EP2321641A4 - Gene methylation in cancer diagnosis - Google Patents

Gene methylation in cancer diagnosis

Info

Publication number
EP2321641A4
EP2321641A4 EP09805602A EP09805602A EP2321641A4 EP 2321641 A4 EP2321641 A4 EP 2321641A4 EP 09805602 A EP09805602 A EP 09805602A EP 09805602 A EP09805602 A EP 09805602A EP 2321641 A4 EP2321641 A4 EP 2321641A4
Authority
EP
European Patent Office
Prior art keywords
cancer diagnosis
gene methylation
methylation
gene
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09805602A
Other languages
German (de)
French (fr)
Other versions
EP2321641A2 (en
Inventor
Arief Budiman
Rebecca Maloney
Yulia Korshunova
Jared Ordway
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Genomics LLC
Original Assignee
Orion Genomics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Genomics LLC filed Critical Orion Genomics LLC
Publication of EP2321641A2 publication Critical patent/EP2321641A2/en
Publication of EP2321641A4 publication Critical patent/EP2321641A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP09805602A 2008-08-08 2009-08-07 Gene methylation in cancer diagnosis Withdrawn EP2321641A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8753008P 2008-08-08 2008-08-08
PCT/US2009/053122 WO2010017461A2 (en) 2008-08-08 2009-08-07 Gene methylation in cancer diagnosis

Publications (2)

Publication Number Publication Date
EP2321641A2 EP2321641A2 (en) 2011-05-18
EP2321641A4 true EP2321641A4 (en) 2012-03-21

Family

ID=41664214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09805602A Withdrawn EP2321641A4 (en) 2008-08-08 2009-08-07 Gene methylation in cancer diagnosis

Country Status (5)

Country Link
US (1) US20110217706A1 (en)
EP (1) EP2321641A4 (en)
AU (1) AU2009279464A1 (en)
CA (1) CA2733565A1 (en)
WO (1) WO2010017461A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274767A1 (en) 2013-01-23 2014-09-18 The Johns Hopkins University Dna methylation markers for metastatic prostate cancer
CN110055330B (en) * 2019-04-30 2022-10-11 上海奕谱生物科技有限公司 Tumor marker STAMP-EP9 based on methylation modification and application thereof
CN114829631A (en) * 2019-10-14 2022-07-29 建喾立嗣股份公司 Composition for diagnosing liver cancer by using CPG methylation change in specific gene and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050233340A1 (en) 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for assessing CpG methylation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HOLEMON H ET AL.: "MethylScreen: DNA methylation density monitoring using quantitative PCR", BIOTECHNIQUES, vol. 43, no. 5, 2007, pages 683 - 693, XP002667851 *
LASKO ET AL: "The use of receiver operating characteristic curves in biomedical informatics", JOURNAL OF BIOMEDICAL INFORMATICS, ACADEMIC PRESS, NEW YORK, NY, US, vol. 38, no. 5, 1 October 2005 (2005-10-01), pages 404 - 415, XP005101005, ISSN: 1532-0464, DOI: 10.1016/J.JBI.2005.02.008 *
ORDWAY J M ET AL.: "Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets", CARCINOGENESIS, vol. 27, no. 12, 4 September 2006 (2006-09-04), pages 2409 - 2423, XP002667849 *
ORDWAY JARED M ET AL.: "Genome wide DNA methylation scanning reveals novel and powerful biomarkers for breast cancer", 14 April 2007 (2007-04-14), XP002667850, Retrieved from the Internet <URL:http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={F73AEFD5-1FB2-4CB9-829D-1FA9535CEDF7}&SKey={E521AE75-A4A8-4596-92D7-71EDC2610DBC}&MKey={E3F4019C-0A43-4514-8F66-B86DC90CD935}&AKey={728BCE9C-121B-46B9-A8EE-DC51FDFC6C15}> [retrieved on 20120123] *
ORDWAY JARED M ET AL.: "MethylMapper: a method for high-throughput, multilocus bisulfite sequence analysis and reporting", BIOTECHNIQUES, vol. 39, no. 4, 2005, pages 464 - 467, XP002667852 *
See also references of WO2010017461A2 *

Also Published As

Publication number Publication date
EP2321641A2 (en) 2011-05-18
CA2733565A1 (en) 2010-02-11
WO2010017461A2 (en) 2010-02-11
AU2009279464A1 (en) 2010-02-11
US20110217706A1 (en) 2011-09-08
WO2010017461A3 (en) 2010-06-17

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Legal Events

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Effective date: 20110307

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AX Request for extension of the european patent

Extension state: AL BA RS

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ORION GENOMICS, LLC

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A4 Supplementary search report drawn up and despatched

Effective date: 20120222

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/68 20060101ALI20120214BHEP

Ipc: G06F 19/00 20110101ALI20120214BHEP

Ipc: G01N 33/48 20060101AFI20120214BHEP

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Effective date: 20140301