HK1226142A1 - 高靈敏度電噴射接口 - Google Patents

高靈敏度電噴射接口

Info

Publication number
HK1226142A1
HK1226142A1 HK16114532A HK16114532A HK1226142A1 HK 1226142 A1 HK1226142 A1 HK 1226142A1 HK 16114532 A HK16114532 A HK 16114532A HK 16114532 A HK16114532 A HK 16114532A HK 1226142 A1 HK1226142 A1 HK 1226142A1
Authority
HK
Hong Kong
Prior art keywords
high sensitivity
electrospray interface
sensitivity electrospray
interface
sensitivity
Prior art date
Application number
HK16114532A
Other languages
English (en)
Inventor
Norman Dovichi
Liangliang Sun
Guijie Zhu
Original Assignee
Univ Notre Dame Du Lac
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Notre Dame Du Lac filed Critical Univ Notre Dame Du Lac
Publication of HK1226142A1 publication Critical patent/HK1226142A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
HK16114532A 2013-08-29 2016-12-21 高靈敏度電噴射接口 HK1226142A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361871562P 2013-08-29 2013-08-29

Publications (1)

Publication Number Publication Date
HK1226142A1 true HK1226142A1 (zh) 2017-09-22

Family

ID=52587387

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16114532A HK1226142A1 (zh) 2013-08-29 2016-12-21 高靈敏度電噴射接口

Country Status (6)

Country Link
US (2) US9465014B2 (zh)
EP (1) EP3042190B1 (zh)
JP (1) JP6601819B2 (zh)
CN (1) CN105723213B (zh)
HK (1) HK1226142A1 (zh)
WO (1) WO2015031820A1 (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3042190B1 (en) * 2013-08-29 2024-04-03 University of Notre Dame du Lac High sensitivity electrospray interface
WO2016010748A1 (en) 2014-07-14 2016-01-21 Li-Cor, Inc. Analyte separator with electrohydrodynamic taylor cone jet blotter
JP6498497B2 (ja) * 2015-04-01 2019-04-10 学校法人慶應義塾 シースレスｃｅ−ｍｓ用スプレーデバイスの作成方法、シースレスｃｅ−ｍｓ用スプレーデバイス、及び、シースレスｃｅ−ｍｓ装置
JP6598253B2 (ja) * 2015-05-18 2019-10-30 株式会社Ｈｕｍａｎｉｘ １細胞あるいは超微小域分子の電場捕獲・遊離分離・分子検出法
RU2608362C2 (ru) * 2015-06-11 2017-01-18 Общество с ограниченной ответственностью "Альфа" (ООО "Альфа") Устройство стабильного электрораспыления при атмосферном давлении растворов веществ для источников ионов
WO2017095813A1 (en) * 2015-11-30 2017-06-08 Intabio, Inc. Devices and methods for sample characterization
CN108604526B (zh) * 2015-12-31 2021-07-20 圣母大学 经由动电泵驱接口的esi-ms
CN108604527B (zh) * 2016-02-01 2021-03-23 利康公司 毛细管电泳喷墨分配
CN106057630B (zh) * 2016-06-02 2017-10-27 中国检验检疫科学研究院 一种离子溅射镀膜毛细管喷雾电离装置
EP3497433A1 (en) 2016-08-08 2019-06-19 Li-Cor, Inc. Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting
CN109564188A (zh) * 2016-08-08 2019-04-02 利康公司 微芯片电泳喷墨式分配
JP7078228B2 (ja) * 2016-09-23 2022-05-31 ユニヴァーシティー オブ ノートル ダム デュ ラック 検体の一段階のキャピラリ等電集束及び移動
WO2018058131A1 (en) * 2016-09-26 2018-03-29 University Of Notre Dame Du Lac Methods and apparatus for mitigation of current reversal in capillary zone electrophoresis-electrospray devices
US11073522B2 (en) * 2016-10-03 2021-07-27 Lincoln Memorial University Structural validation of very long chain dicarboxylic acids
CN106783511B (zh) * 2017-02-27 2018-07-13 中国计量科学研究院 基于极性反转电压策略的纳喷雾离子源及其操作方法
WO2019008492A1 (en) * 2017-07-07 2019-01-10 Dh Technologies Development Pte. Ltd. ELECTRODEBULATING INTERFACE DEVICE AND ASSOCIATED METHODS
US20190019662A1 (en) * 2017-07-14 2019-01-17 Purdue Research Foundation Electrophoretic mass spectrometry probes and systems and uses thereof
JP7333326B2 (ja) 2018-01-29 2023-08-24 インタバイオ， エルエルシー 試料の特性評価のための装置、方法およびキット
CN108201654B (zh) * 2018-03-28 2023-10-13 南方医科大学南方医院 一种多用途喷洒导管
US10658168B2 (en) * 2018-05-03 2020-05-19 Perkinelmer Health Sciences Canada, Inc. Multiple gas flow ionizer
WO2019222531A1 (en) 2018-05-17 2019-11-21 Gmj Technologies, Llc Apparatuses for optical and mass spectrometry detection
EP3811397B1 (en) 2018-05-31 2024-09-18 Intabio, Llc Methods for interfacing microfluidic systems with mass spectrometry
US11117131B2 (en) 2018-08-22 2021-09-14 International Business Machines Corporation Electrokinetically separating, encapsulating and extracting analytes on a microfluidic device
US11640901B2 (en) 2018-09-05 2023-05-02 Protein Metrics, Llc Methods and apparatuses for deconvolution of mass spectrometry data
US11346844B2 (en) * 2019-04-26 2022-05-31 Protein Metrics Inc. Intact mass reconstruction from peptide level data and facilitated comparison with experimental intact observation
US20220120758A1 (en) * 2019-06-06 2022-04-21 Fudan University Method and device for protein sequence analysis
US11285484B2 (en) 2019-08-12 2022-03-29 Intabio, Llc Multichannel isoelectric focusing devices and high voltage power supplies
US11087964B2 (en) * 2019-11-21 2021-08-10 Thermo Finnigan Llc Method and apparatus for improved electrospray emitter lifetime
US11340200B2 (en) * 2020-03-08 2022-05-24 The Board Of Regents Of The University Of Oklahoma Electrospray assisted capillary device for processing ultra low-volume samples
CN111266140B (zh) * 2020-03-09 2021-07-16 厦门大学 无油分选-直接注入-icpms单细胞分析系统
CN111413172A (zh) * 2020-04-17 2020-07-14 山东省分析测试中心 一种原位酶解-直接质谱分析系统及分析方法
US11988652B2 (en) 2020-11-18 2024-05-21 Thermo Finnigan Llc Packed tip electrospray emitter
CN114496717A (zh) * 2022-01-18 2022-05-13 中国科学院成都生物研究所 电喷雾的激发装置及离子化方法
CN118648084A (zh) * 2022-02-02 2024-09-13 沃特世科技公司 纳米喷雾反应性喷雾器

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US5115131A (en) * 1991-05-15 1992-05-19 The University Of North Carolina At Chapel Hill Microelectrospray method and apparatus
US5245186A (en) * 1991-11-18 1993-09-14 The Rockefeller University Electrospray ion source for mass spectrometry
US5444208A (en) * 1993-03-29 1995-08-22 Fmc Corporation Multiple source plasma generation and injection device
US5423964A (en) * 1993-08-02 1995-06-13 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
DE4444229C2 (de) * 1994-03-10 1996-07-25 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer
US5868322A (en) * 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US6690006B2 (en) * 2001-05-24 2004-02-10 New Objective, Inc. Method and apparatus for multiple electrospray sample introduction
GB0226160D0 (en) * 2002-11-08 2002-12-18 Diagnoswiss Sa Apparatus for dispensing a sample in electrospray mass spectrometers
JP2004317469A (ja) * 2003-04-10 2004-11-11 Ajinomoto Co Inc 質量分析用ナノ・スプレーイオン化用極細管
JP3991023B2 (ja) * 2003-10-31 2007-10-17 株式会社日立ハイテクノロジーズ 質量分析装置
US7662936B2 (en) * 2004-04-07 2010-02-16 Genentech, Inc. Mass spectrometry of antibody conjugates
JP3871689B2 (ja) * 2004-08-25 2007-01-24 ヒューマン・メタボローム・テクノロジーズ株式会社 電気泳動測定によるイオン性化合物の移動時間予測方法
EP2038413A4 (en) * 2006-06-28 2010-01-06 Lineagen Inc DEVICES, COMPOSITIONS AND METHODS FOR MONITORING THE PROGRESS OF CHRONIC OBSTRUCTIVE LUNG DISORDERS UNDER QUICK OR SLOW DEGRADING CONDITIONS
JP2011513738A (ja) 2008-03-07 2011-04-28 ザ ユニバーシティー オブ ブリティッシュ コロンビア 質量分析と接続する自己完結型キャピラリ電気泳動システム
US9234880B2 (en) 2011-06-03 2016-01-12 University Of Washington Through Its Center For Commercialization Sheath-flow electrospray interface
CN102324375B (zh) * 2011-07-22 2013-12-04 中国科学院上海有机化学研究所 一种质谱纳喷雾电极及其制作方法和应用
EP2780117A2 (en) * 2011-11-18 2014-09-24 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University System and method for providing a micron-scale continuous liquid jet
WO2013166297A2 (en) 2012-05-03 2013-11-07 Medimmune, Llc Method for analyzing sample components
EP3042190B1 (en) * 2013-08-29 2024-04-03 University of Notre Dame du Lac High sensitivity electrospray interface

Also Published As

Publication number Publication date
CN105723213B (zh) 2019-09-13
EP3042190B1 (en) 2024-04-03
EP3042190A1 (en) 2016-07-13
CN105723213A (zh) 2016-06-29
US20150311056A1 (en) 2015-10-29
EP3042190A4 (en) 2017-04-05
WO2015031820A1 (en) 2015-03-05
US9465014B2 (en) 2016-10-11
US9362102B2 (en) 2016-06-07
JP2016534353A (ja) 2016-11-04
US20150233877A1 (en) 2015-08-20
JP6601819B2 (ja) 2019-11-06
EP3042190C0 (en) 2024-04-03

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