
| DK3405467T3 (da) | 2021-10-04 |
| US10392361B2 (en) | 2019-08-27 |
| AR107402A1 (es) | 2018-04-25 |
| LT3405467T (lt) | 2021-11-10 |
| AU2017210249A1 (en) | 2018-08-09 |
| HUE056979T2 (hu) | 2022-04-28 |
| SG11201806250QA (en) | 2018-08-30 |
| EP3405467A1 (en) | 2018-11-28 |
| ITUB20160227A1 (it) | 2017-07-21 |
| AU2017210249B2 (en) | 2020-06-18 |
| US20190031636A1 (en) | 2019-01-31 |
| TW201730173A (zh) | 2017-09-01 |
| CN108602808A (zh) | 2018-09-28 |
| RS62461B1 (sr) | 2021-11-30 |
| ES2891549T3 (es) | 2022-01-28 |
| EA201891456A1 (ru) | 2019-01-31 |
| TWI722099B (zh) | 2021-03-21 |
| IL260661B (en) | 2021-01-31 |
| EP3405467B1 (en) | 2021-08-04 |
| CY1124686T1 (el) | 2022-07-22 |
| PL3405467T3 (pl) | 2022-01-24 |
| SI3405467T1 (sl) | 2022-01-31 |
| CN108602808B (zh) | 2021-11-02 |
| HRP20211636T1 (hr) | 2022-02-04 |
| PT3405467T (pt) | 2021-10-07 |
| JOP20170012B1 (ar) | 2021-08-17 |
| EA036157B1 (ru) | 2020-10-07 |
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