HK1210790A1 - Modified factor polypeptides and uses thereof - Google Patents

Modified factor polypeptides and uses thereof

Info

Publication number
HK1210790A1
HK1210790A1 HK15111538.9A HK15111538A HK1210790A1 HK 1210790 A1 HK1210790 A1 HK 1210790A1 HK 15111538 A HK15111538 A HK 15111538A HK 1210790 A1 HK1210790 A1 HK 1210790A1
Authority
HK
Hong Kong
Prior art keywords
modified factor
factor polypeptides
polypeptides
modified
factor
Prior art date
Application number
HK15111538.9A
Other languages
English (en)
Chinese (zh)
Inventor
Christopher Thanos
Edwin L Madison
Original Assignee
Catalyst Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalyst Biosciences Inc filed Critical Catalyst Biosciences Inc
Publication of HK1210790A1 publication Critical patent/HK1210790A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
HK15111538.9A 2012-07-25 2015-11-23 Modified factor polypeptides and uses thereof HK1210790A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261741806P 2012-07-25 2012-07-25
PCT/US2013/032616 WO2014018120A1 (en) 2012-07-25 2013-03-15 Modified factor x polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
HK1210790A1 true HK1210790A1 (en) 2016-05-06

Family

ID=48040462

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111538.9A HK1210790A1 (en) 2012-07-25 2015-11-23 Modified factor polypeptides and uses thereof

Country Status (18)

Country Link
US (2) US9145552B2 (ru)
EP (1) EP2877487B1 (ru)
JP (2) JP6363600B2 (ru)
KR (1) KR102049900B1 (ru)
CN (1) CN104755492A (ru)
AU (1) AU2013293573B2 (ru)
BR (1) BR112015001628A2 (ru)
CA (1) CA2879785C (ru)
EA (1) EA028865B1 (ru)
ES (1) ES2704083T3 (ru)
HK (1) HK1210790A1 (ru)
IL (1) IL236449B (ru)
IN (1) IN2015DN01404A (ru)
MX (1) MX365612B (ru)
NZ (1) NZ703148A (ru)
SG (1) SG11201500579SA (ru)
WO (1) WO2014018120A1 (ru)
ZA (1) ZA201500097B (ru)

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ES2400306T3 (es) 2005-10-21 2013-04-09 Catalyst Biosciences, Inc. Proteasas modificadas que inhiben la activación del complemento
SG10201503055TA (en) 2006-07-05 2015-06-29 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
WO2008127702A2 (en) * 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypetides and uses thereof
TWI465247B (zh) 2008-04-11 2014-12-21 Catalyst Biosciences Inc 經修飾的因子ｖｉｉ多肽和其用途
TWI595004B (zh) 2010-11-03 2017-08-11 介控生化科技公司 經修飾之第九因子多胜肽及其用途
MX365612B (es) 2012-07-25 2019-06-07 Catalyst Biosciences Inc Polipeptidos de factor x modificados y usos de los mismos.
KR101988705B1 (ko) 2013-09-24 2019-06-12 화이자 인코포레이티드 재조합 인간 응고 인자 Xa 단백질의 이질적 집단을 포함하는 조성물
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US10676730B2 (en) 2015-01-07 2020-06-09 Inserm (Institut National De La Sante Et De La Recherche Medicale) Mutated factor X polypeptides and uses thereof for the treatment of haemophilia
US10655119B2 (en) 2015-07-25 2020-05-19 Inserm (Institut National De La Sante Et De La Recherche Medicale) Mutated factor X polypeptides and uses thereof for the treatment of haemophilia
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FR3050992A1 (fr) * 2016-05-06 2017-11-10 Lab Francais Du Fractionnement Mutants du facteur x
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EP3831843A1 (en) * 2019-12-08 2021-06-09 Royal College Of Surgeons In Ireland A hemostatic agent and uses thereof
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CN115725594A (zh) * 2022-03-03 2023-03-03 南京医科大学 Pipiserpin蛋白在蚊媒种群控制中的应用
CN114681597A (zh) * 2022-03-11 2022-07-01 兆科药业（合肥）有限公司 蝰蛇蛇毒血凝酶在制备用于逆转凝血因子Xa抑制剂的抗凝作用的药物中的应用
CN116426510B (zh) * 2023-06-13 2023-09-22 北京沃森赛瑟生物技术有限公司 含修饰Xa因子的利伐沙班检测试剂盒及检测方法与应用

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Also Published As

Publication number Publication date
US9856467B2 (en) 2018-01-02
WO2014018120A1 (en) 2014-01-30
JP2015524801A (ja) 2015-08-27
NZ703148A (en) 2016-08-26
US20140234290A1 (en) 2014-08-21
EA028865B1 (ru) 2018-01-31
IL236449A0 (en) 2015-02-26
MX2015001083A (es) 2015-04-08
MX365612B (es) 2019-06-07
SG11201500579SA (en) 2015-02-27
CN104755492A (zh) 2015-07-01
EP2877487B1 (en) 2018-10-17
CA2879785A1 (en) 2014-01-30
IN2015DN01404A (ru) 2015-07-03
US20140030247A1 (en) 2014-01-30
ES2704083T3 (es) 2019-03-14
JP2018183147A (ja) 2018-11-22
BR112015001628A2 (pt) 2017-11-07
JP6363600B2 (ja) 2018-07-25
AU2013293573A1 (en) 2015-02-05
IL236449B (en) 2019-02-28
CA2879785C (en) 2019-06-18
EP2877487A1 (en) 2015-06-03
ZA201500097B (en) 2016-09-28
KR102049900B1 (ko) 2019-11-28
AU2013293573B2 (en) 2016-10-27
US9145552B2 (en) 2015-09-29
KR20160073937A (ko) 2016-06-27
EA201500172A1 (ru) 2015-09-30

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230321