HK1251218A1 - 製造恩雜魯胺晶形的程序 - Google Patents

製造恩雜魯胺晶形的程序

Info

Publication number
HK1251218A1
HK1251218A1 HK18109971.4A HK18109971A HK1251218A1 HK 1251218 A1 HK1251218 A1 HK 1251218A1 HK 18109971 A HK18109971 A HK 18109971A HK 1251218 A1 HK1251218 A1 HK 1251218A1
Authority
HK
Hong Kong
Prior art keywords
producing
crystal form
enzalutamide
enzalutamide crystal
producing enzalutamide
Prior art date
Application number
HK18109971.4A
Other languages
English (en)
Inventor
Yusuke Suzuki
Shuichi Nakagawa
Tsuyoshi Kitamura
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of HK1251218A1 publication Critical patent/HK1251218A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86Oxygen and sulfur atoms, e.g. thiohydantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16Isothiocyanates
    • C07C331/28Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B33/00After-treatment of single crystals or homogeneous polycrystalline material with defined structure
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Glass Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
HK18109971.4A 2015-05-29 2018-08-02 製造恩雜魯胺晶形的程序 HK1251218A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015109805 2015-05-29
PCT/JP2016/065729 WO2016194813A1 (ja) 2015-05-29 2016-05-27 エンザルタミド結晶形の製造方法

Publications (1)

Publication Number Publication Date
HK1251218A1 true HK1251218A1 (zh) 2019-01-25

Family

ID=57442345

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18109971.4A HK1251218A1 (zh) 2015-05-29 2018-08-02 製造恩雜魯胺晶形的程序

Country Status (11)

Country Link
US (1) US10118899B2 (zh)
EP (1) EP3305770B1 (zh)
JP (1) JP6753396B2 (zh)
CN (1) CN107635969B (zh)
CA (1) CA2987563C (zh)
ES (1) ES2942618T3 (zh)
HK (1) HK1251218A1 (zh)
MX (1) MX2017014958A (zh)
PL (1) PL3305770T3 (zh)
PT (1) PT3305770T (zh)
WO (1) WO2016194813A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020260469A1 (en) * 2019-06-27 2020-12-30 Synthon B.V. Process for preparation of enzalutamide
WO2021064123A1 (en) 2019-10-03 2021-04-08 Synthon B.V. Pharmaceutical composition comprising enzalutamide
CN111217757B (zh) * 2020-01-06 2021-03-19 武汉大学 一种恩杂鲁胺化合物及其药物组合物制剂
CN111303042A (zh) * 2020-03-25 2020-06-19 北京赛思源生物医药技术有限公司 一种恩杂鲁胺的新晶型
CN114591246A (zh) * 2022-03-25 2022-06-07 重庆华邦制药有限公司 一种恩扎卢胺的纯化方法
CN115536591A (zh) * 2022-09-27 2022-12-30 爱斯特(成都)生物制药股份有限公司 一种连续流制备恩扎卢胺的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52274B2 (sr) * 2005-05-13 2018-05-31 Univ California Jedinjenje diarilhidantoina
CA2790924C (en) 2010-02-24 2016-08-02 Medivation Prostate Therapeutics, Inc. Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
US20130090417A1 (en) * 2010-06-14 2013-04-11 Solvay Specialty Polymers Italy S.P.A. PVDF coating compositions
CN104768935A (zh) 2012-09-11 2015-07-08 雷迪博士实验室有限公司 恩杂鲁胺的多晶型形式及其制备
WO2015054804A1 (zh) 2013-10-14 2015-04-23 杭州普晒医药科技有限公司 恩杂鲁胺的固态形式及其制备方法和用途
US9611225B2 (en) 2014-01-27 2017-04-04 Cadila Healthcare Limited Process for preparation of androgen receptor antagonist
WO2016005875A1 (en) * 2014-07-11 2016-01-14 Shilpa Medicare Limited An improved process for the preparation of enzalutamide
CN104610158A (zh) 2015-02-03 2015-05-13 江苏慧博生物科技有限公司 一种恩杂鲁胺的精制方法
ITUB20151204A1 (it) * 2015-05-28 2016-11-28 Olon Spa Procedimento per la preparazione di enzalutamide

Also Published As

Publication number Publication date
JPWO2016194813A1 (ja) 2018-06-07
EP3305770B1 (en) 2023-03-29
KR20180014015A (ko) 2018-02-07
MX2017014958A (es) 2018-07-06
JP6753396B2 (ja) 2020-09-09
CN107635969B (zh) 2021-08-17
EP3305770A4 (en) 2018-12-12
WO2016194813A1 (ja) 2016-12-08
PL3305770T3 (pl) 2023-06-26
PT3305770T (pt) 2023-04-26
US10118899B2 (en) 2018-11-06
CA2987563C (en) 2024-04-09
CA2987563A1 (en) 2016-12-08
EP3305770A1 (en) 2018-04-11
US20180148417A1 (en) 2018-05-31
CN107635969A (zh) 2018-01-26
ES2942618T3 (es) 2023-06-05

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