PL3305770T3 - Sposób wytwarzania postaci krystalicznej enzalutamidu - Google Patents

Sposób wytwarzania postaci krystalicznej enzalutamidu

Info

Publication number
PL3305770T3
PL3305770T3 PL16803248.0T PL16803248T PL3305770T3 PL 3305770 T3 PL3305770 T3 PL 3305770T3 PL 16803248 T PL16803248 T PL 16803248T PL 3305770 T3 PL3305770 T3 PL 3305770T3
Authority
PL
Poland
Prior art keywords
producing
crystal form
enzalutamide
enzalutamide crystal
producing enzalutamide
Prior art date
Application number
PL16803248.0T
Other languages
English (en)
Inventor
Yusuke Suzuki
Shuichi Nakagawa
Tsuyoshi Kitamura
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of PL3305770T3 publication Critical patent/PL3305770T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Glass Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
PL16803248.0T 2015-05-29 2016-05-27 Sposób wytwarzania postaci krystalicznej enzalutamidu PL3305770T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015109805 2015-05-29
PCT/JP2016/065729 WO2016194813A1 (ja) 2015-05-29 2016-05-27 エンザルタミド結晶形の製造方法

Publications (1)

Publication Number Publication Date
PL3305770T3 true PL3305770T3 (pl) 2023-06-26

Family

ID=57442345

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16803248.0T PL3305770T3 (pl) 2015-05-29 2016-05-27 Sposób wytwarzania postaci krystalicznej enzalutamidu

Country Status (11)

Country Link
US (1) US10118899B2 (pl)
EP (1) EP3305770B1 (pl)
JP (1) JP6753396B2 (pl)
KR (1) KR102666017B1 (pl)
CN (1) CN107635969B (pl)
CA (1) CA2987563C (pl)
ES (1) ES2942618T3 (pl)
MX (1) MX385084B (pl)
PL (1) PL3305770T3 (pl)
PT (1) PT3305770T (pl)
WO (1) WO2016194813A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220242829A1 (en) * 2019-06-27 2022-08-04 Synthon B.V. Process for preparation of enzalutamide
US20220347102A1 (en) 2019-10-03 2022-11-03 Synthon B.V. Pharmaceutical composition comprising enzalutamide
CN111217757B (zh) * 2020-01-06 2021-03-19 武汉大学 一种恩杂鲁胺化合物及其药物组合物制剂
CN111303042A (zh) * 2020-03-25 2020-06-19 北京赛思源生物医药技术有限公司 一种恩杂鲁胺的新晶型
CN114591246A (zh) * 2022-03-25 2022-06-07 重庆华邦制药有限公司 一种恩扎卢胺的纯化方法
CN115536591B (zh) * 2022-09-27 2024-06-25 爱斯特(成都)生物制药股份有限公司 一种连续流制备恩扎卢胺的方法
WO2025125565A1 (en) 2023-12-13 2025-06-19 Krka, D.D., Novo Mesto Tablet comprising enzalutamide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608436C (en) * 2005-05-13 2015-03-24 The Regents Of The University Of California Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders
HUE038637T2 (hu) * 2010-02-24 2018-12-28 Medivation Prostate Therapeutics Llc Eljárás a diaril-tiohidantoin és a diaril-hidantoin vegyületek szintetizálására
US20130090417A1 (en) * 2010-06-14 2013-04-11 Solvay Specialty Polymers Italy S.P.A. PVDF coating compositions
EP2895464A4 (en) 2012-09-11 2016-06-15 Reddys Lab Ltd Dr POLYMORPHIC ENZALUTAMIDE FORMS AND THEIR PREPARATION
CN105188699B (zh) 2013-10-14 2017-04-26 杭州普晒医药科技有限公司 恩杂鲁胺的固态形式及其制备方法和用途
US9611225B2 (en) * 2014-01-27 2017-04-04 Cadila Healthcare Limited Process for preparation of androgen receptor antagonist
US20170190670A1 (en) 2014-07-11 2017-07-06 Shilpa Medicare Limited Improved process for the preparation of enzalutamide
CN104610158A (zh) 2015-02-03 2015-05-13 江苏慧博生物科技有限公司 一种恩杂鲁胺的精制方法
ITUB20151204A1 (it) * 2015-05-28 2016-11-28 Olon Spa Procedimento per la preparazione di enzalutamide

Also Published As

Publication number Publication date
PT3305770T (pt) 2023-04-26
ES2942618T3 (es) 2023-06-05
US20180148417A1 (en) 2018-05-31
KR20180014015A (ko) 2018-02-07
EP3305770A1 (en) 2018-04-11
HK1251218A1 (en) 2019-01-25
EP3305770A4 (en) 2018-12-12
CN107635969B (zh) 2021-08-17
CA2987563A1 (en) 2016-12-08
MX385084B (es) 2025-03-14
CA2987563C (en) 2024-04-09
MX2017014958A (es) 2018-07-06
JP6753396B2 (ja) 2020-09-09
CN107635969A (zh) 2018-01-26
EP3305770B1 (en) 2023-03-29
US10118899B2 (en) 2018-11-06
WO2016194813A1 (ja) 2016-12-08
JPWO2016194813A1 (ja) 2018-06-07
KR102666017B1 (ko) 2024-05-16

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