HK1199443A1 - Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahyd roisoquinoline-4-carboxamides for antimalarial therapies 2--1--n--3--1,2,3,4- -4- - Google Patents

Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahyd roisoquinoline-4-carboxamides for antimalarial therapies 2--1--n--3--1,2,3,4- -4-

Info

Publication number
HK1199443A1
HK1199443A1 HK14112913.3A HK14112913A HK1199443A1 HK 1199443 A1 HK1199443 A1 HK 1199443A1 HK 14112913 A HK14112913 A HK 14112913A HK 1199443 A1 HK1199443 A1 HK 1199443A1
Authority
HK
Hong Kong
Prior art keywords
carboxamides
heteroaryl
oxo
phenyl
substituted
Prior art date
Application number
HK14112913.3A
Other languages
English (en)
Chinese (zh)
Inventor
Rodney Kiplin Guy
Fangyi Zhu
Wendyam Armand Guiguemde
David Floyd
Spencer Knapp
Philip Stein
Steve Castro
Original Assignee
St Jude Childrens Res Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Jude Childrens Res Hospital filed Critical St Jude Childrens Res Hospital
Publication of HK1199443A1 publication Critical patent/HK1199443A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK14112913.3A 2011-08-25 2014-12-24 Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahyd roisoquinoline-4-carboxamides for antimalarial therapies 2--1--n--3--1,2,3,4- -4- HK1199443A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161527594P 2011-08-25 2011-08-25
PCT/IB2012/054305 WO2013027196A1 (en) 2011-08-25 2012-08-24 Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4- tetrahydroisoquinoline-4-carboxamides for antimalarial therapies

Publications (1)

Publication Number Publication Date
HK1199443A1 true HK1199443A1 (en) 2015-07-03

Family

ID=47018313

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14112913.3A HK1199443A1 (en) 2011-08-25 2014-12-24 Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahyd roisoquinoline-4-carboxamides for antimalarial therapies 2--1--n--3--1,2,3,4- -4-

Country Status (19)

Country Link
US (1) US9416124B2 (ja)
EP (1) EP2748147B1 (ja)
JP (1) JP6035334B2 (ja)
CN (1) CN103930404B (ja)
BR (1) BR112014004437B1 (ja)
CA (1) CA2846507C (ja)
CY (1) CY1119748T1 (ja)
DK (1) DK2748147T3 (ja)
ES (1) ES2644082T3 (ja)
HK (1) HK1199443A1 (ja)
HR (1) HRP20171567T1 (ja)
HU (1) HUE034721T2 (ja)
LT (1) LT2748147T (ja)
ME (1) ME02908B (ja)
PL (1) PL2748147T3 (ja)
PT (1) PT2748147T (ja)
RS (1) RS56544B1 (ja)
SI (1) SI2748147T1 (ja)
WO (1) WO2013027196A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200134203A (ko) * 2017-08-21 2020-12-01 나비젠, 인코포레이티드 Ａｒｆ6 억제제 및 관련 방법
EP3892332A1 (en) 2020-04-09 2021-10-13 University Of Kentucky Research Foundation New anti-malarial agents
EP4074314A1 (en) * 2021-04-15 2022-10-19 Valdospan GmbH Isoquinoline derivatives for use as antiviral and antitumour agents
AU2022258682A1 (en) 2021-04-15 2023-10-12 Pags Co., Ltd. Isoquinoline derivatives for use as antiviral and antitumour agents
WO2024083802A1 (en) 2022-10-17 2024-04-25 Valdospan Gmbh Isoquinoline derivatives as protein degraders, e7 degraders, antivirals, tumor therapeutics and immune suppressives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639761A (en) * 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US5409938A (en) * 1994-02-14 1995-04-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof
US6921762B2 (en) * 2001-11-16 2005-07-26 Amgen Inc. Substituted indolizine-like compounds and methods of use
AU2003249713A1 (en) 2002-07-03 2004-01-23 Axys Pharmaceuticals, Inc. 3,4-dihydroisoquinolin-1-one derivatives as inducers of apoptosis
DE10237722A1 (de) 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
DE10312963A1 (de) * 2003-03-24 2004-10-07 Aventis Pharma Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
MY145281A (en) * 2005-03-25 2012-01-13 Glaxo Group Ltd Novel compounds
RU2302417C1 (ru) * 2006-03-14 2007-07-10 Иващенко Андрей Александрович 1-оксо-3-(1н-индол-3-ил)-1,2,3,4-тетрагидроизохинолины, способы их получения, комбинаторная библиотека и фокусированная библиотека
JP2011520951A (ja) * 2008-05-19 2011-07-21 アクテリオン ファーマシューティカルズ リミテッド 抗マラリア薬としての新規なテトラヒドロイソキノリン類
GB0820856D0 (en) * 2008-11-14 2008-12-24 Univ Leuven Kath Novel inhibitors of flavivirus replication

Also Published As

Publication number Publication date
LT2748147T (lt) 2017-10-25
PT2748147T (pt) 2017-11-14
CN103930404B (zh) 2016-08-24
ME02908B (me) 2018-10-20
JP2014524464A (ja) 2014-09-22
HRP20171567T1 (hr) 2017-11-17
SI2748147T1 (sl) 2017-11-30
EP2748147B1 (en) 2017-08-02
BR112014004437A8 (pt) 2018-01-23
WO2013027196A9 (en) 2013-04-18
CA2846507C (en) 2020-03-10
PL2748147T3 (pl) 2018-01-31
DK2748147T3 (da) 2017-11-13
WO2013027196A1 (en) 2013-02-28
CY1119748T1 (el) 2018-06-27
RS56544B1 (sr) 2018-02-28
JP6035334B2 (ja) 2016-11-30
HUE034721T2 (hu) 2018-02-28
BR112014004437B1 (pt) 2021-12-14
CA2846507A1 (en) 2013-02-28
US20140235593A1 (en) 2014-08-21
CN103930404A (zh) 2014-07-16
ES2644082T3 (es) 2017-11-27
US9416124B2 (en) 2016-08-16
EP2748147A1 (en) 2014-07-02
BR112014004437A2 (pt) 2017-03-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230826