SG10201803572UA - Control of carbon dioxide levels and ph in small volume reactors - Google Patents

Control of carbon dioxide levels and ph in small volume reactors

Info

Publication number
SG10201803572UA
SG10201803572UA SG10201803572UA SG10201803572UA SG10201803572UA SG 10201803572U A SG10201803572U A SG 10201803572UA SG 10201803572U A SG10201803572U A SG 10201803572UA SG 10201803572U A SG10201803572U A SG 10201803572UA SG 10201803572U A SG10201803572U A SG 10201803572UA
Authority
SG
Singapore
Prior art keywords
carbon dioxide
control
small volume
dioxide levels
volume reactors
Prior art date
Application number
SG10201803572UA
Inventor
Shireen Goh
Rajeev Ram
Horst Blum
Michelangelo Canzoneri
Original Assignee
Massachusetts Inst Technology
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Sanofi Sa filed Critical Massachusetts Inst Technology
Publication of SG10201803572UA publication Critical patent/SG10201803572UA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Treating Waste Gases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

CONTROL OF CARBON DIOXIDE LEVELS AND PH IN SMALL VOLUME REACTORS 5 Strategies to control the level of dissolved carbon dioxide (C02) concentrations and/or pH in small volume reactor chambers, and associated articles, systems, and methods, are generally provided. In certain embodiments, the reactor chambers can be configured to contain at least one biological cell. 10 Figure 1
SG10201803572UA 2012-10-26 2013-10-25 Control of carbon dioxide levels and ph in small volume reactors SG10201803572UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261719027P 2012-10-26 2012-10-26
US201361869111P 2013-08-23 2013-08-23
EP13306462 2013-10-23

Publications (1)

Publication Number Publication Date
SG10201803572UA true SG10201803572UA (en) 2018-06-28

Family

ID=49551567

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201502917TA SG11201502917TA (en) 2012-10-26 2013-10-25 Control of carbon dioxide levels and ph in small volume reactors
SG10201803572UA SG10201803572UA (en) 2012-10-26 2013-10-25 Control of carbon dioxide levels and ph in small volume reactors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201502917TA SG11201502917TA (en) 2012-10-26 2013-10-25 Control of carbon dioxide levels and ph in small volume reactors

Country Status (10)

Country Link
US (2) US20140127802A1 (en)
EP (1) EP2912157A1 (en)
CN (2) CN104870629A (en)
AU (3) AU2013334168B2 (en)
CA (1) CA2888076C (en)
HK (1) HK1213006A1 (en)
IN (1) IN2015DN03093A (en)
MX (2) MX2015005284A (en)
SG (2) SG11201502917TA (en)
WO (1) WO2014066774A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009060489A1 (en) * 2009-12-29 2011-06-30 Uhde GmbH, 44141 Apparatus and method for controlling the oxygen permeation through non-porous oxygen anions conductive ceramic membranes and their use
IN2015DN03033A (en) 2012-10-26 2015-09-18 Massachusetts Inst Technology
AU2014308719B2 (en) 2013-08-23 2019-12-19 Massachusetts Institute Of Technology Small volume bioreactors with substantially constant working volumes and associated systems and methods
JP6368782B2 (en) * 2014-05-30 2018-08-01 株式会社日立製作所 Pharmaceutical manufacturing support system and pharmaceutical manufacturing support method
CN104128152B (en) * 2014-08-12 2015-09-09 青海合杰工贸集团有限责任公司 A kind of allotment reaction finder
DK3595813T3 (en) * 2017-03-14 2021-07-12 BioGenium Microsystems Oy System and method for irradiation of biological material
CN109517738A (en) * 2018-12-14 2019-03-26 杭州奕安济世生物药业有限公司 A kind of method of carbon dioxide content in regulation bioreactor

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3080647B2 (en) * 1990-10-09 2000-08-28 エーザイ株式会社 Cell culture device
FR2803852B1 (en) * 2000-01-17 2004-11-05 Farzin Sarem CELL AND TISSUE CULTURE DEVICE WITH CONTROLLED CULTURE FLUID CIRCULATION
US20040077075A1 (en) * 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
JP4619291B2 (en) * 2003-09-17 2011-01-26 三菱化学株式会社 Method for producing non-amino organic acid
US7367550B2 (en) 2003-11-18 2008-05-06 Massachusetts Institute Of Technology Peristaltic mixing and oxygenation system
WO2005065419A2 (en) * 2003-12-29 2005-07-21 Am Biosolutions Method of culturing cells
WO2005121307A2 (en) * 2004-06-07 2005-12-22 Bioprocessor Corp. Gas control in a microreactor
CN1763173A (en) * 2005-07-21 2006-04-26 高春平 Hematopoietic stem cell culturing apparatus and method
US9248421B2 (en) * 2005-10-07 2016-02-02 Massachusetts Institute Of Technology Parallel integrated bioreactor device and method
US8178318B2 (en) * 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
SG177555A1 (en) * 2009-07-06 2012-02-28 Genentech Inc Method of culturing eukaryotic cells

Also Published As

Publication number Publication date
AU2013334168A1 (en) 2015-04-30
AU2020250287A1 (en) 2020-11-05
CN104870629A (en) 2015-08-26
AU2018286560A1 (en) 2019-01-24
AU2018286560B2 (en) 2020-07-23
IN2015DN03093A (en) 2015-10-02
WO2014066774A1 (en) 2014-05-01
HK1213006A1 (en) 2016-06-24
CA2888076A1 (en) 2014-05-01
EP2912157A1 (en) 2015-09-02
US20140127802A1 (en) 2014-05-08
MX2015005284A (en) 2015-11-16
CA2888076C (en) 2023-08-08
AU2020250287B2 (en) 2022-07-21
CN107267385A (en) 2017-10-20
SG11201502917TA (en) 2015-05-28
US20170107473A1 (en) 2017-04-20
MX2020014123A (en) 2021-03-25
AU2013334168B2 (en) 2018-10-04
CN107267385B (en) 2021-03-12

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