SI2748147T1 - Substituirani 2-alkil-1-okso-N-fenil-3-heteroaril-1,2,3,4-tetrahidroizokinolin-4-kar- boksamidi za antimalarične terapije - Google Patents
Substituirani 2-alkil-1-okso-N-fenil-3-heteroaril-1,2,3,4-tetrahidroizokinolin-4-kar- boksamidi za antimalarične terapijeInfo
- Publication number
- SI2748147T1 SI2748147T1 SI201231080T SI201231080T SI2748147T1 SI 2748147 T1 SI2748147 T1 SI 2748147T1 SI 201231080 T SI201231080 T SI 201231080T SI 201231080 T SI201231080 T SI 201231080T SI 2748147 T1 SI2748147 T1 SI 2748147T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tetrahydroisoquinoline
- carboxamides
- heteroaryl
- oxo
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161527594P | 2011-08-25 | 2011-08-25 | |
| PCT/IB2012/054305 WO2013027196A1 (en) | 2011-08-25 | 2012-08-24 | Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4- tetrahydroisoquinoline-4-carboxamides for antimalarial therapies |
| EP12772470.6A EP2748147B1 (en) | 2011-08-25 | 2012-08-24 | Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides for antimalarial therapies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2748147T1 true SI2748147T1 (sl) | 2017-11-30 |
Family
ID=47018313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231080T SI2748147T1 (sl) | 2011-08-25 | 2012-08-24 | Substituirani 2-alkil-1-okso-N-fenil-3-heteroaril-1,2,3,4-tetrahidroizokinolin-4-kar- boksamidi za antimalarične terapije |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9416124B2 (sl) |
| EP (1) | EP2748147B1 (sl) |
| JP (1) | JP6035334B2 (sl) |
| CN (1) | CN103930404B (sl) |
| BR (1) | BR112014004437B1 (sl) |
| CA (1) | CA2846507C (sl) |
| CY (1) | CY1119748T1 (sl) |
| DK (1) | DK2748147T3 (sl) |
| ES (1) | ES2644082T3 (sl) |
| HK (1) | HK1199443A1 (sl) |
| HR (1) | HRP20171567T1 (sl) |
| HU (1) | HUE034721T2 (sl) |
| LT (1) | LT2748147T (sl) |
| ME (1) | ME02908B (sl) |
| PL (1) | PL2748147T3 (sl) |
| PT (1) | PT2748147T (sl) |
| RS (1) | RS56544B1 (sl) |
| SI (1) | SI2748147T1 (sl) |
| WO (1) | WO2013027196A1 (sl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200134203A (ko) * | 2017-08-21 | 2020-12-01 | 나비젠, 인코포레이티드 | Ａｒｆ6 억제제 및 관련 방법 |
| EP3892332A1 (en) | 2020-04-09 | 2021-10-13 | University Of Kentucky Research Foundation | New anti-malarial agents |
| JP2024515336A (ja) | 2021-04-15 | 2024-04-08 | アールディーピー ファーマ アーゲー | 抗ウイルス剤及び抗腫瘍剤として使用するためのイソキノリン誘導体 |
| EP4074314A1 (en) * | 2021-04-15 | 2022-10-19 | Valdospan GmbH | Isoquinoline derivatives for use as antiviral and antitumour agents |
| WO2024083802A1 (en) | 2022-10-17 | 2024-04-25 | Valdospan Gmbh | Isoquinoline derivatives as protein degraders, e7 degraders, antivirals, tumor therapeutics and immune suppressives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639761A (en) * | 1994-02-14 | 1997-06-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof |
| US5409938A (en) * | 1994-02-14 | 1995-04-25 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof |
| US6921762B2 (en) * | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
| WO2004004727A1 (en) * | 2002-07-03 | 2004-01-15 | Axys Pharmaceuticals, Inc. | 3,4-dihydroisoquinolin-1-one derivatives as inducers of apoptosis |
| DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| DE10312963A1 (de) | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| PE20100737A1 (es) * | 2005-03-25 | 2010-11-27 | Glaxo Group Ltd | Nuevos compuestos |
| RU2302417C1 (ru) | 2006-03-14 | 2007-07-10 | Иващенко Андрей Александрович | 1-оксо-3-(1н-индол-3-ил)-1,2,3,4-тетрагидроизохинолины, способы их получения, комбинаторная библиотека и фокусированная библиотека |
| US20110281869A1 (en) * | 2008-05-19 | 2011-11-17 | Hamed Aissaoui | Tetrahydroisoquinolines as antimalarial agents |
| GB0820856D0 (en) | 2008-11-14 | 2008-12-24 | Univ Leuven Kath | Novel inhibitors of flavivirus replication |
-
2012
- 2012-08-24 ME MEP-2017-250A patent/ME02908B/me unknown
- 2012-08-24 ES ES12772470.6T patent/ES2644082T3/es active Active
- 2012-08-24 RS RS20171090A patent/RS56544B1/sr unknown
- 2012-08-24 WO PCT/IB2012/054305 patent/WO2013027196A1/en active Application Filing
- 2012-08-24 CA CA2846507A patent/CA2846507C/en active Active
- 2012-08-24 CN CN201280041436.4A patent/CN103930404B/zh active Active
- 2012-08-24 BR BR112014004437-6A patent/BR112014004437B1/pt active IP Right Grant
- 2012-08-24 LT LTEP12772470.6T patent/LT2748147T/lt unknown
- 2012-08-24 PT PT127724706T patent/PT2748147T/pt unknown
- 2012-08-24 PL PL12772470T patent/PL2748147T3/pl unknown
- 2012-08-24 JP JP2014526594A patent/JP6035334B2/ja active Active
- 2012-08-24 HU HUE12772470A patent/HUE034721T2/hu unknown
- 2012-08-24 US US14/240,994 patent/US9416124B2/en active Active
- 2012-08-24 DK DK12772470.6T patent/DK2748147T3/da active
- 2012-08-24 SI SI201231080T patent/SI2748147T1/sl unknown
- 2012-08-24 EP EP12772470.6A patent/EP2748147B1/en active Active
-
2014
- 2014-12-24 HK HK14112913.3A patent/HK1199443A1/xx not_active IP Right Cessation
-
2017
- 2017-10-16 HR HRP20171567TT patent/HRP20171567T1/hr unknown
- 2017-10-20 CY CY20171101092T patent/CY1119748T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2748147A1 (en) | 2014-07-02 |
| RS56544B1 (sr) | 2018-02-28 |
| US9416124B2 (en) | 2016-08-16 |
| PT2748147T (pt) | 2017-11-14 |
| CN103930404B (zh) | 2016-08-24 |
| WO2013027196A1 (en) | 2013-02-28 |
| US20140235593A1 (en) | 2014-08-21 |
| BR112014004437A8 (pt) | 2018-01-23 |
| LT2748147T (lt) | 2017-10-25 |
| JP2014524464A (ja) | 2014-09-22 |
| EP2748147B1 (en) | 2017-08-02 |
| CA2846507A1 (en) | 2013-02-28 |
| BR112014004437A2 (pt) | 2017-03-28 |
| PL2748147T3 (pl) | 2018-01-31 |
| HK1199443A1 (en) | 2015-07-03 |
| CA2846507C (en) | 2020-03-10 |
| CY1119748T1 (el) | 2018-06-27 |
| HRP20171567T1 (hr) | 2017-11-17 |
| ES2644082T3 (es) | 2017-11-27 |
| ME02908B (me) | 2018-10-20 |
| CN103930404A (zh) | 2014-07-16 |
| BR112014004437B1 (pt) | 2021-12-14 |
| HUE034721T2 (hu) | 2018-02-28 |
| JP6035334B2 (ja) | 2016-11-30 |
| WO2013027196A9 (en) | 2013-04-18 |
| DK2748147T3 (da) | 2017-11-13 |
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