HK1246776A1 - 用於hiv治療的異喹啉化合物 - Google Patents
用於hiv治療的異喹啉化合物Info
- Publication number
- HK1246776A1 HK1246776A1 HK18106002.3A HK18106002A HK1246776A1 HK 1246776 A1 HK1246776 A1 HK 1246776A1 HK 18106002 A HK18106002 A HK 18106002A HK 1246776 A1 HK1246776 A1 HK 1246776A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hiv
- treatment
- isoquinoline compounds
- isoquinoline
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462096769P | 2014-12-24 | 2014-12-24 | |
PCT/US2015/000310 WO2016105534A1 (en) | 2014-12-24 | 2015-12-23 | Isoquinoline compounds for the treatment of hiv |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1246776A1 true HK1246776A1 (zh) | 2018-09-14 |
Family
ID=55168341
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103630.0A HK1244271B (zh) | 2014-12-24 | 2018-03-16 | 用於hiv治療的異喹啉化合物 |
HK18106002.3A HK1246776A1 (zh) | 2014-12-24 | 2018-05-09 | 用於hiv治療的異喹啉化合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103630.0A HK1244271B (zh) | 2014-12-24 | 2018-03-16 | 用於hiv治療的異喹啉化合物 |
Country Status (17)
Country | Link |
---|---|
US (1) | US9624195B2 (zh) |
EP (1) | EP3237397B1 (zh) |
JP (1) | JP6356919B2 (zh) |
KR (1) | KR101960624B1 (zh) |
CN (1) | CN107428693B (zh) |
AU (1) | AU2015371257B2 (zh) |
BR (1) | BR112017013440A2 (zh) |
CA (1) | CA2972017C (zh) |
EA (1) | EA201791304A1 (zh) |
ES (1) | ES2705709T3 (zh) |
HK (2) | HK1244271B (zh) |
IL (1) | IL253052A0 (zh) |
MX (1) | MX2017008518A (zh) |
NZ (1) | NZ733125A (zh) |
PT (1) | PT3237397T (zh) |
SG (1) | SG11201705184PA (zh) |
WO (1) | WO2016105534A1 (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ733135A (en) | 2014-12-24 | 2018-06-29 | Gilead Sciences Inc | Fused pyrimidine compounds for the treatment of hiv |
TWI699355B (zh) | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
CN107428693B (zh) | 2014-12-24 | 2020-05-29 | 吉利德科学公司 | 用于hiv治疗的异喹啉化合物 |
BR112017013858A2 (pt) | 2014-12-26 | 2018-02-27 | Univ Emory | n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
MX2020005392A (es) | 2017-12-07 | 2020-12-07 | Univ Emory | N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos. |
KR20220156884A (ko) | 2020-03-20 | 2022-11-28 | 길리애드 사이언시즈, 인코포레이티드 | 4'-c-치환된-2-할로-2'-데옥시아데노신 뉴클레오시드의 프로드러그 및 이의 제조 및 사용 방법 |
CA3195799A1 (en) | 2020-11-11 | 2022-05-19 | Stephen R. Martin | Methods of identifying hiv patients sensitive to therapy with gp120 cd4 binding site-directed antibodies |
CA3235937A1 (en) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
AU2022399845A1 (en) | 2021-12-03 | 2024-05-23 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
US20230212148A1 (en) | 2021-12-03 | 2023-07-06 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
TW202400172A (zh) | 2022-04-06 | 2024-01-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
WO2024006982A1 (en) | 2022-07-01 | 2024-01-04 | Gilead Sciences, Inc. | Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection |
US20240083984A1 (en) | 2022-08-26 | 2024-03-14 | Gilead Sciences, Inc. | Dosing and scheduling regimen for broadly neutralizing antibodies |
WO2024076915A1 (en) | 2022-10-04 | 2024-04-11 | Gilead Sciences, Inc. | 4'-thionucleoside analogues and their pharmaceutical use |
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NZ197420A (en) | 1980-07-01 | 1984-04-27 | Ici Australia Ltd | -(quinazolin-(2-or 4-)(oxy,ylthio or amino)phen(oxy or ylthio)alkanoic acid derivatives |
JPH11209350A (ja) | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
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CA2386955A1 (en) | 1999-11-22 | 2001-05-31 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
GB0002032D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
EP1305291A1 (en) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
EP1318984A1 (en) | 2000-09-20 | 2003-06-18 | MERCK PATENT GmbH | 4-amino-quinazolines |
GB0217015D0 (en) | 2002-07-23 | 2002-08-28 | Bioacta Ltd | Peptide 4 |
AU2003255482A1 (en) | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
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TWI699355B (zh) | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
CN107428693B (zh) | 2014-12-24 | 2020-05-29 | 吉利德科学公司 | 用于hiv治疗的异喹啉化合物 |
-
2015
- 2015-12-23 CN CN201580075766.9A patent/CN107428693B/zh active Active
- 2015-12-23 KR KR1020177020463A patent/KR101960624B1/ko active IP Right Grant
- 2015-12-23 BR BR112017013440-3A patent/BR112017013440A2/pt not_active Application Discontinuation
- 2015-12-23 JP JP2017534246A patent/JP6356919B2/ja active Active
- 2015-12-23 AU AU2015371257A patent/AU2015371257B2/en active Active
- 2015-12-23 EA EA201791304A patent/EA201791304A1/ru unknown
- 2015-12-23 NZ NZ733125A patent/NZ733125A/en not_active IP Right Cessation
- 2015-12-23 CA CA2972017A patent/CA2972017C/en active Active
- 2015-12-23 WO PCT/US2015/000310 patent/WO2016105534A1/en active Application Filing
- 2015-12-23 MX MX2017008518A patent/MX2017008518A/es unknown
- 2015-12-23 EP EP15823844.4A patent/EP3237397B1/en active Active
- 2015-12-23 ES ES15823844T patent/ES2705709T3/es active Active
- 2015-12-23 PT PT15823844T patent/PT3237397T/pt unknown
- 2015-12-23 SG SG11201705184PA patent/SG11201705184PA/en unknown
- 2015-12-23 US US14/998,131 patent/US9624195B2/en active Active
-
2017
- 2017-06-21 IL IL253052A patent/IL253052A0/en unknown
-
2018
- 2018-03-16 HK HK18103630.0A patent/HK1244271B/zh unknown
- 2018-05-09 HK HK18106002.3A patent/HK1246776A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2972017A1 (en) | 2016-06-30 |
JP2018500356A (ja) | 2018-01-11 |
US20160237062A1 (en) | 2016-08-18 |
AU2015371257A1 (en) | 2017-07-13 |
MX2017008518A (es) | 2017-10-25 |
KR20170096049A (ko) | 2017-08-23 |
CN107428693A (zh) | 2017-12-01 |
US9624195B2 (en) | 2017-04-18 |
CN107428693B (zh) | 2020-05-29 |
KR101960624B1 (ko) | 2019-03-20 |
EP3237397B1 (en) | 2018-11-21 |
PT3237397T (pt) | 2019-02-08 |
NZ733125A (en) | 2018-06-29 |
EP3237397A1 (en) | 2017-11-01 |
BR112017013440A2 (pt) | 2018-01-09 |
IL253052A0 (en) | 2017-08-31 |
HK1244271B (zh) | 2019-11-29 |
JP6356919B2 (ja) | 2018-07-11 |
SG11201705184PA (en) | 2017-07-28 |
AU2015371257B2 (en) | 2018-09-06 |
CA2972017C (en) | 2019-06-11 |
WO2016105534A1 (en) | 2016-06-30 |
ES2705709T3 (es) | 2019-03-26 |
EA201791304A1 (ru) | 2017-12-29 |
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