HK1247101A1 - 用於治疗神经肌肉、神经变性、自身免疫、发育和/或代谢疾病的脑源性神经营养因子(bdnf)的诱导表达 - Google Patents

用於治疗神经肌肉、神经变性、自身免疫、发育和/或代谢疾病的脑源性神经营养因子(bdnf)的诱导表达 Download PDF

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Publication number
HK1247101A1
HK1247101A1 HK18106712.4A HK18106712A HK1247101A1 HK 1247101 A1 HK1247101 A1 HK 1247101A1 HK 18106712 A HK18106712 A HK 18106712A HK 1247101 A1 HK1247101 A1 HK 1247101A1
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HK
Hong Kong
Prior art keywords
disease
effective dose
treating
examples
pharmaceutical composition
Prior art date
Application number
HK18106712.4A
Other languages
English (en)
Chinese (zh)
Inventor
Robert Alonso
John Gerard GEISLER
Original Assignee
Mitochon Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitochon Pharmaceuticals, Inc. filed Critical Mitochon Pharmaceuticals, Inc.
Publication of HK1247101A1 publication Critical patent/HK1247101A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
HK18106712.4A 2015-01-22 2016-01-21 用於治疗神经肌肉、神经变性、自身免疫、发育和/或代谢疾病的脑源性神经营养因子(bdnf)的诱导表达 HK1247101A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562106365P 2015-01-22 2015-01-22
US62/106365 2015-01-22
PCT/US2016/014312 WO2016118741A1 (en) 2015-01-22 2016-01-21 Induced expression of brain derived neurotrophic factor (bdnf) for treatment of neuromuscular, neurodegenerative, autoimmune, developmental and/or metabolic diseases

Publications (1)

Publication Number Publication Date
HK1247101A1 true HK1247101A1 (zh) 2018-09-21

Family

ID=55310938

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18106712.4A HK1247101A1 (zh) 2015-01-22 2016-01-21 用於治疗神经肌肉、神经变性、自身免疫、发育和/或代谢疾病的脑源性神经营养因子(bdnf)的诱导表达

Country Status (13)

Country Link
US (6) US9763896B2 (cg-RX-API-DMAC10.html)
EP (2) EP4306167B1 (cg-RX-API-DMAC10.html)
JP (3) JP6951976B2 (cg-RX-API-DMAC10.html)
KR (1) KR102690198B1 (cg-RX-API-DMAC10.html)
CN (2) CN116617195A (cg-RX-API-DMAC10.html)
AU (2) AU2016209255B2 (cg-RX-API-DMAC10.html)
BR (1) BR112017015721A2 (cg-RX-API-DMAC10.html)
CA (1) CA2974092A1 (cg-RX-API-DMAC10.html)
ES (2) ES2961334T3 (cg-RX-API-DMAC10.html)
HK (1) HK1247101A1 (cg-RX-API-DMAC10.html)
MX (2) MX392410B (cg-RX-API-DMAC10.html)
PT (1) PT3247340T (cg-RX-API-DMAC10.html)
WO (1) WO2016118741A1 (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX392410B (es) * 2015-01-22 2025-03-11 Mitochon Pharmaceuticals Inc Expresión inducida de factor neurotrófico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabólicas.
PT3565806T (pt) 2017-01-06 2022-05-19 Rivus Pharmaceuticals Inc Novos derivados de fenilo
MX2019009038A (es) * 2017-01-31 2019-12-09 L Manfredi Paolo D-metadona y sus derivados para uso en el tratamiento de trastornos del sistema nervioso.
WO2018237379A2 (en) 2017-06-23 2018-12-27 Enzo Biochem, Inc. Sphingosine pathway modulating compounds for the treatment of cancers
US10660879B2 (en) 2017-06-23 2020-05-26 Enzo Biochem, Inc. Sphingosine pathway modulating compounds for the treatment of cancers
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
US12637411B2 (en) 2019-01-30 2026-05-26 Mggm Llc Structurally modified opioids for prevention and treatment of diseases and conditions
US20230363418A1 (en) * 2020-09-29 2023-11-16 Cefo Co., Ltd. Composition for preventing or treating neuropsychologic disease, comprising manf
WO2023205625A2 (en) * 2022-04-18 2023-10-26 Mitochon Pharmaceuticals, Inc. 2,4 dnp and prodrugs thereof for treatment of pulmonary and autoimmune diseases
WO2025051360A1 (en) * 2023-09-06 2025-03-13 Instituto de Medicina Molecular João Lobo Antunes Trkb-t1 agonist for the treatment of absence seizure and/or comorbidities

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6664297B1 (en) * 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP2170338A2 (en) 2007-07-06 2010-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dna-pkcs modulates energy regulation and brain function
CN110302385A (zh) * 2013-08-30 2019-10-08 耶鲁大学 新型2,4-二硝基苯酚制剂和使用其的方法
MX392410B (es) * 2015-01-22 2025-03-11 Mitochon Pharmaceuticals Inc Expresión inducida de factor neurotrófico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabólicas.

Also Published As

Publication number Publication date
CN116617195A (zh) 2023-08-22
JP2018502898A (ja) 2018-02-01
EP4306167B1 (en) 2025-12-24
MX2022005937A (es) 2022-06-29
PT3247340T (pt) 2023-10-31
US11717497B2 (en) 2023-08-08
AU2016209255B2 (en) 2021-07-01
ES3057870T3 (en) 2026-03-05
EP4306167A3 (en) 2024-03-20
JP6951976B2 (ja) 2021-10-20
WO2016118741A1 (en) 2016-07-28
US10864173B2 (en) 2020-12-15
US10220006B2 (en) 2019-03-05
US20160213625A1 (en) 2016-07-28
US20210052513A1 (en) 2021-02-25
MX392410B (es) 2025-03-11
JP2021080286A (ja) 2021-05-27
US9763896B2 (en) 2017-09-19
US20190142765A1 (en) 2019-05-16
CA2974092A1 (en) 2016-07-28
EP3247340A1 (en) 2017-11-29
US20170065536A1 (en) 2017-03-09
US20240156750A1 (en) 2024-05-16
JP7440092B2 (ja) 2024-02-28
MX2017009402A (es) 2017-12-04
CN107405315A (zh) 2017-11-28
ES2961334T3 (es) 2024-03-11
KR102690198B1 (ko) 2024-07-30
EP4306167C0 (en) 2025-12-24
EP3247340B1 (en) 2023-08-02
US20180125794A1 (en) 2018-05-10
US9974755B2 (en) 2018-05-22
BR112017015721A2 (pt) 2018-04-10
EP4306167A2 (en) 2024-01-17
AU2016209255A1 (en) 2017-08-10
AU2021240120A1 (en) 2021-10-28
KR20170104597A (ko) 2017-09-15
JP2022173519A (ja) 2022-11-18

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