|
US6391636B1
(en)
|
1994-05-31 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
US6358932B1
(en)
|
1994-05-31 |
2002-03-19 |
Isis Pharmaceticals, Inc. |
Antisense oligonucleotide inhibition of raf gene expression
|
|
US6037136A
(en)
|
1994-10-24 |
2000-03-14 |
Cold Spring Harbor Laboratory |
Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
|
|
US5717100A
(en)
|
1995-10-06 |
1998-02-10 |
Merck & Co., Inc. |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
|
|
AR012634A1
(es)
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
|
AP1246A
(en)
|
1997-05-22 |
2004-02-07 |
Searle & Co |
Substituted pyrazoles as p38 Kinase inhibitors.
|
|
GB9716557D0
(en)
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
US6022884A
(en)
|
1997-11-07 |
2000-02-08 |
Amgen Inc. |
Substituted pyridine compounds and methods of use
|
|
US6204467B1
(en)
|
1998-03-24 |
2001-03-20 |
Ford Global Technologies, Inc. |
Method and apparatus for resistive welding
|
|
ME00275B
(me)
|
1999-01-13 |
2011-02-10 |
Bayer Corp |
ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
|
|
US6316435B2
(en)
|
1999-02-24 |
2001-11-13 |
Supergen, Inc. |
Combination therapy for lymphoproliferative diseases
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
ES2295428T3
(es)
|
2001-10-25 |
2008-04-16 |
Novartis Ag |
Combinaciones que comprenden un inhibidor selectivo de ciclooxigenasa-2.
|
|
ATE374753T1
(de)
|
2001-12-21 |
2007-10-15 |
Vernalis Cambridge Ltd |
3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
|
|
AU2004273615B2
(en)
|
2003-09-23 |
2009-01-15 |
Novartis Ag |
Combination of a VEGF receptor inhibitor with a chemotherapeutic agent
|
|
EP1692113B1
(en)
|
2003-11-14 |
2017-09-27 |
Lorus Therapeutics Inc. |
Aryl imidazoles and their use as anti-cancer agents
|
|
MXPA06007820A
(es)
|
2004-01-09 |
2006-09-01 |
Novartis Ag |
Derivados de fenil-[4-(3-fenil-1h-pirazol-4-il)-pirimidin-2-il]-amina como inhibidores de igf-ir.
|
|
MXPA06014247A
(es)
|
2004-06-10 |
2007-03-12 |
Irm Llc |
Compuestos y composiciones como inhibidores de la proteina quinasa.
|
|
WO2006102079A1
(en)
|
2005-03-17 |
2006-09-28 |
Novartis Ag |
N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2 , 4, 4b-triazafluoren-9-yl)-phenyl] benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase
|
|
US20070099856A1
(en)
*
|
2005-05-13 |
2007-05-03 |
Gumerlock Paul H |
Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen
|
|
AU2006279794B2
(en)
|
2005-08-12 |
2011-04-07 |
Synta Pharmaceuticals Corp. |
Pyrazole compounds that modulate HSP90 activity
|
|
CN102198273A
(zh)
|
2005-08-22 |
2011-09-28 |
诺瓦提斯公司 |
包含pH依赖性药物、pH调节剂和阻滞剂的药物组合物
|
|
WO2007024843A2
(en)
|
2005-08-26 |
2007-03-01 |
Smithkline Beecham Corporation |
Pyrimidinyl-pyrazole inhibitors of aurora kinases
|
|
PE20070427A1
(es)
|
2005-08-30 |
2007-04-21 |
Novartis Ag |
Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas
|
|
CA2643066A1
(en)
|
2006-03-16 |
2007-09-20 |
Pfizer Products Inc. |
Pyrazole compounds
|
|
WO2007115286A2
(en)
|
2006-04-05 |
2007-10-11 |
Novartis Ag. |
Combinations of therapeutic agents for treating cancer
|
|
WO2007123892A2
(en)
|
2006-04-17 |
2007-11-01 |
Arqule Inc. |
Raf inhibitors and their uses
|
|
KR101101675B1
(ko)
|
2006-10-02 |
2011-12-30 |
노파르티스 아게 |
단백질 키나제 억제제로서의 화합물 및 조성물
|
|
KR20090063240A
(ko)
|
2006-10-06 |
2009-06-17 |
아이알엠 엘엘씨 |
단백질 키나제 억제제 및 그의 사용 방법
|
|
KR20090110913A
(ko)
|
2007-02-15 |
2009-10-23 |
노파르티스 아게 |
Ｌｂｈ589와 암을 치료하기 위한 다른 치료제와의 조합물
|
|
US20090022789A1
(en)
|
2007-07-18 |
2009-01-22 |
Supernus Pharmaceuticals, Inc. |
Enhanced formulations of lamotrigine
|
|
AU2008281543A1
(en)
|
2007-08-01 |
2009-02-05 |
Pfizer Inc. |
Pyrazole compounds and their use as Raf inhibitors
|
|
JP2011500649A
(ja)
|
2007-10-19 |
2011-01-06 |
アボット ゲーエムベーハー ウント カンパニー カーゲー |
Ｎ−アリール尿素系薬剤の固体分散体生成物
|
|
CN101861316B
(zh)
|
2007-11-14 |
2013-08-21 |
奥梅-杨森制药有限公司 |
咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
|
|
US8129394B2
(en)
|
2008-03-21 |
2012-03-06 |
Novartis Ag |
Heteroaryl-substituted imidazole compounds and uses thereof
|
|
UA103319C2
(xx)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Сполуки бензенсульфонамідтіазолу та -оксазолу$соединения бензенсульфонамидтиазола и -оксазола
|
|
ATE557015T1
(de)
|
2008-07-24 |
2012-05-15 |
Nerviano Medical Sciences Srl |
3,4-diarylpyrazole als proteinkinaseinhibitoren
|
|
AU2009276699A1
(en)
|
2008-07-28 |
2010-02-04 |
Gilead Sciences, Inc. |
Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds
|
|
US8778929B2
(en)
|
2008-09-29 |
2014-07-15 |
Boehringer Ingelheim International Gmbh |
Substituted heteroaryl inhibitors of B-RAF
|
|
CN102238945B
(zh)
|
2008-10-07 |
2014-10-29 |
阿斯利康(英国)有限公司 |
药物制剂514
|
|
WO2010056662A1
(en)
|
2008-11-11 |
2010-05-20 |
University Of Washington |
Activated wnt-beta-catenin signaling in melanoma
|
|
JP5490137B2
(ja)
|
2008-12-19 |
2014-05-14 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
プロテインキナーゼ阻害薬としての二環式ピラゾール
|
|
AR075180A1
(es)
|
2009-01-29 |
2011-03-16 |
Novartis Ag |
Formulaciones orales solidas de una pirido-pirimidinona
|
|
RU2402602C1
(ru)
|
2009-02-12 |
2010-10-27 |
Государственное учреждение Российский онкологический научный центр им. Н.Н. Блохина РАМН |
КЛЕТОЧНАЯ ЛИНИЯ МЕЛАНОМЫ ЧЕЛОВЕКА mel Rac, ИСПОЛЬЗУЕМАЯ ДЛЯ ПОЛУЧЕНИЯ ПРОТИВООПУХОЛЕВЫХ ВАКЦИН
|
|
WO2010100127A1
(en)
|
2009-03-04 |
2010-09-10 |
Novartis Ag |
Disubstituted imidazole derivatives as modulators of raf kinase
|
|
TWI532484B
(zh)
|
2009-06-08 |
2016-05-11 |
艾伯維有限公司 |
包含凋亡促進劑之固態分散劑
|
|
EP3045457B1
(en)
|
2009-06-15 |
2018-05-09 |
Nerviano Medical Sciences S.r.l. |
Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors
|
|
KR101256018B1
(ko)
|
2009-08-20 |
2013-04-18 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
|
|
AR077975A1
(es)
|
2009-08-28 |
2011-10-05 |
Irm Llc |
Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
|
|
US8242260B2
(en)
|
2009-08-28 |
2012-08-14 |
Novartis Ag |
Compounds and compositions as protein kinase inhibitors
|
|
JP5806239B2
(ja)
|
2010-01-27 |
2015-11-10 |
ネルヴィアーノ・メディカル・サイエンシズ・ソチエタ・ア・レスポンサビリタ・リミタータ |
プロテインキナーゼ阻害剤としての３，４−ジアリールピラゾールのスルホンアミド誘導体
|
|
KR102113960B1
(ko)
|
2010-03-30 |
2020-05-21 |
베르선 코포레이션 |
트롬빈 억제제로서의 다중치환된 방향족 화합물
|
|
WO2012016993A1
(en)
|
2010-08-03 |
2012-02-09 |
Nerviano Medical Sciences S.R.L. |
Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents
|
|
BR112013023970B1
(pt)
|
2011-03-21 |
2021-11-16 |
Valcuria Ab |
Uso de uma combinação de ácido valproico ou um sal farmaceuticamente aceitável deste e prednisona ou dexametasona ou um sal farmaceuticamente aceitável deste
|
|
JP6200884B2
(ja)
|
2011-06-14 |
2017-09-20 |
ノバルティス アーゲー |
骨髄増殖性腫瘍などの癌の治療におけるパノビノスタットおよびルキソリチニブの組合せ
|
|
KR102091295B1
(ko)
|
2011-11-23 |
2020-03-19 |
어레이 바이오파마 인크. |
제약 제제
|
|
RU2015121367A
(ru)
|
2012-11-08 |
2017-01-10 |
Новартис Аг |
Фармацевтическая комбинация, содержащая ингибитор b-raf и ингибитор деацетилазы гистонов, и ее применение при лечении пролиферативных заболеваний
|