EA026500B1 - Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-он в качестве модулятора потенциал-зависимых натриевых каналов - Google Patents

Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-он в качестве модулятора потенциал-зависимых натриевых каналов Download PDF

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EA026500B1
EA026500B1 EA201491251A EA201491251A EA026500B1 EA 026500 B1 EA026500 B1 EA 026500B1 EA 201491251 A EA201491251 A EA 201491251A EA 201491251 A EA201491251 A EA 201491251A EA 026500 B1 EA026500 B1 EA 026500B1
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compound
formula
disorder
compounds
methyl
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EA201491251A
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Russian (ru)
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EA201491251A1 (ru
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Дэвид Р. Витти
Дэвид Т. Макферсон
Джерард М.П. Гиблин
Стивен Дж. Стэнвэй
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Конвердженс Фармасьютикалз Лимитед
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Publication of EA026500B1 publication Critical patent/EA026500B1/ru

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    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems

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EA201491251A 2011-12-22 2012-12-21 Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-он в качестве модулятора потенциал-зависимых натриевых каналов EA026500B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579613P 2011-12-22 2011-12-22
GBGB1122113.2A GB201122113D0 (en) 2011-12-22 2011-12-22 Novel compounds
PCT/GB2012/053233 WO2013093496A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4] nonane- 6 -one compound as voltage-gated sodium channels modulator

Publications (2)

Publication Number Publication Date
EA201491251A1 EA201491251A1 (ru) 2014-11-28
EA026500B1 true EA026500B1 (ru) 2017-04-28

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EA201491251A EA026500B1 (ru) 2011-12-22 2012-12-21 Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-он в качестве модулятора потенциал-зависимых натриевых каналов

Country Status (18)

Country Link
US (3) US9376436B2 (en:Method)
EP (2) EP2797922B1 (en:Method)
JP (2) JP2015502394A (en:Method)
KR (1) KR20140113692A (en:Method)
CN (1) CN104271581B (en:Method)
AU (1) AU2012356386A1 (en:Method)
BR (1) BR112014014940A2 (en:Method)
CA (1) CA2858938C (en:Method)
EA (1) EA026500B1 (en:Method)
ES (1) ES2581327T3 (en:Method)
GB (1) GB201122113D0 (en:Method)
HK (2) HK1203501A1 (en:Method)
IL (1) IL233215A0 (en:Method)
IN (1) IN2014MN01469A (en:Method)
MX (1) MX2014007637A (en:Method)
SG (1) SG11201403356YA (en:Method)
WO (2) WO2013093496A1 (en:Method)
ZA (1) ZA201404269B (en:Method)

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RU2650523C1 (ru) * 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии

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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
MA50371A (fr) * 2017-10-10 2021-03-31 Biogen Inc Procédé de préparation de dérivés spiro
JP7006990B2 (ja) 2017-11-17 2022-02-10 セリックス バイオ プライヴェート リミテッド 眼障害の処置のための組成物及び方法
CN113563258A (zh) * 2021-07-29 2021-10-29 派普医药(江苏)有限公司 一种4-溴-2-(二氟甲基)-5-甲基吡啶的制备方法
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors
TW202322794A (zh) * 2021-09-24 2023-06-16 加拿大商再諾製藥公司 做為鈉通道活化劑之吡啶基衍生物

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WO2007042240A1 (en) * 2005-10-10 2007-04-19 Glaxo Group Limited Quaternary alpha-aminocarboxamide derivatives as modulators of voltage-gated sodium channels
WO2008090115A1 (en) * 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising nk1 receptor antagonists and sodium channel blockers

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2650523C1 (ru) * 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии
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Also Published As

Publication number Publication date
CA2858938A1 (en) 2013-06-27
ES2581327T3 (es) 2016-09-05
CN104271581B (zh) 2016-08-31
US9303032B2 (en) 2016-04-05
US20160185758A1 (en) 2016-06-30
EP2794612A1 (en) 2014-10-29
IL233215A0 (en) 2014-08-31
US20140350040A1 (en) 2014-11-27
EP2794612B1 (en) 2016-04-06
HK1203501A1 (en) 2015-10-30
WO2013093497A1 (en) 2013-06-27
IN2014MN01469A (en:Method) 2015-04-17
US20150225400A1 (en) 2015-08-13
EP2797922B1 (en) 2016-04-06
CN104271581A (zh) 2015-01-07
EA201491251A1 (ru) 2014-11-28
GB201122113D0 (en) 2012-02-01
ZA201404269B (en) 2016-06-29
HK1203492A1 (en) 2015-10-30
WO2013093496A1 (en) 2013-06-27
CA2858938C (en) 2020-03-10
MX2014007637A (es) 2014-09-26
KR20140113692A (ko) 2014-09-24
AU2012356386A1 (en) 2014-07-10
JP2015502394A (ja) 2015-01-22
SG11201403356YA (en) 2014-07-30
BR112014014940A2 (pt) 2017-06-13
JP2015502395A (ja) 2015-01-22
EP2797922A1 (en) 2014-11-05
US9376436B2 (en) 2016-06-28

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