MX2017009402A - Expresion inducida de factor neurotrofico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabolicas. - Google Patents
Expresion inducida de factor neurotrofico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabolicas.Info
- Publication number
- MX2017009402A MX2017009402A MX2017009402A MX2017009402A MX2017009402A MX 2017009402 A MX2017009402 A MX 2017009402A MX 2017009402 A MX2017009402 A MX 2017009402A MX 2017009402 A MX2017009402 A MX 2017009402A MX 2017009402 A MX2017009402 A MX 2017009402A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- disorders
- syndrome
- developmental
- autoimmune
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 3
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 title abstract 3
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 title abstract 3
- 208000012239 Developmental disease Diseases 0.000 title abstract 3
- 208000030159 metabolic disease Diseases 0.000 title abstract 3
- 230000002232 neuromuscular Effects 0.000 title abstract 3
- 230000001363 autoimmune Effects 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 230000000626 neurodegenerative effect Effects 0.000 title abstract 2
- 208000018360 neuromuscular disease Diseases 0.000 title abstract 2
- 101150035467 BDNF gene Proteins 0.000 title 1
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 3
- 208000031277 Amaurotic familial idiocy Diseases 0.000 abstract 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 abstract 2
- 208000035895 Guillain-Barré syndrome Diseases 0.000 abstract 2
- 208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 abstract 2
- 201000000639 Leber hereditary optic neuropathy Diseases 0.000 abstract 2
- 208000035180 MODY Diseases 0.000 abstract 2
- 206010049567 Miller Fisher syndrome Diseases 0.000 abstract 2
- 208000002537 Neuronal Ceroid-Lipofuscinoses Diseases 0.000 abstract 2
- 230000032683 aging Effects 0.000 abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 208000017476 juvenile neuronal ceroid lipofuscinosis Diseases 0.000 abstract 2
- 201000006950 maturity-onset diabetes of the young Diseases 0.000 abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 abstract 2
- 206010028417 myasthenia gravis Diseases 0.000 abstract 2
- 201000007607 neuronal ceroid lipofuscinosis 3 Diseases 0.000 abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000009575 Angelman syndrome Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 208000023328 Basedow disease Diseases 0.000 abstract 1
- 208000001914 Fragile X syndrome Diseases 0.000 abstract 1
- 208000024412 Friedreich ataxia Diseases 0.000 abstract 1
- 208000015023 Graves' disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000006136 Leigh Disease Diseases 0.000 abstract 1
- 208000017507 Leigh syndrome Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 206010028289 Muscle atrophy Diseases 0.000 abstract 1
- 208000003435 Optic Neuritis Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000006289 Rett Syndrome Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 208000016097 disease of metabolism Diseases 0.000 abstract 1
- 231100000673 dose–response relationship Toxicity 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 208000012268 mitochondrial disease Diseases 0.000 abstract 1
- 201000000585 muscular atrophy Diseases 0.000 abstract 1
- 201000006938 muscular dystrophy Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000008736 traumatic injury Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Abstract
Un método para tratar un hospedero de enfermedades/trastornos neuromusculares, neurodegenativos, de desarrollo, autoinmunes y metabólicos relacionados al envejecimiento, como daño traumático, derrame, enfermedad de Huntington, epilepsia, esclerosis múltiple (MS por sus siglas en inglés), lupus, diabetes tipo 1 y tipo 2, diabetes de inicio de madurez del joven (MODY por sus siglas en inglés), miastenia gravis (MG por sus siglas en inglés), artritis reumatoide (RA por sus siglas en inglés), enfermedad de Graves, síndrome de Guillain-Barre (GBS por sus siglas en inglés), síndrome metabólico, distrofia muscular o distrofia muscular de Duchenne (DMD por sus siglas en inglés), quemaduras severas, envejecimiento, esclerosis lateral amiotrófica (ALS por sus siglas en inglés), ataxia de Friedreich, enfermedad de Batten, enfermedad de Alzheimer, neuritis óptica, neuropatía óptica hereditaria de Leber (LHON por sus siglas en inglés), autismo, síndrome de Rett, enfermedad de Batten, síndrome de Angelman, enfermedad de Leigh, síndrome Fragile-X, depresión, enfermedad de Parkinson, enfermedades mitocondriales, trastornos de desarrollo, trastornos de enfermedad metabólica y/o trastornos autoinmunes por inducir expresión BDNF endógena con tratamiento de DNP para proteger de disfunción/trastornos neuromusculares y/o neurodegeneración y/o desgaste muscular, DNP es administrado a ratones diariamente sobre un intervalo de dosis, y subsecuentemente expresión de BDNF en el cerebro muestra un incremento dependiente a dosis y no lineal en expresión.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562106365P | 2015-01-22 | 2015-01-22 | |
| PCT/US2016/014312 WO2016118741A1 (en) | 2015-01-22 | 2016-01-21 | Induced expression of brain derived neurotrophic factor (bdnf) for treatment of neuromuscular, neurodegenerative, autoimmune, developmental and/or metabolic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017009402A true MX2017009402A (es) | 2017-12-04 |
Family
ID=55310938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017009402A MX2017009402A (es) | 2015-01-22 | 2016-01-21 | Expresion inducida de factor neurotrofico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabolicas. |
| MX2022005937A MX2022005937A (es) | 2015-01-22 | 2017-07-18 | Expresion inducida de factor neurotrofico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabolicas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022005937A MX2022005937A (es) | 2015-01-22 | 2017-07-18 | Expresion inducida de factor neurotrofico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabolicas. |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9763896B2 (es) |
| EP (2) | EP3247340B1 (es) |
| JP (3) | JP6951976B2 (es) |
| KR (1) | KR20170104597A (es) |
| CN (2) | CN116617195A (es) |
| AU (2) | AU2016209255B2 (es) |
| BR (1) | BR112017015721A2 (es) |
| CA (1) | CA2974092A1 (es) |
| ES (1) | ES2961334T3 (es) |
| HK (1) | HK1247101A1 (es) |
| MX (2) | MX2017009402A (es) |
| PT (1) | PT3247340T (es) |
| WO (1) | WO2016118741A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017015721A2 (pt) | 2015-01-22 | 2018-04-10 | Mitochon Pharmaceuticals Inc | expressão induzida de fator neurotrófico derivado do cérebro (bdnf) para o tratamento de doenças neuromusculares, neurodegenerativas, autoimunes, do desenvolvimento e/ou metabólicas. |
| PE20191243A1 (es) | 2017-01-06 | 2019-09-16 | Rivus Pharmaceuticals Inc | Nuevos derivados de fenilo |
| KR20190124722A (ko) * | 2017-01-31 | 2019-11-05 | 파올로 엘. 만프레디 | 신경계 장애의 치료에서 사용하기 위한 ｄ-메타돈 및 이의 유도체 |
| CA3061201A1 (en) | 2017-06-23 | 2018-12-27 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
| US10660879B2 (en) | 2017-06-23 | 2020-05-26 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
| KR20220044150A (ko) * | 2020-09-29 | 2022-04-06 | (주)세포바이오 | Manf를 포함하는 신경정신질환의 예방 또는 치료용 조성물 |
| WO2023205625A2 (en) * | 2022-04-18 | 2023-10-26 | Mitochon Pharmaceuticals, Inc. | 2,4 dnp and prodrugs thereof for treatment of pulmonary and autoimmune diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6664297B1 (en) * | 2000-10-18 | 2003-12-16 | Universidade Federal Do Rio De Janeiro | Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP2170338A2 (en) * | 2007-07-06 | 2010-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dna-pkcs modulates energy regulation and brain function |
| CN110302385A (zh) * | 2013-08-30 | 2019-10-08 | 耶鲁大学 | 新型2，4-二硝基苯酚制剂和使用其的方法 |
| BR112017015721A2 (pt) * | 2015-01-22 | 2018-04-10 | Mitochon Pharmaceuticals Inc | expressão induzida de fator neurotrófico derivado do cérebro (bdnf) para o tratamento de doenças neuromusculares, neurodegenerativas, autoimunes, do desenvolvimento e/ou metabólicas. |
-
2016
- 2016-01-21 BR BR112017015721A patent/BR112017015721A2/pt not_active Application Discontinuation
- 2016-01-21 ES ES16703409T patent/ES2961334T3/es active Active
- 2016-01-21 US US15/002,531 patent/US9763896B2/en active Active
- 2016-01-21 WO PCT/US2016/014312 patent/WO2016118741A1/en active Application Filing
- 2016-01-21 CA CA2974092A patent/CA2974092A1/en active Pending
- 2016-01-21 EP EP16703409.9A patent/EP3247340B1/en active Active
- 2016-01-21 PT PT167034099T patent/PT3247340T/pt unknown
- 2016-01-21 KR KR1020177023034A patent/KR20170104597A/ko active IP Right Grant
- 2016-01-21 MX MX2017009402A patent/MX2017009402A/es unknown
- 2016-01-21 AU AU2016209255A patent/AU2016209255B2/en active Active
- 2016-01-21 JP JP2017539363A patent/JP6951976B2/ja active Active
- 2016-01-21 CN CN202211548767.9A patent/CN116617195A/zh active Pending
- 2016-01-21 CN CN201680017379.4A patent/CN107405315A/zh active Pending
- 2016-01-21 EP EP23188878.5A patent/EP4306167A3/en active Pending
- 2016-11-21 US US15/357,412 patent/US9974755B2/en active Active
-
2017
- 2017-07-18 MX MX2022005937A patent/MX2022005937A/es unknown
- 2017-09-18 US US15/707,239 patent/US10220006B2/en active Active
-
2018
- 2018-05-24 HK HK18106712.4A patent/HK1247101A1/zh unknown
-
2019
- 2019-01-17 US US16/250,470 patent/US10864173B2/en active Active
-
2020
- 2020-11-09 US US17/093,193 patent/US11717497B2/en active Active
-
2021
- 2021-03-01 JP JP2021031635A patent/JP7440092B2/ja active Active
- 2021-09-27 AU AU2021240120A patent/AU2021240120A1/en active Pending
-
2022
- 2022-10-03 JP JP2022159466A patent/JP2022173519A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4306167A3 (en) | 2024-03-20 |
| US9763896B2 (en) | 2017-09-19 |
| WO2016118741A1 (en) | 2016-07-28 |
| US11717497B2 (en) | 2023-08-08 |
| KR20170104597A (ko) | 2017-09-15 |
| AU2016209255B2 (en) | 2021-07-01 |
| CN116617195A (zh) | 2023-08-22 |
| CN107405315A (zh) | 2017-11-28 |
| EP3247340B1 (en) | 2023-08-02 |
| JP2018502898A (ja) | 2018-02-01 |
| AU2021240120A1 (en) | 2021-10-28 |
| EP4306167A2 (en) | 2024-01-17 |
| ES2961334T3 (es) | 2024-03-11 |
| PT3247340T (pt) | 2023-10-31 |
| CA2974092A1 (en) | 2016-07-28 |
| BR112017015721A2 (pt) | 2018-04-10 |
| US20170065536A1 (en) | 2017-03-09 |
| JP6951976B2 (ja) | 2021-10-20 |
| US20210052513A1 (en) | 2021-02-25 |
| US20160213625A1 (en) | 2016-07-28 |
| US20180125794A1 (en) | 2018-05-10 |
| JP2022173519A (ja) | 2022-11-18 |
| HK1247101A1 (zh) | 2018-09-21 |
| US10864173B2 (en) | 2020-12-15 |
| US10220006B2 (en) | 2019-03-05 |
| JP7440092B2 (ja) | 2024-02-28 |
| US20190142765A1 (en) | 2019-05-16 |
| JP2021080286A (ja) | 2021-05-27 |
| EP3247340A1 (en) | 2017-11-29 |
| MX2022005937A (es) | 2022-06-29 |
| AU2016209255A1 (en) | 2017-08-10 |
| US9974755B2 (en) | 2018-05-22 |
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