MX2020013695A - Biorreactores de peque?o volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados. - Google Patents

Biorreactores de peque?o volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados.

Info

Publication number
MX2020013695A
MX2020013695A MX2020013695A MX2020013695A MX2020013695A MX 2020013695 A MX2020013695 A MX 2020013695A MX 2020013695 A MX2020013695 A MX 2020013695A MX 2020013695 A MX2020013695 A MX 2020013695A MX 2020013695 A MX2020013695 A MX 2020013695A
Authority
MX
Mexico
Prior art keywords
substantially constant
methods
associated systems
small volume
working volumes
Prior art date
Application number
MX2020013695A
Other languages
English (en)
Inventor
Shireen Goh
Rajeev Jagga Ram
Michelangelo Canzoneri
Horst Blum
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of MX2020013695A publication Critical patent/MX2020013695A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/58Reaction vessels connected in series or in parallel
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Control Of Non-Electrical Variables (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Por lo general se describe el control del volumen en biorreactores y sistemas relacionados; las estrategias de alimentación y/o muestreo se pueden emplear, en algunas modalidades, de manera que el volumen de trabajo dentro del biorreactor permanezca sustancialmente constante.
MX2020013695A 2013-08-23 2016-02-22 Biorreactores de peque?o volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados. MX2020013695A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361869116P 2013-08-23 2013-08-23
EP14306161 2014-07-17

Publications (1)

Publication Number Publication Date
MX2020013695A true MX2020013695A (es) 2021-02-26

Family

ID=51220530

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016002331A MX2016002331A (es) 2013-08-23 2014-08-22 Biorreactores de pequeño volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados.
MX2020013695A MX2020013695A (es) 2013-08-23 2016-02-22 Biorreactores de peque?o volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016002331A MX2016002331A (es) 2013-08-23 2014-08-22 Biorreactores de pequeño volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados.

Country Status (8)

Country Link
US (2) US10479973B2 (es)
EP (1) EP3036317A4 (es)
CN (1) CN105683354A (es)
AU (3) AU2014308719B2 (es)
CA (2) CA2920083C (es)
MX (2) MX2016002331A (es)
SG (2) SG10201800558WA (es)
WO (1) WO2015027140A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2015DN03033A (es) 2012-10-26 2015-09-18 Massachusetts Inst Technology
JP6164580B2 (ja) * 2013-03-13 2017-07-19 国立大学法人 筑波大学 マイクロ流路装置及びこれに関する方法
AU2014308719B2 (en) 2013-08-23 2019-12-19 Massachusetts Institute Of Technology Small volume bioreactors with substantially constant working volumes and associated systems and methods
AU2015341570A1 (en) * 2014-11-07 2017-06-08 Oxy Solutions As Apparatus for dissolving gas into a liquid
US10647954B1 (en) 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
US11566217B2 (en) * 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
IL292337A (en) 2019-10-21 2022-06-01 Flaskworks Llc Cell culture systems and methods
JP2022553955A (ja) 2019-10-22 2022-12-27 ジェンザイム・コーポレーション 統合された連続的バイオ製造におけるインライン生成物監視
AU2020398339A1 (en) * 2019-12-03 2022-07-21 The University Of Adelaide Cell culture microdevice
CN112725151B (zh) * 2021-01-12 2022-09-30 江西省农业科学院农业应用微生物研究所(江西省农村能源研究中心) 一种卧式发酵罐

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658478A (en) 1970-04-07 1972-04-25 Instrumentation Labor Inc Fluid analyzing apparatus
US4442206A (en) 1980-08-21 1984-04-10 Stanford University Method of using isotropic, porous-wall polymeric membrane, hollow-fibers for culture of microbes
US5100781A (en) 1986-05-14 1992-03-31 Gas Research Institute Measurement of gas production of algal clones
US4839292B1 (en) 1987-09-11 1994-09-13 Joseph G Cremonese Cell culture flask utilizing membrane barrier
US5081035A (en) 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
GB8824865D0 (en) 1988-10-24 1988-11-30 Antec Systems Gas sampling device & water trap
US5763266A (en) 1989-06-15 1998-06-09 The Regents Of The University Of Michigan Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
JP3080647B2 (ja) 1990-10-09 2000-08-28 エーザイ株式会社 細胞培養装置
US5856179A (en) * 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
JPH0889232A (ja) 1994-09-22 1996-04-09 Kao Corp 細胞培養装置
JP4074970B2 (ja) 1998-08-26 2008-04-16 エイブル株式会社 細胞濃度及び/または生理活性測定装置
US6290921B1 (en) 1999-11-03 2001-09-18 Foster Wheeler Enegeria Oy Method and apparatus for binding pollutants in flue gas
FR2803852B1 (fr) 2000-01-17 2004-11-05 Farzin Sarem Dispositif de culture cellulaire et tissulaire a circulation de fluide de culture controlee
CN1128215C (zh) 2001-08-04 2003-11-19 梅县梅雁生物工程研究所 气体循环培养红豆杉细胞的方法
CN2510499Y (zh) 2001-11-20 2002-09-11 梅县梅雁生物工程研究所 气体循环式植物细胞培养反应器
TW581119U (en) 2001-12-19 2004-03-21 Univ Nat Cheng Kung Petri dish for microscope
US20050026134A1 (en) 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
US7507579B2 (en) 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US20040077075A1 (en) 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
US20060199260A1 (en) 2002-05-01 2006-09-07 Zhiyu Zhang Microbioreactor for continuous cell culture
JP2004041093A (ja) 2002-07-12 2004-02-12 Mitsubishi Heavy Ind Ltd 細胞培養装置および細胞培養方法
KR20050088476A (ko) 2002-12-30 2005-09-06 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
JP2004337091A (ja) 2003-05-16 2004-12-02 Olympus Corp 細胞培養装置
JP4619291B2 (ja) 2003-09-17 2011-01-26 三菱化学株式会社 非アミノ有機酸の製造方法
US20050266393A1 (en) 2003-10-01 2005-12-01 Baxter Gregory T Circulating flow device for assays of cell cultures, cellular components and cell products
US7367550B2 (en) 2003-11-18 2008-05-06 Massachusetts Institute Of Technology Peristaltic mixing and oxygenation system
WO2005065419A2 (en) 2003-12-29 2005-07-21 Am Biosolutions Method of culturing cells
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
WO2005121307A2 (en) 2004-06-07 2005-12-22 Bioprocessor Corp. Gas control in a microreactor
US7531351B2 (en) 2004-06-14 2009-05-12 Probiogen Ag Liquid-gas-phase exposure reactor for cell culturing
CN100565207C (zh) 2004-10-01 2009-12-02 株式会社日立高新技术 化学分析装置
CN1763173A (zh) 2005-07-21 2006-04-26 高春平 造血干细胞培养装置和方法
US9248421B2 (en) 2005-10-07 2016-02-02 Massachusetts Institute Of Technology Parallel integrated bioreactor device and method
US20070178023A1 (en) * 2005-11-23 2007-08-02 Bioprocessors Corp. Method for performing fed-batch operations in small volume reactors
GB2433266A (en) 2005-12-16 2007-06-20 Kevin Andrew Auton Cell culture vessel
BRPI0814681B1 (pt) 2007-07-11 2018-12-26 Mitsui Chemicals Inc bactéria produtora de álcool isopropílico recombinante do gênero escherichia e método de produzir álcool isopropílico usando a mesma
FR2927906B1 (fr) 2008-02-21 2010-04-02 Eco Solution Procede et dispositif de culture cellulaire en mode continu ouvert.
EP2310493A1 (en) 2008-08-06 2011-04-20 Praxair Technology, Inc. METHOD FOR CONTROLLING pH, OSMOLALITY AND DISSOLVED CARBON DIOXIDE LEVELS IN A MAMMALIAN CELL CULTURE PROCESS TO ENHANCE CELL VIABILITY AND BIOLOGIC PRODUCT YIELD
US8178318B2 (en) 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
WO2010017337A1 (en) 2008-08-06 2010-02-11 Praxair Technology, Inc. System and method for controlling a mammalian cell culture process
CN201276562Y (zh) 2008-10-22 2009-07-22 方民 一种尾气回用好氧生物发酵罐
US20100261242A1 (en) 2009-04-14 2010-10-14 Harvey Jeffrey T Static solid state bioreactor and method for using same
SG177555A1 (en) 2009-07-06 2012-02-28 Genentech Inc Method of culturing eukaryotic cells
EP2483614B1 (en) 2009-09-30 2020-06-24 Global Life Sciences Solutions USA LLC Disposable bioreactor condenser bag and filter heater
US9550970B2 (en) 2010-02-17 2017-01-24 Inq Biosciences Corporation Culture systems, apparatus, and related methods and articles
CN202013342U (zh) 2010-09-03 2011-10-19 上海诺科生物科技有限公司 具有测量化学反应产生的气体种类及量的装置
SI2487233T1 (sl) 2011-02-11 2014-04-30 Krueger A/S Naprava za proizvodnjo bioplina z digestijo organskega materiala
CN102288653A (zh) 2011-05-06 2011-12-21 湖北博凡生物科技有限公司 生化需氧量bod在线测定仪及用其检测的方法
US20130084622A1 (en) 2011-09-30 2013-04-04 Massachusetts Institute Of Technology Device and method for continuous cell culture and other reactions
IN2015DN03033A (es) 2012-10-26 2015-09-18 Massachusetts Inst Technology
IN2015DN03093A (es) 2012-10-26 2015-10-02 Massachusetts Inst Technology
AU2014308719B2 (en) 2013-08-23 2019-12-19 Massachusetts Institute Of Technology Small volume bioreactors with substantially constant working volumes and associated systems and methods

Also Published As

Publication number Publication date
CA2920083A1 (en) 2015-02-26
AU2014308719A1 (en) 2016-02-18
EP3036317A4 (en) 2017-04-12
CN105683354A (zh) 2016-06-15
US20200063082A1 (en) 2020-02-27
AU2020201975A1 (en) 2020-04-09
AU2022200770A1 (en) 2022-02-24
CA3173080A1 (en) 2015-02-26
US11827871B2 (en) 2023-11-28
AU2020201975B2 (en) 2022-01-13
SG11201601068YA (en) 2016-03-30
EP3036317A1 (en) 2016-06-29
CA2920083C (en) 2022-11-15
AU2014308719B2 (en) 2019-12-19
US10479973B2 (en) 2019-11-19
MX2016002331A (es) 2016-06-24
SG10201800558WA (en) 2018-02-27
WO2015027140A1 (en) 2015-02-26
US20160215246A1 (en) 2016-07-28

Similar Documents

Publication Publication Date Title
MX2020013695A (es) Biorreactores de peque?o volumen con volumenes de trabajo sustancialmente constantes y sistemas y metodos relacionados.
MX2021005777A (es) Suministro selectivo de material a celulas.
MX2015017928A (es) Montajes de mezclado incluyendo impulsores magneticos.
PH12015502401A1 (en) Compositions and methods for enhancing microbial stability
EP3310900A4 (en) CELL CULTURE INCUBATORS WITH INTEGRATED CELL MANIPULATION SYSTEMS
GB2528206A (en) Guided article authorship
MX2021008627A (es) Medio de cultivo celular libre de suero.
WO2014164815A3 (en) Adipose tissue combinations, devices, and uses thereof
MX2016004802A (es) Anticuerpos anti-r-espondina (anti-rspo) y metodos de uso.
MX2015010943A (es) Metodos de cultivo por perfusión con microportadores y usos de los mismos.
PH12017500052A1 (en) Myo-inositol and probiotics and uses
WO2014018785A3 (en) Biorefinery control system, components therefor, and methods of use
EP3212821A4 (en) Improved electrochemical bioreactor module and use thereof
MX2019009189A (es) Metodos de cultivo por perfusion con microportadores y usos de los mismos.
MX357675B (es) Anticuerpos anti-jagged y métodos de uso.
EP3654936A4 (en) AMMONIA-COXIDIZING MICRO-ORGANISMS FOR USE AND ADMINISTRATION TO THE UROGENITAL TRACT
EP3030646A4 (en) Methods, apparatuses, and systems for cell and tissue culture
MX2015017414A (es) Bacteria acetogenica.
EP3020801A4 (en) YEAST WITH HIGH CONTENT OF Abu, upsilon-Glu-Abu, AND/OR UPSILON-Glu-Abu-Gly
EP3183333A4 (en) Primary mammalian cell culture systems and methods
SG11201903231WA (en) Microbioreactor module
MX2017001737A (es) Vitamina b2 y sus usos.
MX2015011890A (es) Combinaciones sinergisticas de monoclorourea y monocloroureas modificadas.
AU2018901982A0 (en) Maximising national economic and social utility
AU365075S (en) Activator device with clip