HK1214165A1 - 特定構象抗體生成和使用的方法和組合物 - Google Patents
特定構象抗體生成和使用的方法和組合物Info
- Publication number
- HK1214165A1 HK1214165A1 HK16102295.0A HK16102295A HK1214165A1 HK 1214165 A1 HK1214165 A1 HK 1214165A1 HK 16102295 A HK16102295 A HK 16102295A HK 1214165 A1 HK1214165 A1 HK 1214165A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- conformation
- bodies
- compositions
- generation
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361792588P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/027017 WO2014152157A2 (en) | 2013-03-15 | 2014-03-14 | Methods and compositions for the generation and use of conformation-specific antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1214165A1 true HK1214165A1 (zh) | 2016-07-22 |
Family
ID=51581680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16102295.0A HK1214165A1 (zh) | 2013-03-15 | 2016-02-26 | 特定構象抗體生成和使用的方法和組合物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9688747B2 (zh) |
EP (1) | EP2968548B1 (zh) |
JP (1) | JP6448614B2 (zh) |
CN (1) | CN105283196B (zh) |
AU (1) | AU2014240063B2 (zh) |
CA (1) | CA2903091C (zh) |
ES (1) | ES2835716T3 (zh) |
HK (1) | HK1214165A1 (zh) |
WO (1) | WO2014152157A2 (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
CN103702967A (zh) | 2011-03-14 | 2014-04-02 | 貝丝以色列女执事医疗中心 | 用于治疗增殖性病症的方法和组合物 |
WO2012149334A2 (en) | 2011-04-27 | 2012-11-01 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
WO2012162698A1 (en) | 2011-05-26 | 2012-11-29 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the treatment of immune disorders |
EP2858648B1 (en) | 2012-06-07 | 2018-08-22 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the inhibition of pin1 |
WO2014008404A1 (en) | 2012-07-03 | 2014-01-09 | Washington University | Antibodies to tau |
CU24446B1 (es) | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
US9968579B2 (en) | 2014-07-17 | 2018-05-15 | Beth Isreal Deaconess Medical Center, Inc. | ATRA for modulating Pin1 activity and stability |
WO2016011265A2 (en) | 2014-07-17 | 2016-01-21 | Beth Israel Deaconess Medical Center, Inc. | Biomarkers for pin1-associated disorders |
JO3576B1 (ar) * | 2015-02-26 | 2020-07-05 | Lilly Co Eli | أجسام مضادة لـ tau واستخداماتها |
WO2016145186A1 (en) | 2015-03-12 | 2016-09-15 | Beth Israel Deaconess Medical Center, Inc. | Enhanced atra-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions |
US20200079825A1 (en) * | 2015-07-13 | 2020-03-12 | The General Hostital Corporation | Rare phosphorylated high molecular weight (hmw) tau species that are involved in neuronal uptake and propagation and applications thereof |
EP4169942A1 (en) | 2016-03-11 | 2023-04-26 | Scholar Rock, Inc. | Tgfbeta1-binding immunoglobulins and use thereof |
EP3452508A1 (en) | 2016-05-02 | 2019-03-13 | Prothena Biosciences Limited | Antibodies recognizing tau |
CA3022765A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
CN109415432B (zh) | 2016-05-02 | 2022-07-08 | 普罗塞纳生物科学有限公司 | Tau免疫疗法 |
KR20190129859A (ko) * | 2017-02-10 | 2019-11-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항-d 인자 항체 및 그의 용도 |
MX2019009817A (es) | 2017-02-17 | 2019-11-21 | Denali Therapeutics Inc | Anticuerpos anti-tau y metodos de uso de los mismos. |
KR20200030029A (ko) | 2017-05-02 | 2020-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
CN111587123A (zh) * | 2017-11-09 | 2020-08-25 | 品通治疗有限公司 | 用于生成和使用人源化构象特异性磷酸化的τ抗体的方法和组合物 |
WO2019175735A1 (en) * | 2018-03-11 | 2019-09-19 | Koorosh Shahpasand | Conformation-independent antibodies against neurotoxic tau proteins |
PE20212324A1 (es) | 2019-03-03 | 2021-12-14 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
CN112979797B (zh) * | 2021-04-28 | 2022-04-01 | 中国检验检疫科学研究院 | 一种抗赤羽病病毒单克隆抗体及其制备方法与应用 |
WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
ES2151541T3 (es) | 1992-12-02 | 2001-01-01 | Alkermes Inc | Microesferas que contienen hormona del crecimiento de liberacion prolongada. |
US5861499A (en) | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
US7473423B2 (en) | 1994-04-29 | 2009-01-06 | Mayo Foundation For Medical Education And Research | Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
BR9509201A (pt) | 1994-09-09 | 1997-12-30 | Takeda Chemical Industries Ltd | Preparação de liberação sustemtada uso de um sal de metal polivalente insolúvel em água ou ligeiramente solúvel em água e processo para produzir uma preparação de liberação sustentada |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
PT831787E (pt) | 1995-06-07 | 2002-02-28 | Alkermes Inc | Composicao para libertacao sustentada da hormona de crescimento humano |
ZA965368B (en) | 1995-07-14 | 1997-01-14 | Novo Nordisk As | A pharmaceutical formulation |
US6696248B1 (en) | 1995-08-18 | 2004-02-24 | Morphosys Ag | Protein/(poly)peptide libraries |
US6462173B1 (en) | 1997-09-08 | 2002-10-08 | Max-Planck-Gesellschaft Zur Forderung Der | Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases |
US6441140B1 (en) | 1998-09-04 | 2002-08-27 | Cell Signaling Technology, Inc. | Production of motif-specific and context-independent antibodies using peptide libraries as antigens |
CA2476776A1 (en) * | 2002-02-21 | 2003-09-04 | Duke University | Reagents and treatment methods for autoimmune diseases |
US7161060B1 (en) | 2002-07-16 | 2007-01-09 | Albert Einstein College Of Medicine Of Yeshiva University | Transgenic mice comprising a genomic human tau transgene |
EP1484336A1 (en) | 2003-06-02 | 2004-12-08 | Pevion Biotech Ltd. | Methods for synthesizing conformationally constrained peptides, peptidometics and the use thereof as synthetic vaccines |
US20080058276A1 (en) | 2006-01-13 | 2008-03-06 | Cornell Research Foundation, Inc. | Alzheimer's disease therapeutics based on pin-1 catalyzed conformational changes in phosphorylated amyloid precursor protein |
WO2008060331A2 (en) * | 2006-05-19 | 2008-05-22 | Amgen Inc. | Antibodies to sars coronavirus |
KR20100090258A (ko) | 2007-10-16 | 2010-08-13 | 에스비아이 바이오테크 가부시키가이샤 | 항bst2 항체 |
AU2008312802A1 (en) * | 2007-10-19 | 2009-04-23 | Immunas Pharma, Inc. | Antibody capable of specifically binding to abeta oligomer, and use thereof |
EA023477B1 (ru) | 2009-10-02 | 2016-06-30 | Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния | МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, СВЯЗЫВАЮЩЕЕ ДОМЕН γ-С ФИБРИНА ИЛИ ФИБРИНОГЕНА |
US8771693B2 (en) * | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
WO2012149334A2 (en) * | 2011-04-27 | 2012-11-01 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
-
2014
- 2014-03-14 US US14/776,924 patent/US9688747B2/en active Active
- 2014-03-14 JP JP2016502309A patent/JP6448614B2/ja active Active
- 2014-03-14 EP EP14768309.8A patent/EP2968548B1/en active Active
- 2014-03-14 WO PCT/US2014/027017 patent/WO2014152157A2/en active Application Filing
- 2014-03-14 AU AU2014240063A patent/AU2014240063B2/en active Active
- 2014-03-14 ES ES14768309T patent/ES2835716T3/es active Active
- 2014-03-14 CN CN201480015102.9A patent/CN105283196B/zh active Active
- 2014-03-14 CA CA2903091A patent/CA2903091C/en active Active
-
2016
- 2016-02-26 HK HK16102295.0A patent/HK1214165A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2968548B1 (en) | 2020-09-09 |
CN105283196A (zh) | 2016-01-27 |
WO2014152157A3 (en) | 2014-12-24 |
EP2968548A2 (en) | 2016-01-20 |
AU2014240063A1 (en) | 2015-09-17 |
WO2014152157A8 (en) | 2015-09-17 |
CN105283196B (zh) | 2018-10-12 |
US9688747B2 (en) | 2017-06-27 |
JP2016515129A (ja) | 2016-05-26 |
WO2014152157A2 (en) | 2014-09-25 |
EP2968548A4 (en) | 2016-11-30 |
ES2835716T3 (es) | 2021-06-23 |
CA2903091A1 (en) | 2014-09-25 |
US20160031977A1 (en) | 2016-02-04 |
JP6448614B2 (ja) | 2019-01-09 |
AU2014240063B2 (en) | 2019-04-11 |
CA2903091C (en) | 2022-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1214165A1 (zh) | 特定構象抗體生成和使用的方法和組合物 | |
IL289821B (en) | Preparations and methods for immunotherapy | |
HK1220387A1 (zh) | 用於免疫療法的組合物和方法 | |
EP3008170A4 (en) | SC-CELLS AND COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF | |
HK1211866A1 (zh) | 抗氧化劑組合物及其使用方法 | |
HK1214171A1 (zh) | 賽尼克韋羅組合物及其製備和使用方法 | |
IL265876A (en) | Preparations that include 15-ohepa and methods of using them | |
IL285527A (en) | Preparations and methods for immunotherapy | |
SI2981303T1 (sl) | Sestavek polnila za zdravljenje lipoatrofije | |
HK1220374A1 (zh) | 用於治療碳氧血紅蛋白血症的組合物和方法 | |
GB201300628D0 (en) | Compositions comprising 15-OHEPA and methods of using the same |