HK1246776A1 - 用於hiv治療的異喹啉化合物 - Google Patents

用於hiv治療的異喹啉化合物

Info

Publication number
HK1246776A1
HK1246776A1 HK18106002.3A HK18106002A HK1246776A1 HK 1246776 A1 HK1246776 A1 HK 1246776A1 HK 18106002 A HK18106002 A HK 18106002A HK 1246776 A1 HK1246776 A1 HK 1246776A1
Authority
HK
Hong Kong
Prior art keywords
hiv
treatment
isoquinoline compounds
isoquinoline
compounds
Prior art date
Application number
HK18106002.3A
Other languages
English (en)
Inventor
P‧揚薩
R‧L‧馬克曼
Y‧E‧胡
E‧蘭斯登
Original Assignee
吉利德科學公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 吉利德科學公司 filed Critical 吉利德科學公司
Publication of HK1246776A1 publication Critical patent/HK1246776A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK18106002.3A 2014-12-24 2018-05-09 用於hiv治療的異喹啉化合物 HK1246776A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462096769P 2014-12-24 2014-12-24
PCT/US2015/000310 WO2016105534A1 (en) 2014-12-24 2015-12-23 Isoquinoline compounds for the treatment of hiv

Publications (1)

Publication Number Publication Date
HK1246776A1 true HK1246776A1 (zh) 2018-09-14

Family

ID=55168341

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18103630.0A HK1244271B (zh) 2014-12-24 2018-03-16 用於hiv治療的異喹啉化合物
HK18106002.3A HK1246776A1 (zh) 2014-12-24 2018-05-09 用於hiv治療的異喹啉化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18103630.0A HK1244271B (zh) 2014-12-24 2018-03-16 用於hiv治療的異喹啉化合物

Country Status (17)

Country Link
US (1) US9624195B2 (zh)
EP (1) EP3237397B1 (zh)
JP (1) JP6356919B2 (zh)
KR (1) KR101960624B1 (zh)
CN (1) CN107428693B (zh)
AU (1) AU2015371257B2 (zh)
BR (1) BR112017013440A2 (zh)
CA (1) CA2972017C (zh)
EA (1) EA201791304A1 (zh)
ES (1) ES2705709T3 (zh)
HK (2) HK1244271B (zh)
IL (1) IL253052A0 (zh)
MX (1) MX2017008518A (zh)
NZ (1) NZ733125A (zh)
PT (1) PT3237397T (zh)
SG (1) SG11201705184PA (zh)
WO (1) WO2016105534A1 (zh)

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CN107428693B (zh) 2014-12-24 2020-05-29 吉利德科学公司 用于hiv治疗的异喹啉化合物
BR112017013858A2 (pt) 2014-12-26 2018-02-27 Univ Emory n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
MX2020005392A (es) 2017-12-07 2020-12-07 Univ Emory N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos.
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Also Published As

Publication number Publication date
CA2972017A1 (en) 2016-06-30
JP2018500356A (ja) 2018-01-11
US20160237062A1 (en) 2016-08-18
AU2015371257A1 (en) 2017-07-13
MX2017008518A (es) 2017-10-25
KR20170096049A (ko) 2017-08-23
CN107428693A (zh) 2017-12-01
US9624195B2 (en) 2017-04-18
CN107428693B (zh) 2020-05-29
KR101960624B1 (ko) 2019-03-20
EP3237397B1 (en) 2018-11-21
PT3237397T (pt) 2019-02-08
NZ733125A (en) 2018-06-29
EP3237397A1 (en) 2017-11-01
BR112017013440A2 (pt) 2018-01-09
IL253052A0 (en) 2017-08-31
HK1244271B (zh) 2019-11-29
JP6356919B2 (ja) 2018-07-11
SG11201705184PA (en) 2017-07-28
AU2015371257B2 (en) 2018-09-06
CA2972017C (en) 2019-06-11
WO2016105534A1 (en) 2016-06-30
ES2705709T3 (es) 2019-03-26
EA201791304A1 (ru) 2017-12-29

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