HK1197060A1 - 酪氨酸激酶抑制劑 - Google Patents

酪氨酸激酶抑制劑

Info

Publication number
HK1197060A1
HK1197060A1 HK14110443A HK14110443A HK1197060A1 HK 1197060 A1 HK1197060 A1 HK 1197060A1 HK 14110443 A HK14110443 A HK 14110443A HK 14110443 A HK14110443 A HK 14110443A HK 1197060 A1 HK1197060 A1 HK 1197060A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
tyrosine kinase
brutons tyrosine
brutons
kinase
Prior art date
Application number
HK14110443A
Other languages
English (en)
Inventor
Christine Brotherton-Pleiss
Saul Jaime-Figueroa
Francisco Javier Lopez-Tapia
Yan Lou
Timothy D Owens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46690498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1197060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of HK1197060A1 publication Critical patent/HK1197060A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK14110443A 2011-08-17 2014-10-20 酪氨酸激酶抑制劑 HK1197060A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161524374P 2011-08-17 2011-08-17
US201261649991P 2012-05-22 2012-05-22
PCT/EP2012/065844 WO2013024078A1 (en) 2011-08-17 2012-08-14 Inhibitors of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
HK1197060A1 true HK1197060A1 (zh) 2015-01-02

Family

ID=46690498

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14110443A HK1197060A1 (zh) 2011-08-17 2014-10-20 酪氨酸激酶抑制劑

Country Status (22)

Country Link
US (1) US8889682B2 (zh)
EP (1) EP2744804B1 (zh)
JP (1) JP5823616B2 (zh)
KR (1) KR20140052032A (zh)
CN (1) CN103748088A (zh)
AR (1) AR087543A1 (zh)
AU (1) AU2012296888A1 (zh)
BR (1) BR112014003582A2 (zh)
CA (1) CA2841801A1 (zh)
CL (1) CL2014000350A1 (zh)
CO (1) CO6842020A2 (zh)
CR (1) CR20140027A (zh)
EA (1) EA024689B1 (zh)
EC (1) ECSP14013212A (zh)
HK (1) HK1197060A1 (zh)
IL (1) IL230561A0 (zh)
MA (1) MA35419B1 (zh)
MX (1) MX349372B (zh)
PE (1) PE20140865A1 (zh)
TW (1) TW201311669A (zh)
WO (1) WO2013024078A1 (zh)
ZA (1) ZA201400739B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
CA2852964A1 (en) 2011-11-03 2013-05-10 F. Hoffmann-La Roche Ag Bicyclic piperazine compounds
TWI553004B (zh) * 2011-11-03 2016-10-11 建南德克公司 ８－氟基呔－１（２ｈ）－酮化合物
JP5976828B2 (ja) 2011-11-03 2016-08-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｂｔｋ活性阻害剤としてのアルキル化ピペラジン化合物
WO2013157021A1 (en) 2012-04-20 2013-10-24 Advinus Therapeutics Limited Bicyclic compounds, compositions and medicinal applications thereof
CN104662018B (zh) 2012-04-20 2017-10-24 阿迪维纳斯治疗有限公司 取代的杂双环化合物、组合物及其医疗应用
EP3550031A1 (en) 2012-07-24 2019-10-09 Pharmacyclics, LLC Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
AU2013299557B2 (en) 2012-08-10 2017-06-22 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as Bruton's tyrosine kinase (BTK) inhibitors
EP2920162B1 (en) * 2012-11-16 2017-04-19 F. Hoffmann-La Roche AG Inhibitors of bruton's tyrosine kinase
JP6042995B2 (ja) * 2012-11-30 2016-12-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトン型チロシンキナーゼの阻害薬
US9556147B2 (en) 2013-03-05 2017-01-31 Hoffmann-La Inc. Inhibitors of bruton's tyrosine kinase
CN104177338B (zh) * 2013-05-22 2018-04-03 南京勇山生物科技有限公司 一类布鲁顿激酶抑制剂
MX2015018038A (es) * 2013-07-03 2016-03-16 Hoffmann La Roche Compuestos de heteroaril-piridona y aza-piridona-amida.
DK3026050T3 (en) 2013-07-26 2019-02-18 Carna Biosciences Inc NEW TRIAZINE DERIVATIVE
CA2925177A1 (en) * 2013-09-20 2015-03-26 Carna Biosciences, Inc. Novel triazine derivative
RU2646758C2 (ru) 2013-12-05 2018-03-07 Ф. Хоффманн-Ля Рош Аг Гетероарил пиридоны и азапиридоны с электрофильной функциональностью
EP3042903B1 (en) 2015-01-06 2019-08-14 Impetis Biosciences Ltd. Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
CA2974449C (en) 2015-01-22 2023-08-29 Sanofi-Aventis Deutschland Gmbh Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
US10208024B2 (en) 2015-10-23 2019-02-19 Array Biopharma Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
AU2021267373A1 (en) 2020-05-06 2022-12-08 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
WO2023009709A1 (en) * 2021-07-29 2023-02-02 Ajax Therapeutics, Inc. Pyrazolo piperazines as jak2 inhibitors
EP4430042A1 (en) 2021-11-09 2024-09-18 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN115073299B (zh) * 2022-06-14 2024-06-25 爱斯特（成都）生物制药股份有限公司 一种制备2-氟-3-三氟甲基苯胺的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7683064B2 (en) * 2008-02-05 2010-03-23 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
DK2242749T3 (da) * 2008-02-05 2013-06-17 Hoffmann La Roche Nye pyridinoner og pyridazinoner
CN102066366B (zh) * 2008-06-24 2014-04-16 霍夫曼-拉罗奇有限公司 新型取代的吡啶-2-酮和哒嗪-3-酮
US8299077B2 (en) * 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
AR082590A1 (es) * 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
TWI553004B (zh) * 2011-11-03 2016-10-11 建南德克公司 ８－氟基呔－１（２ｈ）－酮化合物
US9192664B2 (en) * 2011-12-05 2015-11-24 Immunomedics, Inc. Therapeutic use of anti-CD22 antibodies for inducing trogocytosis

Also Published As

Publication number Publication date
KR20140052032A (ko) 2014-05-02
IL230561A0 (en) 2014-03-31
AR087543A1 (es) 2014-04-03
EP2744804A1 (en) 2014-06-25
WO2013024078A1 (en) 2013-02-21
US8889682B2 (en) 2014-11-18
ECSP14013212A (es) 2014-03-31
EP2744804B1 (en) 2017-05-17
MA35419B1 (fr) 2014-09-01
MX349372B (es) 2017-07-26
JP5823616B2 (ja) 2015-11-25
MX2014001653A (es) 2014-03-21
CR20140027A (es) 2014-03-13
ZA201400739B (en) 2016-01-27
EA024689B1 (ru) 2016-10-31
BR112014003582A2 (pt) 2017-03-14
CO6842020A2 (es) 2014-01-20
PE20140865A1 (es) 2014-07-19
CA2841801A1 (en) 2013-02-21
US20130045965A1 (en) 2013-02-21
JP2014521734A (ja) 2014-08-28
TW201311669A (zh) 2013-03-16
EA201490452A1 (ru) 2014-05-30
CL2014000350A1 (es) 2014-08-22
AU2012296888A1 (en) 2014-01-23
CN103748088A (zh) 2014-04-23

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