HK1198920A1 - Method of treating a proliferative disease - Google Patents
Method of treating a proliferative diseaseInfo
- Publication number
- HK1198920A1 HK1198920A1 HK14112437.0A HK14112437A HK1198920A1 HK 1198920 A1 HK1198920 A1 HK 1198920A1 HK 14112437 A HK14112437 A HK 14112437A HK 1198920 A1 HK1198920 A1 HK 1198920A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treating
- proliferative disease
- proliferative
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161558619P | 2011-11-11 | 2011-11-11 | |
PCT/US2012/064269 WO2013070996A1 (fr) | 2011-11-11 | 2012-11-09 | Procédé de traitement d'une maladie proliférative |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1198920A1 true HK1198920A1 (en) | 2015-06-19 |
Family
ID=47279036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14112437.0A HK1198920A1 (en) | 2011-11-11 | 2014-12-10 | Method of treating a proliferative disease |
Country Status (11)
Country | Link |
---|---|
US (1) | US11007194B2 (fr) |
EP (1) | EP2776037B1 (fr) |
JP (1) | JP6150813B2 (fr) |
CN (2) | CN108542906A (fr) |
AU (1) | AU2012335663B2 (fr) |
BR (1) | BR112014011223A8 (fr) |
CA (1) | CA2855243C (fr) |
HK (1) | HK1198920A1 (fr) |
MX (1) | MX354725B (fr) |
RU (1) | RU2622015C2 (fr) |
WO (1) | WO2013070996A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
SI2882440T1 (sl) * | 2012-08-07 | 2019-05-31 | Novartis Ag | Farmacevtske kombinacije, ki vsebujejo inhibitor B-RAF, inhibitor EGFR in neobvezno inhibitor PI3K-alfa |
SG11201810793XA (en) | 2016-06-03 | 2018-12-28 | Giordano Caponigro | Pharmaceutical combinations |
US11590133B2 (en) * | 2016-12-11 | 2023-02-28 | Memorial Sloan Kettering Cancer Center | Methods and compositions for treatment of BRAF mutant cancers |
CN110256408B (zh) * | 2018-07-12 | 2022-03-22 | 深圳市塔吉瑞生物医药有限公司 | 一种二芳基吡唑化合物及包含该化合物的组合物及其用途 |
TWI817018B (zh) | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療braf相關的疾病和失調症之化合物 |
WO2023230554A1 (fr) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combinaison d'un inhibiteur de braf, d'un inhibiteur d'egfr et d'un antagoniste de pd-1 pour le traitement du cancer colorectal msi-h/dmmr, avec mutation v600e de braf |
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AR012634A1 (es) | 1997-05-02 | 2000-11-08 | Sugen Inc | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
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DK1692113T3 (en) | 2003-11-14 | 2018-01-08 | Lorus Therapeutics Inc | ARYLIMIDAZOLES AND USE THEREOF AS ANTICANCES |
CA2551948A1 (fr) | 2004-01-09 | 2005-07-28 | Novartis Ag | Derives de phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl]-amine utilises comme inhibiteurs du recepteur igf-1r |
US7745437B2 (en) | 2004-06-10 | 2010-06-29 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
CA2601766A1 (fr) | 2005-03-17 | 2006-09-28 | Novartis Ag | N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2, 4, 4b-triazafluoren-9-yle)-phenyl] benzamides utilises en tant qu'inhibiteurs de tyrosine/threonine kinase, en particulier la b-raf kinase |
US20070099856A1 (en) * | 2005-05-13 | 2007-05-03 | Gumerlock Paul H | Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen |
CA2618377A1 (fr) | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Composes pyrazoles modulant l'activite de la proteine hsp90 |
BRPI0614870A2 (pt) | 2005-08-22 | 2011-04-19 | Novartis Ag | composições farmacêuticas |
EP1917258A2 (fr) | 2005-08-26 | 2008-05-07 | SmithKline Beecham Corporation | Inhibiteurs de pyrimidinyl-pyrazole d'aurora kinases |
TWI387592B (zh) | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
CA2643066A1 (fr) | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazoles |
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US7501430B2 (en) | 2006-04-17 | 2009-03-10 | Arqule, Inc. | RAF inhibitors and their uses |
US8202876B2 (en) | 2006-10-02 | 2012-06-19 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
US20100087464A1 (en) | 2006-10-06 | 2010-04-08 | Irm Llc | Protein kinase inhibitors and methods for using thereof |
RU2009134223A (ru) | 2007-02-15 | 2011-03-20 | Новартис АГ (CH) | Комбинация lbh589 с другими терапевтическими средствами, предназначенная для лечения рака |
US20090022789A1 (en) | 2007-07-18 | 2009-01-22 | Supernus Pharmaceuticals, Inc. | Enhanced formulations of lamotrigine |
EA201000113A1 (ru) | 2007-08-01 | 2010-08-30 | Пфайзер Инк. | Пиразольные соединения |
MX2010004291A (es) | 2007-10-19 | 2010-08-02 | Abbott Gmbh & Co Kg | Producto de dispersion solida de farmacos basados en n-aril urea. |
JP5433582B2 (ja) | 2007-11-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | イミダゾ[1,2−a]ピリジン誘導体およびmGluR2受容体の正のアロステリック調節因子としてのその使用 |
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UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
PT2324008E (pt) | 2008-07-24 | 2012-06-25 | Nerviano Medical Sciences Srl | 3,4-diarilpirazoles como inibidores da proteína quinase |
CN102123987A (zh) | 2008-07-28 | 2011-07-13 | 吉里德科学公司 | 亚环烷基和亚杂环烷基组蛋白脱乙酰酶抑制剂化合物 |
PE20110294A1 (es) | 2008-09-29 | 2011-05-26 | Boehringer Ingelheim Int | Compuestos heterociclicos como inhibidores de enzimas de senal especifica |
CN102238945B (zh) | 2008-10-07 | 2014-10-29 | 阿斯利康(英国)有限公司 | 药物制剂514 |
US20110293750A1 (en) | 2008-11-11 | 2011-12-01 | Yale University | Activated wnt-beta-catenin signaling in melanoma |
EP2373664B1 (fr) | 2008-12-19 | 2013-06-12 | Nerviano Medical Sciences S.r.l. | Pyrazoles bicycliques en tant qu'inhibiteurs de protéines kinases |
AR075180A1 (es) | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
RU2402602C1 (ru) * | 2009-02-12 | 2010-10-27 | Государственное учреждение Российский онкологический научный центр им. Н.Н. Блохина РАМН | КЛЕТОЧНАЯ ЛИНИЯ МЕЛАНОМЫ ЧЕЛОВЕКА mel Rac, ИСПОЛЬЗУЕМАЯ ДЛЯ ПОЛУЧЕНИЯ ПРОТИВООПУХОЛЕВЫХ ВАКЦИН |
WO2010100127A1 (fr) | 2009-03-04 | 2010-09-10 | Novartis Ag | Dérivés d'imidazole disubstitués en tant que modulateurs de la protéine kinase raf |
TWI532484B (zh) | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
EP2443117B1 (fr) | 2009-06-15 | 2016-03-23 | Nerviano Medical Sciences S.r.l. | Dérivés de pyrimidinylpyrrolopyridinone substitués, procédé pour leur préparation et leur utilisation en tant qu'inhibiteurs de kinase |
KR101256018B1 (ko) | 2009-08-20 | 2013-04-18 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물 |
AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
US8791265B2 (en) | 2010-01-27 | 2014-07-29 | Nerviano Medical Sciences S.R.L. | Sulfonamido derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors |
CA2829790C (fr) | 2010-03-30 | 2018-06-05 | Verseon Corporation | Composes aromatiques multisubstitues utilises comme inhibiteurs de la thrombine |
US9114137B2 (en) | 2010-08-03 | 2015-08-25 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
JP5999724B2 (ja) | 2011-03-21 | 2016-09-28 | ヴァルキュリア アクチアボラグValcuria AB | Hdac阻害剤及びステロイドを含む医薬組成物及びその使用 |
CN103608012A (zh) | 2011-06-14 | 2014-02-26 | 诺华股份有限公司 | 在癌症如骨髓增殖性肿瘤治疗中的帕比司他与鲁索利替尼的组合 |
LT2782557T (lt) | 2011-11-23 | 2018-12-27 | Array Biopharma, Inc. | Farmacinės kompozicijos |
US20150283136A1 (en) | 2012-11-08 | 2015-10-08 | Novartis Ag | Pharmaceutical combination comprising a b-raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases |
-
2012
- 2012-11-09 CA CA2855243A patent/CA2855243C/fr active Active
- 2012-11-09 BR BR112014011223A patent/BR112014011223A8/pt not_active Application Discontinuation
- 2012-11-09 MX MX2014005726A patent/MX354725B/es active IP Right Grant
- 2012-11-09 CN CN201810135736.8A patent/CN108542906A/zh active Pending
- 2012-11-09 AU AU2012335663A patent/AU2012335663B2/en active Active
- 2012-11-09 WO PCT/US2012/064269 patent/WO2013070996A1/fr active Application Filing
- 2012-11-09 JP JP2014541283A patent/JP6150813B2/ja active Active
- 2012-11-09 US US14/355,903 patent/US11007194B2/en active Active
- 2012-11-09 RU RU2014117707A patent/RU2622015C2/ru active
- 2012-11-09 CN CN201280054663.0A patent/CN103917236A/zh active Pending
- 2012-11-09 EP EP12795175.4A patent/EP2776037B1/fr active Active
-
2014
- 2014-12-10 HK HK14112437.0A patent/HK1198920A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
RU2014117707A (ru) | 2015-12-20 |
US20140275136A1 (en) | 2014-09-18 |
EP2776037A1 (fr) | 2014-09-17 |
CN108542906A (zh) | 2018-09-18 |
WO2013070996A1 (fr) | 2013-05-16 |
BR112014011223A2 (pt) | 2017-05-09 |
CA2855243A1 (fr) | 2013-05-16 |
RU2622015C2 (ru) | 2017-06-08 |
US11007194B2 (en) | 2021-05-18 |
JP6150813B2 (ja) | 2017-06-21 |
MX354725B (es) | 2018-03-16 |
AU2012335663B2 (en) | 2015-12-24 |
MX2014005726A (es) | 2014-05-28 |
BR112014011223A8 (pt) | 2023-01-31 |
CN103917236A (zh) | 2014-07-09 |
JP2014533272A (ja) | 2014-12-11 |
CA2855243C (fr) | 2020-04-14 |
AU2012335663A1 (en) | 2014-05-29 |
EP2776037B1 (fr) | 2019-01-09 |
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