HK1206797A1 - Non-invasive determination of methylome of fetus or tumor from plasma - Google Patents

Non-invasive determination of methylome of fetus or tumor from plasma

Info

Publication number
HK1206797A1
HK1206797A1 HK15107437.9A HK15107437A HK1206797A1 HK 1206797 A1 HK1206797 A1 HK 1206797A1 HK 15107437 A HK15107437 A HK 15107437A HK 1206797 A1 HK1206797 A1 HK 1206797A1
Authority
HK
Hong Kong
Prior art keywords
methylome
fetus
tumor
plasma
invasive determination
Prior art date
Application number
HK15107437.9A
Other languages
English (en)
Chinese (zh)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee Chan
Yuk-Ming Dennis Lo
Miu Fan Lun
Peiyong Jiang
Wai Man Chan
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1206797(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of HK1206797A1 publication Critical patent/HK1206797A1/xx

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    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
HK15107437.9A 2012-09-20 2015-08-03 Non-invasive determination of methylome of fetus or tumor from plasma HK1206797A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
PCT/AU2013/001088 WO2014043763A1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (1)

Publication Number Publication Date
HK1206797A1 true HK1206797A1 (en) 2016-01-15

Family

ID=50340462

Family Applications (3)

Application Number Title Priority Date Filing Date
HK15107437.9A HK1206797A1 (en) 2012-09-20 2015-08-03 Non-invasive determination of methylome of fetus or tumor from plasma
HK15107703.6A HK1207124A1 (en) 2012-09-20 2015-08-10 Non-invasive determination of methylome of fetus or tumor from plasma
HK19100229.2A HK1257868A1 (zh) 2012-09-20 2019-01-07 從血漿無創測定腫瘤的甲基化組

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK15107703.6A HK1207124A1 (en) 2012-09-20 2015-08-10 Non-invasive determination of methylome of fetus or tumor from plasma
HK19100229.2A HK1257868A1 (zh) 2012-09-20 2019-01-07 從血漿無創測定腫瘤的甲基化組

Country Status (27)

Country Link
EP (6) EP4335929A3 (ko)
JP (5) JP6317354B2 (ko)
KR (5) KR20230145530A (ko)
CN (2) CN117757932A (ko)
AU (4) AU2013317708C1 (ko)
BR (3) BR122021021825B1 (ko)
CA (2) CA3122779A1 (ko)
CY (1) CY1124139T1 (ko)
DK (4) DK3536807T3 (ko)
EA (1) EA201500327A1 (ko)
ES (3) ES2665273T5 (ko)
FI (2) FI3536807T3 (ko)
HK (3) HK1206797A1 (ko)
HR (2) HRP20240210T1 (ko)
HU (2) HUE066054T2 (ko)
IL (4) IL299444B1 (ko)
LT (2) LT3354747T (ko)
MX (1) MX360034B (ko)
MY (2) MY187444A (ko)
NZ (2) NZ717423A (ko)
PH (1) PH12015500547A1 (ko)
PL (3) PL3354747T3 (ko)
PT (4) PT3536807T (ko)
SG (2) SG11201501927VA (ko)
TW (5) TWI640634B (ko)
WO (1) WO2014043763A1 (ko)
ZA (1) ZA201501772B (ko)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335354B (en) 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
ES2665273T5 (es) * 2012-09-20 2023-10-02 Univ Hong Kong Chinese Determinación no invasiva de metiloma del feto o tumor de plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10017824B2 (en) * 2013-07-30 2018-07-10 Bgi Genomics Co., Limited Method for determining nucleic acid composition of nucleic acid mixture
US10174375B2 (en) * 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US12054771B2 (en) * 2014-02-18 2024-08-06 Bionano Genomics, Inc. Methods of determining nucleic acid structural information
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
WO2015169947A1 (en) 2014-05-09 2015-11-12 Lifecodexx Ag Detection of dna that originates from a specific cell-type and related methods
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
DK3543356T3 (da) * 2014-07-18 2021-10-11 Univ Hong Kong Chinese Analyse af methyleringsmønster af væv i DNA-blanding
EP3172341A4 (en) 2014-07-25 2018-03-28 University of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
CN113957124A (zh) 2015-02-10 2022-01-21 香港中文大学 用于癌症筛查和胎儿分析的突变检测
US10689706B2 (en) * 2015-07-20 2020-06-23 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in a DNA mixture
HUE057821T2 (hu) 2015-07-23 2022-06-28 Univ Hong Kong Chinese Sejtmentes DNS fragmentációs mintázatának elemzése
TWI793586B (zh) 2015-08-12 2023-02-21 香港中文大學 血漿dna之單分子定序
TWI767888B (zh) 2015-09-22 2022-06-21 香港中文大學 藉由母體血漿ｄｎａ之淺深度測序以準確定量胎兒ｄｎａ含量
US10260088B2 (en) * 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
US20180327825A1 (en) * 2015-11-09 2018-11-15 Progenity, Inc. Methods for determining the origin of dna molecules
EP3168309B8 (en) 2015-11-10 2020-06-03 Eurofins LifeCodexx GmbH Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female
EP3390657B1 (en) 2015-12-17 2020-09-16 Illumina, Inc. Distinguishing methylation levels in complex biological samples
EP3411505A4 (en) * 2016-02-02 2020-01-15 Guardant Health, Inc. DETECTION AND DIAGNOSIS OF CANCER EVOLUTION
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
KR102522067B1 (ko) * 2016-05-03 2023-04-13 유니버시티 헬스 네트워크 무-세포 메틸화된 dna의 포획 방법 및 이의 이용
US20190256921A1 (en) * 2016-05-04 2019-08-22 Queen's University At Kingston Cell-free detection of methylated tumour dna
KR102482616B1 (ko) * 2016-05-30 2022-12-28 더 차이니즈 유니버시티 오브 홍콩 혈액 내 무세포 dna를 사용하는 혈액 장애의 검출
WO2017218908A2 (en) * 2016-06-16 2017-12-21 The Johns Hopkins University Methods and system for epigenetic analysis
US11999998B2 (en) 2016-08-24 2024-06-04 Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof
CN109890984B (zh) * 2016-10-19 2024-03-29 香港中文大学 通过母体血浆dna的甲基化和大小谱分析进行胎龄评估
AU2017347790B2 (en) 2016-10-24 2024-06-13 Grail, Inc. Methods and systems for tumor detection
KR20230062684A (ko) 2016-11-30 2023-05-09 더 차이니즈 유니버시티 오브 홍콩 소변 및 기타 샘플에서의 무세포 dna의 분석
WO2018112100A2 (en) * 2016-12-13 2018-06-21 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
BR112019014208A2 (pt) * 2017-01-11 2020-03-17 Quest Diagnostics Investments Llc Métodos para detectar diagnóstico falso-positivo de aneuploidia cromossômica em um feto e para detectar diagnóstico aneuploidiadiagnóstico de aneuploidia cromossômica falso-positiva em um feto.
RS65618B1 (sr) * 2017-01-24 2024-07-31 Bgi Genomics Co Ltd Postupak za utvrđivanje frakcije nukleinskih kiselina bez ćelija iz prethodno određenog izvora u biološkom uzorku
EP4421489A2 (en) 2017-01-25 2024-08-28 The Chinese University of Hong Kong Diagnostic applications using nucleic acid fragments
CN107247873B (zh) * 2017-03-29 2020-04-14 电子科技大学 一种差异甲基化位点识别方法
EP3622091A4 (en) * 2017-05-12 2021-02-17 President and Fellows of Harvard College UNIVERSAL EARLY CANCER DIAGNOSIS
WO2019010564A1 (en) * 2017-07-12 2019-01-17 University Health Network DETECTION AND CLASSIFICATION OF CANCER USING METHYLOME ANALYSIS
US11900604B2 (en) * 2017-07-12 2024-02-13 Ande Corporation Adaptive expert system for analysis and classification of DNA sample data
DK3658684T3 (da) * 2017-07-26 2023-10-09 Univ Hong Kong Chinese Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer
WO2019055819A1 (en) 2017-09-14 2019-03-21 Grail, Inc. METHODS FOR PREPARING A SEQUENCING LIBRARY FROM SINGLE STRANDED DNA
WO2019067973A1 (en) 2017-09-28 2019-04-04 Grail, Inc. ENRICHMENT OF SHORT NUCLEIC ACID FRAGMENTS IN THE PREPARATION OF SEQUENCING LIBRARIES
US11168356B2 (en) 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
TWI834642B (zh) 2018-03-13 2024-03-11 美商格瑞爾有限責任公司 異常片段偵測及分類
EP3766076A4 (en) * 2018-03-15 2021-12-29 Grail, Inc. Tissue-specific methylation marker
CA3094717A1 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
US20210104297A1 (en) * 2018-04-16 2021-04-08 Grail, Inc. Systems and methods for determining tumor fraction in cell-free nucleic acid
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US11932899B2 (en) * 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN109448789A (zh) * 2018-09-17 2019-03-08 上海派森诺生物科技股份有限公司 一种基于perl语言的种群特异SNP位点的自动化分析方法
CN113286881A (zh) 2018-09-27 2021-08-20 格里尔公司 甲基化标记和标靶甲基化探针板
CN109295230A (zh) * 2018-10-24 2019-02-01 福建翊善生物科技有限公司 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法
GB2595076B8 (en) 2018-11-21 2023-08-23 Agilent Technologies Inc Methods for targeted nucleic acid library formation
ES2968457T3 (es) * 2018-12-19 2024-05-09 Univ Hong Kong Chinese Características de los extremos del ADN extracelular circulante
US20200239965A1 (en) 2018-12-21 2020-07-30 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free dna samples
WO2020163410A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
CA3127894A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
WO2020192680A1 (en) 2019-03-25 2020-10-01 The Chinese University Of Hong Kong Determining linear and circular forms of circulating nucleic acids
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
SG11202112246UA (en) * 2019-05-03 2021-12-30 Univ Cornell Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes
JP2022544626A (ja) * 2019-08-19 2022-10-19 グリーン クロス ゲノム コーポレーション 核酸断片間距離情報を用いた染色体異常検出方法
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
GB201915469D0 (en) 2019-10-24 2019-12-11 Univ London Cancer detection methods
EP4066245A1 (en) * 2019-11-27 2022-10-05 Grail, LLC Systems and methods for evaluating longitudinal biological feature data
GB2612412A (en) 2020-01-31 2023-05-03 Avida Biomed Inc Systems and methods for targeted nucleic acid capture
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
CN115443507A (zh) * 2020-02-28 2022-12-06 格里尔公司 鉴定可鉴别或指示癌症病状的甲基化模式
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测11种癌症的探针组合物
RU2738675C1 (ru) * 2020-07-28 2020-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов
CN112813148A (zh) * 2021-02-02 2021-05-18 博淼生物科技（北京）有限公司 飞行时间质谱检测5-羟甲基胞嘧啶的方法
CN118302816A (zh) * 2021-09-28 2024-07-05 行动基因(智财)有限公司 甲基化生物标记选择装置及方法
KR20230059423A (ko) 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
CN118215743A (zh) * 2021-11-04 2024-06-18 通用诊断股份公司 用于制备用于基因测序的生物样品的系统和方法
CN115064211B (zh) * 2022-08-15 2023-01-24 臻和(北京)生物科技有限公司 一种基于全基因组甲基化测序的ctDNA预测方法及装置
CN115612723B (zh) * 2022-09-26 2023-07-14 广州女娲生命科技有限公司 植入前胚胎的筛选方法
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
CN117025753A (zh) * 2023-08-15 2023-11-10 广州女娲生命科技有限公司 检测染色体变异的方法和装置
CN117079822B (zh) * 2023-10-17 2024-01-02 北京大学第三医院（北京大学第三临床医学院） 一种妊娠早中期四因子预测胎儿脑损伤的系统

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
DE60207979T2 (de) 2002-03-05 2006-09-28 Epigenomics Ag Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten
US20040171037A1 (en) * 2002-11-19 2004-09-02 Jing Li Amplified genes involved in cancer
US20060183128A1 (en) 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
WO2005090607A1 (en) * 2004-03-08 2005-09-29 Rubicon Genomics, Inc. Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation
JP2008545418A (ja) 2005-05-27 2008-12-18 ジョン ウェイン キャンサー インスティチュート 癌の診断、予後診断、および治療のための遊離循環ｄｎａの使用
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
TWI335354B (en) * 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
EP2173897A2 (en) 2007-06-19 2010-04-14 Oncomethylome Sciences SA Improved urine sample collecting and processing
HUE061020T2 (hu) 2007-07-23 2023-05-28 Univ Hong Kong Chinese Nukleinsav-szekvencia kiegyensúlyozatlanságának meghatározására
US20110028333A1 (en) 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
US20120208711A1 (en) * 2009-10-02 2012-08-16 Centre For Addiction And Mental Health Method for Analysis of DNA Methylation Profiles of Cell-Free Circulating DNA in Bodily Fluids
FI3783110T3 (fi) * 2009-11-05 2023-03-02 Fetaalisen genomin analyysi maternaalisesta biologisesta näytteestä
JP5770737B2 (ja) 2009-11-06 2015-08-26 ザ チャイニーズ ユニバーシティ オブ ホンコン サイズに基づくゲノム分析
WO2011091046A1 (en) * 2010-01-19 2011-07-28 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
PL2529032T3 (pl) * 2010-01-26 2017-07-31 Nipd Genetics Ltd Sposoby i kompozycje do nieinwazyjnego prenatalnego diagnozowania aneuploidii płodu
KR102136041B1 (ko) 2010-04-29 2020-07-20 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 게놈 모델에 대한 데이터 통합을 이용하는 경로 인지 알고리즘 （ｐａｒａｄｉｇｍ）
GB201007944D0 (en) 2010-05-12 2010-06-30 Univ Aberystwyth Methods
EP2576832B1 (en) 2010-05-25 2016-05-04 The Johns Hopkins University Compositions and methods for detecting a neoplasia
CA2806291C (en) * 2010-07-23 2023-08-29 President And Fellows Of Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
CA2802111A1 (en) * 2010-07-23 2012-01-26 Esoterix Genetic Laboratories, Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
WO2012031329A1 (en) 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
EP2646579B1 (en) 2010-11-30 2017-06-14 The Chinese University Of Hong Kong Detection of genetic or molecular aberrations associated with cancer
ES2665273T5 (es) 2012-09-20 2023-10-02 Univ Hong Kong Chinese Determinación no invasiva de metiloma del feto o tumor de plasma

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