HK1203492A1 - 2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4]nonane- 6 -one compounds as voltage - gated sodium channels modulators - Google Patents

2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4]nonane- 6 -one compounds as voltage - gated sodium channels modulators Download PDF

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Publication number
HK1203492A1
HK1203492A1 HK15103930.0A HK15103930A HK1203492A1 HK 1203492 A1 HK1203492 A1 HK 1203492A1 HK 15103930 A HK15103930 A HK 15103930A HK 1203492 A1 HK1203492 A1 HK 1203492A1
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Hong Kong
Prior art keywords
voltage
spiro
diaza
nonane
pyridin
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HK15103930.0A
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English (en)
Chinese (zh)
Inventor
David R. Witty
David T. Macpherson
Gerard M. P. Giblin
Steven J. Stanway
Antonio K. K. VONG
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Convergence Pharmaceuticals Limited
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Publication of HK1203492A1 publication Critical patent/HK1203492A1/xx

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems

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  • Immunology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15103930.0A 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4]nonane- 6 -one compounds as voltage - gated sodium channels modulators HK1203492A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161579613P 2011-12-22 2011-12-22
GB201122113 2011-12-22
US201161579613P 2011-12-22
GBGB1122113.2A GB201122113D0 (en) 2011-12-22 2011-12-22 Novel compounds
PCT/GB2012/053234 WO2013093497A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4] nonane- 6 -one compounds as voltage - gated sodium channels modulators

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Publication Number Publication Date
HK1203492A1 true HK1203492A1 (en) 2015-10-30

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HK15103930.0A HK1203492A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4]nonane- 6 -one compounds as voltage - gated sodium channels modulators
HK15104075.3A HK1203501A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4]nonane- 6 -one compound as voltage-gated sodium channels modulator

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HK15104075.3A HK1203501A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4]nonane- 6 -one compound as voltage-gated sodium channels modulator

Country Status (18)

Country Link
US (3) US9376436B2 (en:Method)
EP (2) EP2794612B1 (en:Method)
JP (2) JP2015502395A (en:Method)
KR (1) KR20140113692A (en:Method)
CN (1) CN104271581B (en:Method)
AU (1) AU2012356386A1 (en:Method)
BR (1) BR112014014940A2 (en:Method)
CA (1) CA2858938C (en:Method)
EA (1) EA026500B1 (en:Method)
ES (1) ES2581327T3 (en:Method)
GB (1) GB201122113D0 (en:Method)
HK (2) HK1203492A1 (en:Method)
IL (1) IL233215A0 (en:Method)
IN (1) IN2014MN01469A (en:Method)
MX (1) MX2014007637A (en:Method)
SG (1) SG11201403356YA (en:Method)
WO (2) WO2013093497A1 (en:Method)
ZA (1) ZA201404269B (en:Method)

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GB201122113D0 (en) * 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) * 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
RU2650523C1 (ru) * 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии
SG11202002707VA (en) * 2017-10-10 2020-04-29 Biogen Inc Process for preparing spiro derivatives
AU2018367909B2 (en) 2017-11-17 2022-03-10 Cellix Bio Private Limited Compositions and methods for the treatment of eye disorders
CN113563258A (zh) * 2021-07-29 2021-10-29 派普医药(江苏)有限公司 一种4-溴-2-(二氟甲基)-5-甲基吡啶的制备方法
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors
US20230150972A1 (en) * 2021-09-24 2023-05-18 Xenon Pharmaceuticals Inc. Pyridinyl derivatives as sodium channel activators

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Also Published As

Publication number Publication date
EP2794612A1 (en) 2014-10-29
GB201122113D0 (en) 2012-02-01
CA2858938C (en) 2020-03-10
US20140350040A1 (en) 2014-11-27
KR20140113692A (ko) 2014-09-24
US20150225400A1 (en) 2015-08-13
EP2794612B1 (en) 2016-04-06
EP2797922A1 (en) 2014-11-05
US20160185758A1 (en) 2016-06-30
ZA201404269B (en) 2016-06-29
US9303032B2 (en) 2016-04-05
IN2014MN01469A (en:Method) 2015-04-17
WO2013093497A1 (en) 2013-06-27
IL233215A0 (en) 2014-08-31
JP2015502395A (ja) 2015-01-22
MX2014007637A (es) 2014-09-26
EP2797922B1 (en) 2016-04-06
ES2581327T3 (es) 2016-09-05
EA026500B1 (ru) 2017-04-28
CA2858938A1 (en) 2013-06-27
CN104271581B (zh) 2016-08-31
AU2012356386A1 (en) 2014-07-10
JP2015502394A (ja) 2015-01-22
BR112014014940A2 (pt) 2017-06-13
WO2013093496A1 (en) 2013-06-27
SG11201403356YA (en) 2014-07-30
EA201491251A1 (ru) 2014-11-28
CN104271581A (zh) 2015-01-07
US9376436B2 (en) 2016-06-28
HK1203501A1 (en) 2015-10-30

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