HK1244248A1 - 兩性黴素b的衍生物 - Google Patents

兩性黴素b的衍生物

Info

Publication number
HK1244248A1
HK1244248A1 HK18103742.5A HK18103742A HK1244248A1 HK 1244248 A1 HK1244248 A1 HK 1244248A1 HK 18103742 A HK18103742 A HK 18103742A HK 1244248 A1 HK1244248 A1 HK 1244248A1
Authority
HK
Hong Kong
Prior art keywords
amphotericin
derivatives
Prior art date
Application number
HK18103742.5A
Other languages
English (en)
Inventor
Martin D Burke
Arun P Thottumkara
Kevin T Mellem
Zachary K Sweeney
Elena S Koltun
Original Assignee
Sfunga Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sfunga Therapeutics Inc filed Critical Sfunga Therapeutics Inc
Publication of HK1244248A1 publication Critical patent/HK1244248A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK18103742.5A 2015-04-15 2018-03-18 兩性黴素b的衍生物 HK1244248A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562147949P 2015-04-15 2015-04-15
PCT/US2016/027703 WO2016168568A1 (en) 2015-04-15 2016-04-15 Derivatives of amphotericin b

Publications (1)

Publication Number Publication Date
HK1244248A1 true HK1244248A1 (zh) 2018-08-03

Family

ID=57126898

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103742.5A HK1244248A1 (zh) 2015-04-15 2018-03-18 兩性黴素b的衍生物

Country Status (8)

Country Link
US (3) US9957290B2 (zh)
EP (2) EP3283171B1 (zh)
JP (3) JP7240811B2 (zh)
CA (2) CA3213127A1 (zh)
ES (1) ES2880029T3 (zh)
HK (1) HK1244248A1 (zh)
PT (1) PT3283171T (zh)
WO (1) WO2016168568A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3055030B1 (en) 2013-10-07 2018-05-02 The Board of Trustees of the University of Illionis Amphotericin b derivatives with improved therapeutic index
EA037093B1 (ru) * 2014-06-12 2021-02-04 Сионоги Энд Ко., Лтд. Производное полиенового макролида
EP3283171B1 (en) * 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
JP7477177B2 (ja) * 2018-09-07 2024-05-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
BR112022001866A2 (pt) * 2019-08-08 2022-03-29 Univ Illinois Derivados de amida híbridos de anfotericina b
WO2021026450A1 (en) * 2019-08-08 2021-02-11 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity
WO2022003181A1 (fr) * 2020-07-03 2022-01-06 Nanotracks Diagnostics Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée
FR3112145A1 (fr) * 2020-07-03 2022-01-07 Nanotracks Diagnostics Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations
IL300441A (en) * 2020-08-10 2023-04-01 Univ Illinois Amphotericin B hybrid amide histology

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350164A3 (en) * 1988-06-13 1991-07-24 Beecham Group Plc Amphotericin derivatives
GB8829592D0 (en) 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
CA2082951C (en) 1991-03-15 1999-12-21 Robert M. Platz Pulmonary administration of granulocyte colony stimulating factor
GB9203476D0 (en) * 1992-02-19 1992-04-08 Smithkline Beecham Plc Novel compounds
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US5606038A (en) 1995-04-10 1997-02-25 Competitive Technologies, Inc. Amphiphilic polyene macrolide antibiotic compounds
PL180253B1 (pl) * 1995-05-13 2001-01-31 Politechnika Gdanska Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
JP4208294B2 (ja) 1998-07-17 2009-01-14 株式会社アマダ 剪断・曲げ複合機
US6664241B2 (en) 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
EP1987049A1 (en) * 2006-02-23 2008-11-05 ETH Zürich Amphotericin derivatives
JP5240704B2 (ja) * 2007-10-05 2013-07-17 国立大学法人群馬大学 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法
CN104520309B (zh) * 2012-06-15 2018-05-04 布里特股份公司 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
EP3055030B1 (en) * 2013-10-07 2018-05-02 The Board of Trustees of the University of Illionis Amphotericin b derivatives with improved therapeutic index
WO2015164289A1 (en) * 2014-04-21 2015-10-29 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
WO2015175875A1 (en) 2014-05-16 2015-11-19 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
EA037093B1 (ru) * 2014-06-12 2021-02-04 Сионоги Энд Ко., Лтд. Производное полиенового макролида
WO2016014779A1 (en) 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
WO2016040779A1 (en) 2014-09-12 2016-03-17 The Board Of Trustees Of The University Of Illinois Urea derivatives of polyene macrolide antibiotics
US10087206B2 (en) 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
WO2016112243A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Urea derivatives of amphotericin b derived from secondary amines
US20180273571A1 (en) 2015-01-08 2018-09-27 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
EP3283171B1 (en) * 2015-04-15 2021-05-26 Sfunga Therapeutics, Inc. Derivatives of amphotericin b

Also Published As

Publication number Publication date
CA3021061A1 (en) 2016-10-20
ES2880029T3 (es) 2021-11-23
US20180273572A1 (en) 2018-09-27
EP3283171A4 (en) 2019-03-13
US20200262858A1 (en) 2020-08-20
US9957290B2 (en) 2018-05-01
JP2021075570A (ja) 2021-05-20
US10597420B2 (en) 2020-03-24
JP7240811B2 (ja) 2023-03-16
EP3283171A1 (en) 2018-02-21
PT3283171T (pt) 2021-07-14
CA3213127A1 (en) 2016-10-20
EP3283171B1 (en) 2021-05-26
US10882883B2 (en) 2021-01-05
US20160304548A1 (en) 2016-10-20
JP2023030103A (ja) 2023-03-07
CA3021061C (en) 2023-10-24
WO2016168568A1 (en) 2016-10-20
EP3929203A1 (en) 2021-12-29
JP2018514522A (ja) 2018-06-07

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