HK1209458A1 - Method of producing recombinant iduronate-2-sulfatase - Google Patents

Method of producing recombinant iduronate-2-sulfatase Download PDF

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Publication number
HK1209458A1
HK1209458A1 HK15110043.9A HK15110043A HK1209458A1 HK 1209458 A1 HK1209458 A1 HK 1209458A1 HK 15110043 A HK15110043 A HK 15110043A HK 1209458 A1 HK1209458 A1 HK 1209458A1
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HK
Hong Kong
Prior art keywords
protein
cell
recombinant
day
cells
Prior art date
Application number
HK15110043.9A
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English (en)
Chinese (zh)
Inventor
‧張
C‧张
‧博爾戈
F‧博尔戈
Original Assignee
夏尔人类遗传性治疗公司
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Application filed by 夏尔人类遗传性治疗公司 filed Critical 夏尔人类遗传性治疗公司
Publication of HK1209458A1 publication Critical patent/HK1209458A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
    • C12Y108/99—Oxidoreductases acting on sulfur groups as donors (1.8) with other acceptors (1.8.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/40—Nucleotides, nucleosides or bases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15110043.9A 2012-06-29 2013-06-28 Method of producing recombinant iduronate-2-sulfatase HK1209458A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261666712P 2012-06-29 2012-06-29
US61/666,712 2012-06-29
PCT/US2013/048601 WO2014005036A1 (en) 2012-06-29 2013-06-28 Method of producing recombinant iduronate-2-sulfatase

Publications (1)

Publication Number Publication Date
HK1209458A1 true HK1209458A1 (en) 2016-04-01

Family

ID=49778402

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15110043.9A HK1209458A1 (en) 2012-06-29 2013-06-28 Method of producing recombinant iduronate-2-sulfatase
HK15110518.5A HK1209790A1 (en) 2012-06-29 2013-06-28 Method of producing recombinant iduronate-2-sulfatase

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15110518.5A HK1209790A1 (en) 2012-06-29 2013-06-28 Method of producing recombinant iduronate-2-sulfatase

Country Status (21)

Country Link
US (1) US20140004097A1 (cg-RX-API-DMAC7.html)
EP (1) EP2867367A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015523074A (cg-RX-API-DMAC7.html)
KR (1) KR20150037908A (cg-RX-API-DMAC7.html)
CN (1) CN104583414A (cg-RX-API-DMAC7.html)
AU (1) AU2013282417A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014032544A2 (cg-RX-API-DMAC7.html)
CA (1) CA2877492A1 (cg-RX-API-DMAC7.html)
CL (1) CL2014003569A1 (cg-RX-API-DMAC7.html)
CO (1) CO7240395A2 (cg-RX-API-DMAC7.html)
CR (1) CR20140587A (cg-RX-API-DMAC7.html)
DO (1) DOP2014000297A (cg-RX-API-DMAC7.html)
EA (1) EA201492185A1 (cg-RX-API-DMAC7.html)
HK (2) HK1209458A1 (cg-RX-API-DMAC7.html)
IL (1) IL236324A0 (cg-RX-API-DMAC7.html)
IN (1) IN2014DN11272A (cg-RX-API-DMAC7.html)
MX (1) MX2015000188A (cg-RX-API-DMAC7.html)
PE (1) PE20150603A1 (cg-RX-API-DMAC7.html)
PH (1) PH12014502870A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201408755TA (cg-RX-API-DMAC7.html)
WO (1) WO2014005036A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160145589A1 (en) 2011-06-24 2016-05-26 Green Cross Corporation Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
US9150841B2 (en) 2012-06-29 2015-10-06 Shire Human Genetic Therapies, Inc. Cells for producing recombinant iduronate-2-sulfatase
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
AU2013296557B2 (en) * 2012-07-31 2019-04-18 Bioasis Technologies Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
WO2014160438A1 (en) 2013-03-13 2014-10-02 Bioasis Technologies Inc. Fragments of p97 and uses thereof
WO2015126729A1 (en) * 2014-02-19 2015-08-27 Bioasis Technologies, Inc. P97-ids fusion proteins
CN107250372B (zh) 2015-02-05 2022-11-01 R.P.谢勒技术有限责任公司 活化的甲酰甘氨酸生成酶及其生成和使用方法
CN108290059A (zh) * 2015-10-07 2018-07-17 乔尔·胡伊赞加 重设生物途径以防御和修复来自人类老化的退化
US12102689B2 (en) 2015-11-09 2024-10-01 R.P. Scherer Technologies, Llc Anti-CD22 antibody-maytansine conjugates and methods of use thereof
AU2017301691B2 (en) * 2016-07-25 2022-07-21 Repligen Corporation Alternating tangential flow rapid harvesting
EP3692070A1 (en) 2017-10-02 2020-08-12 Denali Therapeutics Inc. Fusion proteins comprising enzyme replacement therapy enzymes

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AU4330597A (en) 1996-08-30 1998-03-19 Life Technologies, Inc. Serum-free mammalian cell culture medium, and uses thereof
DE60032349T2 (de) * 1999-04-26 2007-07-12 Genentech, Inc., South San Francisco Zellenzuchtverfahren für glycoproteine
US6890736B1 (en) * 2002-09-20 2005-05-10 Immunex Corporation Methods for producing proteins in cultured cells
EP1592786B8 (en) * 2003-02-11 2012-03-21 Shire Human Genetic Therapies, Inc. Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies using a formylglycine generating enzyme (fge)
US20050019914A1 (en) * 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
WO2005113765A2 (en) * 2004-05-06 2005-12-01 Biomarin Pharmaceutical Inc. Methods of activation of sulfatases and methods and compositions of using the same
EP1885753B1 (en) * 2005-06-03 2011-07-27 Ares Trading S.A. Production of recombinant Il-18 binding protein
CA2630782C (en) * 2005-12-08 2015-02-03 Amgen Inc. Improved host cells and culture methods
PL2245145T3 (pl) * 2008-01-18 2017-07-31 Biomarin Pharmaceutical Inc. Wytwarzanie aktywnych wysoce fosforylowanych ludzkich enzymów sulfatazy lizosomalnej i ich zastosowania
HRP20190690T1 (hr) * 2009-10-09 2019-06-28 Armagen, Inc. Postupci i pripravci za povećanje aktiviteta iduronat-2-sulfataze u centralnom nervnom sustavu
US20130196410A1 (en) * 2010-03-05 2013-08-01 Alnylam Pharmaceuticals, Inc Compositions and methods for modifying the glycosylation pattern of a polypeptide
US8545837B2 (en) 2010-06-25 2013-10-01 Shire Human Genetic Therapies, Inc. Methods and compositions for CNS delivery of iduronate-2-sulfatase
KR101158673B1 (ko) * 2011-06-24 2012-07-03 주식회사 지씨바이오 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법
US9150841B2 (en) * 2012-06-29 2015-10-06 Shire Human Genetic Therapies, Inc. Cells for producing recombinant iduronate-2-sulfatase

Also Published As

Publication number Publication date
CR20140587A (es) 2015-04-06
AU2013282417A1 (en) 2015-01-29
CN104583414A (zh) 2015-04-29
HK1209790A1 (en) 2016-04-08
IN2014DN11272A (cg-RX-API-DMAC7.html) 2015-10-09
IL236324A0 (en) 2015-02-26
EP2867367A1 (en) 2015-05-06
PE20150603A1 (es) 2015-05-27
MX2015000188A (es) 2015-04-08
SG11201408755TA (en) 2015-02-27
US20140004097A1 (en) 2014-01-02
CL2014003569A1 (es) 2015-04-17
PH12014502870A1 (en) 2015-02-23
EA201492185A1 (ru) 2015-10-30
WO2014005036A1 (en) 2014-01-03
CA2877492A1 (en) 2014-01-03
EP2867367A4 (en) 2016-02-24
JP2015523074A (ja) 2015-08-13
BR112014032544A2 (pt) 2017-08-01
DOP2014000297A (es) 2015-04-15
KR20150037908A (ko) 2015-04-08
CO7240395A2 (es) 2015-04-17

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