HK1208676A1 - 新的苯並氮雜衍生物及其醫藥用途 - Google Patents

新的苯並氮雜衍生物及其醫藥用途

Info

Publication number
HK1208676A1
HK1208676A1 HK15109366.0A HK15109366A HK1208676A1 HK 1208676 A1 HK1208676 A1 HK 1208676A1 HK 15109366 A HK15109366 A HK 15109366A HK 1208676 A1 HK1208676 A1 HK 1208676A1
Authority
HK
Hong Kong
Prior art keywords
pharmaceutical use
benzazepine derivative
novel benzazepine
novel
derivative
Prior art date
Application number
HK15109366.0A
Other languages
English (en)
Inventor
北元克典
春日井宣慶
片岡浩代
大澤靖
久野祐花
藤枝廣樹
酒井啟太
永野裕樹
高橋直希
井土徹
竹内光明
車塚大輔
宮澤俊行
原田聰子
後藤泉
淺野幸康
山田由里枝
岡部守男
Original Assignee
Sanwa Kagaku Kenkyusho Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co filed Critical Sanwa Kagaku Kenkyusho Co
Publication of HK1208676A1 publication Critical patent/HK1208676A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK15109366.0A 2012-12-26 2015-09-24 新的苯並氮雜衍生物及其醫藥用途 HK1208676A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012281908 2012-12-26
PCT/JP2013/084937 WO2014104209A1 (ja) 2012-12-26 2013-12-26 新規ベンゾアゼピン誘導体及びその医薬用途

Publications (1)

Publication Number Publication Date
HK1208676A1 true HK1208676A1 (zh) 2016-03-11

Family

ID=51021283

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15109366.0A HK1208676A1 (zh) 2012-12-26 2015-09-24 新的苯並氮雜衍生物及其醫藥用途

Country Status (15)

Country Link
US (1) US9586905B2 (zh)
EP (1) EP2940008B1 (zh)
JP (2) JP5968466B2 (zh)
KR (1) KR101983880B1 (zh)
CN (1) CN104884436B (zh)
AU (1) AU2013367084B2 (zh)
BR (1) BR112015015663A2 (zh)
CA (1) CA2889239C (zh)
DK (1) DK2940008T3 (zh)
ES (1) ES2633981T3 (zh)
HK (1) HK1208676A1 (zh)
MX (1) MX362478B (zh)
PL (1) PL2940008T3 (zh)
RU (1) RU2642783C2 (zh)
WO (1) WO2014104209A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2940008T3 (pl) * 2012-12-26 2017-10-31 Sanwa Kagaku Kenkyusho Co Nowa pochodna benzoazepiny i jej zastosowanie farmaceutyczne
JP2022055368A (ja) * 2019-02-19 2022-04-08 株式会社三和化学研究所 ベンゾアゼピン誘導体の製造方法及びその中間体
JPWO2020171055A1 (zh) * 2019-02-19 2020-08-27

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952573A (en) * 1988-03-23 1990-08-28 Laboratoirs Alcon S.A. Compounds having GABA like activity, and use of same in tissue irrigating solutions
US5258510A (en) 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5753677A (en) 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
US5985869A (en) 1989-10-20 1999-11-16 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
JP2905909B2 (ja) * 1991-04-19 1999-06-14 大塚製薬株式会社 バソプレシン拮抗剤
WO1991005549A1 (en) * 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
CN100384825C (zh) 1994-06-15 2008-04-30 大塚制药株式会社 苯并杂环衍生物
JPH09221476A (ja) 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
TW359669B (en) * 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
JP2964031B2 (ja) * 1995-12-15 1999-10-18 大塚製薬株式会社 ベンゾアゼピン誘導体
JP2926335B2 (ja) 1997-06-13 1999-07-28 大塚製薬株式会社 医薬組成物
JPH111456A (ja) 1997-06-13 1999-01-06 Otsuka Pharmaceut Co Ltd アミド誘導体
ES2327620T3 (es) * 2001-11-16 2009-11-02 Astellas Pharma Inc. Derivado de 4,4-difluoro-1,2,3,4-tetraidro-5h-1-benzacepina o sales del mismo.
JP4238978B2 (ja) * 2003-04-22 2009-03-18 大塚製薬株式会社 ベンゾアゼピン化合物及びその製造法
ZA200508080B (en) * 2003-04-28 2007-03-28 Astellas Pharma Inc 4,4-difluoro-1,2,3,4-tetrhydro-5H-1-benzazepine derivative or salt thereof
ME00320B (me) 2003-06-17 2011-05-10 Janssen Pharmaceutica Nv Supstituisani spirobenzazepini
EP1867639A1 (en) 2005-03-25 2007-12-19 Kissei Pharmaceutical Co., Ltd. Urea derivative, medicinal composition containing the same, and medicinal use of these
US7825111B2 (en) 2006-09-22 2010-11-02 Janssen Pharmaceutica Nv Substituted spiroheterocycles
BRPI0811200A8 (pt) * 2007-05-10 2015-09-22 Bristol Myers Squibb Co Tetra-hidrobenzapinas arilóxi- e heteroarilóxi-substituídas e uso das mesmas para bloquear percepção de norepinefrina, dopamina, e serotonina
DK2860175T3 (da) * 2012-06-11 2018-01-29 Tacurion Fremgangsmåde til fremstilling af 4,4,7-trifluor-1,2,3,4-tetrahydro-5h-1-benzazepin-forbindelse og intermediat til syntese deraf
PL2940008T3 (pl) * 2012-12-26 2017-10-31 Sanwa Kagaku Kenkyusho Co Nowa pochodna benzoazepiny i jej zastosowanie farmaceutyczne

Also Published As

Publication number Publication date
MX2015008399A (es) 2015-09-23
JP2016199575A (ja) 2016-12-01
AU2013367084B2 (en) 2017-06-08
JP6231621B2 (ja) 2017-11-15
WO2014104209A1 (ja) 2014-07-03
PL2940008T3 (pl) 2017-10-31
JP5968466B2 (ja) 2016-08-10
ES2633981T3 (es) 2017-09-26
US20150291533A1 (en) 2015-10-15
AU2013367084A1 (en) 2015-05-28
CA2889239C (en) 2020-10-27
DK2940008T3 (en) 2017-08-07
EP2940008A4 (en) 2016-05-18
US9586905B2 (en) 2017-03-07
EP2940008B1 (en) 2017-05-17
RU2015131020A (ru) 2017-01-30
EP2940008A1 (en) 2015-11-04
MX362478B (es) 2019-01-11
RU2642783C2 (ru) 2018-01-26
BR112015015663A2 (pt) 2017-07-11
KR20150098614A (ko) 2015-08-28
CN104884436B (zh) 2017-06-13
CN104884436A (zh) 2015-09-02
CA2889239A1 (en) 2014-07-03
KR101983880B1 (ko) 2019-05-29
JPWO2014104209A1 (ja) 2017-01-19

Similar Documents

Publication Publication Date Title
IL274988A (en) Carbamoylpyridone-polycyclic compounds and their pharmaceutical use
HK1205690A1 (zh) 藥物组合物及其施用
IL252566B (en) Pharmacy preparations and methods
IL234628A0 (en) Imidazolyl-pyrimidines are converted into amino-indolyl and their use as drugs
EP2828258A4 (en) NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE
EP2867209A4 (en) COMPOUNDS AND THEIR THERAPEUTIC USES
EP2718283A4 (en) INDAZOLE AND PYRROLOPYRIDINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
EP2875014A4 (en) ANTI-MUCUS MEDICAMENTS AND USES THEREOF
HK1208676A1 (zh) 新的苯並氮雜衍生物及其醫藥用途
PT2597084T (pt) Derivado de n-hidroxiformamida e medicamento contendo o mesmo
GB201208315D0 (en) Pharmaceutical methods and compositions
EP2817004A4 (en) BOUVARDIN DERIVATIVES AND THEIR THERAPEUTIC USES
SG11201406942SA (en) Trans-2-decenoic acid derivative and drug containing same
GB201112578D0 (en) Pharmaceutical preparation and use

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20211224