HK1252674A1 - 在肺癌診斷中的mirna指紋 - Google Patents

在肺癌診斷中的mirna指紋

Info

Publication number
HK1252674A1
HK1252674A1 HK18111981.8A HK18111981A HK1252674A1 HK 1252674 A1 HK1252674 A1 HK 1252674A1 HK 18111981 A HK18111981 A HK 18111981A HK 1252674 A1 HK1252674 A1 HK 1252674A1
Authority
HK
Hong Kong
Prior art keywords
diagnosis
lung cancer
mirna fingerprint
mirna
fingerprint
Prior art date
Application number
HK18111981.8A
Other languages
English (en)
Inventor
Andreas Keller
Eckart Meese
Anne Borries
Markus Beier
Original Assignee
Hummingbird Diagnostics Gmbh
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Publication date
Application filed by Hummingbird Diagnostics Gmbh filed Critical Hummingbird Diagnostics Gmbh
Publication of HK1252674A1 publication Critical patent/HK1252674A1/zh

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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
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    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30Unsupervised data analysis
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK18111981.8A 2009-06-05 2018-09-18 在肺癌診斷中的mirna指紋 HK1252674A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18445209P 2009-06-05 2009-06-05
US21397109P 2009-08-03 2009-08-03
US28752109P 2009-12-17 2009-12-17
EP09015668A EP2336353A1 (en) 2009-12-17 2009-12-17 miRNA fingerprints in the diagnosis of diseases

Publications (1)

Publication Number Publication Date
HK1252674A1 true HK1252674A1 (zh) 2019-05-31

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HK18111981.8A HK1252674A1 (zh) 2009-06-05 2018-09-18 在肺癌診斷中的mirna指紋

Country Status (10)

Country Link
US (7) US9187785B2 (zh)
EP (9) EP2336353A1 (zh)
DK (1) DK2883966T3 (zh)
ES (1) ES2642395T3 (zh)
HK (1) HK1252674A1 (zh)
HU (1) HUE035009T2 (zh)
NO (1) NO2883966T3 (zh)
PL (1) PL2883966T3 (zh)
PT (1) PT2883966T (zh)
WO (3) WO2010139812A1 (zh)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008147974A1 (en) 2007-05-23 2008-12-04 University Of South Florida Micro-rnas modulating immunity and inflammation
US20100233704A1 (en) * 2009-02-25 2010-09-16 Cepheid Methods of detecting lung cancer
EP2422298A4 (en) * 2009-04-24 2014-09-03 Virkar Hemant METHOD FOR DATA MAPPING IN SMALLER DIMENSIONS
EP2336353A1 (en) * 2009-12-17 2011-06-22 febit holding GmbH miRNA fingerprints in the diagnosis of diseases
WO2011076144A1 (en) * 2009-12-24 2011-06-30 Fudan University Compositions and methods for microrna expession profiling in plasma of lung cancer
US20120015830A1 (en) * 2010-06-21 2012-01-19 Diogenix, Inc. Microrna profiles for evaluating multiple sclerosis
CN103168235B (zh) 2010-07-16 2016-01-13 阿姆斯特丹自由大学及阿姆斯特丹自由大学医疗中心基金会 用于分析受试者血样中疾病标记物的存在的方法
US20120107825A1 (en) * 2010-11-01 2012-05-03 Winger Edward E Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna
US20130310276A1 (en) * 2010-12-22 2013-11-21 Ruprecht-Karls University of Heidelberg Microrna for diagnosis of pancreatic cancer
CN102127548A (zh) * 2010-12-28 2011-07-20 浙江大学 单链非编码MicroRNA二及其用途
EP2505663A1 (en) * 2011-03-30 2012-10-03 IFOM Fondazione Istituto Firc di Oncologia Molecolare A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids
US20120244530A1 (en) 2011-01-26 2012-09-27 Cepheid Methods of detecting lung cancer
US20120214682A1 (en) * 2011-01-28 2012-08-23 Bigwood Douglas W Microrna signatures indicative of immunomodulating therapy for multiple sclerosis
US20130331290A1 (en) * 2011-01-28 2013-12-12 Febit Holding Gmbh Complex mirna sets as novel biomarkers for lung diseases
CN102643812B (zh) * 2011-02-18 2016-02-10 中国科学院上海药物研究所 人miR-1227的反义寡聚核苷酸及其应用
JP5934726B2 (ja) * 2011-03-18 2016-06-15 フェレニヒング フォール クリステリック ホーヘル オンデルウィス,ウェテンシャペリク オンデルツォーケン パティエンテンツォルフ 疾患マーカーの存在を被験者の血液サンプルで分析する方法
WO2012135091A2 (en) * 2011-03-28 2012-10-04 The Johns Hopkins University Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac)
WO2012161124A1 (ja) * 2011-05-20 2012-11-29 国立大学法人愛媛大学 マイクロrna又はその発現系を含む組成物
EP2718463B1 (en) * 2011-06-08 2016-01-20 Comprehensive Biomarker Center GmbH Complex sets of mirnas as non-invasive biomarkers for dilated cardiomyopathy
CN102851282B (zh) * 2011-06-30 2014-10-08 上海市肿瘤研究所 用于区分原发性肺癌与癌旁组织的microRNA标志物
CN102250904B (zh) * 2011-07-13 2013-11-13 中国科学技术大学 一种预防和/或治疗黑色素瘤的药物
DE102011108254A1 (de) * 2011-07-22 2013-01-24 RUHR-UNIVERSITäT BOCHUM Pantumormarker
US20130059753A1 (en) * 2011-09-01 2013-03-07 Holy and Undivided Trinity of Queen Elizabeth, near Dublin Global Analysis of Serum microRNAs as Potential Biomarkers for Lung Adenocarcinoma
EP2578696A1 (en) * 2011-10-06 2013-04-10 febit holding GmbH MiRNAs as non-invasive biomarkers for diagnosis
GB2536374B (en) * 2011-10-19 2016-10-26 Council Scient Ind Res Biomarkers useful for detection of types, grades and stages of human breast cancer
NO3051026T3 (zh) * 2011-10-21 2018-07-28
US9745578B2 (en) 2011-11-30 2017-08-29 Cedars-Sinai Medical Center Targeting microRNA miR-409-3P to treat prostate cancer
CA2799163A1 (en) 2011-12-18 2013-06-18 20/20 Genesystems, Inc. Methods and algorithms for aiding in the detection of cancer
US9447471B2 (en) 2011-12-29 2016-09-20 Quest Diagnostics Investments Incorporated Microrna profiling for diagnosis of dysplastic nevi and melanoma
WO2013106766A2 (en) * 2012-01-13 2013-07-18 The Research Foundation Of State University Of New York THERAPEUTIC INDICATIONS OF miR-1291
WO2013104131A1 (zh) * 2012-01-13 2013-07-18 北京命码生科科技有限公司 microRNA标准化的内参基因及其用途
EP3360977A3 (en) * 2012-03-07 2018-10-10 Hummingbird Diagnostics GmbH Mi-rna based treatment monitoring in multiple sclerosis
WO2013131567A1 (en) * 2012-03-07 2013-09-12 Febit Holding Gmbh Mirna based treatment monitoring in multiple sclerosis
WO2013155980A1 (zh) * 2012-04-19 2013-10-24 中国科学院上海生命科学研究院 自身免疫性疾病相关的microRNA及其应用
EP2657348B1 (en) * 2012-04-27 2017-11-15 Siemens Aktiengesellschaft Diagnostic miRNA profiles in multiple sclerosis
US8846316B2 (en) 2012-04-30 2014-09-30 Industrial Technology Research Institute Biomarker for human liver cancer
US20150126621A1 (en) * 2012-05-15 2015-05-07 New York University METHOD FOR PREDICTING RECURRENCE OF MELANOMA USING miRNA ALTERATIONS
CN102676526B (zh) * 2012-05-16 2013-05-29 北京旷博生物技术有限公司 乳腺癌分子标志物miR-30c-1-3p
DK2687607T3 (en) 2012-07-19 2015-04-07 St Josef Und St Elisabeth Hospital Gmbh MicroRNA-profiles in the diagnosis of multiple sclerosis
US20150232939A1 (en) * 2012-10-26 2015-08-20 Gabriella Sozzi Micro-rna biomarkers for haemolysis and methods of using same
CN103045597B (zh) * 2013-01-11 2014-06-11 南京大学 微小核苷酸hsa-miR-1909及其应用
CN103305602A (zh) * 2013-03-08 2013-09-18 深圳市人民医院 一种基于液相芯片检测痰液microRNAs用于早期肺癌诊断的方法
KR20150069375A (ko) * 2013-12-13 2015-06-23 연세대학교 산학협력단 줄기세포로부터 연골세포로의 분화 촉진용 조성물
EP3760741A1 (en) * 2013-12-19 2021-01-06 Hummingbird Diagnostics GmbH Mirnas as non-invasive biomarkers for parkinson's disease
ES2936812T3 (es) * 2013-12-20 2023-03-22 Acetylon Pharmaceuticals Inc Biomarcadores de histona desacetilasa 6 (HDAC6) en mieloma múltiple
PL406989A1 (pl) 2014-01-29 2015-08-03 Gdański Uniwersytet Medyczny Profil mikro RNA we krwi jako test wykrywania raka płuca
RU2017101354A (ru) * 2014-06-18 2018-07-18 Торэй Индастриз, Инк. Набор или устройство для обнаружения рака легкого и способ обнаружения
WO2016094330A2 (en) * 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
JP6974182B2 (ja) * 2015-03-04 2021-12-01 ハミングバード・ダイアグノスティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングHummingbird Diagnostics GmbH 健康のサイン
PL411561A1 (pl) 2015-03-13 2016-09-26 Gdański Uniwersytet Medyczny Profil mikroRNA skojarzony z profilem markerów białkowych krwi jako test wykrywania raka płuca
CN104789683B (zh) * 2015-05-01 2018-08-28 北京博奥医学检验所有限公司 用于诊治癌转移的生物标志物及其用途
EP3292213A1 (en) 2015-05-04 2018-03-14 Academisch Medisch Centrum Biomarkers for the detection of aspirin insensitivity
KR102552776B1 (ko) * 2015-11-30 2023-07-10 (주)아모레퍼시픽 miRNA를 포함하는 흑색종 전이 억제용 조성물
EP3184645A1 (de) 2015-12-22 2017-06-28 Siemens Healthcare GmbH Diagnostische mirna signaturen in ms und cis patienten
JPWO2017110687A1 (ja) * 2015-12-24 2018-10-18 公益財団法人がん研究会 miRNAにより肺癌の原因を特定する方法、マーカー、検出キット、及び治療薬をスクリーニングするための方法
US20190112668A1 (en) * 2016-04-01 2019-04-18 Toray Industries, Inc. Kit or device for detecting malignant brain tumor and method for detecting same
US20210095342A1 (en) * 2016-05-09 2021-04-01 The Children's Hospital Of Philadelphia Functional targets of mir-6891-5p & applications thereof
WO2018041726A1 (en) 2016-08-27 2018-03-08 Academisch Medisch Centrum Biomarkers for determining the presence of an unstable atherosclerotic plaque
KR101721811B1 (ko) * 2016-12-28 2017-03-30 경북대학교 산학협력단 microRNA-30b, microRNA-133a 또는 microRNA-202-5p의 억제제를 포함하는 항암용 약학적 조성물
US10733214B2 (en) 2017-03-20 2020-08-04 International Business Machines Corporation Analyzing metagenomics data
US11535895B2 (en) 2017-04-06 2022-12-27 University Of Maryland, Baltimore Methods of detecting lung cancer
KR20200019849A (ko) 2017-06-29 2020-02-25 도레이 카부시키가이샤 폐암의 검출을 위한 키트, 디바이스 및 방법
WO2019000017A1 (en) * 2017-06-29 2019-01-03 The University Of Sydney INTRACELLULAR MICRO-RNA SIGNATURES OF INSULIN-PRODUCING CELLS
US20200239967A1 (en) * 2017-10-03 2020-07-30 Geneseq Pty. Ltd. Method of diagnosis, staging and monitoring of melanoma using microrna gene expression
CN109706146B (zh) * 2017-10-25 2023-06-06 上海翔琼生物技术有限公司 小rna组成的指纹图谱在人的癌性胸腔积液诊断和治疗中的应用
CN109288361B (zh) * 2018-10-10 2020-05-12 童小鸾 一种服装机械用的衣架
CN109207599A (zh) * 2018-11-12 2019-01-15 觅瑞(杭州)生物科技有限公司 一种用于非小细胞肺癌诊断的外周血miRNA标志物
CN109224076B (zh) * 2018-11-14 2021-11-19 苏州吉玛基因股份有限公司 与肺癌诊疗相关的基因miR-140-3P及其mimics和应用
CN111197070A (zh) * 2018-11-16 2020-05-26 南京迈西可生物科技有限公司 鉴定rna分子中2`-o-甲基化修饰的方法及其应用
US11948684B2 (en) * 2019-06-20 2024-04-02 Latha Chakravarthy Diagnostic process for disease detection using gene expression based multi layer PCA classifier
EP4257982A3 (en) * 2019-08-26 2024-03-06 Liquid Lung DX Biomarkers for the diagnosis of lung cancers
JP7473941B2 (ja) * 2019-11-07 2024-04-24 学校法人産業医科大学 中皮腫の診断補助方法及び診断用キット
KR102288359B1 (ko) * 2019-12-06 2021-08-10 주식회사 레피겐엠디 면역력 감소에 의한 질병의 발병 위험 예측용 다중 유전자 마커 및 이를 이용한 질병의 발병 위험 예측 방법
EP3862441A3 (en) * 2020-02-04 2021-10-27 Artemisia S.p.A. Method for the early diagnosis of cancer by means of ddpcr analysis of mirna and protein markers in liquid biopsy
EP3862442A3 (en) * 2020-02-04 2021-10-27 Artemisia S.p.A. Method for the early diagnosis of cancer by means of ddpcr analysis of mirna in liquid biopsy
CN112501295B (zh) * 2020-12-01 2023-03-31 上海米然生物科技有限公司 miRNA组合、含其的试剂盒及在肺癌诊断中的应用
CN111793692A (zh) * 2020-08-04 2020-10-20 中国科学院昆明动物研究所 一种特征miRNA表达谱组合及肺鳞癌早期预测方法
US20220073992A1 (en) * 2020-11-24 2022-03-10 Hossein Abdul Tehrani Abdul Tehrani Diagnosis of chronic kidney disease (ckd) and its subgroups
RU2755651C1 (ru) * 2020-12-21 2021-09-17 федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ им. ак. Е.Н. Мешалкина» Минздрава России) Аналитическая система для диагностики рака лёгкого при помощи свободных и ассоциированных с клетками крови циркулирующих микроРНК
EP4355882A2 (en) * 2021-06-15 2024-04-24 Modernatx, Inc. Engineered polynucleotides for cell-type or microenvironment-specific expression
WO2024002599A1 (en) * 2022-06-28 2024-01-04 Hummingbird Diagnostics Gmbh Novel signatures for lung cancer detection
WO2024009221A1 (en) * 2022-07-04 2024-01-11 Artificial Intelligence Expert Srl Method and system for multi-cancer management in subject
CN115820858B (zh) * 2022-11-18 2023-06-20 昆明医科大学第一附属医院 一种血清在制备云南宣威肺癌诊断药物中的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020168640A1 (en) * 2001-02-22 2002-11-14 Min Li Biochips comprising nucleic acid/protein conjugates
US20030186248A1 (en) * 2002-03-29 2003-10-02 Erlander Mark G. Interpreting cytological specimens via molecular histological signatures
EP2322650A1 (en) * 2004-05-14 2011-05-18 Rosetta Genomics Ltd MicroRNAs and uses thereof
EP2290069A3 (en) 2004-05-28 2011-08-10 Asuragen, Inc. Methods and compositions involving microRNA
US20060019258A1 (en) * 2004-07-20 2006-01-26 Illumina, Inc. Methods and compositions for detection of small interfering RNA and micro-RNA
ES2536438T3 (es) * 2006-01-05 2015-05-25 The Ohio State University Research Foundation Métodos y composiciones basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón
AU2007299748A1 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention
CA2669600A1 (en) * 2006-11-13 2008-05-29 Source Precision Medicine, Inc. D/B/A Source Mdx Gene expression profiling for identification, monitoring, and treatment of lung cancer
US20120064520A1 (en) 2007-03-01 2012-03-15 Ranit Aharonov Diagnosis and prognosis of various types of cancers
US20100178653A1 (en) 2007-03-27 2010-07-15 Rosetta Genomics Ltd. Gene expression signature for classification of cancers
EP2188395A4 (en) 2007-08-17 2010-10-13 Catalyst Assets Llc USE OF MICRO-RNA ASSOCIATED WITH CANCER OF THE HUMAN BLADDER FOR DIAGNOSIS AND PROGNOSIS
WO2009033185A1 (en) * 2007-09-06 2009-03-12 University Of Massachusetts Virus-specific mirna signatures for diagnosis and therapeutic treatment of viral infection
EP3112464A1 (en) * 2007-09-14 2017-01-04 The Ohio State University Research Foundation Mirna expression in human peripheral blood microvesicles and uses thereof
WO2009036332A1 (en) * 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
CA2700215A1 (en) 2007-10-31 2009-05-07 Rosetta Genomics Ltd. Diagnosis and prognosis of specific cancers
CN101424640B (zh) 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
AU2008329755A1 (en) * 2007-11-30 2009-06-04 The Ohio State University Research Foundation MicroRNA expression profiling and targeting in peripheral blood in lung cancer
WO2009099905A2 (en) 2008-02-01 2009-08-13 Memorial Health Inc. Molecular signatures and biomarkers associated with melanoma and methods of use thereof
CA2717030A1 (en) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna signatures associated with cytogenetics and prognosis in acute myeloid leukemia (aml) and uses thereof
US20110160290A1 (en) * 2008-05-21 2011-06-30 Muneesh Tewari Use of extracellular rna to measure disease
US20110107440A1 (en) 2008-06-04 2011-05-05 Andor Pivarcsi Skin cancer associated micrornas
WO2010054233A1 (en) * 2008-11-08 2010-05-14 The Wistar Institute Of Anatomy And Biology Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers
CN101475984A (zh) 2008-12-15 2009-07-08 江苏命码生物科技有限公司 一种非小细胞肺癌检测标记物及其检测方法、相关生物芯片和试剂盒
EP2336353A1 (en) * 2009-12-17 2011-06-22 febit holding GmbH miRNA fingerprints in the diagnosis of diseases

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