HK1213006A1 - 小容积反应器中二氧化碳水平和ph的控制 - Google Patents

小容积反应器中二氧化碳水平和ph的控制 Download PDF

Info

Publication number
HK1213006A1
HK1213006A1 HK16101064.1A HK16101064A HK1213006A1 HK 1213006 A1 HK1213006 A1 HK 1213006A1 HK 16101064 A HK16101064 A HK 16101064A HK 1213006 A1 HK1213006 A1 HK 1213006A1
Authority
HK
Hong Kong
Prior art keywords
carbon dioxide
control
small volume
dioxide levels
volume reactors
Prior art date
Application number
HK16101064.1A
Other languages
English (en)
Chinese (zh)
Inventor
Shireen GOH
Rajeev Jagga RAM
Horst Blum
Michelangelo Canzoneri
Original Assignee
Massachusetts Institute Of Technology
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute Of Technology, Sanofi filed Critical Massachusetts Institute Of Technology
Publication of HK1213006A1 publication Critical patent/HK1213006A1/zh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Treating Waste Gases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16101064.1A 2012-10-26 2013-10-25 小容积反应器中二氧化碳水平和ph的控制 HK1213006A1 (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261719027P 2012-10-26 2012-10-26
US61/719,027 2012-10-26
US201361869111P 2013-08-23 2013-08-23
US61/869,111 2013-08-23
EP13306462.6 2013-10-23
EP13306462 2013-10-23
PCT/US2013/066832 WO2014066774A1 (en) 2012-10-26 2013-10-25 Control of carbon dioxide levels and ph in small volume reactors

Publications (1)

Publication Number Publication Date
HK1213006A1 true HK1213006A1 (zh) 2016-06-24

Family

ID=49551567

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101064.1A HK1213006A1 (zh) 2012-10-26 2013-10-25 小容积反应器中二氧化碳水平和ph的控制

Country Status (10)

Country Link
US (2) US20140127802A1 (enExample)
EP (1) EP2912157A1 (enExample)
CN (2) CN104870629A (enExample)
AU (3) AU2013334168B2 (enExample)
CA (1) CA2888076C (enExample)
HK (1) HK1213006A1 (enExample)
IN (1) IN2015DN03093A (enExample)
MX (2) MX378896B (enExample)
SG (2) SG10201803572UA (enExample)
WO (1) WO2014066774A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009060489A1 (de) * 2009-12-29 2011-06-30 Uhde GmbH, 44141 Vorrichtung und Verfahren zur Regelung der Sauerstoffpermeation durch nicht-poröse Sauerstoffanionen leitende keramische Membranen und deren Verwendung
CN114106988A (zh) * 2012-10-26 2022-03-01 麻省理工学院 化学反应器中的湿度控制
EP3036317A4 (en) 2013-08-23 2017-04-12 Massachusetts Institute of Technology Small volume bioreactors with substantially constant working volumes and associated systems and methods
US10296718B2 (en) 2014-05-30 2019-05-21 Hitachi, Ltd. Medicine production support system and medicine production support method
CN104128152B (zh) * 2014-08-12 2015-09-09 青海合杰工贸集团有限责任公司 一种调配反应观察装置
US20210146353A1 (en) * 2017-03-14 2021-05-20 BioGenium Microsystems Oy A system and a method for irradiating biological material
CN109517738A (zh) * 2018-12-14 2019-03-26 杭州奕安济世生物药业有限公司 一种调控生物反应器中二氧化碳含量的方法
CN114989977A (zh) * 2022-06-16 2022-09-02 中山大学 一种用于多细胞相互作用及药物筛选的肿瘤类器官芯片及其制备方法
JP7430005B1 (ja) * 2022-11-24 2024-02-09 株式会社シェルタージャパン 藻類増殖制御装置

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3080647B2 (ja) * 1990-10-09 2000-08-28 エーザイ株式会社 細胞培養装置
FR2803852B1 (fr) * 2000-01-17 2004-11-05 Farzin Sarem Dispositif de culture cellulaire et tissulaire a circulation de fluide de culture controlee
WO2003093406A2 (en) * 2002-05-01 2003-11-13 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
WO2005026349A1 (ja) * 2003-09-17 2005-03-24 Mitsubishi Chemical Corporation 非アミノ有機酸の製造方法
US7367550B2 (en) 2003-11-18 2008-05-06 Massachusetts Institute Of Technology Peristaltic mixing and oxygenation system
WO2005065419A2 (en) * 2003-12-29 2005-07-21 Am Biosolutions Method of culturing cells
WO2005121307A2 (en) * 2004-06-07 2005-12-22 Bioprocessor Corp. Gas control in a microreactor
CN1763173A (zh) * 2005-07-21 2006-04-26 高春平 造血干细胞培养装置和方法
US9248421B2 (en) * 2005-10-07 2016-02-02 Massachusetts Institute Of Technology Parallel integrated bioreactor device and method
US8178318B2 (en) * 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
PL2451936T3 (pl) * 2009-07-06 2020-02-28 F. Hoffmann-La Roche Ag Sposób hodowli komórek eukariotycznych

Also Published As

Publication number Publication date
CA2888076A1 (en) 2014-05-01
WO2014066774A1 (en) 2014-05-01
MX378896B (es) 2025-03-11
AU2013334168B2 (en) 2018-10-04
CN104870629A (zh) 2015-08-26
IN2015DN03093A (enExample) 2015-10-02
CN107267385B (zh) 2021-03-12
AU2018286560B2 (en) 2020-07-23
CN107267385A (zh) 2017-10-20
US20170107473A1 (en) 2017-04-20
AU2013334168A1 (en) 2015-04-30
AU2020250287B2 (en) 2022-07-21
AU2018286560A1 (en) 2019-01-24
CA2888076C (en) 2023-08-08
EP2912157A1 (en) 2015-09-02
US20140127802A1 (en) 2014-05-08
MX2015005284A (es) 2015-11-16
SG11201502917TA (en) 2015-05-28
AU2020250287A1 (en) 2020-11-05
SG10201803572UA (en) 2018-06-28
MX2020014123A (es) 2021-03-25

Similar Documents

Publication Publication Date Title
HK1213006A1 (zh) 小容积反应器中二氧化碳水平和ph的控制
WO2014197568A3 (en) Rna-guideded transcriptional regulation
WO2013006631A8 (en) A system for extended storage of red blood cells and methods of use
WO2011094572A3 (en) Hanging drop devices, systems and/or methods
BR112014031424A2 (pt) tratamento de células pluripotentes
WO2013159035A8 (en) Highly sensitive surveillance using detection of cell free dna
WO2010083170A3 (en) Cell stimulation using quantum dots
WO2009154753A3 (en) Catalytic materials, electrodes, and systems for water electrolysis and other electrochemical techniques
WO2011133902A3 (en) Cell culture medium comprising small peptides
WO2013124326A9 (de) Einweg abscheider zur rückhaltung und rückführung von zellen
MX2015004516A (es) Procedimientos y sistemas para optimizar el sistema de cultivo de celulas de perfusion.
WO2013028747A3 (en) System and method for mobile water treatment
WO2012072096A8 (en) Method for cellular rna expression
MX2013009620A (es) Sistema magneticamente acoplado para mezclado.
SA516380011B1 (ar) طريقة ومعالجة لتحفيز بئر
WO2014035919A3 (en) Transport of dissolved species through a barrier
MX344896B (es) Método de operación de la fermentación de un substrato gaseoso que contiene monóxido de carbono.
WO2014132101A3 (en) Bioreactor system and methods for alternative cell culture between static and dynamic
WO2014012115A3 (en) Method for inducing cells to less mature state
WO2011028264A3 (en) Methods and systems involving materials and electrodes for water electrolysis and other electrochemical techniques
WO2012016172A3 (en) Genetically modified microbes producing increased levels of acetyl-coa derived compounds
WO2010042484A3 (en) Photobioreactor system with high specific growth rate and low dilution rate
WO2013012889A3 (en) Regulatory polynucleotides and uses thereof
MX2015000281A (es) Generacion electroquimica de derivados de urea clorados.
WO2012127164A3 (fr) Cellule electrochimique symetrique