HK1203833A1 - Polynucleotides for treating oncogenic viral polypeptide positive tumors - Google Patents

Polynucleotides for treating oncogenic viral polypeptide positive tumors Download PDF

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Publication number
HK1203833A1
HK1203833A1 HK15104469.7A HK15104469A HK1203833A1 HK 1203833 A1 HK1203833 A1 HK 1203833A1 HK 15104469 A HK15104469 A HK 15104469A HK 1203833 A1 HK1203833 A1 HK 1203833A1
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HK
Hong Kong
Prior art keywords
polypeptide
deletion
point mutation
oncogenic
nucleotide sequence
Prior art date
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HK15104469.7A
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English (en)
Chinese (zh)
Inventor
John H. Lee
Daniel W. VERMEER
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Sanford Health
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Publication of HK1203833A1 publication Critical patent/HK1203833A1/xx

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HK15104469.7A 2012-01-24 2013-01-23 Polynucleotides for treating oncogenic viral polypeptide positive tumors HK1203833A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261590089P 2012-01-24 2012-01-24
US61/590,089 2012-01-24
PCT/US2013/022696 WO2013112549A1 (en) 2012-01-24 2013-01-23 Polynucleotides for treating oncogenic viral polypeptide positive tumors

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HK1203833A1 true HK1203833A1 (en) 2015-11-06

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HK15104469.7A HK1203833A1 (en) 2012-01-24 2013-01-23 Polynucleotides for treating oncogenic viral polypeptide positive tumors

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US (3) US9492526B2 (enExample)
EP (2) EP3269387B1 (enExample)
JP (2) JP6219849B2 (enExample)
KR (1) KR102195196B1 (enExample)
CN (2) CN110042110A (enExample)
DK (1) DK2806889T3 (enExample)
ES (1) ES2646590T3 (enExample)
HK (1) HK1203833A1 (enExample)
IN (1) IN2014DN06118A (enExample)
WO (1) WO2013112549A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10722564B2 (en) 2014-11-13 2020-07-28 Université de Genéve Tri-segmented arenaviruses as vaccine vectors
CN107921117B (zh) 2015-06-10 2022-06-07 霍欧奇帕生物科技有限公司 Hpv疫苗
US11214598B2 (en) 2015-11-04 2022-01-04 Hookipa Biotech Gmbh Vaccines against hepatitis B virus
EP3960197A1 (en) 2015-11-12 2022-03-02 Hookipa Biotech GmbH Arenavirus particles as cancer vaccines
CA3008437A1 (en) 2016-01-08 2017-07-13 Vaccibody As Therapeutic anticancer neoepitope vaccine
GB201605210D0 (en) 2016-03-29 2016-05-11 Oxford Immunotec Ltd Assay
KR20190033483A (ko) * 2016-06-03 2019-03-29 이투빅스 코포레이션 인간 파필로마바이러스 (hpv)-연관 질환의 치료를 위한 조성물 및 방법
CN106655327A (zh) * 2016-10-18 2017-05-10 云南中烟工业有限责任公司 一种压缩式充电装置
EP3929770B1 (en) * 2016-11-11 2023-03-22 Google LLC Methods, systems, and media for modifying the presentation of video content on a user device based on a consumption of the user device
AU2019231654B2 (en) * 2018-03-06 2025-12-11 Precigen, Inc. Human papillomavirus vaccines and uses of the same
KR102712588B1 (ko) * 2020-05-25 2024-10-02 (주)진매트릭스 사람 파필로마바이러스의 구조적으로 변형된 키메라 폴리펩타이드 및 그 폴리펩타이드를 포함하는 재조합 단백질 및 그 단백질의 용도
WO2021241928A1 (ko) * 2020-05-25 2021-12-02 (주)진매트릭스 사람 파필로마바이러스의 구조적으로 변형된 키메라 폴리펩타이드 및 그 폴리펩타이드를 포함하는 재조합 단백질, 그 단백질의 용도

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Publication number Priority date Publication date Assignee Title
GB9717953D0 (en) * 1997-08-22 1997-10-29 Smithkline Beecham Biolog Vaccine
JP2002516096A (ja) * 1998-05-26 2002-06-04 インスティチュート オブ モレキュラー アンド セル バイオロジー 転写調節に使用するための、CREB結合タンパク質および関連するp300由来のポリペプチド
CN1720060B (zh) 2002-10-03 2011-12-14 惠氏控股公司 人乳头瘤病毒多肽和免疫原性组合物
TW200844231A (en) 2007-05-15 2008-11-16 Transgene Sa Vectors for multiple gene expression
WO2010129339A2 (en) * 2009-04-28 2010-11-11 The Johns Hopkins University Compositions and methods for enhancing antigen-specific immune responses
CN102002105B (zh) * 2009-09-03 2013-01-23 中国疾病预防控制中心病毒病预防控制所 Hpv 16型e7e6融合蛋白基因、表达载体、方法、细胞和用途

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Publication number Publication date
EP2806889B1 (en) 2017-08-16
DK2806889T3 (da) 2017-11-20
EP3269387A1 (en) 2018-01-17
US20180237477A1 (en) 2018-08-23
JP6655051B2 (ja) 2020-02-26
CN110042110A (zh) 2019-07-23
US20150023996A1 (en) 2015-01-22
EP2806889A4 (en) 2016-04-20
KR102195196B1 (ko) 2020-12-28
CN104159607A (zh) 2014-11-19
ES2646590T3 (es) 2017-12-14
WO2013112549A1 (en) 2013-08-01
JP2018038405A (ja) 2018-03-15
JP2015506179A (ja) 2015-03-02
US20160376324A1 (en) 2016-12-29
JP6219849B2 (ja) 2017-10-25
US9969779B2 (en) 2018-05-15
KR20140131929A (ko) 2014-11-14
EP2806889A1 (en) 2014-12-03
IN2014DN06118A (enExample) 2015-08-14
EP3269387B1 (en) 2019-07-17
US9492526B2 (en) 2016-11-15

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