HK1252055A1 - 使用動態bh3分析評估毒性的組合物和方法 - Google Patents
使用動態bh3分析評估毒性的組合物和方法Info
- Publication number
- HK1252055A1 HK1252055A1 HK18111387.8A HK18111387A HK1252055A1 HK 1252055 A1 HK1252055 A1 HK 1252055A1 HK 18111387 A HK18111387 A HK 18111387A HK 1252055 A1 HK1252055 A1 HK 1252055A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- profiling
- compositions
- dynamic
- methods
- assessing toxicity
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
- G01N33/5079—Mitochondria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562153475P | 2015-04-27 | 2015-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1252055A1 true HK1252055A1 (zh) | 2019-05-10 |
Family
ID=57198812
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18111387.8A HK1252055A1 (zh) | 2015-04-27 | 2018-09-05 | 使用動態bh3分析評估毒性的組合物和方法 |
HK18111390.3A HK1252058A1 (zh) | 2015-04-27 | 2018-09-05 | 高通量bh3分析:在較少數量的細胞上進行bh3分析的快速和可擴展的技術 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18111390.3A HK1252058A1 (zh) | 2015-04-27 | 2018-09-05 | 高通量bh3分析:在較少數量的細胞上進行bh3分析的快速和可擴展的技術 |
Country Status (7)
Country | Link |
---|---|
US (4) | US20180120297A1 (zh) |
EP (2) | EP3289094B1 (zh) |
JP (3) | JP6814745B2 (zh) |
AU (2) | AU2016253957C1 (zh) |
CA (2) | CA2983022C (zh) |
HK (2) | HK1252055A1 (zh) |
WO (2) | WO2016176288A1 (zh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040171809A1 (en) | 2002-09-09 | 2004-09-02 | Korsmeyer Stanley J. | BH3 peptides and method of use thereof |
EP2008106A2 (en) | 2006-03-31 | 2008-12-31 | Dana-Farber Cancer Institute | Methods of determining cellular chemosensitivity |
WO2014047342A1 (en) * | 2012-09-19 | 2014-03-27 | Dana-Farber Cancer Institute, Inc. | Dynamic bh3 profiling |
CA2922503C (en) | 2013-09-19 | 2021-10-26 | Dana-Farber Cancer Institute, Inc. | Methods of bh3 profiling |
CN107406881B (zh) | 2015-01-12 | 2021-05-25 | 尤特罗皮克斯制药股份有限公司 | 用于指导癌症治疗的内容相关的诊断测试 |
AU2016232833A1 (en) | 2015-03-18 | 2017-10-12 | Dana-Farber Cancer Institute, Inc. | Selective Mcl-1 binding peptides |
CA2982928A1 (en) | 2015-04-20 | 2016-10-27 | Tolero Pharmaceuticals, Inc. | Predicting response to alvocidib by mitochondrial profiling |
EP3289094B1 (en) | 2015-04-27 | 2024-06-05 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for assessing toxicity using dynamic bh3 profiling |
EP3298021B1 (en) | 2015-05-18 | 2019-05-01 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs having increased bioavailability |
US10568887B2 (en) | 2015-08-03 | 2020-02-25 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
US11198715B2 (en) | 2016-07-22 | 2021-12-14 | Massachusetts Institute Of Technology | Selective Bfl-1 peptides |
WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
CN110234659A (zh) * | 2016-12-19 | 2019-09-13 | 特雷罗药物股份有限公司 | 用于敏感性分析的分析肽和方法 |
US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
US11286299B2 (en) | 2018-09-17 | 2022-03-29 | Massachusetts Institute Of Technology | Peptides selective for Bcl-2 family proteins |
KR20210099066A (ko) | 2018-12-04 | 2021-08-11 | 스미토모 다이니폰 파마 온콜로지, 인크. | 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체 |
JP2022523771A (ja) * | 2019-02-26 | 2022-04-26 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | ライブセルイメージング(live cell imaging)動的BH3プロファイリング |
JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病(aml)の処置 |
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CA2922503C (en) | 2013-09-19 | 2021-10-26 | Dana-Farber Cancer Institute, Inc. | Methods of bh3 profiling |
EP3289094B1 (en) | 2015-04-27 | 2024-06-05 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for assessing toxicity using dynamic bh3 profiling |
US11092602B2 (en) | 2015-07-06 | 2021-08-17 | Whitehead Institute For Biomedical Research | Methods and compositions relating to proteasome inhibitor resistance |
JP2022523771A (ja) | 2019-02-26 | 2022-04-26 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | ライブセルイメージング(live cell imaging)動的BH3プロファイリング |
-
2016
- 2016-04-27 EP EP16787045.0A patent/EP3289094B1/en active Active
- 2016-04-27 JP JP2017555779A patent/JP6814745B2/ja active Active
- 2016-04-27 CA CA2983022A patent/CA2983022C/en active Active
- 2016-04-27 EP EP16787039.3A patent/EP3288964B1/en active Active
- 2016-04-27 US US15/569,851 patent/US20180120297A1/en not_active Abandoned
- 2016-04-27 WO PCT/US2016/029495 patent/WO2016176288A1/en active Application Filing
- 2016-04-27 AU AU2016253957A patent/AU2016253957C1/en active Active
- 2016-04-27 US US15/568,994 patent/US10761086B2/en active Active
- 2016-04-27 WO PCT/US2016/029510 patent/WO2016176299A1/en active Application Filing
- 2016-04-27 AU AU2016255749A patent/AU2016255749B2/en active Active
- 2016-04-27 CA CA2983024A patent/CA2983024A1/en active Pending
- 2016-04-27 JP JP2017555780A patent/JP6802185B2/ja active Active
-
2018
- 2018-09-05 HK HK18111387.8A patent/HK1252055A1/zh unknown
- 2018-09-05 HK HK18111390.3A patent/HK1252058A1/zh unknown
-
2020
- 2020-07-27 US US16/939,736 patent/US11867688B2/en active Active
- 2020-12-03 JP JP2020200805A patent/JP2021036915A/ja not_active Withdrawn
-
2021
- 2021-02-26 US US17/186,344 patent/US20210255167A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US11867688B2 (en) | 2024-01-09 |
AU2016253957C1 (en) | 2021-04-01 |
EP3288964B1 (en) | 2024-02-21 |
WO2016176288A1 (en) | 2016-11-03 |
AU2016253957B2 (en) | 2020-10-22 |
JP6802185B2 (ja) | 2020-12-16 |
EP3288964A1 (en) | 2018-03-07 |
JP2018514210A (ja) | 2018-06-07 |
JP2018520638A (ja) | 2018-08-02 |
JP6814745B2 (ja) | 2021-01-20 |
CA2983024A1 (en) | 2016-11-03 |
HK1252058A1 (zh) | 2019-05-10 |
US20180128813A1 (en) | 2018-05-10 |
EP3289094B1 (en) | 2024-06-05 |
CA2983022A1 (en) | 2016-11-03 |
AU2016255749A1 (en) | 2017-10-19 |
US10761086B2 (en) | 2020-09-01 |
CA2983022C (en) | 2023-03-07 |
EP3289094A4 (en) | 2018-10-31 |
AU2016255749B2 (en) | 2021-10-14 |
EP3289094A1 (en) | 2018-03-07 |
JP2021036915A (ja) | 2021-03-11 |
AU2016253957A1 (en) | 2017-10-19 |
EP3288964A4 (en) | 2018-10-31 |
WO2016176299A1 (en) | 2016-11-03 |
US20210041419A1 (en) | 2021-02-11 |
US20180120297A1 (en) | 2018-05-03 |
US20210255167A1 (en) | 2021-08-19 |
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