CN111529481B - 用于治疗视觉障碍的组合物和方法 - Google Patents

用于治疗视觉障碍的组合物和方法 Download PDF

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Publication number
CN111529481B
CN111529481B CN202010136027.9A CN202010136027A CN111529481B CN 111529481 B CN111529481 B CN 111529481B CN 202010136027 A CN202010136027 A CN 202010136027A CN 111529481 B CN111529481 B CN 111529481B
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CN
China
Prior art keywords
pharmaceutical composition
lanosterol
formulated
ophthalmic
use according
Prior art date
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Application number
CN202010136027.9A
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English (en)
Chinese (zh)
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CN111529481A (zh
Inventor
张康
侯睿
蔡惠民
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Kangrui Biological Pharmaceutical Technology Co ltd
University of California San Diego UCSD
Original Assignee
Guangzhou Kangrui Biological Pharmaceutical Technology Co ltd
University of California San Diego UCSD
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Priority to CN202010136027.9A priority Critical patent/CN111529481B/zh
Publication of CN111529481A publication Critical patent/CN111529481A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CN202010136027.9A 2014-08-22 2015-08-24 用于治疗视觉障碍的组合物和方法 Active CN111529481B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010136027.9A CN111529481B (zh) 2014-08-22 2015-08-24 用于治疗视觉障碍的组合物和方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462040721P 2014-08-22 2014-08-22
US62/040,721 2014-08-22
US201562194120P 2015-07-17 2015-07-17
US62/194,120 2015-07-17
CN201580057679.0A CN107206009B (zh) 2014-08-22 2015-08-24 用于治疗视觉障碍的组合物和方法
CN202010136027.9A CN111529481B (zh) 2014-08-22 2015-08-24 用于治疗视觉障碍的组合物和方法
PCT/US2015/046453 WO2016029199A1 (en) 2014-08-22 2015-08-24 Compositions and methods to treat vision disorders

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580057679.0A Division CN107206009B (zh) 2014-08-22 2015-08-24 用于治疗视觉障碍的组合物和方法

Publications (2)

Publication Number Publication Date
CN111529481A CN111529481A (zh) 2020-08-14
CN111529481B true CN111529481B (zh) 2023-09-15

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CN201580057679.0A Active CN107206009B (zh) 2014-08-22 2015-08-24 用于治疗视觉障碍的组合物和方法

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Country Link
US (1) US10471076B2 (enExample)
EP (1) EP3182977B1 (enExample)
JP (1) JP6706020B2 (enExample)
KR (1) KR20170048426A (enExample)
CN (2) CN111529481B (enExample)
AU (1) AU2015305199A1 (enExample)
BR (1) BR112017003529A2 (enExample)
CA (1) CA2958868A1 (enExample)
EA (1) EA035798B1 (enExample)
HK (1) HK1243325A1 (enExample)
MX (1) MX2017002374A (enExample)
SG (1) SG11201701377YA (enExample)
WO (1) WO2016029199A1 (enExample)

Families Citing this family (15)

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BR112017003529A2 (pt) 2014-08-22 2019-08-20 Guangzhou Kangrui Biological Pharmaceutical Tech Co Ltd composições e métodos para tratar distúrbios visuais.
EP3328389A1 (en) * 2015-07-27 2018-06-06 Catacore, Inc. Compositions for the treatment of cataracts
CN109481450B (zh) * 2015-09-02 2021-07-23 盛世泰科生物医药技术(苏州)有限公司 一种用于预防和治疗白内障的眼用制剂及其制备方法
CN107397745A (zh) * 2016-08-24 2017-11-28 上海毕傲图生物科技有限公司 唑类化合物眼用制剂
CN106344587A (zh) * 2016-08-24 2017-01-25 上海毕傲图生物科技有限公司 羊毛甾醇类化合物眼用制剂
JP6704535B2 (ja) * 2017-01-25 2020-06-03 中山大学中山眼科中心 ラノステロールプロドラッグ化合物、その製造方法及び応用
WO2019097434A1 (en) * 2017-11-17 2019-05-23 Mahmood Piraee Combinations of lanosterol or 25-hydroxycholesterol including derivatives thereof useful in the treatment of lens disorders
CN109985052A (zh) * 2017-12-29 2019-07-09 上海蓝木化工有限公司 三萜类化合物的新用途
MX2020010502A (es) * 2018-04-05 2021-03-25 Calasia Pharmaceuticals Inc Agentes farmacológicos para el tratamiento de enfermedades oculares.
WO2020020306A1 (zh) * 2018-07-25 2020-01-30 中山大学中山眼科中心 一种羊毛甾醇前药化合物的晶型及其应用
US12329763B2 (en) * 2019-03-04 2025-06-17 Guangzhou Ocusun Ophthalmic Biotechnology Co., Ltd. Composition of lanosterol prodrug compound, preparation method therefor and use thereof
MX2021009520A (es) 2021-08-06 2023-02-07 Foodvica S A De C V Composicion oftalmica para el tratamiento de trastornos visuales.
CN115737654B (zh) * 2021-09-03 2025-11-21 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂
CN114796451B (zh) * 2022-02-09 2023-06-06 上海瑞吉康生物医药有限公司 使用多肽治疗白内障的方法
WO2023198192A1 (zh) * 2022-04-15 2023-10-19 广州润尔眼科生物科技有限公司 甾体化合物在制备预防和/或治疗老花眼的药物中的应用

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WO2006059357A2 (en) * 2004-12-03 2006-06-08 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/ or reversing ocular diseases related with ocular neovascularization
CN101959503A (zh) * 2008-02-29 2011-01-26 财团法人名古屋产业科学研究所 眼后节到达用脂质体和眼后节疾病用医药组合物

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WO2005084208A2 (en) * 2004-02-27 2005-09-15 New York University A novel class of sterol ligands and their uses in regulation of cholesterol and gene expression
US20100068251A1 (en) * 2006-10-10 2010-03-18 Jina Pharmaceuticals, Inc. Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof
MX2011001411A (es) * 2008-08-05 2011-03-15 Amazonia Fitomedicamentos Ltda Usos farmaceuticos de lanosta-8,24-dien-3-ols.
SG11201500288QA (en) * 2012-07-17 2015-02-27 Univ Michigan Inhibitors of alpha-crystallin aggregation for the treatment for cataract
KR20150046300A (ko) * 2012-08-31 2015-04-29 보오슈 앤드 롬 인코포레이팃드 오메가-3 지방산을 함유하는 안과용 조성물
BR112017003529A2 (pt) 2014-08-22 2019-08-20 Guangzhou Kangrui Biological Pharmaceutical Tech Co Ltd composições e métodos para tratar distúrbios visuais.

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WO2006059357A2 (en) * 2004-12-03 2006-06-08 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/ or reversing ocular diseases related with ocular neovascularization
CN101959503A (zh) * 2008-02-29 2011-01-26 财团法人名古屋产业科学研究所 眼后节到达用脂质体和眼后节疾病用医药组合物

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Also Published As

Publication number Publication date
CN107206009A (zh) 2017-09-26
SG11201701377YA (en) 2017-03-30
WO2016029199A1 (en) 2016-02-25
JP6706020B2 (ja) 2020-06-03
EP3182977A4 (en) 2018-04-11
EA035798B1 (ru) 2020-08-12
EA201790397A1 (ru) 2017-08-31
CA2958868A1 (en) 2016-02-25
US10471076B2 (en) 2019-11-12
JP2017525769A (ja) 2017-09-07
US20170065617A1 (en) 2017-03-09
BR112017003529A2 (pt) 2019-08-20
HK1243325A1 (zh) 2018-07-13
MX2017002374A (es) 2017-09-15
KR20170048426A (ko) 2017-05-08
EP3182977A1 (en) 2017-06-28
CN111529481A (zh) 2020-08-14
AU2015305199A1 (en) 2017-04-13
EP3182977B1 (en) 2021-05-05
CN107206009B (zh) 2020-03-27

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