HK1203943A1 - 喹唑啉二酮衍生物 - Google Patents

喹唑啉二酮衍生物

Info

Publication number
HK1203943A1
HK1203943A1 HK15104398.3A HK15104398A HK1203943A1 HK 1203943 A1 HK1203943 A1 HK 1203943A1 HK 15104398 A HK15104398 A HK 15104398A HK 1203943 A1 HK1203943 A1 HK 1203943A1
Authority
HK
Hong Kong
Prior art keywords
quinazolinedione derivative
quinazolinedione
derivative
Prior art date
Application number
HK15104398.3A
Other languages
English (en)
Inventor
村田毅
河田發夫
新妻諭
原聰亮
羽田樹人
島田英輝
田中浩
三尾俊之
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of HK1203943A1 publication Critical patent/HK1203943A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15104398.3A 2012-04-24 2015-05-11 喹唑啉二酮衍生物 HK1203943A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012098954 2012-04-24
PCT/JP2013/062006 WO2013161853A1 (ja) 2012-04-24 2013-04-24 キナゾリンジオン誘導体

Publications (1)

Publication Number Publication Date
HK1203943A1 true HK1203943A1 (zh) 2015-11-06

Family

ID=49483161

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15104398.3A HK1203943A1 (zh) 2012-04-24 2015-05-11 喹唑啉二酮衍生物

Country Status (15)

Country Link
US (1) US9567304B2 (zh)
EP (1) EP2842946B1 (zh)
JP (1) JP6130828B2 (zh)
KR (1) KR20150003849A (zh)
CN (1) CN104379568A (zh)
AR (1) AR090835A1 (zh)
AU (1) AU2013253541A1 (zh)
BR (1) BR112014026305A2 (zh)
CA (1) CA2871453A1 (zh)
HK (1) HK1203943A1 (zh)
MX (1) MX2014012992A (zh)
RU (1) RU2014146993A (zh)
SG (1) SG11201406860SA (zh)
TW (1) TW201348213A (zh)
WO (1) WO2013161853A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013161851A1 (ja) 2012-04-24 2013-10-31 中外製薬株式会社 ベンズアミド誘導体
EP3061749B1 (en) * 2013-10-23 2019-02-27 Chugai Seiyaku Kabushiki Kaisha Quinazolinone and isoquinolinone derivative
CA2961033A1 (en) 2014-09-11 2016-03-17 Takeda Pharmaceutical Company Limited Heterocyclic compound
MX2018000677A (es) 2015-08-31 2018-05-07 Toray Industries Derivado de urea y uso del mismo.
US10280145B2 (en) 2015-08-31 2019-05-07 Toray Industries, Inc. Urea derivative and use therefor
WO2018138050A1 (de) 2017-01-26 2018-08-02 Bayer Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
US20230060425A1 (en) 2019-02-26 2023-03-02 Bayer Aktiengesellschaft Fused bicyclic heterocycle derivatives as pesticides
CN110218193A (zh) * 2019-07-08 2019-09-10 山东大学 3-羟基喹唑啉-2,4(1h,3h)-二酮类衍生物及其制备方法与应用
CN112608282B (zh) * 2019-12-20 2022-07-26 山东先达农化股份有限公司 一种含喹唑啉二酮和n-o结构的化合物及其制备方法和应用

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DK570987A (da) 1986-12-01 1988-06-02 Hoffmann La Roche Oxadiazol-, thiadiazol- og triazolforbindelser
JP2751309B2 (ja) 1988-02-16 1998-05-18 三菱化学株式会社 ピラゾール類およびこれを有効成分とする殺虫、殺ダニ、殺菌剤
JPH05255268A (ja) 1992-03-17 1993-10-05 Mitsubishi Kasei Corp ピラゾールカルボキサミド類、これを有効成分とする殺虫、殺ダニ剤および農園芸用殺菌剤
TW225528B (zh) 1992-04-03 1994-06-21 Ciba Geigy Ag
JP3488890B2 (ja) 1993-11-09 2004-01-19 アグロカネショウ株式会社 ３−ｎ−置換キナゾリノン誘導体、その製造法および該化合物を含有する除草剤
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
MXPA00006605A (es) 1999-07-02 2004-12-09 Pfizer Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
WO2003053958A1 (en) 2001-12-20 2003-07-03 Celltech R & D Limited Quinazolinedione derivatives
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JPWO2005063709A1 (ja) 2003-12-25 2007-07-19 日本新薬株式会社 アミド誘導体及び医薬
US7511062B2 (en) 2004-05-18 2009-03-31 Schering Corporation Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors
AU2005290413A1 (en) 2004-10-08 2006-04-13 Banyu Pharmaceutical Co., Ltd. Method for producing thioether compound
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FR2921926B1 (fr) * 2007-10-03 2009-12-04 Sanofi Aventis Derives de quinazolinedione,leur preparation et leurs applications therapeutiques.
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ES2478823T3 (es) 2008-04-23 2014-07-23 Takeda Pharmaceutical Company Limited Derivados de iminopiridina y uso de los mismos
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JP2012505881A (ja) 2008-10-15 2012-03-08 ギリアード サイエンシーズ， インコーポレイテッド ステアロイル−ＣｏＡデサチュラーゼの阻害剤として使用するための３−ヒドロキナゾリン−４−オン誘導体
EP2370438A1 (en) 2008-12-04 2011-10-05 Exelixis, Inc. Imidazo [1,2a]pyridine derivatives, their use as s1p1 agonists and methods for their production
KR20120099650A (ko) * 2009-10-23 2012-09-11 노파르티스 아게 Ｂｃｒ-ａｂｌ, ｃ-ｋｉｔ, ｄｄｒ1, ｄｄｒ2 또는 ｐｄｇｆ-ｒ 키나제 활성에 의해 매개된 증식성 장애 및 다른 병적 상태의 치료 방법
JO3634B1 (ar) * 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
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TWI527800B (zh) 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用
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Also Published As

Publication number Publication date
US20150141400A1 (en) 2015-05-21
MX2014012992A (es) 2015-08-14
TW201348213A (zh) 2013-12-01
KR20150003849A (ko) 2015-01-09
SG11201406860SA (en) 2014-11-27
AU2013253541A1 (en) 2014-11-20
WO2013161853A1 (ja) 2013-10-31
EP2842946B1 (en) 2016-09-28
EP2842946A4 (en) 2015-09-09
CN104379568A (zh) 2015-02-25
RU2014146993A (ru) 2016-06-10
AR090835A1 (es) 2014-12-10
BR112014026305A2 (pt) 2017-06-27
EP2842946A1 (en) 2015-03-04
CA2871453A1 (en) 2013-10-31
JP6130828B2 (ja) 2017-05-17
US9567304B2 (en) 2017-02-14
JPWO2013161853A1 (ja) 2015-12-24

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