HK1215795A1 - 鵝膏毒素衍生物 - Google Patents
鵝膏毒素衍生物Info
- Publication number
- HK1215795A1 HK1215795A1 HK16103769.5A HK16103769A HK1215795A1 HK 1215795 A1 HK1215795 A1 HK 1215795A1 HK 16103769 A HK16103769 A HK 16103769A HK 1215795 A1 HK1215795 A1 HK 1215795A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- amatoxin derivatives
- amatoxin
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6831—Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13001074.7A EP2774624A1 (en) | 2013-03-04 | 2013-03-04 | Amatoxin derivatives |
PCT/EP2014/000614 WO2014135282A1 (en) | 2013-03-04 | 2014-03-10 | Amatoxin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1215795A1 true HK1215795A1 (zh) | 2016-09-15 |
Family
ID=47826817
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14113008.7A HK1200312A1 (zh) | 2013-03-04 | 2014-12-24 | 毒傘肽衍生物 |
HK16103769.5A HK1215795A1 (zh) | 2013-03-04 | 2016-04-01 | 鵝膏毒素衍生物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14113008.7A HK1200312A1 (zh) | 2013-03-04 | 2014-12-24 | 毒傘肽衍生物 |
Country Status (19)
Country | Link |
---|---|
US (1) | US9982018B2 (zh) |
EP (2) | EP2774624A1 (zh) |
KR (1) | KR20160006162A (zh) |
AR (1) | AR095019A1 (zh) |
AU (1) | AU2014224928B2 (zh) |
CA (1) | CA2903614C (zh) |
DK (1) | DK2964264T3 (zh) |
ES (1) | ES2652182T3 (zh) |
HK (2) | HK1200312A1 (zh) |
IL (1) | IL240863B (zh) |
MX (1) | MX366503B (zh) |
NO (1) | NO2964264T3 (zh) |
NZ (1) | NZ710729A (zh) |
RU (1) | RU2695370C2 (zh) |
SG (1) | SG11201507089PA (zh) |
TW (1) | TW201441248A (zh) |
UA (1) | UA117364C2 (zh) |
WO (1) | WO2014135282A1 (zh) |
ZA (1) | ZA201505790B (zh) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170052600A (ko) | 2014-09-12 | 2017-05-12 | 제넨테크, 인크. | 시스테인 가공된 항체 및 콘주게이트 |
WO2016040868A1 (en) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anti-cll-1 antibodies and immunoconjugates |
MY186334A (en) | 2014-09-12 | 2021-07-12 | Genentech Inc | Anti-her2 antibodies and immunoconjugates |
US9938323B2 (en) | 2014-11-06 | 2018-04-10 | Novartis Ag | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase |
IL284264B (en) * | 2015-03-04 | 2022-09-01 | Univ Texas | Methods for the treatment of cancer containing hemizygous loss of tp53 |
JP6863900B2 (ja) * | 2015-03-09 | 2021-04-21 | ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規アマトキシン−抗体コンジュゲート |
JP6632118B2 (ja) * | 2015-09-04 | 2020-01-15 | 学校法人 岩手医科大学 | 腫瘍の再発を抑制する医薬 |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
WO2017191579A1 (en) | 2016-05-05 | 2017-11-09 | Novartis Ag | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
US20170370906A1 (en) | 2016-05-27 | 2017-12-28 | Genentech, Inc. | Bioanalytical analysis of site-specific antibody drug conjugates |
KR20190039085A (ko) | 2016-06-17 | 2019-04-10 | 마젠타 테라퓨틱스 인코포레이티드 | 세포의 고갈을 위한 조성물 및 방법 |
WO2017219029A2 (en) | 2016-06-17 | 2017-12-21 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+cells |
EP3494139B1 (en) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
US11446388B2 (en) | 2016-12-23 | 2022-09-20 | Heidelberg Pharma Research Gmbh | Amanitin antibody conjugates |
US10576161B2 (en) | 2017-01-20 | 2020-03-03 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD137+ cells |
EP3738608A4 (en) * | 2017-08-18 | 2021-12-08 | Sichuan Baili Pharm Co. Ltd | NON-NATURAL AMATOXIN TYPE ANTIBODY CONJUGATE |
WO2019084064A2 (en) | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS |
CA3079215A1 (en) | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+ cells |
WO2019197654A1 (en) * | 2018-04-13 | 2019-10-17 | Heidelberg Pharma Research Gmbh | Targeted amatoxin conjugate for the treatment of solid tumors |
AU2020263959A1 (en) | 2019-04-24 | 2021-11-25 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
US20230173087A1 (en) | 2019-05-23 | 2023-06-08 | Heidelberg Pharma Research Gmbh | Antibody drug conjugates with cleavable linkers |
KR102092817B1 (ko) * | 2019-08-22 | 2020-03-24 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
CN111308100B (zh) * | 2020-04-13 | 2023-04-21 | 北京维德维康生物技术有限公司 | 一种检测β-鹅膏毒肽的酶联免疫试剂盒及其制备和应用 |
JP2023542910A (ja) | 2020-09-18 | 2023-10-12 | アラリス バイオテック アーゲー | アミノ酸に基づくリンカーを使用したトランスグルタミナーゼコンジュゲーション方法 |
PE20231512A1 (es) | 2020-10-25 | 2023-09-26 | Araris Biotech Ag | Medios y metodos para producir conjugados de ligador-anticuerpo |
KR20230159480A (ko) * | 2021-03-19 | 2023-11-21 | 하이델베르크 파마 리서치 게엠베하 | B-림프구 특이적 아마톡신 항체 접합체 |
WO2023072934A1 (en) | 2021-10-25 | 2023-05-04 | Araris Biotech Ag | Methods for producing antibody-linker conjugates |
WO2023161291A1 (en) | 2022-02-22 | 2023-08-31 | Araris Biotech Ag | Peptide linkers comprising two or more payloads |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
CA2649114A1 (en) * | 2006-04-12 | 2007-10-25 | Crosslink Genetics Corporation | Compositions and methods for modulating gene expression |
ATE521366T1 (de) | 2006-05-27 | 2011-09-15 | Faulstich Heinz Dr | Anwendung von amatoxin-konjugaten und phallotoxin-konjugaten mit makromolekülen zur krebstherapie und therapie von entzündungen |
EP2416805B1 (en) | 2009-04-08 | 2013-07-24 | Heinz Dr. Faulstich | Amatoxin antibody conjugates for the treatment of cancer |
PT3192529T (pt) * | 2009-04-08 | 2020-04-16 | Deutsches Krebsforsch | Componentes terapêuticos de ligação à superfície celular armados com amatoxina destinados à terapia de tumores |
EP2436398B1 (en) * | 2010-09-30 | 2013-01-23 | Heidelberg Pharma GmbH | Amatoxin-conjugates with improved linkers |
EP2497499A1 (en) * | 2011-03-10 | 2012-09-12 | Heidelberg Pharma GmbH | Amatoxin-conjugates with improved linkages |
-
2013
- 2013-03-04 EP EP13001074.7A patent/EP2774624A1/en not_active Withdrawn
-
2014
- 2014-03-04 TW TW103107305A patent/TW201441248A/zh unknown
- 2014-03-05 AR ARP140100717A patent/AR095019A1/es unknown
- 2014-03-10 EP EP14709884.2A patent/EP2964264B1/en active Active
- 2014-03-10 KR KR1020157027378A patent/KR20160006162A/ko not_active Application Discontinuation
- 2014-03-10 WO PCT/EP2014/000614 patent/WO2014135282A1/en active Application Filing
- 2014-03-10 NO NO14709884A patent/NO2964264T3/no unknown
- 2014-03-10 NZ NZ710729A patent/NZ710729A/en unknown
- 2014-03-10 DK DK14709884.2T patent/DK2964264T3/en active
- 2014-03-10 RU RU2015142093A patent/RU2695370C2/ru active
- 2014-03-10 SG SG11201507089PA patent/SG11201507089PA/en unknown
- 2014-03-10 AU AU2014224928A patent/AU2014224928B2/en active Active
- 2014-03-10 MX MX2015011583A patent/MX366503B/es active IP Right Grant
- 2014-03-10 CA CA2903614A patent/CA2903614C/en active Active
- 2014-03-10 ES ES14709884.2T patent/ES2652182T3/es active Active
- 2014-03-10 US US14/769,970 patent/US9982018B2/en active Active
- 2014-10-03 UA UAA201509530A patent/UA117364C2/uk unknown
- 2014-12-24 HK HK14113008.7A patent/HK1200312A1/zh unknown
-
2015
- 2015-08-12 ZA ZA2015/05790A patent/ZA201505790B/en unknown
- 2015-08-26 IL IL240863A patent/IL240863B/en active IP Right Grant
-
2016
- 2016-04-01 HK HK16103769.5A patent/HK1215795A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2774624A1 (en) | 2014-09-10 |
AU2014224928B2 (en) | 2017-10-19 |
ZA201505790B (en) | 2017-11-29 |
TW201441248A (zh) | 2014-11-01 |
NZ710729A (en) | 2019-05-31 |
BR112015021838A2 (pt) | 2017-07-18 |
WO2014135282A8 (en) | 2015-09-17 |
US20160002298A1 (en) | 2016-01-07 |
CA2903614A1 (en) | 2014-09-12 |
CA2903614C (en) | 2021-07-06 |
NO2964264T3 (zh) | 2018-02-10 |
MX366503B (es) | 2019-07-11 |
ES2652182T3 (es) | 2018-01-31 |
EP2964264B1 (en) | 2017-09-13 |
US9982018B2 (en) | 2018-05-29 |
DK2964264T3 (en) | 2017-12-11 |
RU2695370C2 (ru) | 2019-07-23 |
SG11201507089PA (en) | 2015-10-29 |
IL240863B (en) | 2019-02-28 |
RU2015142093A (ru) | 2017-04-07 |
UA117364C2 (uk) | 2018-07-25 |
WO2014135282A1 (en) | 2014-09-12 |
HK1200312A1 (zh) | 2015-08-07 |
AU2014224928A1 (en) | 2015-09-10 |
EP2964264A1 (en) | 2016-01-13 |
MX2015011583A (es) | 2016-07-29 |
KR20160006162A (ko) | 2016-01-18 |
IL240863A0 (en) | 2015-10-29 |
AR095019A1 (es) | 2015-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1215795A1 (zh) | 鵝膏毒素衍生物 | |
SG11201506100XA (en) | Pyridazinone-amides derivatives | |
ZA201601333B (en) | Oxoquinazolinyl-butanamide derivatives | |
SG11201605189YA (en) | Imidazopyrazinone derivatives | |
HK1213566A1 (zh) | 新的四唑酮衍生物 | |
AU353644S (en) | Stamphousing | |
EP3009444A4 (en) | ALPHA-oxoacyl-Amino-caprolactam derivative | |
AU4899P (en) | Herbie53 Iresine herbstii | |
AU353328S (en) | Kettlebell | |
AU353329S (en) | Kettlebell | |
AU353327S (en) | Kettlebell | |
AU353326S (en) | Kettlebell | |
AU353325S (en) | Kettlebell | |
AP00812S1 (en) | Stumbelbloc | |
AU2013231V (en) | Bonsca7200 Scaevola aemula | |
AU353341S (en) | Playsuit | |
AU354283S (en) | Playsuit | |
AP2013000703S (en) | Adwura wura | |
AP2013000704S (en) | Gramoquat | |
GB201311071D0 (en) | Autodefrost | |
AP2013000606S (en) | Loftank | |
AP2013000605S (en) | Aquatank | |
AP2013000598S (en) | Nestank | |
AP2013000597S (en) | Blueflame bioslurrigaz | |
AP2013000596S (en) | Kentank |