WO2012138255A3 - Трициклические производные ν,ν' -замещенных 3,7-диазабицикло[3.3.1]нонанов и лекарственные средства на их основе - Google Patents

Трициклические производные ν,ν' -замещенных 3,7-диазабицикло[3.3.1]нонанов и лекарственные средства на их основе Download PDF

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Publication number
WO2012138255A3
WO2012138255A3 PCT/RU2012/000239 RU2012000239W WO2012138255A3 WO 2012138255 A3 WO2012138255 A3 WO 2012138255A3 RU 2012000239 W RU2012000239 W RU 2012000239W WO 2012138255 A3 WO2012138255 A3 WO 2012138255A3
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WIPO (PCT)
Prior art keywords
nonanes
diazabicyclo
substituted
drugs based
tricyclic derivatives
Prior art date
Application number
PCT/RU2012/000239
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English (en)
French (fr)
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WO2012138255A2 (ru
Inventor
Максим Эдуардович ЗАПОЛЬСКИЙ
Николай Серафимович Зефиров
Владимир Александрович ПАЛЮЛИН
Мстислав Игоревич ЛАВРОВ
Original Assignee
Zapolsky Maxim Eduardovich
Zefirov Nikolai Serafimovich
Palyulin Vladimir Alexandrovich
Lavrov Mstislav Igorevich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zapolsky Maxim Eduardovich, Zefirov Nikolai Serafimovich, Palyulin Vladimir Alexandrovich, Lavrov Mstislav Igorevich filed Critical Zapolsky Maxim Eduardovich
Priority to US14/110,432 priority Critical patent/US9440985B2/en
Priority to EA201301135A priority patent/EA024758B1/ru
Priority to EP12768097.3A priority patent/EP2695883B1/en
Publication of WO2012138255A2 publication Critical patent/WO2012138255A2/ru
Publication of WO2012138255A3 publication Critical patent/WO2012138255A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к новым производным 3,6,9-триазатрицикло[7.3.1.1]тетрадекан-4,8,12- трионам общей формулы (1), являющимся аллостерическими модуляторами АМРА рецепторов, и к лекарственным средствам на их основе, которые могут быть использованы для лечения болезни Альцгеймера, болезни Паркинсона и других нейродегенеративных патологий.
PCT/RU2012/000239 2011-04-06 2012-04-02 Трициклические производные ν,ν'-замещенных 3,7-диазабицикло[3.3.1]нонанов, обладающие фармакологической активностью, и лекарственные средства на их основе WO2012138255A2 (ru)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/110,432 US9440985B2 (en) 2011-04-06 2012-04-02 Tricyclic derivatives of N,N′-substituted 3,7-diazabicyclo [3.3.1]nonanes and drugs based thereon
EA201301135A EA024758B1 (ru) 2011-04-06 2012-04-02 Трициклические производные n,n'-замещенных 3,7-диазабицикло[3.3.1]нонанов и лекарственные средства на их основе
EP12768097.3A EP2695883B1 (en) 2011-04-06 2012-04-02 Tricyclic derivatives of n,n'-substituted 3,7-diazabicyclo [3.3.1]nonanes and drugs based thereon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011113043 2011-04-06
RU2011113043/04A RU2480470C2 (ru) 2011-04-06 2011-04-06 Трициклические производные n,n'-замещенных 3,7-диазабицикло[3.3.1]нонанов, обладающие фармакологической активностью, и лекарственные средства на их основе

Publications (2)

Publication Number Publication Date
WO2012138255A2 WO2012138255A2 (ru) 2012-10-11
WO2012138255A3 true WO2012138255A3 (ru) 2013-01-10

Family

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Family Applications (1)

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PCT/RU2012/000239 WO2012138255A2 (ru) 2011-04-06 2012-04-02 Трициклические производные ν,ν'-замещенных 3,7-диазабицикло[3.3.1]нонанов, обладающие фармакологической активностью, и лекарственные средства на их основе

Country Status (5)

Country Link
US (1) US9440985B2 (ru)
EP (1) EP2695883B1 (ru)
EA (1) EA024758B1 (ru)
RU (1) RU2480470C2 (ru)
WO (1) WO2012138255A2 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2726313C1 (ru) * 2019-07-30 2020-07-13 Общество с ограниченной ответственностью "Кью Эм Фарма" Применение производных N,N"-замещенных 3,7-диазабицикло[3.3.1]нонанов для терапии депрессии
RU2700595C1 (ru) * 2019-07-30 2019-09-18 Общество с ограниченной ответственностью "Кью Эм Фарма" Производное 3,6,9-триазатрициклотетрадекана и его применение для лечения депрессии
RU2725632C1 (ru) * 2019-08-26 2020-07-03 федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се Фармацевтическая композиция в форме капсул, обладающая ноотропным действием

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011006653A1 (en) * 2009-07-14 2011-01-20 Ac Immune S.A. An agent for restoring lost memory on the basis of n,n'-substituted 3,7-diazabicyclo[3.3.1] nonanes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096911A1 (en) * 2001-06-01 2002-12-05 Neurosearch A/S Novel heteroaryl-diazabicyclo-alkanes as cns-modulators
RU2333211C1 (ru) * 2006-11-01 2008-09-10 Институт физиологически активных веществ Российской Академии наук N,n`-замещенные 3, 7-диазабицикло[3.3.1]нонаны, обладающие фармакологической активностью, фармацевтические композиции на их основе и способ их применения

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011006653A1 (en) * 2009-07-14 2011-01-20 Ac Immune S.A. An agent for restoring lost memory on the basis of n,n'-substituted 3,7-diazabicyclo[3.3.1] nonanes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2695883A4 *

Also Published As

Publication number Publication date
EP2695883A4 (en) 2014-08-27
RU2011113043A (ru) 2012-10-27
US9440985B2 (en) 2016-09-13
EA201301135A1 (ru) 2014-02-28
EA024758B1 (ru) 2016-10-31
US20150274743A1 (en) 2015-10-01
WO2012138255A2 (ru) 2012-10-11
EP2695883A2 (en) 2014-02-12
RU2480470C2 (ru) 2013-04-27
EP2695883B1 (en) 2016-03-23

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