HK1223929A1 - -氨基- -二氫- -二氮雜萘 -二酮鈉鹽的晶型 - Google Patents
-氨基- -二氫- -二氮雜萘 -二酮鈉鹽的晶型Info
- Publication number
- HK1223929A1 HK1223929A1 HK16112165.6A HK16112165A HK1223929A1 HK 1223929 A1 HK1223929 A1 HK 1223929A1 HK 16112165 A HK16112165 A HK 16112165A HK 1223929 A1 HK1223929 A1 HK 1223929A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- diazanaphthalene
- dihydro
- amino
- sodium salt
- crystalline forms
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10002067 | 2010-03-01 | ||
| EP10075744 | 2010-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1223929A1 true HK1223929A1 (zh) | 2017-08-11 |
Family
ID=43828190
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16112165.6A HK1223929A1 (zh) | 2010-03-01 | 2016-10-24 | -氨基- -二氫- -二氮雜萘 -二酮鈉鹽的晶型 |
| HK16112162.9A HK1223836A1 (zh) | 2010-03-01 | 2016-10-24 | -氨基- -二氫- -二氮雜萘 -二酮鈉鹽的晶型 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16112162.9A HK1223836A1 (zh) | 2010-03-01 | 2016-10-24 | -氨基- -二氫- -二氮雜萘 -二酮鈉鹽的晶型 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8772294B2 (zh) |
| EP (2) | EP2774920A1 (zh) |
| JP (2) | JP6061081B2 (zh) |
| KR (1) | KR101770011B1 (zh) |
| CN (3) | CN105859634B (zh) |
| AU (1) | AU2011223226B2 (zh) |
| BR (1) | BR112012021857B1 (zh) |
| CA (1) | CA2791327C (zh) |
| CH (1) | CH704794B1 (zh) |
| CY (1) | CY1115585T1 (zh) |
| DK (1) | DK2542535T3 (zh) |
| ES (1) | ES2487221T3 (zh) |
| HK (2) | HK1223929A1 (zh) |
| HR (1) | HRP20140752T1 (zh) |
| IL (1) | IL221680A (zh) |
| NZ (1) | NZ601689A (zh) |
| PL (1) | PL2542535T3 (zh) |
| PT (1) | PT2542535E (zh) |
| RS (1) | RS53492B1 (zh) |
| RU (1) | RU2585677C2 (zh) |
| SI (1) | SI2542535T1 (zh) |
| WO (1) | WO2011107295A1 (zh) |
| ZA (1) | ZA201206264B (zh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105859634B (zh) * | 2010-03-01 | 2019-06-28 | 梅特里奥药品股份公司 | 5-氨基-2,3-二氢-(2,3-二氮杂萘)-1,4-二酮钠盐的晶型 |
| US10258620B2 (en) | 2014-12-18 | 2019-04-16 | Metriopharm Ag | Crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, pharmaceutical preparations containing the same and method for the production of said form |
| KR102535960B1 (ko) * | 2016-02-16 | 2023-05-23 | 메트리오팜 아게 | 5-아미노-2,3-디하이드로프탈라진-1,4-디온의 새로운 결정질 형태 |
| CN109071461B (zh) * | 2016-02-16 | 2022-06-21 | 麦翠奥制药公司 | 制备5-氨基-2,3-二氢酞嗪-1,4-二酮结晶体的方法 |
| EP3248602A1 (en) | 2016-05-26 | 2017-11-29 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the treatment of inflammatory and/or degenerative disorders of the tendons, ligaments of the joints, articular capsules and bursae |
| RU2625267C1 (ru) * | 2016-09-22 | 2017-07-12 | Общество с ограниченной ответственностью "АБИДАФАРМА" | Способ производства нестерильных субстанций безводного "тамерита" и/или двухводного "галавита" - натриевых солей 5-амино-2,3-дигидрофталазин-1,4-диона (варианты) и способы дальнейшей их переработки в стерильные лекарственные препараты |
| CA3042956A1 (en) * | 2016-11-07 | 2018-05-11 | Metriopharm Ag | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the treatment of chronic progressive multiple sclerosis |
| CN106810501B (zh) * | 2017-01-23 | 2019-09-10 | 湖北新德晟材料科技有限公司 | 一种利用一锅法合成鲁米诺或异鲁米诺的方法 |
| RU2635769C1 (ru) * | 2017-02-08 | 2017-11-15 | Адмир Мусаевич Абидов | Лекарственный препарат на основе 5-амино-2,3-дигидрофталазин-1,4-диона в виде быстрорастворимой пленки для трансбуккального введения |
| RU2673452C1 (ru) * | 2017-08-15 | 2018-11-27 | Межрегиональное общественное учреждение "Институт инженерной физики" | Способ получения активной фармацевтической субстанции, представляющей собой аминодигидрофталазиндион натрия |
| EP3511325A1 (en) | 2018-01-11 | 2019-07-17 | MetrioPharm AG | Method for solubilizing 5-amino-2,3-dihydro-1,4-phthalazinedione |
| EP3870175A1 (en) * | 2018-10-26 | 2021-09-01 | Immunopharma Plus D.o.o | Oral aminodihydrophthalazinedione compositions and their use the treatment of non-viral hepatitis |
| EP3858328A1 (en) | 2020-01-31 | 2021-08-04 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the inhalatory treatment of inflammatory pulmonary diseases |
| EP3858358A1 (en) | 2020-01-31 | 2021-08-04 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the treatment of rare chronic inflammatory pulmonary diseases |
| EP4125802A1 (en) | 2020-03-25 | 2023-02-08 | MetrioPharm AG | 5-amino-2,3-dihydro-1,4-phthalazinedione for treatment of acute lung injury |
| JP2023529022A (ja) | 2020-06-10 | 2023-07-06 | メトリオファーム アーゲー | コロナウイルス感染症の治療のための化合物 |
| EP3981405A1 (en) | 2020-10-08 | 2022-04-13 | MetrioPharm AG | Compound for the treatment of coronaviral infections |
| AU2021304254A1 (en) | 2020-07-09 | 2023-02-16 | Metriopharm Ag | Glucocorticoid-sparing agent |
| CN116963738A (zh) | 2020-12-02 | 2023-10-27 | 麦翠奥制药公司 | 用于SARS-CoV-2感染的后遗症的预防和治疗的鲁米诺 |
| RU2756568C1 (ru) * | 2021-03-24 | 2021-10-01 | Акционерное общество "Щелково Агрохим" | Способ получения натриевой соли 5-амино-2,3-дигидро-1,4-фталазиндиона в гидратированной или безводной форме |
| EP4193994A1 (en) | 2021-12-08 | 2023-06-14 | MetrioPharm AG | Combination of 5-amino-2,3-dihydro-1,4-phtalazinedione and a 6'-methoxycinchonan-9-ol for use in the treatment of coronaviral infections |
| EP4209219A1 (en) | 2022-01-07 | 2023-07-12 | MetrioPharm AG | Combination of budesonide and 5-amino-2,3-dihydro-1,4-phtalazinedione |
| EP4248963A1 (en) | 2022-03-25 | 2023-09-27 | MetrioPharm AG | Combination of 5-amino-2,3-dihydro-1,4-phtalazinedione and a fumaric acid ester |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089086C (zh) * | 1988-03-31 | 2002-08-14 | 兰德尔·L·米尔斯 | 鲁米纳得类药物 |
| CH683965A5 (it) * | 1993-02-19 | 1994-06-30 | Limad Marketing Exp & Imp | Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici. |
| CH683966A5 (it) | 1993-02-19 | 1994-06-30 | Limad Marketing Exp & Imp | Composti della classe dei ftalidrazidici come sostanze attive in agenti anti-ipossici e di difesa. |
| RU2113222C1 (ru) | 1997-09-30 | 1998-06-20 | Закрытое акционерное общество "Центр современной медицины "Медикор" | Иммуномодулирующее средство |
| RU2138264C1 (ru) | 1999-05-06 | 1999-09-27 | Абидов Муса Тажудинович | Способ получения лекарственного препарата галавит |
| WO2001072305A1 (fr) * | 2000-03-28 | 2001-10-04 | Ramazanov, Ziadin Magomedovich | Composition médicamenteuse et procédé de fabrication correspondant |
| RU2169139C1 (ru) | 2000-08-02 | 2001-06-20 | Закрытое акционерное общество "Центр современной медицины "Медикор" | Способ получения щелочных и щелочноземельных солей 5-амино-2,3-дигидро-1,4-фталазиндиона |
| RU2167659C1 (ru) | 2000-08-02 | 2001-05-27 | Закрытое акционерное общество "Центр современной медицины "Медикор" | Способ коррекции иммунной системы живого организма |
| RU2211036C2 (ru) | 2001-11-20 | 2003-08-27 | Общество с ограниченной ответственностью "Абидофарма" | Лекарственный препарат (варианты) и способ его производства |
| RU2222327C2 (ru) | 2002-03-22 | 2004-01-27 | Общество с ограниченной ответственностью "Абидофарма" | Способ получения лекарственного препарата |
| US7326690B2 (en) | 2002-10-30 | 2008-02-05 | Bach Pharma, Inc. | Modulation of cell fates and activities by phthalazinediones |
| RU2238730C1 (ru) | 2003-02-17 | 2004-10-27 | Абидов Муса Тажудинович | Лекарственный препарат |
| RU2302863C2 (ru) | 2003-04-18 | 2007-07-20 | Общество с ограниченной ответственностью "Абидофарма" | Лекарственный препарат (варианты) |
| CN1217193C (zh) * | 2003-07-30 | 2005-08-31 | 中国药科大学 | 心肌肌钙蛋白鲁米诺化学发光免疫分析检测方法 |
| AU2003301513A1 (en) | 2003-08-04 | 2005-02-15 | Valery Khazhmuratovich Zhilov | Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon |
| PL231885B1 (pl) * | 2009-01-16 | 2019-04-30 | Abidopharma Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wytwarzania soli 5-amino-2,3-dihydroftalazyno-1,4-di onu z metalami alkalicznymi, ich kompozycje farmaceutyczne i ich zastosowanie |
| US20100222584A1 (en) | 2009-02-06 | 2010-09-02 | Bach Pharma, Inc. | Pharmaceutical grade phthalazinediones, process for their preparation and pharmaceutical compositions containing them |
| CN105859634B (zh) * | 2010-03-01 | 2019-06-28 | 梅特里奥药品股份公司 | 5-氨基-2,3-二氢-(2,3-二氮杂萘)-1,4-二酮钠盐的晶型 |
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