HK1202238A1 - Transplantation of human neural cells for treatment of neurodegenerative conditions - Google Patents

Transplantation of human neural cells for treatment of neurodegenerative conditions Download PDF

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Publication number
HK1202238A1
HK1202238A1 HK15102713.5A HK15102713A HK1202238A1 HK 1202238 A1 HK1202238 A1 HK 1202238A1 HK 15102713 A HK15102713 A HK 15102713A HK 1202238 A1 HK1202238 A1 HK 1202238A1
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Hong Kong
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neural stem
neurons
stem cells
spinal cord
expanded population
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HK15102713.5A
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English (en)
Chinese (zh)
Inventor
．馬莎拉
M．马莎拉
．喬
K．K．乔
．黑茲爾
T．G．黑兹尔
垣花修
．科利亞索斯
V．科利亚索斯
閻軍
阎军
．賴爾
P．J．赖尔
．維拉多
M．J．维拉多
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神经干公司
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Publication of HK1202238A1 publication Critical patent/HK1202238A1/xx

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]

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  • Developmental Biology & Embryology (AREA)
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  • Wood Science & Technology (AREA)
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  • Ophthalmology & Optometry (AREA)
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HK15102713.5A 2004-11-17 2015-03-17 Transplantation of human neural cells for treatment of neurodegenerative conditions HK1202238A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62922004P 2004-11-17 2004-11-17
US62/629,220 2004-11-17

Publications (1)

Publication Number Publication Date
HK1202238A1 true HK1202238A1 (en) 2015-09-25

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HK15102713.5A HK1202238A1 (en) 2004-11-17 2015-03-17 Transplantation of human neural cells for treatment of neurodegenerative conditions

Country Status (13)

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US (6) US7691629B2 (cs)
EP (2) EP2913393B8 (cs)
JP (3) JP5424559B2 (cs)
KR (2) KR101505347B1 (cs)
CN (2) CN104042629A (cs)
ES (1) ES2537004T3 (cs)
HK (1) HK1202238A1 (cs)
IL (2) IL183092A (cs)
IN (1) IN2014CN03629A (cs)
NO (1) NO340914B1 (cs)
PH (1) PH12015501195B1 (cs)
RU (2) RU2434636C2 (cs)
WO (1) WO2006055685A2 (cs)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838292B1 (en) 2001-03-29 2010-11-23 University Of Louisville Research Foundation, Inc. Methods for obtaining adult human olfactory progenitor cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
ES2537004T3 (es) 2004-11-17 2015-06-01 Neuralstem, Inc. Trasplante de células neurales humanas para el tratamiento de afecciones neurodegenerativas
US20060216276A1 (en) 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
CA2747757C (en) * 2008-12-19 2020-11-03 Ethicon, Incorporated Umbilical cord tissue derived cells for treating neuropathic pain and spasticity
PL2379088T3 (pl) 2008-12-19 2018-07-31 DePuy Synthes Products, Inc. Leczenie płuca oraz chorób i zaburzeń płucnych
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
US10386360B2 (en) 2009-03-13 2019-08-20 University Of Central Florida Research Foundation, Inc. Bio-microelectromechanical system transducer and associated methods
BRPI1013409A2 (pt) 2009-03-26 2018-01-16 Advanced Tech And Regenerative Medicine Llc células de tecido de cordão umbilical humano como terapia para doença de alzheimer
US9163216B1 (en) 2009-04-23 2015-10-20 University Of Central Florida Research Foundation, Inc. Method for culturing skeletal muscle for tissue engineering
US8815584B1 (en) 2009-04-23 2014-08-26 University Of Central Florida Research Foundation, Inc. Method of co-culturing mammalian muscle cells and motoneurons
US8828721B1 (en) 2009-05-28 2014-09-09 University Of Central Florida Research Foundation, Inc. Method of myelinating isolated motoneurons
US9404140B1 (en) 2009-11-03 2016-08-02 The University Of Central Florida Research Foundation, Inc. Patterned cardiomyocyte culture on microelectrode array
US9489474B2 (en) 2010-02-05 2016-11-08 University Of Central Florida Research Foundation, Inc. Model and methods for identifying points of action in electrically active cells
EP2585171B1 (en) 2010-04-23 2018-12-26 University Of Central Florida Research Foundation, Inc. Formation of neuromuscular junctions in a defined system
CN103237553A (zh) * 2010-07-28 2013-08-07 神经干细胞公司 治疗和/或逆转神经退行性疾病和/或病症的方法
US9498554B2 (en) 2012-07-24 2016-11-22 S.C. Johnson & Son, Inc. Dispensing device
JP2015524674A (ja) 2012-08-17 2015-08-27 ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション，インコーポレイテッド 哺乳動物系の機能的なインビトロ細胞モデルについての方法、システム、および組成物
US10357517B1 (en) 2012-10-01 2019-07-23 University Of South Florida Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592
RU2515475C1 (ru) * 2012-11-15 2014-05-10 Федеральное государственное бюджетное учреждение науки ИНСТИТУТ ЦИТОЛОГИИ РОССИЙСКОЙ АКАДЕМИИ НАУК Способ стимуляции образования децидуальной оболочки эндометрия в эксперименте
US10694747B2 (en) 2012-11-21 2020-06-30 S. C. Johnson & Son, Inc. Dispenser comprising only one single hinge
CA2899445C (en) 2013-01-30 2023-04-04 University Of Central Florida Research Foundation, Inc. Devices and systems for mimicking heart function
WO2014138003A1 (en) * 2013-03-04 2014-09-12 Neuralstem, Inc. Compositions comprising an immunosuppressive drug and/or neural stem cells and methods of using same for the treatment of neurodegenerative diseases and/or disorders
JP6756610B2 (ja) 2013-04-26 2020-09-16 メモリアル スローン ケタリング キャンサー センター 多分化能細胞および多能性細胞の分化を方向付けることによって発生させる皮質介在ニューロンおよびその他のニューロン細胞
CN104278008B (zh) 2013-07-12 2020-08-21 北京宏冠再生医学科技有限公司 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途
KR101675123B1 (ko) * 2014-06-27 2016-11-14 연세대학교 산학협력단 Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물
JP6889107B2 (ja) * 2014-06-27 2021-06-18 アンジオクライン・バイオサイエンス・インコーポレイテッドＡｎｇｉｏｃｒｉｎｅ Ｂｉｏｓｃｉｅｎｃｅ， Ｉｎｃ． アデノウイルスｅ４ｏｒｆ１を発現する神経系細胞、並びに、その製造および使用方法
US10935541B2 (en) 2014-08-07 2021-03-02 University Of Central Florida Research Foundation, Inc. Devices and methods comprising neuromuscular junctions
CN107148275A (zh) 2014-10-20 2017-09-08 神经干细胞公司 包含编码生长因子的外源多核苷酸的稳定的神经干细胞及其使用方法
US10286009B2 (en) * 2015-05-16 2019-05-14 Asterias Biotherapeutics, Inc. Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury
US11028369B2 (en) 2015-08-13 2021-06-08 Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. Induced extended pluripotent stem cells, method of making and using
CN108934168B (zh) 2015-11-30 2022-05-03 北昊干细胞与再生医学研究院有限公司 用于将非多能细胞重编程为多能干细胞的改进方法
WO2017135753A1 (ko) * 2016-02-05 2017-08-10 경북대학교 산학협력단 혈관내피성장인자를 과발현한 줄기세포를 유효성분으로 포함하는 퇴행성 신경질환의 예방 또는 치료용 약학적 조성물
US11920155B2 (en) 2016-03-30 2024-03-05 Asterias Biotherapeutics, Inc. Oligodendrocyte progenitor cell compositions
FR3058892B1 (fr) * 2016-11-23 2021-04-09 Univ Bordeaux Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere
CN106619722A (zh) * 2016-12-05 2017-05-10 上海安集协康生物技术股份有限公司 一种治疗脑部损伤类疾病的神经干细胞注射液
JP6500051B2 (ja) * 2017-03-17 2019-04-10 哲丸 村田 組織処理方法
EP3630948A4 (en) 2017-05-31 2020-12-30 Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd. METHOD OF CHEMICALLY INDUCED CELL LINE REPROGRAMMING
WO2020061371A2 (en) 2018-09-19 2020-03-26 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
CA3127213A1 (en) 2019-01-23 2020-07-30 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
CN111494422B (zh) * 2019-01-29 2022-04-29 中国科学院遗传与发育生物学研究所 治疗脊髓损伤的产品及其应用
EP4082445A4 (en) * 2019-12-27 2024-07-17 Rainbow Inc. INTEGRATED SYSTEM FOR CELL-FREE INTRACRANIAL DELIVERY
CN115166260B (zh) * 2022-07-11 2023-06-13 东南大学 血浆脑细胞来源外泌体中维生素d结合蛋白在诊断抑郁症中的应用
CN118064356A (zh) 2022-11-22 2024-05-24 浙江霍德生物工程有限公司 前脑神经前体细胞在治疗与前脑神经细胞的死亡和/或功能不全相关的疾病中的应用
WO2025097051A1 (en) 2023-11-03 2025-05-08 Axent Biosciences Inc. Thermoreversible polymers with improved stability and methods and uses thereof

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0233838A3 (en) 1986-02-04 1990-01-31 Incyte Pharmaceuticals, Inc. Neurite-promoting factor and process for the manufacture thereof
US4753635A (en) 1986-05-23 1988-06-28 Jacqueline Sagen Inducing analgesia by implantation of cells releasing neuroactive substances
NZ226750A (en) 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
WO1990001541A1 (en) 1988-08-04 1990-02-22 Amrad Corporation Limited In vitro propagation of embryonic stem cells
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US4980174A (en) 1988-12-23 1990-12-25 Jacqueline Sagen Method for alleviating depression
WO1991002003A1 (en) 1989-08-04 1991-02-21 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
US5411883A (en) 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
WO1991009936A1 (en) 1989-12-26 1991-07-11 Hana Biologics, Inc. Proliferated neuron progenitor cell product and process
US5196315A (en) 1990-05-01 1993-03-23 The Johns Hopkins University Human neuronal cell line
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US6071889A (en) 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US5981165A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US6399369B1 (en) 1991-07-08 2002-06-04 Neurospheres Holdings Ltd. Multipotent neural stem cell cDNA libraries
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
US7361505B1 (en) 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
EP0594669B9 (en) 1991-07-08 2008-03-19 NeuroSpheres Holdings Ltd. Growth factor-responsive neural progenitor cells which can be proliferated in vitro.
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5750376A (en) 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US6497872B1 (en) 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
US5175103A (en) 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons
ATE178801T1 (de) 1991-11-22 1999-04-15 Genentech Inc Tgf-beta zur verbesserung der regeneration von neuronalem gewebe
US5672499A (en) 1992-07-27 1997-09-30 California Institute Of Technology Immoralized neural crest stem cells and methods of making
JPH08500245A (ja) 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
AU4995193A (en) 1992-08-04 1994-03-03 Regeneron Pharmaceuticals, Inc. Method of enhancing differentiation and survival of neuronal precursor cells
WO1994004675A2 (en) 1992-08-19 1994-03-03 Richard Kroczek Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family
DE69334344D1 (de) 1992-10-28 2010-11-18 Neurospheres Holding Ltd Biologische Faktoren und neuronale Stammzellen
EP0728194B1 (en) 1993-11-09 2003-01-08 Neurospheres Holdings Ltd. In situ modification and manipulation of stem cells of the central nervous system
AU714837B2 (en) 1994-09-23 2000-01-13 Neurospheres Holdings Ltd In vitro models of CNS function and dysfunction
WO1996015226A1 (en) 1994-11-14 1996-05-23 Neurospheres Holdings Ltd. Regulation of neural stem cell proliferation
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5735505A (en) * 1995-04-03 1998-04-07 Data Connections, Inc. Cable pulley device and method
US5753505A (en) 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US5770414A (en) 1996-02-20 1998-06-23 The Regents Of The University Of California Regulatable retrovirus system for genetic modification of cells
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
JP3467154B2 (ja) * 1996-10-14 2003-11-17 パロマ工業株式会社 吸収式空調機
AU7258098A (en) 1997-04-24 1998-11-13 California Institute Of Technology Methods for differentiating neural stem cells
CA2294737A1 (en) 1997-07-04 1999-01-14 University Of Utah Research Foundation Neuron-restricted precursor cells
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US5932473A (en) * 1997-09-30 1999-08-03 Becton Dickinson And Company Preparation of a cell culture substrate coated with poly-D-lysine
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
WO2000017323A1 (en) * 1998-09-22 2000-03-30 Neuralstem Biopharmaceuticals, Ltd. Stable neural stem cell lines
US6284539B1 (en) 1998-10-09 2001-09-04 Neuralstem Biopharmaceuticals, Ltd. Method for generating dopaminergic cells derived from neural precursors
US6531464B1 (en) 1999-12-07 2003-03-11 Inotek Pharmaceutical Corporation Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives
HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
US6696039B2 (en) 2001-04-23 2004-02-24 Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
WO2003000852A2 (en) 2001-06-22 2003-01-03 The University Of Texas System Method of producing region-specific neurons from human neuronal stem cells
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
WO2003046141A2 (en) * 2001-11-26 2003-06-05 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
WO2004072264A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Fate determination by hes 1 in hematopoietic stem-progenitor cells and uses thereof
ES2537004T3 (es) * 2004-11-17 2015-06-01 Neuralstem, Inc. Trasplante de células neurales humanas para el tratamiento de afecciones neurodegenerativas
WO2008002250A1 (en) 2006-06-30 2008-01-03 Elena Kozlova Improved stem cells for transplantation and methods for production thereof
CN103237553A (zh) * 2010-07-28 2013-08-07 神经干细胞公司 治疗和/或逆转神经退行性疾病和/或病症的方法

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