HK1208672A1 - 用於對腦內所蓄積的 蛋白質進行成像的新的化合物 - Google Patents
用於對腦內所蓄積的 蛋白質進行成像的新的化合物Info
- Publication number
- HK1208672A1 HK1208672A1 HK15109324.1A HK15109324A HK1208672A1 HK 1208672 A1 HK1208672 A1 HK 1208672A1 HK 15109324 A HK15109324 A HK 15109324A HK 1208672 A1 HK1208672 A1 HK 1208672A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tau
- novel compound
- imaging
- brain
- protein accumulated
- Prior art date
Links
- 102000013498 tau Proteins Human genes 0.000 title 2
- 108010026424 tau Proteins Proteins 0.000 title 2
- 210000004556 brain Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Hospice & Palliative Care (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2012/083286 WO2014097474A1 (ja) | 2012-12-21 | 2012-12-21 | 脳内に蓄積したタウタンパク質をイメージングするための新規化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1208672A1 true HK1208672A1 (zh) | 2016-03-11 |
Family
ID=50287280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15109324.1A HK1208672A1 (zh) | 2012-12-21 | 2015-09-23 | 用於對腦內所蓄積的 蛋白質進行成像的新的化合物 |
Country Status (12)
Country | Link |
---|---|
US (4) | US10604516B2 (zh) |
EP (1) | EP2767532B1 (zh) |
JP (1) | JP5422782B1 (zh) |
KR (2) | KR102053484B1 (zh) |
CN (2) | CN107412788B (zh) |
AU (2) | AU2012397435B2 (zh) |
CA (1) | CA2894994C (zh) |
DK (1) | DK2767532T3 (zh) |
HK (1) | HK1208672A1 (zh) |
SG (1) | SG11201504901PA (zh) |
TW (1) | TWI627166B (zh) |
WO (1) | WO2014097474A1 (zh) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102053484B1 (ko) | 2012-12-21 | 2019-12-06 | 국립연구개발법인 양자과학기술연구개발기구 | 뇌 안에 축적된 타우 단백질을 이미징하기 위한 신규한 화합물 |
KR102005068B1 (ko) * | 2015-03-27 | 2019-07-30 | 주식회사 휴엔 | 1,2 나프토퀴논 유도체 및 이의 제조방법 |
CN105985299B (zh) * | 2015-11-10 | 2018-10-12 | 济南大学 | 一种高选择性超灵敏分析二价铁离子的荧光探针 |
CN106008374B (zh) * | 2016-06-07 | 2018-07-27 | 四川大学 | 吡嗪类化合物及其在医药上的用途 |
CN106632139A (zh) * | 2016-12-13 | 2017-05-10 | 青岛科技大学 | 苯并噻唑‑2‑甲醛及其衍生物合成的新方法 |
JP7008299B2 (ja) * | 2017-03-10 | 2022-01-25 | 国立大学法人滋賀医科大学 | 神経難病の画像診断薬及び体外診断薬 |
JPWO2019026797A1 (ja) * | 2017-07-31 | 2020-06-18 | 国立大学法人静岡大学 | 凝集タンパク質の検出に適した化合物 |
GB201712567D0 (en) | 2017-08-04 | 2017-09-20 | Karin & Sten Mortstedt Cbd Solutions Ab | Selective ligands for tau aggregates |
JP6831802B2 (ja) * | 2018-01-12 | 2021-02-17 | 上海富吉医療器械有限公司Shanghai Chartwell Medical Instrument Co., Ltd. | 放射性核種標識化合物及びこれを含有するイメージング剤 |
JP7293343B2 (ja) * | 2018-05-09 | 2023-06-19 | アプリノイア セラピューティクス リミテッド | ヘテロアリール化合物及びその使用 |
JP7460176B2 (ja) | 2019-02-27 | 2024-04-02 | 国立研究開発法人量子科学技術研究開発機構 | αシヌクレイン凝集体結合剤及びイメージング方法 |
EP4058065A4 (en) | 2019-11-13 | 2023-05-03 | Aprinoia Therapeutics Limited | COMPOUNDS FOR DEGRADING TAU PROTEIN AGGREGATES AND THEIR USES |
KR102344676B1 (ko) * | 2020-02-12 | 2021-12-30 | 한국과학기술연구원 | 타우 응집체에 선택적으로 결합하는 근적외선 형광 탐침자로서 유효한 신규 화합물 및 이의 제조방법 |
US20230133538A1 (en) * | 2020-03-18 | 2023-05-04 | Dana-Farber Cancer Institute, Inc. | Targeted degraders of aberrant tau based on the pet tracer pbb3 |
KR20230057381A (ko) | 2020-08-25 | 2023-04-28 | 내셔널 인스티튜츠 포 퀀텀 사이언스 앤드 테크놀로지 | 신규 화합물, α-시누클레인 응집체 결합제 및 그 이용 |
WO2023163033A1 (ja) * | 2022-02-24 | 2023-08-31 | 国立研究開発法人量子科学技術研究開発機構 | 新規化合物、αシヌクレイン凝集体結合剤及びその利用 |
CN115353498B (zh) * | 2022-09-01 | 2023-08-08 | 坛墨质检科技股份有限公司 | 一种苯并噻唑类锌离子荧光探针及其制备方法 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3833863A (en) * | 1971-12-27 | 1974-09-03 | Eastman Kodak Co | Styryl and arylbutadienyl dye lasers |
JPS5553333A (en) | 1978-10-16 | 1980-04-18 | Hitachi Ltd | Composite type electrophotographic plate |
JPS61275836A (ja) * | 1985-05-31 | 1986-12-05 | Fuji Photo Film Co Ltd | ハロゲン化銀写真乳剤 |
US5264329A (en) | 1989-09-18 | 1993-11-23 | Dupont (U.K.) Limited | Radiation sensitive compositions |
GB8921116D0 (en) * | 1989-09-18 | 1989-11-01 | Du Pont | Improvements in or relating to radiation sensitive compositions |
WO2002016333A2 (en) | 2000-08-24 | 2002-02-28 | University Of Pittsburgh | Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease |
US7118730B2 (en) * | 2002-12-16 | 2006-10-10 | Bf Research Institute, Inc. | Quinoline derivative as diagnostic probe for disease with tau protein accumulation |
ES2379169T3 (es) | 2003-05-19 | 2012-04-23 | Irm Llc | Composiciones y compuestos inmunosupresores |
MXPA06001742A (es) * | 2003-08-13 | 2006-08-11 | Bf Res Inst Inc | Sondas para enfermedades en las cuales se acumula amiloide, agentes para tincion del amiloide, farmacos para tratamiento y profilaxis de enfermedades con amiloide acumulado, y sondas para diagnostico de ovillos neurofibrilares y agentes para tincion |
AU2003304416A1 (en) | 2003-08-13 | 2005-03-07 | Bf Research Institute, Inc. | Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change |
WO2005058374A1 (en) * | 2003-12-15 | 2005-06-30 | Tongji Medical Center | Methods and compositions for modulating tau in vivo |
ZA200707226B (en) * | 2005-02-28 | 2009-09-30 | Taisho Pharmaceutical Co Ltd | Radioactive halogen-labelled phenyloxyaniline derivatives |
JP2007106755A (ja) | 2005-09-13 | 2007-04-26 | Japan Health Science Foundation | アミロイドイメージング用プローブ |
WO2007034282A2 (en) | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists |
CA2631905A1 (en) | 2005-12-01 | 2007-06-07 | William E. Klunk | Isotopically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins |
TW200736252A (en) * | 2006-01-27 | 2007-10-01 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
US7678819B2 (en) * | 2006-12-07 | 2010-03-16 | The Trustees Of The University Of Pennsylvania | Acetylene derivatives and their use for binding and imaging amyloid plaques |
EP2103611A4 (en) | 2006-12-25 | 2010-06-30 | Univ Tohoku | benzoxazole |
CN101293878B (zh) * | 2007-04-25 | 2010-12-15 | 中国科学院上海应用物理研究所 | 苯并噻唑苯胺类化合物及其制备方法和应用 |
KR20100135235A (ko) | 2008-02-14 | 2010-12-24 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | 신경학적 기능이상을 검출하기 위한 조영제 |
JP5603855B2 (ja) | 2008-04-04 | 2014-10-08 | アビッド レディオファーマシューティカルズ、インク. | 神経変成疾患の放射性薬剤による画像化 |
US8420052B2 (en) | 2008-07-24 | 2013-04-16 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying AD pathology |
WO2010017094A2 (en) * | 2008-07-31 | 2010-02-11 | The General Hospital Corporation | CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING |
US8193363B2 (en) | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
CA2737028C (en) * | 2008-09-23 | 2017-06-27 | Wista Laboratories Ltd. | Ligands for aggregated tau molecules |
JPWO2010087315A1 (ja) | 2009-01-29 | 2012-08-02 | 株式会社林原生物化学研究所 | 抗アルツハイマー病剤 |
JP5591720B2 (ja) * | 2009-01-29 | 2014-09-17 | 株式会社林原 | 抗神経変性疾患剤 |
US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
WO2010111303A2 (en) * | 2009-03-23 | 2010-09-30 | Siemens Medical Solutions Usa, Inc. | Imaging agents for detecting neurological disorders |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
WO2011045415A2 (en) | 2009-10-15 | 2011-04-21 | Guerbet | New imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
KR101116234B1 (ko) * | 2009-10-29 | 2014-03-06 | (주)퓨쳐켐 | (3-플루오로-2-히드록시)프로필 작용기가 도입된 아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
US9133343B2 (en) * | 2009-11-30 | 2015-09-15 | Enzo Biochem, Inc. | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications |
EP2701695B1 (en) * | 2011-04-26 | 2019-04-03 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating pufas |
KR102053484B1 (ko) | 2012-12-21 | 2019-12-06 | 국립연구개발법인 양자과학기술연구개발기구 | 뇌 안에 축적된 타우 단백질을 이미징하기 위한 신규한 화합물 |
US9447054B2 (en) | 2014-01-15 | 2016-09-20 | Korea Institute Of Radiological & Medical Sciences | Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient |
WO2015188368A1 (en) | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles |
JP6815318B2 (ja) | 2014-12-23 | 2021-01-20 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
WO2016132998A1 (ja) | 2015-02-19 | 2016-08-25 | Jnc株式会社 | ベンゾチオフェンを有する液晶性化合物、液晶組成物および液晶表示素子 |
EP3270917A4 (en) | 2015-03-18 | 2018-08-08 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
WO2017030814A1 (en) | 2015-08-19 | 2017-02-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
TW201722957A (zh) | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產(第二)有限公司 | 化學化合物 |
TW201722958A (zh) | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產(第二)有限公司 | 化學化合物 |
US10300155B2 (en) | 2015-12-31 | 2019-05-28 | Washington University | Alpha-synuclein ligands |
US10059878B2 (en) | 2016-02-17 | 2018-08-28 | Jnc Corporation | Liquid crystal composition and liquid crystal display device |
JP6696312B2 (ja) | 2016-06-15 | 2020-05-20 | Jnc株式会社 | 液晶組成物および液晶表示素子 |
PE20190227A1 (es) | 2016-07-12 | 2019-02-13 | H Lundbeck As | Anticuerpos especificos para la tau hiperfosforilada y sus metodos de uso |
WO2018017370A1 (en) | 2016-07-20 | 2018-01-25 | Anahit Ghochikyan | Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
CA3209295A1 (en) | 2016-11-01 | 2018-06-07 | Arvinas, Inc. | Tau-protein targeting protacs and associated methods of use |
US10723717B2 (en) | 2016-12-23 | 2020-07-28 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides |
US20210154184A1 (en) | 2017-07-12 | 2021-05-27 | Dana-Farber Cancer Institute, Inc. | Compounds for tau protein degradation |
JP7293343B2 (ja) | 2018-05-09 | 2023-06-19 | アプリノイア セラピューティクス リミテッド | ヘテロアリール化合物及びその使用 |
CA3102214A1 (en) | 2018-06-29 | 2020-01-02 | Dana-Farber Cancer Institute, Inc. | Ligands to cereblon (crbn) |
JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのe3ユビキチンリガーゼ結合活性を有するキメラ(protac)化合物を標的とし、アルファ-シヌクレインタンパク質を標的とするタンパク質分解 |
WO2021011913A1 (en) | 2019-07-17 | 2021-01-21 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
-
2012
- 2012-12-21 KR KR1020157007665A patent/KR102053484B1/ko active IP Right Grant
- 2012-12-21 DK DK12884742.3T patent/DK2767532T3/en active
- 2012-12-21 CA CA2894994A patent/CA2894994C/en active Active
- 2012-12-21 CN CN201710407246.4A patent/CN107412788B/zh active Active
- 2012-12-21 WO PCT/JP2012/083286 patent/WO2014097474A1/ja active Application Filing
- 2012-12-21 US US14/346,914 patent/US10604516B2/en active Active
- 2012-12-21 JP JP2013530441A patent/JP5422782B1/ja active Active
- 2012-12-21 AU AU2012397435A patent/AU2012397435B2/en active Active
- 2012-12-21 EP EP12884742.3A patent/EP2767532B1/en active Active
- 2012-12-21 KR KR1020197035497A patent/KR20190136125A/ko not_active Application Discontinuation
- 2012-12-21 CN CN201280076347.3A patent/CN104736524B/zh active Active
- 2012-12-21 SG SG11201504901PA patent/SG11201504901PA/en unknown
-
2013
- 2013-12-20 TW TW102147556A patent/TWI627166B/zh active
-
2015
- 2015-09-23 HK HK15109324.1A patent/HK1208672A1/zh unknown
-
2017
- 2017-06-27 AU AU2017204357A patent/AU2017204357B2/en active Active
-
2020
- 2020-02-21 US US16/798,226 patent/US20200262829A1/en not_active Abandoned
-
2021
- 2021-09-16 US US17/477,479 patent/US11667628B2/en active Active
-
2023
- 2023-05-08 US US18/144,547 patent/US20240083893A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2894994A1 (en) | 2014-06-26 |
KR20150095610A (ko) | 2015-08-21 |
EP2767532A1 (en) | 2014-08-20 |
CN107412788A (zh) | 2017-12-01 |
US20240083893A1 (en) | 2024-03-14 |
CN104736524B (zh) | 2017-06-23 |
US20150239878A1 (en) | 2015-08-27 |
CA2894994C (en) | 2019-11-12 |
AU2017204357B2 (en) | 2019-04-18 |
AU2017204357A1 (en) | 2017-08-10 |
CN107412788B (zh) | 2021-06-18 |
KR102053484B1 (ko) | 2019-12-06 |
EP2767532B1 (en) | 2016-07-13 |
WO2014097474A1 (ja) | 2014-06-26 |
DK2767532T3 (en) | 2016-09-12 |
US11667628B2 (en) | 2023-06-06 |
EP2767532A4 (en) | 2014-09-10 |
AU2012397435B2 (en) | 2017-03-30 |
SG11201504901PA (en) | 2015-07-30 |
US20200262829A1 (en) | 2020-08-20 |
US10604516B2 (en) | 2020-03-31 |
CN104736524A (zh) | 2015-06-24 |
TWI627166B (zh) | 2018-06-21 |
US20220056020A1 (en) | 2022-02-24 |
JPWO2014097474A1 (ja) | 2017-01-12 |
JP5422782B1 (ja) | 2014-02-19 |
TW201441214A (zh) | 2014-11-01 |
AU2012397435A1 (en) | 2015-08-06 |
KR20190136125A (ko) | 2019-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1208672A1 (zh) | 用於對腦內所蓄積的 蛋白質進行成像的新的化合物 | |
HK1209768A1 (zh) | 抗體 | |
HK1205269A1 (zh) | 包括堆叠式集成元件的通電眼科鏡片 | |
EP2820476A4 (en) | 360-DEGREE IMAGE SYSTEM | |
EP2856759A4 (en) | STEREOSCOPIC VIDEO IMAGING | |
ZA201406100B (en) | Filter element | |
EP2856928A4 (en) | IMAGING SYSTEM | |
EP2911296A4 (en) | COMMON MODE FILTER | |
EP2745157A4 (en) | IMAGING OBJECTIVE | |
SG2013083357A (en) | Filter element | |
ZA201500873B (en) | Switchable exhale filter system | |
EP2689718A4 (en) | IMAGING SYSTEM | |
EP2718760A4 (en) | IMAGING LENSES | |
EP2911203A4 (en) | SOLID STATE IMAGE RECORDING ELEMENT | |
EP2735261A4 (en) | IMAGING SYSTEM | |
EP2761353A4 (en) | FIGURE LENS | |
ZA201408213B (en) | Anti-transglutaminase 2 antibodies | |
GB201418163D0 (en) | Techniques for video compression | |
EP2932327A4 (en) | DOUBLE Q IMAGING SYSTEM | |
EP2718759A4 (en) | IMAGING LENSES | |
GB201217225D0 (en) | Image filtering | |
EP2687147A4 (en) | IMAGING SYSTEM | |
EP2712539A4 (en) | IMAGING SYSTEM | |
KR101178336B9 (ko) | 횡형 압력식 개별여과/역세 방법 및 그 장치 | |
SG10201707733WA (en) | Novel compounds for imaging tau proteins that accumulate in brain |