JP7121859B2 - 安息香酸塩または安息香酸誘導体を含む、抗n-メチル-d-アスパラギン酸受容体脳炎を予防または治療するための医薬組成物 - Google Patents
安息香酸塩または安息香酸誘導体を含む、抗n-メチル-d-アスパラギン酸受容体脳炎を予防または治療するための医薬組成物 Download PDFInfo
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- JP7121859B2 JP7121859B2 JP2021526187A JP2021526187A JP7121859B2 JP 7121859 B2 JP7121859 B2 JP 7121859B2 JP 2021526187 A JP2021526187 A JP 2021526187A JP 2021526187 A JP2021526187 A JP 2021526187A JP 7121859 B2 JP7121859 B2 JP 7121859B2
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- VZYCZNZBPPHOFY-UHFFFAOYSA-N thioproperazine Chemical compound C12=CC(S(=O)(=O)N(C)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 VZYCZNZBPPHOFY-UHFFFAOYSA-N 0.000 description 1
- 229960003397 thioproperazine Drugs 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 229960005013 tiotixene Drugs 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- 229960004496 zotepine Drugs 0.000 description 1
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Radiology & Medical Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
実施例
Claims (15)
- 有効量の安息香酸塩を含む、必要とする対象における抗N-メチル-D-アスパラギン酸受容体(NMDAR)脳炎を予防または治療するための医薬組成物であって、
前記の安息香酸塩は、抗NMDAR脳炎を予防または治療するために静脈内免疫グロブリンによる免疫療法と組み合わせて上記対象に投与されることを特徴とする、医薬組成物。 - 上記の安息香酸塩は、安息香酸ナトリウム、安息香酸カリウム、安息香酸カルシウム、または安息香酸マグネシウムである、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、安息香酸ナトリウムである、請求項1に記載の医薬組成物。
- 上記の抗NMDAR脳炎は、NMDARの機能低下によって引き起こされる、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、対象におけるNMDAR機能を増強または活性化する、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、200mg/日~2000mg/日の範囲の量で上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、400mg/日~1800mg/日の範囲の量で上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、450mg/日~1500mg/日の範囲の量で上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、500mg/日~1000mg/日の範囲の量で上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、1ヶ月間~2年間の期間範囲で上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、4週間~12ヶ月間の期間範囲で上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の安息香酸塩は、抗NMDAR脳炎を予防または治療するために追加の有効成分と組み合わせて上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の追加の有効成分は、抗精神病薬である、請求項12に記載の医薬組成物。
- 上記の安息香酸塩は、抗NMDAR脳炎を予防または治療するために追加の治療と組み合わせて上記対象に投与される、請求項1に記載の医薬組成物。
- 上記の追加の治療は、心理療法、電気けいれん療法(ECT)、血漿交換、ステロイドによるパルス療法、またはそれらの任意の組み合わせを含む、請求項14に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201862698558P | 2018-07-16 | 2018-07-16 | |
US62/698,558 | 2018-07-16 | ||
PCT/MY2019/000025 WO2020017950A1 (en) | 2018-07-16 | 2019-07-16 | Benzoic acid or a salt thereof for use in preventing or treating anti-n-methyl-d-aspartate receptor encephalitis |
Publications (2)
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JP2021530567A JP2021530567A (ja) | 2021-11-11 |
JP7121859B2 true JP7121859B2 (ja) | 2022-08-18 |
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JP2021526187A Active JP7121859B2 (ja) | 2018-07-16 | 2019-07-16 | 安息香酸塩または安息香酸誘導体を含む、抗n-メチル-d-アスパラギン酸受容体脳炎を予防または治療するための医薬組成物 |
Country Status (10)
Country | Link |
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US (1) | US20210228515A1 (ja) |
EP (1) | EP3823609A4 (ja) |
JP (1) | JP7121859B2 (ja) |
KR (1) | KR102615988B1 (ja) |
CN (1) | CN112437661A (ja) |
AU (2) | AU2019304850B2 (ja) |
CA (1) | CA3102371A1 (ja) |
MY (1) | MY195960A (ja) |
TW (1) | TWI726355B (ja) |
WO (1) | WO2020017950A1 (ja) |
Families Citing this family (1)
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MX2022001396A (es) * | 2019-08-01 | 2022-03-25 | Aptinyx Inc | Metodos para tratar trastornos asociados con niveles elevados de anticuerpos que interactuan con el receptor de nmda. |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2014191992A1 (en) | 2013-05-28 | 2014-12-04 | Sarah Herzog Memorial Hospital-Ezrath Nashim | Autoimmune-induced glutamatergic receptor dysfunction methods and treatments |
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2019
- 2019-07-15 TW TW108124912A patent/TWI726355B/zh active
- 2019-07-16 JP JP2021526187A patent/JP7121859B2/ja active Active
- 2019-07-16 WO PCT/MY2019/000025 patent/WO2020017950A1/en unknown
- 2019-07-16 AU AU2019304850A patent/AU2019304850B2/en active Active
- 2019-07-16 CA CA3102371A patent/CA3102371A1/en active Pending
- 2019-07-16 US US17/258,180 patent/US20210228515A1/en active Pending
- 2019-07-16 CN CN201980042941.2A patent/CN112437661A/zh active Pending
- 2019-07-16 EP EP19838008.1A patent/EP3823609A4/en active Pending
- 2019-07-16 KR KR1020217000780A patent/KR102615988B1/ko active IP Right Grant
- 2019-07-16 MY MYPI2020006680A patent/MY195960A/en unknown
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2022
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2014191992A1 (en) | 2013-05-28 | 2014-12-04 | Sarah Herzog Memorial Hospital-Ezrath Nashim | Autoimmune-induced glutamatergic receptor dysfunction methods and treatments |
Non-Patent Citations (4)
Title |
---|
Acta Neuropsychiatrica,2015年,27(3), pp.159-167 |
Biological Psychiatry,2015年,77(6),pp.e27-e29 |
JAMA Psychiatry,2013年,70(12),pp.1267-1275 |
Neuroimmunology and Neuroinflammation,2016年,3,pp.189-191 |
Also Published As
Publication number | Publication date |
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MY195960A (en) | 2023-02-27 |
WO2020017950A1 (en) | 2020-01-23 |
AU2022201030A1 (en) | 2022-03-10 |
US20210228515A1 (en) | 2021-07-29 |
TWI726355B (zh) | 2021-05-01 |
KR102615988B1 (ko) | 2023-12-20 |
KR20210021356A (ko) | 2021-02-25 |
JP2021530567A (ja) | 2021-11-11 |
EP3823609A4 (en) | 2022-04-20 |
CN112437661A (zh) | 2021-03-02 |
TW202011949A (zh) | 2020-04-01 |
AU2019304850B2 (en) | 2022-06-02 |
AU2019304850A1 (en) | 2020-11-26 |
CA3102371A1 (en) | 2020-01-23 |
EP3823609A1 (en) | 2021-05-26 |
AU2022201030B2 (en) | 2023-10-05 |
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