SG11201806250QA - Process for the synthesis of intermediates of nebivolol - Google Patents
Process for the synthesis of intermediates of nebivololInfo
- Publication number
- SG11201806250QA SG11201806250QA SG11201806250QA SG11201806250QA SG11201806250QA SG 11201806250Q A SG11201806250Q A SG 11201806250QA SG 11201806250Q A SG11201806250Q A SG 11201806250QA SG 11201806250Q A SG11201806250Q A SG 11201806250QA SG 11201806250Q A SG11201806250Q A SG 11201806250QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- vettola
- livornese
- laboratori
- guidotti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Silicon Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization MD 1111101110101011111 HO 1111101110111011111011110111011011111011 III International Bureau ... ..1 j (10) International Publication Number (43) International Publication Date ..... ....r;,' WO 2017/125900 Al 27 July 2017 (27.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 407/04 (2006.01) C07D 311/58 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/IB2017/050332 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: 23 January 2017 (23.01.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 102016000005775 21 January 2016 (21.01.2016) IT (84) Designated States (unless otherwise indicated, for every (71) Applicant: MENARINI INTERNATIONAL OPERA- TIONS LUXEMBOURG S.A. [LU/LU]; 1, Avenue de la Gare, L-1611 Luxembourg (LU). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: BARTOLI, Sandra; c/o Laboratori Guidotti S.p.A., Via Livornese 897, La Vettola, 56122 Pisa (IT). MANNUCCI, Serena; c/o Laboratori Guidotti S.p.A., Via Livornese 897, La Vettola, 56122 Pisa (IT). GRISELLI, Alessio; c/o Laboratori Guidotti S.p.A., Via Livornese 897, La Vettola, 56122 Pisa (IT). STEFANINI, Alessio; c/o TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: Laboratori Guidotti S.p.A., Via Livornese 897, La Vettola, 56122 Pisa (IT). with international search report (Art. 21(3)) Agents: GERMINARIO, Claudio et al.; c/o Societa' Itali- ana Brevetti S.p.A., Piazza di Pietra, 39, 00186 Rome (IT). (74) Title: PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBWOLOL (54) 0 0 OA} / ott:, / 0 • . ,K\" Il k k , . ...,.. f . P. OW Oio; gAlj © © tz. kin el i 0: 11 t• IN 1-1 (57) : The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chro - O manyl haloketones of formula III and 6-fluoro-2-(oxiran-2-y1) chromans of formula I. The intermediates thus obtained can be used \" for the synthesis of Nebivolol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUB2016A000227A ITUB20160227A1 (en) | 2016-01-21 | 2016-01-21 | Process for the synthesis of Nebivolol intermediates |
| PCT/IB2017/050332 WO2017125900A1 (en) | 2016-01-21 | 2017-01-23 | Process for the synthesis of intermediates of nebivolol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201806250QA true SG11201806250QA (en) | 2018-08-30 |
Family
ID=56507764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201806250QA SG11201806250QA (en) | 2016-01-21 | 2017-01-23 | Process for the synthesis of intermediates of nebivolol |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10392361B2 (en) |
| EP (1) | EP3405467B1 (en) |
| KR (1) | KR102669221B1 (en) |
| CN (1) | CN108602808B (en) |
| AR (1) | AR107402A1 (en) |
| AU (1) | AU2017210249B2 (en) |
| CY (1) | CY1124686T1 (en) |
| DK (1) | DK3405467T3 (en) |
| EA (1) | EA036157B1 (en) |
| ES (1) | ES2891549T3 (en) |
| HK (1) | HK1255476A1 (en) |
| HR (1) | HRP20211636T1 (en) |
| HU (1) | HUE056979T2 (en) |
| IL (1) | IL260661B (en) |
| IT (1) | ITUB20160227A1 (en) |
| JO (1) | JOP20170012B1 (en) |
| LT (1) | LT3405467T (en) |
| PL (1) | PL3405467T3 (en) |
| PT (1) | PT3405467T (en) |
| RS (1) | RS62461B1 (en) |
| SG (1) | SG11201806250QA (en) |
| SI (1) | SI3405467T1 (en) |
| TW (1) | TWI722099B (en) |
| WO (1) | WO2017125900A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110082451B (en) * | 2019-05-23 | 2021-12-24 | 南京趣酶生物科技有限公司 | SFC detection method for preparation process of 2-chloro-1- (6-fluoro-chroman-2-) ethanol chiral alcohol intermediate |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337432C (en) | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| CN1091088C (en) * | 1995-02-03 | 2002-09-18 | 钟渊化学工业株式会社 | Processes for producing 'alpha'-halo ketones, 'alpha'-halohydrine and epoxides |
| HUP0200092A3 (en) * | 1999-02-16 | 2003-02-28 | Kaneka Corp | Substituted acetylpyridine derivatives and process for the preparation of intermediates for optically active betha-3 agonist by the use of the same |
| US7560575B2 (en) * | 2005-12-28 | 2009-07-14 | Acino Pharma Ag | Process for preparation of racemic Nebivolol |
| ITMI20061889A1 (en) * | 2006-10-03 | 2008-04-04 | Zambon Spa | NEBIVOLOL PREPARATION PROCESS |
| PL2102196T3 (en) | 2006-11-27 | 2012-12-31 | Zach System Spa | Process for preparing nebivolol |
| CN102164906A (en) * | 2008-09-24 | 2011-08-24 | Zach系统股份公司 | Method for preparing nebivolol |
| DE102010005953A1 (en) | 2010-01-27 | 2011-07-28 | Corden PharmaChem GmbH, 68305 | Process for the preparation of nebivolol |
| IT1397962B1 (en) * | 2010-02-11 | 2013-02-04 | Menarini Int Operations Lu Sa | PROCESS FOR NEBIVOLOL PREPARATION. |
| CN102190647A (en) * | 2010-03-12 | 2011-09-21 | 浙江海翔药业股份有限公司 | Preparation method of nebivolol intermediate |
| IT1402974B1 (en) * | 2010-11-30 | 2013-09-27 | Menarini Int Operations Lu Sa | PROCESS FOR NEBIVOLOL PREPARATION. |
-
2016
- 2016-01-21 IT ITUB2016A000227A patent/ITUB20160227A1/en unknown
-
2017
- 2017-01-19 JO JOP/2017/0012A patent/JOP20170012B1/en active
- 2017-01-20 AR ARP170100154A patent/AR107402A1/en unknown
- 2017-01-20 TW TW106102131A patent/TWI722099B/en active
- 2017-01-23 RS RS20211165A patent/RS62461B1/en unknown
- 2017-01-23 ES ES17702954T patent/ES2891549T3/en active Active
- 2017-01-23 US US16/071,741 patent/US10392361B2/en active Active
- 2017-01-23 CN CN201780007784.2A patent/CN108602808B/en active Active
- 2017-01-23 WO PCT/IB2017/050332 patent/WO2017125900A1/en active Application Filing
- 2017-01-23 LT LTEPPCT/IB2017/050332T patent/LT3405467T/en unknown
- 2017-01-23 HU HUE17702954A patent/HUE056979T2/en unknown
- 2017-01-23 PL PL17702954T patent/PL3405467T3/en unknown
- 2017-01-23 PT PT17702954T patent/PT3405467T/en unknown
- 2017-01-23 SI SI201730948T patent/SI3405467T1/en unknown
- 2017-01-23 EP EP17702954.3A patent/EP3405467B1/en active Active
- 2017-01-23 KR KR1020187023497A patent/KR102669221B1/en active IP Right Grant
- 2017-01-23 SG SG11201806250QA patent/SG11201806250QA/en unknown
- 2017-01-23 DK DK17702954.3T patent/DK3405467T3/en active
- 2017-01-23 EA EA201891456A patent/EA036157B1/en unknown
- 2017-01-23 HR HRP20211636TT patent/HRP20211636T1/en unknown
- 2017-01-23 AU AU2017210249A patent/AU2017210249B2/en active Active
-
2018
- 2018-07-19 IL IL260661A patent/IL260661B/en active IP Right Grant
- 2018-11-15 HK HK18114650.2A patent/HK1255476A1/en unknown
-
2021
- 2021-11-03 CY CY20211100946T patent/CY1124686T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE056979T2 (en) | 2022-04-28 |
| EP3405467A1 (en) | 2018-11-28 |
| WO2017125900A1 (en) | 2017-07-27 |
| TWI722099B (en) | 2021-03-21 |
| CN108602808A (en) | 2018-09-28 |
| LT3405467T (en) | 2021-11-10 |
| DK3405467T3 (en) | 2021-10-04 |
| EA036157B1 (en) | 2020-10-07 |
| AR107402A1 (en) | 2018-04-25 |
| KR20180101546A (en) | 2018-09-12 |
| TW201730173A (en) | 2017-09-01 |
| CN108602808B (en) | 2021-11-02 |
| SI3405467T1 (en) | 2022-01-31 |
| PL3405467T3 (en) | 2022-01-24 |
| ES2891549T3 (en) | 2022-01-28 |
| HRP20211636T1 (en) | 2022-02-04 |
| KR102669221B1 (en) | 2024-05-24 |
| EP3405467B1 (en) | 2021-08-04 |
| PT3405467T (en) | 2021-10-07 |
| US10392361B2 (en) | 2019-08-27 |
| JOP20170012B1 (en) | 2021-08-17 |
| CY1124686T1 (en) | 2022-07-22 |
| AU2017210249A1 (en) | 2018-08-09 |
| RS62461B1 (en) | 2021-11-30 |
| AU2017210249B2 (en) | 2020-06-18 |
| HK1255476A1 (en) | 2019-08-16 |
| ITUB20160227A1 (en) | 2017-07-21 |
| US20190031636A1 (en) | 2019-01-31 |
| IL260661B (en) | 2021-01-31 |
| EA201891456A1 (en) | 2019-01-31 |
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