HK1202921A1 - Method for the detection of a binding partner of a multispecific binder - Google Patents

Method for the detection of a binding partner of a multispecific binder

Info

Publication number
HK1202921A1
HK1202921A1 HK15103324.4A HK15103324A HK1202921A1 HK 1202921 A1 HK1202921 A1 HK 1202921A1 HK 15103324 A HK15103324 A HK 15103324A HK 1202921 A1 HK1202921 A1 HK 1202921A1
Authority
HK
Hong Kong
Prior art keywords
detection
binding partner
multispecific binder
multispecific
binder
Prior art date
Application number
HK15103324.4A
Other languages
English (en)
Chinese (zh)
Inventor
Kay-Gunnar Stubenrauch
Uwe Wessels
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1202921A1 publication Critical patent/HK1202921A1/xx

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
HK15103324.4A 2012-02-01 2015-04-01 Method for the detection of a binding partner of a multispecific binder HK1202921A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12153457 2012-02-01
EP12182505 2012-08-31
PCT/EP2013/051604 WO2013113663A1 (en) 2012-02-01 2013-01-29 Method for the detection of a binding partner of a multispecific binder

Publications (1)

Publication Number Publication Date
HK1202921A1 true HK1202921A1 (en) 2015-10-09

Family

ID=47624068

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103324.4A HK1202921A1 (en) 2012-02-01 2015-04-01 Method for the detection of a binding partner of a multispecific binder

Country Status (11)

Country Link
US (3) US9945869B2 (ja)
EP (1) EP2810074B1 (ja)
JP (3) JP2015507193A (ja)
KR (1) KR20140128314A (ja)
CN (2) CN106443016B (ja)
BR (1) BR112014017630A8 (ja)
CA (1) CA2859268A1 (ja)
HK (1) HK1202921A1 (ja)
MX (1) MX349661B (ja)
RU (1) RU2620563C2 (ja)
WO (1) WO2013113663A1 (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013113663A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
WO2014009474A1 (en) 2012-07-13 2014-01-16 F. Hoffmann-La Roche Ag Method for the detection of a multispecific binder
CN105683755B (zh) * 2013-11-05 2019-08-13 豪夫迈·罗氏有限公司 陷阱分子和检测分子的用途及其相关试剂盒和组合物
CN104109197B (zh) * 2013-11-13 2017-05-10 叶森 一种双识别抗体片段的制备方法及其应用
WO2017055399A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Cellular based fret assay for the determination of simultaneous binding
JP6622392B2 (ja) 2015-10-02 2019-12-18 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Pd1とtim3に特異的な二重特異性抗体
RS63663B1 (sr) 2017-04-03 2022-11-30 Hoffmann La Roche Imunokonjugati anti-pd-1 antitela sa mutantom il-2 ili sa il-15
CA3052532A1 (en) 2017-04-05 2018-10-11 F. Hoffmann-La Roche Ag Bispecific antibodies specifically binding to pd1 and lag3
WO2019235420A1 (ja) 2018-06-04 2019-12-12 中外製薬株式会社 複合体を検出する方法
EP3969907A1 (en) * 2019-05-13 2022-03-23 F. Hoffmann-La Roche AG Interference-suppressed pharmacokinetic immunoassay
WO2022065052A1 (ja) * 2020-09-24 2022-03-31 株式会社Jvcケンウッド 捕捉用抗体、固相担体、検出用抗体、固相担体粒子、並びに検出対象物質の測定キット及び測定方法
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源(北京)药物研究有限责任公司 检测游离vegf的方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219730A (en) 1982-09-28 1993-06-15 New York University Idiotype-anti-idiotype immunoassay
US4828981A (en) 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
EP0170302A1 (fr) 1984-06-27 1986-02-05 l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
EP0243471A4 (en) 1985-10-22 1989-07-11 Cooper Lipotech Inc SOLID PHASE LIPOSOME IMMUNOANALYSIS SYSTEM.
JP2992974B2 (ja) 1988-11-03 1999-12-20 イゲン,インコーポレーテッド 電気化学ルミネセンス検定
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
IL100866A (en) 1991-02-06 1995-10-31 Igen Inc Luminescence test method and device based on magnetic tiny particles, containing many magnets
EP0651761B1 (en) 1992-07-13 2002-10-09 Bionebraska, Inc. Method for modification of recombinant polypeptides
JPH097096A (ja) 1995-06-20 1997-01-10 Alpine Electron Inc 緊急車両接近時の報知方法
JPH0975096A (ja) * 1995-09-14 1997-03-25 Snow Brand Milk Prod Co Ltd ラクトフェリンの測定法
CA2309599C (en) * 1997-11-21 2009-03-17 Unilever Plc Improvements in or relating to displacement assays
JPH11352129A (ja) * 1998-06-04 1999-12-24 Mizuho Medeii:Kk 検出装置及び検出方法
US6753189B1 (en) 1998-06-04 2004-06-22 Mizuho Medy Co., Ltd. Detection apparatus and method for the same
AU774575C (en) * 1999-11-16 2005-09-08 Genentech Inc. Elisa for VEGF
GB0007088D0 (en) * 2000-03-23 2000-05-17 Torsana A S Detection of immunological memory determining the position of loci of pathologyand therapeutic t-cell conjugates
US6984494B2 (en) 2000-08-15 2006-01-10 Genentech, Inc. Analytical method
US7341837B2 (en) 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
WO2006096697A2 (en) * 2005-03-08 2006-09-14 Tanox, Inc. Methods for determining the bivalency of protein and antibody therapeutics
US7494776B2 (en) * 2005-07-07 2009-02-24 Beckman Coulter, Inc. Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands
NZ589687A (en) 2005-07-21 2012-09-28 Genmab As Potency assays for antibody drug substance binding to an FC receptor
ZA200801154B (en) * 2005-07-21 2009-07-29 Genmab As Potency assays for antibody drug substance binding to an FC receptor
KR101551984B1 (ko) * 2006-10-04 2015-09-09 제넨테크, 인크. Vegf용 elisa
EP1917854A1 (en) 2006-11-06 2008-05-07 F. Hoffmann-La Roche Ag Method for producing anti idiotypic antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
EP2297209A4 (en) * 2008-06-03 2012-08-01 Abbott Lab IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
JP5634405B2 (ja) * 2008-10-07 2014-12-03 ユィロス・パテント・アクチボラグGyros Patent AB 試料中のアナライトの検出のための半逐次アッセイ
SG175004A1 (en) 2009-04-02 2011-11-28 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
WO2010115589A1 (en) 2009-04-07 2010-10-14 Roche Glycart Ag Trivalent, bispecific antibodies
PE20120540A1 (es) 2009-05-27 2012-05-09 Hoffmann La Roche Anticuerpos triespecificos o tetraespecificos
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
SG2014014823A (en) * 2009-10-19 2014-07-30 Hoffmann La Roche Non-cross-reactive anti igg antibodies
CN102207504A (zh) * 2011-03-23 2011-10-05 北京华创远航科技有限公司 一种酶联检测试剂盒及其制备方法
BR112014011535A2 (pt) 2011-12-19 2017-05-09 Hoffmann La Roche método para a determinação in vitro e imunológica de presença da presença e/ou da quantidade de um parceiro de ligação, método in vitro e utilização de um anticorpo
WO2013113663A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
US20130231462A1 (en) * 2012-02-27 2013-09-05 Bio-Rad Laboratories, Inc. Anti-immune complex antibodies
WO2014009474A1 (en) 2012-07-13 2014-01-16 F. Hoffmann-La Roche Ag Method for the detection of a multispecific binder

Also Published As

Publication number Publication date
CN104105966A (zh) 2014-10-15
US20140342382A1 (en) 2014-11-20
EP2810074A1 (en) 2014-12-10
MX349661B (es) 2017-08-08
US9945869B2 (en) 2018-04-17
CN106443016A (zh) 2017-02-22
CA2859268A1 (en) 2013-08-08
JP6678792B2 (ja) 2020-04-08
CN104105966B (zh) 2016-10-26
RU2014133701A (ru) 2016-03-27
BR112014017630A2 (ja) 2017-06-20
JP2015507193A (ja) 2015-03-05
BR112014017630A8 (pt) 2017-07-11
US20210055304A1 (en) 2021-02-25
CN106443016B (zh) 2019-08-13
JP2017223710A (ja) 2017-12-21
WO2013113663A1 (en) 2013-08-08
MX2014008762A (es) 2014-08-27
EP2810074B1 (en) 2017-08-23
JP6502441B2 (ja) 2019-04-17
US10761097B2 (en) 2020-09-01
US20180328942A1 (en) 2018-11-15
KR20140128314A (ko) 2014-11-05
JP2019113564A (ja) 2019-07-11
RU2620563C2 (ru) 2017-05-26

Similar Documents

Publication Publication Date Title
HK1202921A1 (en) Method for the detection of a binding partner of a multispecific binder
HK1203517A1 (en) Multispecific antibodies
HK1201920A1 (zh) 用於檢測多特異性結合物的游離結合搭檔的方法
ZA201501833B (en) Method for obtaining 1-kestone
GB201202492D0 (en) Search method
GB201212937D0 (en) Method
HK1208731A1 (en) Method for the detection of a multispecific binder
GB201212932D0 (en) Method
GB201213636D0 (en) Method
GB201222693D0 (en) Novel method
GB201212934D0 (en) Method
GB201210858D0 (en) Method
PL2928936T3 (pl) Spoiwo
EP2709853A4 (en) BINDER
EP2529947A4 (en) BINDER
EP2880048A4 (en) METHOD
EP2868485A4 (en) BINDER
GB201202198D0 (en) Method
GB201418808D0 (en) Search method
GB201211393D0 (en) Method
GB201222737D0 (en) Method
GB201217688D0 (en) Method
GB201214029D0 (en) method
GB201210147D0 (en) Method
EP2798353A4 (en) BINDING DETECTION METHOD