HK1204340A1 - Protein and gene biomarkers for rejection of organ transplants - Google Patents

Protein and gene biomarkers for rejection of organ transplants

Info

Publication number
HK1204340A1
HK1204340A1 HK15104780.9A HK15104780A HK1204340A1 HK 1204340 A1 HK1204340 A1 HK 1204340A1 HK 15104780 A HK15104780 A HK 15104780A HK 1204340 A1 HK1204340 A1 HK 1204340A1
Authority
HK
Hong Kong
Prior art keywords
rejection
protein
organ transplants
gene biomarkers
biomarkers
Prior art date
Application number
HK15104780.9A
Other languages
English (en)
Chinese (zh)
Inventor
Minnie M Sarwal
Li Li
Tara Sigdel
Amit Kaushal
Wenzhong Xiao
Atul J Butte
Purvesh Khatri
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of HK1204340A1 publication Critical patent/HK1204340A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
HK15104780.9A 2010-03-25 2015-05-19 Protein and gene biomarkers for rejection of organ transplants HK1204340A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34107110P 2010-03-25 2010-03-25
US201161452288P 2011-03-14 2011-03-14

Publications (1)

Publication Number Publication Date
HK1204340A1 true HK1204340A1 (en) 2015-11-13

Family

ID=44673660

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15104780.9A HK1204340A1 (en) 2010-03-25 2015-05-19 Protein and gene biomarkers for rejection of organ transplants

Country Status (6)

Country Link
US (3) US9535075B2 (fr)
EP (2) EP2550371A4 (fr)
CA (1) CA2794255C (fr)
ES (1) ES2798114T3 (fr)
HK (1) HK1204340A1 (fr)
WO (1) WO2011119980A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011006119A2 (fr) 2009-07-09 2011-01-13 The Scripps Research Institute Profils d'expression génique associés à une néphropathie chronique de l'allogreffe
CN102854323B (zh) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 移植肾排斥反应早期诊断试剂盒及其使用方法
CN102854306B (zh) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 用于预警肾移植后排斥反应的试剂盒及其使用方法
CN102854305B (zh) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 移植肾排斥反应预警试剂盒及其使用方法
WO2013187556A1 (fr) * 2012-06-14 2013-12-19 Scripps Korea Antibody Institute Nouvel anticorps spécifique de clec14a et ses utilisations
EP2698636A1 (fr) 2012-08-13 2014-02-19 Fundació Institut d'Investigació Biomèdica de Bellvitge Procédés et réactifs pour la prévention et/ou le traitement d'un rejet de greffe
US9816088B2 (en) 2013-03-15 2017-11-14 Abvitro Llc Single cell bar-coding for antibody discovery
WO2015035203A1 (fr) * 2013-09-06 2015-03-12 Immucor Gti Diagnostics, Inc. Compositions et méthodes pour évaluer un rejet aigu de transplantation rénale
US20160376652A1 (en) * 2013-09-06 2016-12-29 Immucor Gti Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
CN103698508B (zh) * 2014-01-08 2016-05-18 陈娟 一种结缔组织病早期肺间质病变诊断试剂盒
WO2015138803A1 (fr) * 2014-03-12 2015-09-17 Icahn School Of Medicine At Mount Sinai Procédé d'identification de receveurs d'allogreffe de rein à risque de lésion chronique
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3825418A3 (fr) * 2014-05-22 2021-09-15 The Scripps Research Institute Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11572587B2 (en) 2014-06-26 2023-02-07 Icahn School Of Medicine At Mount Sinai Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets
CN104198691B (zh) * 2014-08-14 2016-08-17 上海睿康生物科技有限公司 一种稳定的α-淀粉酶检测试剂盒
EP3194593B1 (fr) 2014-09-15 2019-02-06 AbVitro LLC Séquençage à haut débit de banque de nucléotides
WO2016075232A1 (fr) * 2014-11-12 2016-05-19 Institut National De La Sante Et De La Recherche Medicale Signature génique associée à une tolérance à une allogreffe rénale
WO2017066390A1 (fr) * 2015-10-13 2017-04-20 The Trustees Of The University Of Pennsylvania Méthodes d'utilisation d'exosomes enrichis comme plateforme pour surveiller l'état d'un organe
WO2017100259A1 (fr) * 2015-12-08 2017-06-15 Icahn School Of Medicine At Mount Sinai Prévision, réalisée avant la transplantation, du rejet aigu du greffon après transplantation
WO2019107673A1 (fr) * 2017-11-29 2019-06-06 서울대학교병원 Marqueur biologique permettant de surveiller le rejet médié par des anticorps lors d'une transplantation incompatible avec le groupe sanguin abo
CN112236137A (zh) 2018-04-16 2021-01-15 西奈山伊坎医学院 利用移植前接受者血液中转录组标志预测急性排斥反应和肾脏同种异体移植物丧失的方法和试剂盒
JP2022531660A (ja) * 2019-05-06 2022-07-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 移植拒絶反応の非ｈｌａマーカー
EP4177608A1 (fr) 2021-11-05 2023-05-10 Medizinische Hochschule Hannover Panel de biomarqueurs pour le diagnostic d'un dysfonctionnement pulmonaire
WO2024068521A1 (fr) * 2022-09-26 2024-04-04 Fundación Para La Formación E Investigación Sanitaria De La Región De Murcia Procédé in vitro pour prédiction de rejet de greffe d'organe

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591570A (en) 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US6882301B2 (en) 1986-06-03 2005-04-19 Time Domain Corporation Time domain radio transmission system
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0937159A4 (fr) 1996-02-08 2004-10-20 Affymetrix Inc Speciation de micro-organismes a partir de microplaquettes et caracterisation des phenotypes de ceux-ci
DE69823206T2 (de) 1997-07-25 2004-08-19 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Verfahren zur herstellung einer bio-informatik-datenbank
US20030104371A1 (en) 1997-09-24 2003-06-05 Strom Terry B. Methods of evaluating transplant rejection
DK1032662T3 (da) 1997-11-07 2006-07-03 Trillium Therapeutics Inc Fremgangsmåder og sammensætninger til immunmodulation
US6607879B1 (en) 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
US6235311B1 (en) 1998-03-18 2001-05-22 Bristol-Myers Squibb Company Pharmaceutical composition containing a combination of a statin and aspirin and method
JP4197393B2 (ja) 1998-03-31 2008-12-17 旭化成ファーマ株式会社 ＩｇＡ腎症の検査法
US20050025769A1 (en) * 1999-01-22 2005-02-03 Fujisawa Pharmaceutical Company, Ltd. Method of suppressing ongoing acute allograft rejection
AU2001292959A1 (en) 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
AU2002243905B2 (en) 2001-01-26 2007-11-08 Emory University Methods of inducing organ transplant tolerance and correcting hemoglobinopathies
WO2002092124A1 (fr) 2001-05-11 2002-11-21 Wyeth Procedes pour diagnostiquer et traiter une ischemie et une lesion de reperfusion et compositions utilisees a cette fin
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
WO2003005972A2 (fr) 2001-07-13 2003-01-23 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Procede d'identification de la tolerance a un transplant chez des receveurs
US20070134261A1 (en) 2001-12-03 2007-06-14 Hancock Robert E Effectors of innate immunity
PT1567138E (pt) 2002-11-21 2011-04-11 Genzyme Corp Utilização de derivados de diamida para inibição de rejeição crónica de transplante
WO2004074815A2 (fr) 2003-02-14 2004-09-02 Beth Israel Deaconess Medical Center, Inc. Prediction des rejets de greffe
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
JP2007516693A (ja) 2003-06-09 2007-06-28 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン 癌の治療および診断のための組成物および方法
WO2005094200A2 (fr) 2003-06-20 2005-10-13 University Of Florida Biomarqueurs permettant de differencier des diabetes de types 1 et 2
JP4316617B2 (ja) 2003-12-03 2009-08-19 ノバルティス アクチエンゲゼルシャフト 移植片拒絶反応のバイオマーカー
CA2553551C (fr) 2004-01-21 2020-12-15 The Board Of Trustees Of The Leland Stanford Junior University Procedes et compositions pour la determination de phenotype a tolerance vis-a-vis du greffon chez un sujet
US8053182B2 (en) 2004-01-30 2011-11-08 The Trustees Of The University Of Pennsylvania Predictors of transplant rejection determined by peripheral blood gene-expression profiling
WO2006033664A1 (fr) 2004-03-08 2006-03-30 Avalon Pharmaceuticals Determination de genes lies au cancer et cibles therapeutiques utilisant des techniques cytogenetiques moleculaires
US20070232658A1 (en) 2004-04-08 2007-10-04 Jurgen Wagner Protein Kinase C Inhibitors for the Treatment of Autoimmune Diseases and of Transplant Rejiction
WO2006014755A2 (fr) 2004-07-20 2006-02-09 Wyeth Procedes d'identification de patients a risque de developper une encephalite suite a une immunotherapie pour la maladie d'alzheimer
US7820382B2 (en) 2004-08-03 2010-10-26 Bauer A Robert Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
US20080280282A1 (en) 2004-08-03 2008-11-13 Bauer Jr A Robert Method for early detection of various cancers and gastrointestinal disease and monitoring of transplanted organs
GB0502042D0 (en) 2005-02-01 2005-03-09 Univ Glasgow Materials and methods for diagnosis and treatment of chronic fatigue syndrome
US7741038B2 (en) * 2005-03-14 2010-06-22 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for evaluating graft survival in a solid organ transplant recipient
US7666596B2 (en) 2005-05-23 2010-02-23 University Of Alberta Tissue rejection
EP1731620A1 (fr) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé diagnostique d'une tolérance immunitaire dans une greffe
US20090118162A1 (en) 2005-06-07 2009-05-07 Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival
WO2006133420A2 (fr) 2005-06-08 2006-12-14 Millennium Pharmaceuticals, Inc. Methode d'identification, d'evaluation et de traitement de patients suivant un traitement anticancereux
WO2007050588A2 (fr) 2005-10-25 2007-05-03 Renovar Incorporated Systemes et procedes pour caracteriser des pathologies et des maladies associees a une transplantation d'organe et a la sante d'organes
CA2641079A1 (fr) 2006-02-06 2007-08-16 Rappaport Family Institute For Research In The Medical Sciences Methodes et trousse pour le diagnostic du diabete de type 1
GB0605217D0 (en) 2006-03-15 2006-04-26 Novartis Ag Method and compositions for assessing acute rejection
US20090324618A1 (en) 2006-03-24 2009-12-31 Armstrong Scott A Novel signature self renewal gene expression programs
GB0607943D0 (en) 2006-04-21 2006-05-31 Novartis Ag Biomarkers for chronic transplant dysfunction
JP5171812B2 (ja) 2006-04-27 2013-03-27 ユニベルシテ ドゥ モントリオール 移植片対宿主病のリスクの評価および低減
WO2008084331A2 (fr) 2006-06-21 2008-07-17 Hopitaux Universitaires De Geneve Biomarqeurs pour des troubles rénaux
WO2008009132A1 (fr) 2006-07-21 2008-01-24 The Governors Of The University Of Alberta Rejet tissulaire
CA2661487A1 (fr) 2006-08-28 2008-03-06 Source Precision Medicine Etablissement de profil d'expression genique pour l'identification, la surveillance et le traitement d'un rejet de greffon
EP2506172A1 (fr) 2006-11-03 2012-10-03 Baylor Research Institute Diagnostic de mélanome métastatique et indicateurs de surveillance d'immunosuppression par l'analyse de micro-réseau de leucocytes de sang
ES2324751B1 (es) 2007-01-04 2010-05-31 Institut D'investigacions Biomediques August Pi I Sunyer (Idibaps) Metodos y kits para diagnosticar y/o pronosticar el estado de tolerancia en el trasplante de higado.
US20090155784A1 (en) 2007-01-22 2009-06-18 Wyeth Assessment of asthma and allergen-dependent gene expression
EP1958637A1 (fr) 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Composition pharmaceutique pour le traitement de maladies induites par IL-8
JP2010524456A (ja) 2007-04-16 2010-07-22 イプソゲン 乳癌に罹患している雌哺乳動物に対する臨床転帰の傾向を評価する方法
JPWO2009044899A1 (ja) 2007-10-03 2011-02-17 協和発酵キリン株式会社 細胞の増殖を制御する核酸
KR20110005708A (ko) 2008-04-09 2011-01-18 더 유니버시티 오브 브리티시 콜롬비아 심장 동종이식 급성 거부반응 진단방법
US20110189680A1 (en) * 2008-05-30 2011-08-04 The University Of British Columbia Methods of Diagnosing Rejection of a Kidney Allograft Using Genomic or Proteomic Expression Profiling
US8426142B2 (en) 2008-06-02 2013-04-23 Eisai R&D Management Co., Ltd. IgA nephropathy testing method and test kit
US20110201519A1 (en) 2008-08-18 2011-08-18 Sarwal Minnie M Methods and Compositions for Determining a Graft Tolerant Phenotype in a Subject
KR100928403B1 (ko) 2008-10-01 2009-11-26 경북대학교 산학협력단 티지비엠 신증의 진단용 조성물 및 키트
EP2387618B1 (fr) * 2009-01-15 2014-05-21 The Board of Trustees of The Leland Stanford Junior University Panel de biomarqueurs pour le diagnostic et la prédiction d'un rejet de greffon
US8734786B2 (en) 2009-09-16 2014-05-27 Northwestern University Use of ECDI-fixed cell tolerance as a method for preventing allograft rejection
CN103154736B (zh) 2010-05-13 2016-04-06 新泽西医科和牙科大学 用于检测和诊断神经变性疾病的诊断性自身抗体谱

Also Published As

Publication number Publication date
EP2550371A1 (fr) 2013-01-30
WO2011119980A1 (fr) 2011-09-29
US20210199669A1 (en) 2021-07-01
EP2803735A1 (fr) 2014-11-19
EP2803735B1 (fr) 2020-03-25
US11768208B2 (en) 2023-09-26
EP2550371A4 (fr) 2013-11-20
US20170227549A1 (en) 2017-08-10
US20130143755A1 (en) 2013-06-06
CA2794255C (fr) 2020-01-14
US9535075B2 (en) 2017-01-03
CA2794255A1 (fr) 2011-09-29
ES2798114T3 (es) 2020-12-09

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