HK1202563A1 - Sequence symmetric modified igg4 bispecific antibodies igg4 - Google Patents
Sequence symmetric modified igg4 bispecific antibodies igg4Info
- Publication number
- HK1202563A1 HK1202563A1 HK15103109.5A HK15103109A HK1202563A1 HK 1202563 A1 HK1202563 A1 HK 1202563A1 HK 15103109 A HK15103109 A HK 15103109A HK 1202563 A1 HK1202563 A1 HK 1202563A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- igg4
- bispecific antibodies
- symmetric modified
- sequence symmetric
- sequence
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1203051.6A GB201203051D0 (en) | 2012-02-22 | 2012-02-22 | Biological products |
PCT/EP2013/053614 WO2013124450A1 (en) | 2012-02-22 | 2013-02-22 | Sequence symmetric modified igg4 bispecific antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1202563A1 true HK1202563A1 (en) | 2015-10-02 |
Family
ID=45940018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15103109.5A HK1202563A1 (en) | 2012-02-22 | 2015-03-27 | Sequence symmetric modified igg4 bispecific antibodies igg4 |
Country Status (16)
Country | Link |
---|---|
US (2) | US10221251B2 (xx) |
EP (2) | EP2817332B1 (xx) |
JP (2) | JP6308952B2 (xx) |
KR (2) | KR102077331B1 (xx) |
CN (2) | CN104321341B (xx) |
AU (2) | AU2013224003B2 (xx) |
CA (1) | CA2864439C (xx) |
DK (2) | DK3156416T3 (xx) |
EA (1) | EA035050B1 (xx) |
ES (2) | ES2768780T3 (xx) |
GB (1) | GB201203051D0 (xx) |
HK (1) | HK1202563A1 (xx) |
IL (1) | IL234102B (xx) |
MX (1) | MX356288B (xx) |
SG (1) | SG11201404789XA (xx) |
WO (1) | WO2013124450A1 (xx) |
Families Citing this family (55)
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JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
KR102467302B1 (ko) | 2007-09-26 | 2022-11-14 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
EP2543730B1 (en) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
US9334331B2 (en) | 2010-11-17 | 2016-05-10 | Chugai Seiyaku Kabushiki Kaisha | Bispecific antibodies |
CA2853230C (en) | 2011-10-31 | 2021-11-23 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
GB201203071D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
GB201203051D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
KR101895634B1 (ko) | 2013-05-31 | 2018-09-05 | 한미약품 주식회사 | 변이된 힌지 영역을 포함하는 IgG4 Fc 단편 |
RU2758952C1 (ru) | 2013-09-27 | 2021-11-03 | Чугаи Сейяку Кабусики Кайся | Способ получения полипептидного гетеромультимера |
EP2944962A1 (en) * | 2014-05-14 | 2015-11-18 | UCB Biopharma SPRL | Method for determining antibody specificity |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
TWI691512B (zh) * | 2015-02-20 | 2020-04-21 | 日商橘生藥品工業股份有限公司 | Fc融合高親和性IgE受體α鏈 |
JP7082484B2 (ja) * | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
KR20180050321A (ko) | 2015-08-07 | 2018-05-14 | 이미지냅 인코포레이티드 | 분자를 표적화하기 위한 항원 결합 구조체 |
KR20180091918A (ko) | 2015-12-28 | 2018-08-16 | 추가이 세이야쿠 가부시키가이샤 | Fc 영역 함유 폴리펩타이드의 정제를 효율화하기 위한 방법 |
MX2018010988A (es) | 2016-03-14 | 2019-01-21 | Chugai Pharmaceutical Co Ltd | Farmaco terapeutico que induce lesion celular para usarse en terapia de cancer. |
CA3016563A1 (en) | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
EP3523329A1 (en) * | 2016-10-06 | 2019-08-14 | GlaxoSmithKline Intellectual Property Development Limited | Antibodies with reduced binding to process impurities |
WO2018081448A1 (en) | 2016-10-26 | 2018-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
CN118047864A (zh) | 2016-12-23 | 2024-05-17 | 百时美施贵宝公司 | 用于改进生物分析和生物加工特性的治疗性免疫球蛋白g4的设计 |
WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
CN110621697B (zh) | 2017-05-25 | 2023-06-27 | 百时美施贵宝公司 | 拮抗性cd40单克隆抗体及其用途 |
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EP3641802A1 (en) | 2017-06-22 | 2020-04-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of fibrosis with agents capable of inhibiting the activation of mucosal-associated invariant t (mait) cells |
US11372001B2 (en) | 2017-07-06 | 2022-06-28 | Nitto Boseki Co., Ltd. | Anti-human IgG4 monoclonal antibody and methods of making and using same |
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WO2019088143A1 (ja) * | 2017-11-01 | 2019-05-09 | 中外製薬株式会社 | 生物活性が低下した抗体バリアントおよびアイソフォーム |
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EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
KR20210005169A (ko) | 2018-04-25 | 2021-01-13 | 프로메테우스 바이오사이언시즈, 인크. | 최적화된 항tl1a 항체 |
DE202019005887U1 (de) | 2018-07-03 | 2023-06-14 | Marengo Therapeutics, Inc. | Anti-TCR-Antikörpermoleküle und Verwendungen davon |
AR117091A1 (es) | 2018-11-19 | 2021-07-07 | Bristol Myers Squibb Co | Anticuerpos monoclonales antagonistas contra cd40 y sus usos |
JP2022517324A (ja) | 2019-01-03 | 2022-03-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 癌を患っている被験者における、cd8陽性t細胞依存性免疫応答を増強させるための方法及び医薬組成物 |
SG11202109061YA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
SG11202109122SA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Anti-tcr antibody molecules and uses thereof |
JP2022521750A (ja) | 2019-02-21 | 2022-04-12 | マレンゴ・セラピューティクス,インコーポレーテッド | カルレティキュリンに結合する多機能性分子およびその使用 |
GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
JP2022522662A (ja) | 2019-02-21 | 2022-04-20 | マレンゴ・セラピューティクス,インコーポレーテッド | T細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用 |
EP3999540A1 (en) | 2019-07-16 | 2022-05-25 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Antibodies having specificity for cd38 and uses thereof |
CN113416258B (zh) * | 2019-10-24 | 2023-08-29 | 北京免疫方舟医药科技有限公司 | 一种多特异性抗体及其制备方法和用途 |
MX2022004942A (es) | 2019-10-24 | 2022-07-27 | Prometheus Biosciences Inc | Anticuerpos humanizados contra el ligando 1a de tipo tnf (tl1a) y usos de los mismos. |
EP4084821A4 (en) | 2020-01-03 | 2024-04-24 | Marengo Therapeutics Inc | CD33-BINDING MULTIFUNCTIONAL MOLECULES AND THEIR USES |
WO2021198880A1 (en) * | 2020-03-31 | 2021-10-07 | Medimmune, Llc | Stabilized igg4 antibodies and uses thereof |
CA3180321A1 (en) | 2020-04-24 | 2021-10-28 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
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KR20230074144A (ko) | 2020-08-26 | 2023-05-26 | 마렝고 테라퓨틱스, 인크. | NKp30에 결합하는 항체 분자 및 이의 용도 |
JP2023542080A (ja) | 2020-08-26 | 2023-10-05 | マレンゴ・セラピューティクス,インコーポレーテッド | カルレティキュリンに結合する多機能性分子およびその使用 |
CN116761824A (zh) * | 2021-01-18 | 2023-09-15 | 上海药明合联生物技术有限公司 | 工程化抗-trop2抗体及其抗体-药物偶联物 |
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-
2012
- 2012-02-22 GB GBGB1203051.6A patent/GB201203051D0/en not_active Ceased
-
2013
- 2013-02-22 EP EP13705504.2A patent/EP2817332B1/en active Active
- 2013-02-22 AU AU2013224003A patent/AU2013224003B2/en active Active
- 2013-02-22 EA EA201491569A patent/EA035050B1/ru not_active IP Right Cessation
- 2013-02-22 CN CN201380016707.5A patent/CN104321341B/zh active Active
- 2013-02-22 KR KR1020147026256A patent/KR102077331B1/ko active IP Right Grant
- 2013-02-22 SG SG11201404789XA patent/SG11201404789XA/en unknown
- 2013-02-22 DK DK16180209.5T patent/DK3156416T3/da active
- 2013-02-22 EP EP16180209.5A patent/EP3156416B1/en active Active
- 2013-02-22 CN CN201810388711.9A patent/CN108586615B/zh active Active
- 2013-02-22 KR KR1020207003552A patent/KR20200018706A/ko not_active IP Right Cessation
- 2013-02-22 JP JP2014558131A patent/JP6308952B2/ja active Active
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