BRPI1015540A2 - ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750'' - Google Patents
''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750''Info
- Publication number
- BRPI1015540A2 BRPI1015540A2 BRPI1015540A BRPI1015540A BRPI1015540A2 BR PI1015540 A2 BRPI1015540 A2 BR PI1015540A2 BR PI1015540 A BRPI1015540 A BR PI1015540A BR PI1015540 A BRPI1015540 A BR PI1015540A BR PI1015540 A2 BRPI1015540 A2 BR PI1015540A2
- Authority
- BR
- Brazil
- Prior art keywords
- cyanoethylheterocyclylcarboxamide
- substituted
- compound
- cyanoethylheterocyclylcarboxamide compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17627909P | 2009-05-07 | 2009-05-07 | |
US18562909P | 2009-06-10 | 2009-06-10 | |
PCT/GB2010/050736 WO2010128324A1 (en) | 2009-05-07 | 2010-05-05 | Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI1015540A2 true BRPI1015540A2 (pt) | 2019-09-24 |
Family
ID=42271991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1015540A BRPI1015540A2 (pt) | 2009-05-07 | 2010-05-05 | ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750'' |
Country Status (22)
Country | Link |
---|---|
US (2) | US8193239B2 (pt) |
EP (1) | EP2427445A1 (pt) |
JP (1) | JP2012526093A (pt) |
KR (1) | KR20120034639A (pt) |
CN (1) | CN102574830A (pt) |
AR (1) | AR076551A1 (pt) |
AU (1) | AU2010244218B2 (pt) |
BR (1) | BRPI1015540A2 (pt) |
CA (1) | CA2759581A1 (pt) |
CL (1) | CL2011002787A1 (pt) |
CO (1) | CO6450612A2 (pt) |
CR (1) | CR20110579A (pt) |
CU (1) | CU20110204A7 (pt) |
EA (1) | EA201190235A1 (pt) |
EC (1) | ECSP11011439A (pt) |
IL (1) | IL215615A0 (pt) |
MX (1) | MX2011011661A (pt) |
SG (1) | SG175090A1 (pt) |
TW (1) | TW201041889A (pt) |
UY (1) | UY32611A (pt) |
WO (1) | WO2010128324A1 (pt) |
ZA (1) | ZA201108962B (pt) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101351120B1 (ko) | 2009-06-10 | 2014-01-15 | 추가이 세이야쿠 가부시키가이샤 | 4환성 화합물 |
KR101362589B1 (ko) | 2010-08-20 | 2014-02-12 | 추가이 세이야쿠 가부시키가이샤 | 4환성 화합물을 포함하는 조성물 |
UY33905A (es) * | 2011-02-11 | 2012-08-31 | Glaxosmithkline Llc | Inhibidores de la catepsina c |
WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
US10668075B2 (en) | 2012-09-25 | 2020-06-02 | Chugai Seiyaku Kabushiki Kaisha | RET inhibitor |
UY35391A (es) | 2013-03-14 | 2014-09-30 | Boehringer Ingelheim Int | Acido 2-aza-biciclo[2.2.1]heptano-3-carboxilico (bencil-cianometil)-amidas sustituidas inhibidores de catepsina c |
US8889708B2 (en) | 2013-03-14 | 2014-11-18 | Boehringer Ingelheim International Gmbh | Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C |
WO2014140078A1 (en) * | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin c |
JP6441831B2 (ja) | 2013-03-14 | 2018-12-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | カテプシンcの置換2−アザ−ビシクロ[2.2.2]オクタン−3−カルボン酸(ベンジル−シアノ−メチル)−アミド阻害剤 |
CA2914132A1 (en) | 2013-06-21 | 2014-12-24 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
US9790231B2 (en) | 2013-06-24 | 2017-10-17 | Lupin Limited | Chromane and chromene derivatives and their use as CRAC modulators |
JP6408008B2 (ja) * | 2013-09-09 | 2018-10-17 | プロザイメックス・アクティーゼルスカブProZymex A/S | ジペプチジルペプチダーゼiインヒビターとしてのペプチジルニトリル化合物 |
NO2699580T3 (pt) | 2014-01-24 | 2018-02-24 | ||
AR100187A1 (es) | 2014-04-25 | 2016-09-14 | Chugai Pharmaceutical Co Ltd | Composición farmacéutica que contiene un inhibidor de alk (quinasa de linfoma anaplásico) |
KR20220042486A (ko) | 2014-04-25 | 2022-04-05 | 추가이 세이야쿠 가부시키가이샤 | 4환성 화합물의 신규 결정 |
ES2664810T3 (es) | 2014-06-12 | 2018-04-23 | Pfizer Limited | Derivados de imidazopiridazina como moduladores de la actividad del receptor GABAA |
WO2016016242A1 (en) | 2014-08-01 | 2016-02-04 | Boehringer Ingelheim International Gmbh | Substituted oxetanes and their use as inhibitors of cathepsin c |
TWI765410B (zh) | 2014-08-08 | 2022-05-21 | 日商中外製藥股份有限公司 | 4環性化合物的非晶質體的用途 |
MX367316B (es) | 2014-09-12 | 2019-08-15 | Boehringer Ingelheim Int | Inhibidores espirociclicos de catepsina c. |
BR112017013982A2 (pt) | 2015-01-16 | 2018-01-02 | Chugai Seiyaku Kabushiki Kaisha | fármaco de combinação |
WO2016139355A1 (en) | 2015-03-05 | 2016-09-09 | Prozymex A/S | N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors |
JP6783426B2 (ja) * | 2015-03-05 | 2020-11-11 | ニュープロザイム・セラピューティクス・アンパルトセルスカブNeuprozyme Therapeutics ApS | ジペプチジルペプチダーゼi阻害剤としてのペプチジルニトリル化合物 |
CN106478629A (zh) * | 2015-08-24 | 2017-03-08 | 上海医药工业研究院 | 一种利格列汀的制备工艺 |
MX2018010374A (es) | 2016-03-01 | 2019-03-28 | Propellon Therapeutics Inc | Inhibidores del enlace proteína-proteína de wdr5. |
EP3423437A4 (en) | 2016-03-01 | 2019-07-24 | Propellon Therapeutics Inc. | INHIBITORS OF THE LINK BETWEEN THE WDR5 PROTEIN AND ITS LIAISON PARTNERS |
KR20190035781A (ko) * | 2016-07-29 | 2019-04-03 | 인스메드 인코포레이티드 | 기관지확장증을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드 |
KR20210032439A (ko) * | 2018-07-17 | 2021-03-24 | 인스메드 인코포레이티드 | 염증성 장 질환을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드 |
KR20210032431A (ko) * | 2018-07-17 | 2021-03-24 | 인스메드 인코포레이티드 | 루푸스 신염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드 |
JP7167171B2 (ja) | 2018-09-04 | 2022-11-08 | 中外製薬株式会社 | 4環性化合物の製造方法 |
TW202214616A (zh) | 2020-08-26 | 2022-04-16 | 大陸商四川海思科製藥有限公司 | 一種作為二肽基肽酶1抑制劑的腈衍生物及其用途 |
JP2023551488A (ja) | 2020-12-04 | 2023-12-08 | 瑞石生物医薬有限公司 | カテプシンcの小分子阻害剤及びその医薬的使用 |
JP2024505715A (ja) * | 2021-02-05 | 2024-02-07 | メッドシャイン ディスカバリー インコーポレイテッド | 1,4-オキサゼパンを含む縮合環誘導体 |
WO2023160541A1 (zh) * | 2022-02-22 | 2023-08-31 | 四川海思科制药有限公司 | 一种含氮杂环化合物的制备方法 |
WO2024008680A1 (en) | 2022-07-06 | 2024-01-11 | Chiesi Farmaceutici S.P.A. | Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
ES2264937T3 (es) | 1999-07-30 | 2007-02-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Nuevos compuestos derivados de succinato, utiles como inhibidores de cisteina-proteasa. |
CA2395179A1 (en) | 1999-12-24 | 2001-07-05 | F. Hoffmann-La Roche Ag | Nitrile derivatives as cathepsin k inhibitors |
PL367527A1 (en) | 2001-06-27 | 2005-02-21 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
JP4357293B2 (ja) | 2001-06-27 | 2009-11-04 | スミスクライン ビーチャム コーポレーション | ジペプチジルペプチダーゼ阻害剤としてのフルオロピロリジン類 |
US6995180B2 (en) * | 2002-10-23 | 2006-02-07 | Bristol Myers Squibb Company | Glycinenitrile-based inhibitors of dipeptidyl peptidase IV and methods |
US20070099958A1 (en) * | 2003-06-18 | 2007-05-03 | Prozymex A/S | Protease inhibitors |
US7504413B2 (en) * | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
-
2010
- 2010-05-05 EP EP10719056A patent/EP2427445A1/en not_active Withdrawn
- 2010-05-05 KR KR1020117029122A patent/KR20120034639A/ko not_active Application Discontinuation
- 2010-05-05 AU AU2010244218A patent/AU2010244218B2/en not_active Ceased
- 2010-05-05 WO PCT/GB2010/050736 patent/WO2010128324A1/en active Application Filing
- 2010-05-05 SG SG2011072774A patent/SG175090A1/en unknown
- 2010-05-05 BR BRPI1015540A patent/BRPI1015540A2/pt not_active IP Right Cessation
- 2010-05-05 CA CA2759581A patent/CA2759581A1/en not_active Abandoned
- 2010-05-05 MX MX2011011661A patent/MX2011011661A/es not_active Application Discontinuation
- 2010-05-05 CN CN2010800307151A patent/CN102574830A/zh active Pending
- 2010-05-05 JP JP2012509091A patent/JP2012526093A/ja active Pending
- 2010-05-05 EA EA201190235A patent/EA201190235A1/ru unknown
- 2010-05-06 UY UY0001032611A patent/UY32611A/es not_active Application Discontinuation
- 2010-05-06 TW TW099114513A patent/TW201041889A/zh unknown
- 2010-05-06 US US12/774,996 patent/US8193239B2/en not_active Expired - Fee Related
- 2010-05-07 AR ARP100101567A patent/AR076551A1/es unknown
-
2011
- 2011-10-06 IL IL215615A patent/IL215615A0/en unknown
- 2011-10-31 CO CO11147437A patent/CO6450612A2/es not_active Application Discontinuation
- 2011-11-07 CU CU20110204A patent/CU20110204A7/es unknown
- 2011-11-07 CR CR20110579A patent/CR20110579A/es unknown
- 2011-11-07 EC EC2011011439A patent/ECSP11011439A/es unknown
- 2011-11-07 CL CL2011002787A patent/CL2011002787A1/es unknown
- 2011-12-06 ZA ZA2011/08962A patent/ZA201108962B/en unknown
-
2012
- 2012-06-04 US US13/488,248 patent/US20120329775A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CO6450612A2 (es) | 2012-05-31 |
EP2427445A1 (en) | 2012-03-14 |
US20100286118A1 (en) | 2010-11-11 |
UY32611A (es) | 2010-12-31 |
CU20110204A7 (es) | 2012-03-15 |
CR20110579A (es) | 2012-01-09 |
MX2011011661A (es) | 2011-11-18 |
TW201041889A (en) | 2010-12-01 |
ZA201108962B (en) | 2012-08-29 |
US20120329775A1 (en) | 2012-12-27 |
US8193239B2 (en) | 2012-06-05 |
CA2759581A1 (en) | 2010-11-11 |
IL215615A0 (en) | 2011-12-29 |
EA201190235A1 (ru) | 2012-05-30 |
AU2010244218B2 (en) | 2012-07-19 |
WO2010128324A1 (en) | 2010-11-11 |
AU2010244218A1 (en) | 2011-11-03 |
ECSP11011439A (es) | 2011-12-30 |
JP2012526093A (ja) | 2012-10-25 |
CL2011002787A1 (es) | 2012-06-22 |
AR076551A1 (es) | 2011-06-22 |
CN102574830A (zh) | 2012-07-11 |
KR20120034639A (ko) | 2012-04-12 |
SG175090A1 (en) | 2011-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |