HK1243325A1 - 用於治疗视觉障碍的组合物和方法 - Google Patents

用於治疗视觉障碍的组合物和方法 Download PDF

Info

Publication number
HK1243325A1
HK1243325A1 HK18102775.7A HK18102775A HK1243325A1 HK 1243325 A1 HK1243325 A1 HK 1243325A1 HK 18102775 A HK18102775 A HK 18102775A HK 1243325 A1 HK1243325 A1 HK 1243325A1
Authority
HK
Hong Kong
Prior art keywords
lanosterol
crystallin
ophthalmic
subject
lens
Prior art date
Application number
HK18102775.7A
Other languages
English (en)
Chinese (zh)
Inventor
张康
張康
侯睿
蔡惠民
Original Assignee
优美佳生物技术有限公司
加利福尼亚大学董事会
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 优美佳生物技术有限公司, 加利福尼亚大学董事会 filed Critical 优美佳生物技术有限公司
Publication of HK1243325A1 publication Critical patent/HK1243325A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
HK18102775.7A 2014-08-22 2015-08-24 用於治疗视觉障碍的组合物和方法 HK1243325A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462040721P 2014-08-22 2014-08-22
US62/040,721 2014-08-22
US201562194120P 2015-07-17 2015-07-17
US62/194,120 2015-07-17
PCT/US2015/046453 WO2016029199A1 (en) 2014-08-22 2015-08-24 Compositions and methods to treat vision disorders

Publications (1)

Publication Number Publication Date
HK1243325A1 true HK1243325A1 (zh) 2018-07-13

Family

ID=55351326

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18102775.7A HK1243325A1 (zh) 2014-08-22 2015-08-24 用於治疗视觉障碍的组合物和方法

Country Status (13)

Country Link
US (1) US10471076B2 (enExample)
EP (1) EP3182977B1 (enExample)
JP (1) JP6706020B2 (enExample)
KR (1) KR20170048426A (enExample)
CN (2) CN111529481B (enExample)
AU (1) AU2015305199A1 (enExample)
BR (1) BR112017003529A2 (enExample)
CA (1) CA2958868A1 (enExample)
EA (1) EA035798B1 (enExample)
HK (1) HK1243325A1 (enExample)
MX (1) MX2017002374A (enExample)
SG (1) SG11201701377YA (enExample)
WO (1) WO2016029199A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2958868A1 (en) 2014-08-22 2016-02-25 Guangzhou Kangrui Biological Pharmaceutical Technology Co., Ltd. Compositions and methods to treat vision disorders
WO2017019808A1 (en) * 2015-07-27 2017-02-02 Catacore, Inc Compositions for the treatment of cataracts
CN109364020B (zh) * 2015-09-02 2021-12-28 盛世泰科生物医药技术(苏州)有限公司 一种用于预防和治疗白内障的眼用制剂及其制备方法
CN106344587A (zh) * 2016-08-24 2017-01-25 上海毕傲图生物科技有限公司 羊毛甾醇类化合物眼用制剂
CN107397745A (zh) * 2016-08-24 2017-11-28 上海毕傲图生物科技有限公司 唑类化合物眼用制剂
ES2890667T3 (es) * 2017-01-25 2022-01-21 Guangzhou Ocusun Ophthalmic Biotechnology Co Ltd Compuesto de profármaco de lanosterol y su uso del mismo
GB2581656A (en) * 2017-11-17 2020-08-26 Piraee Mahmood Combinations of lanosterol or 25-hydroxycholesterol including derivatives thereof useful in the treatment of lens disorders
CN109985052A (zh) * 2017-12-29 2019-07-09 上海蓝木化工有限公司 三萜类化合物的新用途
US11872236B2 (en) 2018-04-05 2024-01-16 Calasia Pharmaceuticals, Inc. Pharmacological agents for treating ocular diseases
JP7046266B2 (ja) * 2018-07-25 2022-04-01 グアンジョウ オクスン オフサルミク バイオテクノロジー カンパニーリミテッド ラノステロールプロドラッグ化合物の結晶形及びその使用
US12329763B2 (en) * 2019-03-04 2025-06-17 Guangzhou Ocusun Ophthalmic Biotechnology Co., Ltd. Composition of lanosterol prodrug compound, preparation method therefor and use thereof
MX2021009520A (es) 2021-08-06 2023-02-07 Foodvica S A De C V Composicion oftalmica para el tratamiento de trastornos visuales.
CN115737654B (zh) 2021-09-03 2025-11-21 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂
CN116570706A (zh) * 2022-02-09 2023-08-11 上海瑞吉康生物医药有限公司 使用多肽治疗白内障的方法
WO2023198192A1 (zh) * 2022-04-15 2023-10-19 广州润尔眼科生物科技有限公司 甾体化合物在制备预防和/或治疗老花眼的药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216106B2 (en) * 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
WO2005084208A2 (en) * 2004-02-27 2005-09-15 New York University A novel class of sterol ligands and their uses in regulation of cholesterol and gene expression
US7517870B2 (en) 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
US20100068251A1 (en) * 2006-10-10 2010-03-18 Jina Pharmaceuticals, Inc. Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof
WO2009107753A1 (ja) * 2008-02-29 2009-09-03 財団法人 名古屋産業科学研究所 後眼部到達用リポソーム及び後眼部疾患用医薬組成物
RU2476226C2 (ru) * 2008-08-05 2013-02-27 Амазония Фитомедикаментос Лтда Фармацевтические применения ланоста-8,24-диен-3-олов
CA2878946A1 (en) * 2012-07-17 2014-01-23 Regents Of The University Of Michigan Non-surgical method of treatment for cataract
EP2890363A1 (en) * 2012-08-31 2015-07-08 Bausch & Lomb Incorporated Ophthalmic compositions with omega-3 fatty acids
CA2958868A1 (en) 2014-08-22 2016-02-25 Guangzhou Kangrui Biological Pharmaceutical Technology Co., Ltd. Compositions and methods to treat vision disorders

Also Published As

Publication number Publication date
JP6706020B2 (ja) 2020-06-03
US10471076B2 (en) 2019-11-12
EA201790397A1 (ru) 2017-08-31
CN111529481B (zh) 2023-09-15
JP2017525769A (ja) 2017-09-07
EP3182977A4 (en) 2018-04-11
MX2017002374A (es) 2017-09-15
SG11201701377YA (en) 2017-03-30
EA035798B1 (ru) 2020-08-12
KR20170048426A (ko) 2017-05-08
CN107206009A (zh) 2017-09-26
WO2016029199A1 (en) 2016-02-25
BR112017003529A2 (pt) 2019-08-20
CN111529481A (zh) 2020-08-14
EP3182977A1 (en) 2017-06-28
AU2015305199A1 (en) 2017-04-13
CA2958868A1 (en) 2016-02-25
CN107206009B (zh) 2020-03-27
US20170065617A1 (en) 2017-03-09
EP3182977B1 (en) 2021-05-05

Similar Documents

Publication Publication Date Title
CN107206009B (zh) 用于治疗视觉障碍的组合物和方法
Gros et al. The role of lysosomes in metabolic and autoimmune diseases
US20190117675A1 (en) Compositions And Methods To Treat And/Or Prevent Vision Disorders Of The Lens Of The Eye
Zhao et al. Lanosterol reverses protein aggregation in cataracts
JP6209791B2 (ja) 白内障を処置するためのα−クリスタリン凝集の阻害剤
JP4571695B2 (ja) 疾患関連タンパク質
JP2018035197A (ja) Ａｐｐ特異性のｂａｃｅ（ａｓｂｉ）およびその使用
JP2021512906A (ja) 妊娠患者におけるファブリー病の治療のためのミガラスタットの使用
KR20030066813A (ko) Ｄ-아미노산 산화효소와 ｄ-아스파르테이트 산화효소길항제를 이용한 ｃｎｓ 질환의 치료
Liang et al. miR-328-3p affects axial length via multiple routes and anti-miR-328-3p possesses a potential to control myopia progression
TW201805004A (zh) 用於預防具風險病患之阿茲海默症之㗁衍生物
Zou et al. Rod-Cone Dystrophy Related WDR34 Is Essential for Ciliary Integrity and Survival of Mammalian Photoreceptor Cells
US20200140500A1 (en) High throughput methods, protein inhibitors, and uses thereof
CN117177742A (zh) 溶酶体相关膜蛋白靶向化合物及其用途
JP2025532963A (ja) 眼の細胞および組織への治療用薬剤のａｒｒｄｃ１介在性の微小小胞体に基づく送達
WO2023028257A1 (en) Compositions and methods for treating neurodegenerative disorders
Long et al. Advances in RPGR gene therapy for X-linked retinitis pigmentosa: From preclinical insights to clinical application
HK40011572A (en) Non-surgical method of treatment for cataract
US20110144077A1 (en) Treatment of retinal degeneration