HK1187614A1 - 咪唑並吡嗪 - Google Patents

咪唑並吡嗪

Info

Publication number
HK1187614A1
HK1187614A1 HK14100577.5A HK14100577A HK1187614A1 HK 1187614 A1 HK1187614 A1 HK 1187614A1 HK 14100577 A HK14100577 A HK 14100577A HK 1187614 A1 HK1187614 A1 HK 1187614A1
Authority
HK
Hong Kong
Prior art keywords
pyrazines
imidazo
imidazo pyrazines
Prior art date
Application number
HK14100577.5A
Other languages
English (en)
Inventor
Kin-Chun Thomas Luk
Michael Soth
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1187614A1 publication Critical patent/HK1187614A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK14100577.5A 2011-03-17 2014-01-20 咪唑並吡嗪 HK1187614A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161453601P 2011-03-17 2011-03-17
PCT/EP2012/054415 WO2012123470A1 (en) 2011-03-17 2012-03-14 Imidazo pyrazines

Publications (1)

Publication Number Publication Date
HK1187614A1 true HK1187614A1 (zh) 2014-04-11

Family

ID=45855775

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14100577.5A HK1187614A1 (zh) 2011-03-17 2014-01-20 咪唑並吡嗪

Country Status (12)

Country Link
US (1) US8673905B2 (zh)
EP (1) EP2686319B1 (zh)
JP (1) JP5796094B2 (zh)
KR (1) KR101561756B1 (zh)
CN (1) CN103429593B (zh)
BR (1) BR112013019160A2 (zh)
CA (1) CA2830131A1 (zh)
ES (1) ES2590928T3 (zh)
HK (1) HK1187614A1 (zh)
MX (1) MX340574B (zh)
RU (1) RU2600327C2 (zh)
WO (1) WO2012123470A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9653770B2 (en) 2014-10-21 2017-05-16 At&T Intellectual Property I, L.P. Guided wave coupler, coupling module and methods for use therewith
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
MA43169B1 (fr) 2015-11-06 2022-05-31 Incyte Corp Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma
EP3400221B1 (en) 2016-01-05 2020-08-26 Incyte Corporation Pyrazol / imidazol substituted pyridines as pi3k-gamma inhibitors
TW201803871A (zh) 2016-06-24 2018-02-01 英塞特公司 作為PI3K-γ抑制劑之雜環化合物
WO2018191476A1 (en) * 2017-04-12 2018-10-18 Magenta Therapeutics, Inc. Aryl hydrocarbon receptor antagonists and uses thereof
WO2019079469A1 (en) 2017-10-18 2019-04-25 Incyte Corporation CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED WITH HYDROXY TERTIARY GROUPS AS INHIBITORS OF PI3K-GAMMA
CN111918651B (zh) 2018-01-29 2024-01-30 默克专利股份有限公司 Gcn2抑制剂及其用途
AU2019212969A1 (en) 2018-01-29 2020-08-13 Merck Patent Gmbh GCN2 inhibitors and uses thereof
JP2021535182A (ja) 2018-09-05 2021-12-16 インサイト・コーポレイションIncyte Corporation ホスホイノシチド3−キナーゼ(pi3k)阻害剤の結晶形態
CN111646978B (zh) * 2020-06-11 2021-12-21 浙江大学 N2-取代烷氧芳环-2-氨基嘧啶类衍生物及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186832B2 (en) 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
EP1790650B1 (en) * 2004-08-31 2014-03-26 Msd Kk NEW SUBSTITUTED IMIDAZOLE DERIVATIVES
WO2007028051A2 (en) * 2005-09-02 2007-03-08 Abbott Laboratories Novel imidazo based heterocycles
US20070055743A1 (en) 2005-09-02 2007-03-08 Pirtle Ross M Remote control media player
JP2010500365A (ja) * 2006-08-07 2010-01-07 インサイト・コーポレイション キナーゼ阻害剤としてのトリアゾロトリアジン
AU2007311480A1 (en) 2006-10-16 2008-04-24 Forma Therapeutics, Inc. Pyrido [2, 3-d] pyrimidines and their use as kinase inhibitors
PE20080931A1 (es) * 2006-11-08 2008-07-19 Schering Corp Imidazopirazinas como inhibidores de proteina quinasa
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
MX2009013729A (es) * 2007-06-14 2010-01-25 Schering Corp Imidazopirazinas como inhibidores de proteina quinasa.
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
MX2010012457A (es) * 2008-05-13 2010-12-07 Irm Llc Heterociclos que contienen nitrogeno fusionado y composiciones de los mismos como inhibidores de cinasa.

Also Published As

Publication number Publication date
ES2590928T3 (es) 2016-11-24
US8673905B2 (en) 2014-03-18
CA2830131A1 (en) 2012-09-20
KR20130133870A (ko) 2013-12-09
KR101561756B1 (ko) 2015-10-19
RU2013142881A (ru) 2015-04-27
CN103429593B (zh) 2015-09-09
CN103429593A (zh) 2013-12-04
JP2014508180A (ja) 2014-04-03
EP2686319B1 (en) 2016-07-13
RU2600327C2 (ru) 2016-10-20
EP2686319A1 (en) 2014-01-22
MX2013010183A (es) 2013-10-03
JP5796094B2 (ja) 2015-10-21
MX340574B (es) 2016-07-13
WO2012123470A1 (en) 2012-09-20
US20120238564A1 (en) 2012-09-20
BR112013019160A2 (pt) 2016-10-04

Similar Documents

Publication Publication Date Title
HK1212984A1 (zh) 咪唑並吡啶化合物
HK1208444A1 (zh) 吡咯並苯二氮卓類
HK1208217A1 (zh) 吡咯並苯並二氮雜卓
IL229513A0 (en) imidazopyridine compounds
SG11201401021TA (en) Pyrrolobenzodiazepines
IL232570B (en) Bicyclic derivatives of dihydroisoquinoline-1-one
ZA201401577B (en) New bicyclic dihydroquinoline-2-one derivatives
HK1187614A1 (zh) 咪唑並吡嗪
SI2771327T1 (sl) Novi pirazinski derivati
PT2694513E (pt) Derivados de pirazolopirimidina
EP2752136A4 (en) ELECTRIC BED
HK1206727A1 (zh) 吡嗪衍生物
EP2667871A4 (en) SUITS
GB2490711B (en) Wheel-supporting arrangement
EP2938862A4 (en) MULTI-PURPOSE SUPPORT
GB2512771B (en) Ablutionary fitting
AU337589S (en) Bed
AU341508S (en) Shorts
AU341509S (en) Shorts

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230314