HK1199639A1 - Aryl urea derivatives as n-formyl peptide receptor like-1 (fprl-1) receptor modulators n--1 (fprl-1) - Google Patents

Aryl urea derivatives as n-formyl peptide receptor like-1 (fprl-1) receptor modulators n--1 (fprl-1)

Info

Publication number
HK1199639A1
HK1199639A1 HK15100088.6A HK15100088A HK1199639A1 HK 1199639 A1 HK1199639 A1 HK 1199639A1 HK 15100088 A HK15100088 A HK 15100088A HK 1199639 A1 HK1199639 A1 HK 1199639A1
Authority
HK
Hong Kong
Prior art keywords
fprl
receptor
urea derivatives
formyl peptide
aryl urea
Prior art date
Application number
HK15100088.6A
Other languages
English (en)
Chinese (zh)
Inventor
Richard L Beard
Tien T Duong
John E Donello
Veena Viswanath
Michael E Garst
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of HK1199639A1 publication Critical patent/HK1199639A1/xx

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
HK15100088.6A 2011-11-10 2015-01-06 Aryl urea derivatives as n-formyl peptide receptor like-1 (fprl-1) receptor modulators n--1 (fprl-1) HK1199639A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161558121P 2011-11-10 2011-11-10
PCT/US2012/063702 WO2013070600A1 (en) 2011-11-10 2012-11-06 Aryl urea derivatives as n-formyl peptide receptor like-1 (fprl-1) receptor modulators

Publications (1)

Publication Number Publication Date
HK1199639A1 true HK1199639A1 (en) 2015-07-10

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HK15100088.6A HK1199639A1 (en) 2011-11-10 2015-01-06 Aryl urea derivatives as n-formyl peptide receptor like-1 (fprl-1) receptor modulators n--1 (fprl-1)

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US (2) US8541577B2 (ru)
EP (2) EP2776389B1 (ru)
JP (1) JP6181060B2 (ru)
KR (1) KR101982370B1 (ru)
CN (1) CN104169254A (ru)
AU (1) AU2012336013C1 (ru)
BR (1) BR112014011242A2 (ru)
CA (1) CA2855195C (ru)
HK (1) HK1199639A1 (ru)
RU (1) RU2627271C2 (ru)
WO (1) WO2013070600A1 (ru)

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BR112014010042B1 (pt) 2011-10-26 2022-03-03 Allergan, Inc Derivados de amida de aminoácidos n-ureia substituídos como moduladores de receptor tipo receptor de peptídeo formila 1 (fprl-1)
US8492556B2 (en) * 2011-11-10 2013-07-23 Allergan, Inc. 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators
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CA2898301C (en) * 2013-03-06 2021-11-16 Allergan, Inc. Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases
CN105007908B (zh) * 2013-03-06 2017-10-03 阿勒根公司 用于治疗皮肤病的甲酰基肽受体2的激动剂的用途
JP6653253B2 (ja) * 2013-07-16 2020-02-26 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ホルミルペプチド受容体モジュレーターとしてのｎ−尿素置換アミノ酸の誘導体
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
WO2015042071A1 (en) * 2013-09-19 2015-03-26 Allergan, Inc. Diphenyl urea derivatives as formyl peptide receptor modulators
TWI537251B (zh) 2013-10-09 2016-06-11 長庚大學 Ｆｐｒ１拮抗劑的衍生物及其用途
CA2930084A1 (en) 2013-11-21 2015-05-28 Allergan, Inc. Phenylcarbamate derivatives as formyl peptide receptor modulators
ES2752733T3 (es) 2013-11-28 2020-04-06 Kyorin Seiyaku Kk Derivados de urea deuterados o marcados isotópicamente o sales farmacológicamente aceptables de los mismos útiles como agonistas de FPRL-1
US9663457B2 (en) 2014-04-09 2017-05-30 Allergan, Inc. Carbamoyl hydrazine derivatives as formyl peptide modulators
ES2788700T3 (es) 2014-05-21 2020-10-22 Allergan Inc Derivados de imidazol como moduladores del receptor de péptido formilado
CN105884674B (zh) * 2015-01-05 2019-07-26 南开大学 色氨酸衍生物及制备方法和在防治植物病毒、杀菌、杀虫方面的应用
ES2791340T3 (es) * 2015-05-27 2020-11-03 Kyorin Seiyaku Kk Derivado de urea o sal farmacológicamente aceptable del mismo
CN107849049B (zh) 2015-05-27 2021-03-16 杏林制药株式会社 脲衍生物或其药用盐
JP7032323B6 (ja) * 2016-03-28 2023-12-18 アラーガン、インコーポレイテッド Ｎ－ホルミルペプチド受容体モジュレーターとしてのフェニル尿素誘導体
CN109843283B (zh) 2016-10-06 2022-08-30 第一三共株式会社 脲衍生物
GB2561540A (en) 2017-03-13 2018-10-24 Nodthera Ltd Chemical compounds
EA202092094A1 (ru) 2018-03-05 2020-12-10 Бристол-Маерс Сквибб Компани Фенилпирролидиноновые агонисты формилпептидного рецептора 2
EP4234014A1 (en) * 2022-02-28 2023-08-30 Insusense ApS Amino acid based carbamates and/or ureas for the treatment of sortilin dependent diseases

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AU2012336013C1 (en) 2017-12-21
CA2855195C (en) 2018-03-20
US20130331570A1 (en) 2013-12-12
RU2627271C2 (ru) 2017-08-04
US8816076B2 (en) 2014-08-26
CA2855195A1 (en) 2013-05-16
WO2013070600A1 (en) 2013-05-16
AU2012336013B2 (en) 2017-07-27
EP3088385A1 (en) 2016-11-02
BR112014011242A2 (pt) 2021-05-25
US20130123496A1 (en) 2013-05-16
EP2776389B1 (en) 2016-09-21
CN104169254A (zh) 2014-11-26
AU2012336013A1 (en) 2014-05-29
RU2014122750A (ru) 2015-12-20
KR101982370B1 (ko) 2019-09-10
KR20140117356A (ko) 2014-10-07
US8541577B2 (en) 2013-09-24
JP6181060B2 (ja) 2017-08-16
EP2776389A1 (en) 2014-09-17
JP2015502924A (ja) 2015-01-29

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