HK1208701A1 - Means for inhibiting the expression of protein kinase - Google Patents

Means for inhibiting the expression of protein kinase

Info

Publication number
HK1208701A1
HK1208701A1 HK15109144.9A HK15109144A HK1208701A1 HK 1208701 A1 HK1208701 A1 HK 1208701A1 HK 15109144 A HK15109144 A HK 15109144A HK 1208701 A1 HK1208701 A1 HK 1208701A1
Authority
HK
Hong Kong
Prior art keywords
inhibiting
expression
protein kinase
kinase
protein
Prior art date
Application number
HK15109144.9A
Other languages
English (en)
Chinese (zh)
Inventor
約爾格‧考夫曼
奧利弗‧凱爾
安斯加爾‧桑特爾
Original Assignee
Silence Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Silence Therapeutics Ag filed Critical Silence Therapeutics Ag
Publication of HK1208701A1 publication Critical patent/HK1208701A1/xx

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

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  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
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HK15109144.9A 2006-07-21 2015-09-17 Means for inhibiting the expression of protein kinase HK1208701A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06015262 2006-07-21

Publications (1)

Publication Number Publication Date
HK1208701A1 true HK1208701A1 (en) 2016-03-11

Family

ID=38663298

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15109144.9A HK1208701A1 (en) 2006-07-21 2015-09-17 Means for inhibiting the expression of protein kinase

Country Status (12)

Country Link
US (1) US8232256B2 (fr)
EP (2) EP2546337A1 (fr)
JP (3) JP2009544281A (fr)
KR (1) KR101670085B1 (fr)
CN (3) CN101490253A (fr)
AU (1) AU2007276388A1 (fr)
BR (1) BRPI0714875A2 (fr)
CA (1) CA2658550C (fr)
HK (1) HK1208701A1 (fr)
MX (1) MX2009000654A (fr)
RU (1) RU2553561C2 (fr)
WO (1) WO2008009477A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001264317A1 (en) * 2000-06-20 2002-01-02 Koken Co., Ltd. Preparations for oligonucleotide transfer
EP1407787B1 (fr) * 2001-06-20 2009-04-29 Dainippon Sumitomo Pharma Co., Ltd. Procede facilitant le transfert d'acides nucleiques
CA2495072A1 (fr) 2002-08-14 2004-03-11 Atugen Ag Nouvelle mise en application de la proteine kinase n beta
EP1830888B1 (fr) 2004-12-27 2015-08-05 Silence Therapeutics GmbH Complexes lipidiques revetus et leur utilisation
EP2546337A1 (fr) 2006-07-21 2013-01-16 Silence Therapeutics AG Procédé et appareil dans un système de télécommunication
WO2010110314A1 (fr) * 2009-03-27 2010-09-30 協和発酵キリン株式会社 Agent thérapeutique pour hypertension pulmonaire comprenant un acide nucléique
EP2382994A1 (fr) * 2010-04-26 2011-11-02 Maurizio Victor Cattaneo Nanocapsules ciblés à l'aide de ligands pour délivrer l'ARNi et d'autres agents
US9133515B2 (en) 2012-05-16 2015-09-15 Silence Therapeutics Gmbh Use of VEGFR1 as a biomarker
WO2016083623A1 (fr) * 2014-11-28 2016-06-02 Silence Therapeutics Gmbh Moyens pour le traitement de la prééclampsie
CA3043768A1 (fr) 2016-11-29 2018-06-07 PureTech Health LLC Exosomes destines a l'administration d'agents therapeutiques
RU2698199C1 (ru) * 2018-05-18 2019-08-23 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт общей патологии и патофизиологии" Средство для подавления экспрессии генов, связанных с накоплением холестерина макрофагами человека

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013121A1 (fr) 1991-12-24 1993-07-08 Isis Pharmaceuticals, Inc. Oligonucleotides modifies en 2', a ouverture
ATE318832T1 (de) 1990-06-11 2006-03-15 Gilead Sciences Inc Verfahren zur vervendung von nukleinsäureliganden
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
EP1251170A3 (fr) 1992-07-17 2002-10-30 Ribozyme Pharmaceuticals, Inc. Procédé et réactif pour le traitement de maladies animales dépendants de NF-kappaB
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5777153A (en) 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
JPH11510489A (ja) 1995-07-21 1999-09-14 ジンタ・インコーポレイテッド 新規アミド基本カチオン性脂質
DE59708838D1 (de) 1996-08-30 2003-01-09 Jens Peter Fuerste Spiegelselektion und spiegelevolution von nucleinsäuren
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
US5989912A (en) 1996-11-21 1999-11-23 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
CA2217550A1 (fr) 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Lipides cationiques pour therapie genique
US6358523B1 (en) 1996-12-06 2002-03-19 The Regents Of The University Of California Macromolecule-lipid complexes and methods for making and regulating
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
AU6949098A (en) 1997-04-04 1998-10-30 Valentis, Inc. Improved methods of delivery using cationic lipids and helper lipids
WO1998051285A2 (fr) 1997-05-15 1998-11-19 Genzyme Corporation Formulations amphiphiles cationiques
US20030073640A1 (en) 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
CA2301166A1 (fr) 1997-07-24 1999-02-04 Yuan-Peng Zhang Compositions de liposomes pour la distribution des catalyseurs de l'acide nucleique
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
EP1038016A2 (fr) 1997-12-16 2000-09-27 Valentis Inc. Injection sans aiguille de molecules d'acide nucleique formules
WO1999054459A2 (fr) 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Molecules d'acides nucleiques presentant de nouvelles compositions chimiques capables de moduler l'expression genique
US6150345A (en) 1998-08-10 2000-11-21 Regents Of The University Of California Methods for promoting survival of myelin producing cells
FR2788275B1 (fr) 1999-01-11 2002-06-14 Lipha ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US7015040B2 (en) 1999-02-26 2006-03-21 Mirus Bio Corporation Intravascular delivery of nucleic acid
ATE408699T1 (de) 1999-03-10 2008-10-15 Phogen Ltd Verabreichung von nukleinsäuren und proteinen an zellen
WO2000073469A2 (fr) 1999-05-28 2000-12-07 Sugen, Inc. Proteines kinases
EP1064944A1 (fr) 1999-06-25 2001-01-03 Schering Aktiengesellschaft Inhibiteur de la protéine kinase N contenant du Fasudil
CN1228041C (zh) 1999-07-15 2005-11-23 英耐克斯药品股份有限公司 脂质包埋的治疗剂的制备方法
US6133032A (en) 1999-09-09 2000-10-17 Isis Pharmaceutical Inc. Antisense modulation of PI3 kinase p110 beta expression
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
EP1272629A4 (fr) 2000-03-17 2004-12-22 Benitec Australia Ltd Extinction genetique
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
EP1355670A2 (fr) 2000-04-20 2003-10-29 University of British Columbia Procedes permettant d'ameliorer la transfection a mediation splp (particule plasmide-lipide stabilisee) au moyen de destabilisateurs de la membrane endosomale
CA2426244A1 (fr) 2000-10-25 2002-05-02 The University Of British Columbia Formulations de lipides pour une administration ciblee
WO2002044321A2 (fr) 2000-12-01 2002-06-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Petites molecules d'arn mediant l'interference arn
US6394713B1 (en) * 2001-03-05 2002-05-28 Phillip E. Yates, Sr. Drill guide apparatus
WO2003070910A2 (fr) 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated Inhibition induite par interference d'arn du facteur de croissance endothelial vasculaire et expression genetique du recepteur de facteur de croissance endothelial vasculaire au moyen d'acides nucleiques interferents courts (sina)
US20030135033A1 (en) 2002-01-04 2003-07-17 Anke Klippel-Giese Compounds and methods for the identification and/ or validation of a target
GB2397062B (en) 2002-02-20 2005-06-15 Sirna Therapeutics Inc RNA interference mediated inhibition of hepatitis c virus (HCV) gene expression using short interfering nucleic acid (siNA)
DK3222724T3 (en) 2002-08-05 2018-12-03 Silence Therapeutics Gmbh ADDITIONALLY UNKNOWN FORMS OF INTERFERRING RNA MOLECULES
PT2258847T (pt) * 2002-08-05 2017-06-22 Silence Therapeutics Gmbh Outras novas formas de moléculas de arn de interferência
AU2003258075A1 (en) 2002-08-06 2004-02-23 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
EP1393742A1 (fr) * 2002-08-14 2004-03-03 atugen AG Utilisation de la protéine kinase N bêta
CA2495072A1 (fr) 2002-08-14 2004-03-11 Atugen Ag Nouvelle mise en application de la proteine kinase n beta
US7635770B2 (en) 2002-11-14 2009-12-22 Dharmacon, Inc. siRNA targeting protein kinase N-3 (PKN-3)
DE602004019546D1 (de) 2003-08-26 2009-04-02 Smithkline Beecham Corp Heterofunktionelle copolymere von glycerol und polyethylenglykol, ihre konjugate und zusammensetzungen
CN1968714B (zh) 2004-05-05 2013-10-16 赛伦斯治疗公司 脂质、脂质复合物及其应用
JP2008520600A (ja) 2004-11-19 2008-06-19 ノヴォソム アクチェンゲゼルシャフト 局所投与のための医薬組成物におけるまたはそれに関する改善
EP1830888B1 (fr) 2004-12-27 2015-08-05 Silence Therapeutics GmbH Complexes lipidiques revetus et leur utilisation
WO2006074546A1 (fr) 2005-01-13 2006-07-20 Protiva Biotherapeutics, Inc. Arn interferant encapsule dans des lipides
EP2546337A1 (fr) 2006-07-21 2013-01-16 Silence Therapeutics AG Procédé et appareil dans un système de télécommunication
RU2360967C1 (ru) * 2007-10-01 2009-07-10 Химический факультет Московского государственного университета имени М.В.Ломоносова Биокатализатор на основе иммобилизованных клеток бактерий для разложения метилфосфоновой кислоты и ее эфиров

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CN102321626A (zh) 2012-01-18
JP2013172714A (ja) 2013-09-05
EP2049658A2 (fr) 2009-04-22
US20090304678A1 (en) 2009-12-10
CN102321626B (zh) 2014-12-10
RU2009106071A (ru) 2010-08-27
CA2658550A1 (fr) 2008-01-24
BRPI0714875A2 (pt) 2013-05-28
WO2008009477A3 (fr) 2008-05-29
EP2546337A1 (fr) 2013-01-16
WO2008009477A2 (fr) 2008-01-24
MX2009000654A (es) 2009-07-22
KR101670085B1 (ko) 2016-10-28
US8232256B2 (en) 2012-07-31
CN104531701A (zh) 2015-04-22
CN101490253A (zh) 2009-07-22
JP2015128433A (ja) 2015-07-16
RU2553561C2 (ru) 2015-06-20
CA2658550C (fr) 2018-06-19
JP2009544281A (ja) 2009-12-17
AU2007276388A1 (en) 2008-01-24
KR20090039715A (ko) 2009-04-22

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