HK1185347A1 - Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators kcnq2/3 2---3- - Google Patents
Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators kcnq2/3 2---3-Info
- Publication number
- HK1185347A1 HK1185347A1 HK13112725.2A HK13112725A HK1185347A1 HK 1185347 A1 HK1185347 A1 HK 1185347A1 HK 13112725 A HK13112725 A HK 13112725A HK 1185347 A1 HK1185347 A1 HK 1185347A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- kcnq2
- carboxamides
- quinoline
- modulators
- oxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10008921 | 2010-08-27 | ||
PCT/EP2011/004277 WO2012025236A1 (en) | 2010-08-27 | 2011-08-26 | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1185347A1 true HK1185347A1 (en) | 2014-02-14 |
Family
ID=43297040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13112725.2A HK1185347A1 (en) | 2010-08-27 | 2013-11-13 | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators kcnq2/3 2---3- |
Country Status (29)
Country | Link |
---|---|
US (2) | US8653101B2 (el) |
EP (1) | EP2609083B1 (el) |
JP (1) | JP5837933B2 (el) |
KR (1) | KR20130100300A (el) |
CN (1) | CN103068804B (el) |
AR (1) | AR082732A1 (el) |
AU (1) | AU2011295405B2 (el) |
BR (1) | BR112013004562A2 (el) |
CA (1) | CA2809341A1 (el) |
CL (1) | CL2013000520A1 (el) |
CO (1) | CO6700824A2 (el) |
CY (1) | CY1116234T1 (el) |
DK (1) | DK2609083T3 (el) |
EC (1) | ECSP13012453A (el) |
ES (1) | ES2537628T3 (el) |
HK (1) | HK1185347A1 (el) |
HR (1) | HRP20150526T1 (el) |
IL (1) | IL223885A (el) |
MX (1) | MX342119B (el) |
NZ (1) | NZ604745A (el) |
PE (1) | PE20131379A1 (el) |
PL (1) | PL2609083T3 (el) |
PT (1) | PT2609083E (el) |
RS (1) | RS54007B1 (el) |
RU (1) | RU2595894C2 (el) |
SI (1) | SI2609083T1 (el) |
TW (1) | TWI522349B (el) |
WO (1) | WO2012025236A1 (el) |
ZA (1) | ZA201302266B (el) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ604745A (en) * | 2010-08-27 | 2015-01-30 | Gruenenthal Chemie | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators |
EP2609086B1 (en) * | 2010-08-27 | 2015-02-25 | Grünenthal GmbH | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
CN104994857A (zh) * | 2012-10-11 | 2015-10-21 | 格吕伦塔尔有限公司 | Tspo介导的疾病和/或障碍的治疗和/或预防 |
AU2013351550A1 (en) | 2012-11-28 | 2015-07-16 | Grünenthal GmbH | Specific carboxamides as KCNQ2/3 modulators |
US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
AU2013351551A1 (en) | 2012-11-28 | 2015-07-16 | Grunenthal Gmbh | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
JP2016524607A (ja) | 2013-05-16 | 2016-08-18 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Hiv−1インテグラーゼの薬物耐性株を阻害するための化合物 |
CN114727992A (zh) * | 2019-10-07 | 2022-07-08 | D·E·萧尔研究有限责任公司 | 作为Kv1.3钾Shaker通道阻滞剂的芳基亚甲基芳族化合物 |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2513949A1 (de) | 1975-03-29 | 1976-10-07 | Bayer Ag | Azofarbstoffe |
DE2706977A1 (de) | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
FR2482596A1 (fr) | 1980-05-19 | 1981-11-20 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament |
DE3111934A1 (de) | 1981-03-26 | 1982-10-07 | Bayer Ag, 5090 Leverkusen | Oel-in-wasser-emulsionen, verfahren zu deren herstellung und deren verwendung |
FR2509728A1 (fr) | 1981-07-17 | 1983-01-21 | Roussel Uclaf | Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
DE3210063A1 (de) * | 1982-03-19 | 1983-09-22 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
DE3211934A1 (de) | 1982-03-31 | 1983-10-13 | Hoechst Ag, 6230 Frankfurt | Salicylsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
FR2532939A1 (fr) | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
US5359365A (en) | 1991-05-24 | 1994-10-25 | Canon Kabushiki Kaisha | Moving image processing method and apparatus |
US5525611A (en) | 1993-06-04 | 1996-06-11 | Behforouz; Mohammad | Lavendamycin analogs and methods of making and using them |
US6030983A (en) | 1993-06-04 | 2000-02-29 | Ball State University | Lavendamycin analogs, quinoline-5,8-diones and methods of using them |
EP0634169B1 (en) | 1993-06-29 | 2000-01-05 | Takeda Chemical Industries, Ltd. | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis |
EP0716077A1 (de) | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren |
WO1996026925A1 (fr) | 1995-03-01 | 1996-09-06 | Banyu Pharmaceutical Co., Ltd. | Derives de l'arylthioacetamide |
DE19738616A1 (de) | 1997-09-04 | 1999-03-11 | Clariant Gmbh | 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel |
GB9807114D0 (en) | 1998-04-02 | 1998-06-03 | Smithkline Beecham Plc | Novel process |
US6248736B1 (en) * | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents |
JP2000256323A (ja) | 1999-01-08 | 2000-09-19 | Japan Tobacco Inc | 2−オキソキノリン化合物及びその医薬用途 |
WO2000042026A1 (en) | 1999-01-15 | 2000-07-20 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
DE60037321T4 (de) | 1999-08-04 | 2010-01-07 | Icagen, Inc. | Benzanilide als öffner des kaliumkanals |
EP1200086A4 (en) | 1999-08-04 | 2009-05-27 | Icagen Inc | THERAPEUTIC OR PROPHYLACTIC METHODS OF PAIN AND ANXIETY |
PL199781B1 (pl) | 1999-10-25 | 2008-10-31 | Active Biotech Ab | Nowe związki pochodne chinoliny, zastosowanie związków pochodnych chinoliny, zawierające je kompozycje farmaceutyczne i sposób ich wytwarzania |
MXPA03007397A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas. |
EP1361879A1 (en) | 2001-02-20 | 2003-11-19 | Bristol-Myers Squibb Company | 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators |
US6593349B2 (en) | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
WO2002081728A2 (en) | 2001-04-06 | 2002-10-17 | Smithkline Beecham Corporation | Quinoline inhibitors of hyak1 and hyak3 kinases |
BR0314390A (pt) | 2002-09-17 | 2005-07-19 | Pharmacia Corp | Moduladores aromáticos dos receptores hepáticos x |
EP1539767A4 (en) | 2002-09-18 | 2006-07-19 | Univ Missouri | FOR THE DELTA OPIOID RECEPTOR SELECTIVE OPIATANALOGA |
EP1585522B1 (en) | 2002-12-23 | 2010-11-17 | Icagen, Inc. | Quinazolinones as potassium channel modulators |
EP1449841A1 (en) | 2003-02-19 | 2004-08-25 | Bayer CropScience SA | New fungicidal compounds |
WO2004083184A1 (ja) | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | 受容体拮抗剤 |
RU2006115602A (ru) | 2003-10-08 | 2007-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы переносчиков атф-связывающих кассет |
EP1689742B1 (en) | 2003-11-24 | 2010-03-17 | Pfizer, Inc. | Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity |
AR048669A1 (es) | 2004-03-03 | 2006-05-17 | Syngenta Ltd | Derivados biciclicos de bisamida |
WO2005105733A1 (en) | 2004-05-04 | 2005-11-10 | Pfizer Japan Inc. | Ortho substituted aryl or heteroaryl amide compounds |
CA2585490A1 (en) | 2004-11-12 | 2006-05-18 | Galapagos Nv | Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes |
EP1861394A1 (en) | 2005-03-03 | 2007-12-05 | H.Lundbeck A/S | Substituted pyridine derivatives |
DE102005038947A1 (de) | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
DE602006007012D1 (de) | 2005-07-20 | 2009-07-09 | Lilly Co Eli | Pyridinderivate als dipeptedyl-peptidase-hemmer |
EP1922311A2 (en) | 2005-09-09 | 2008-05-21 | Brystol-Myers Squibb Company | Acyclic ikur inhibitors |
JP2009515934A (ja) | 2005-11-18 | 2009-04-16 | ノイロサーチ アクティーゼルスカブ | 新規なキナゾリン誘導体及びこれらの医学的使用 |
JP5202327B2 (ja) | 2005-12-09 | 2013-06-05 | アムジエン・インコーポレーテツド | プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用 |
CA2650412C (en) | 2006-04-13 | 2016-09-27 | Nupathe, Inc. | Transdermal methods and systems for the delivery of anti-migraine compounds |
US7763607B2 (en) | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
WO2007133637A2 (en) | 2006-05-10 | 2007-11-22 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
WO2008007211A1 (en) * | 2006-07-11 | 2008-01-17 | Pfizer Japan Inc. | Substituted n-bicyclicalkyl bicyclic carboxyamide compounds |
AU2007275683B2 (en) | 2006-07-20 | 2012-05-10 | Amgen Inc. | Di-amino-substituted heterocyclic compounds and methods of use |
ES2338278T3 (es) | 2006-07-20 | 2010-05-05 | Amgen Inc. | Derivados de benzo(d)isoxazol como inhibidores de c-kit tirosina quinasa para el tratamiento de enfermedades asociadas con la sobreproduccion de histamina. |
JP2009544732A (ja) | 2006-07-26 | 2009-12-17 | ノバルティス アクチエンゲゼルシャフト | ウンデカプレニルピロホスフェートシンターゼの阻害剤 |
WO2008012532A2 (en) | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
WO2008127274A2 (en) | 2006-09-22 | 2008-10-23 | Ptc Therapeutics, Inc. | Heterocyclic inhibitors of bacterial peptidyl trna hydrolase and uses thereof |
DE102006049452A1 (de) | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
WO2008050199A2 (en) | 2006-10-23 | 2008-05-02 | Pfizer Japan Inc. | Substituted phenylmethyl bicyclocarboxyamide compounds |
US20080221161A1 (en) | 2007-02-09 | 2008-09-11 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
WO2008113006A1 (en) | 2007-03-14 | 2008-09-18 | Xenon Pharmaceuticals Inc. | Methods of using quinolinone compounds in treating sodium channel-mediated diseases or conditions |
US9162984B2 (en) | 2007-03-30 | 2015-10-20 | University Of Rochester | Small-molecule modulators of melanin expression |
EP2172447A4 (en) * | 2007-07-03 | 2011-08-24 | Astellas Pharma Inc | amide |
US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
CN101784515A (zh) | 2007-08-03 | 2010-07-21 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物 |
DE102007044277A1 (de) * | 2007-09-17 | 2009-03-19 | Grünenthal GmbH | Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln |
US8299123B2 (en) | 2007-10-19 | 2012-10-30 | Boehringer Ingelheim International Gmbh | CCR10 antagonists |
US8119656B2 (en) | 2007-12-07 | 2012-02-21 | The Board Of Regents Of The University Of Texas System | Inhibitors of the influenza virus non-structural 1 protein |
CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
US8513295B2 (en) | 2008-09-23 | 2013-08-20 | Georgetown University | Viral and fungal inhibitors |
PT2350093E (pt) | 2008-10-24 | 2012-11-02 | Gruenenthal Gmbh | 4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3 para tratamento da dor, epilepsia e incontinência urinária |
US8367700B2 (en) | 2008-12-17 | 2013-02-05 | Gruenenthal Gmbh | Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators |
WO2010094644A1 (en) | 2009-02-17 | 2010-08-26 | Neurosearch A/S | Substituted pyridine derivatives and their medical use |
WO2010094645A1 (en) * | 2009-02-17 | 2010-08-26 | Neurosearch A/S | Substituted pyridine derivatives and their medical use |
AU2010223555A1 (en) | 2009-03-10 | 2011-11-03 | Grünenthal GmbH | Substituted 3-aminoisoxazolopyridines as KCNQ2/3 modulators |
TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
EP2609086B1 (en) * | 2010-08-27 | 2015-02-25 | Grünenthal GmbH | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
US8470852B2 (en) | 2010-08-27 | 2013-06-25 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
NZ604745A (en) * | 2010-08-27 | 2015-01-30 | Gruenenthal Chemie | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators |
JP5887346B2 (ja) * | 2010-08-27 | 2016-03-16 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Kcnq2/3調節因子としての置換キノリン−3−カルボキサミド |
-
2011
- 2011-08-26 NZ NZ604745A patent/NZ604745A/en not_active IP Right Cessation
- 2011-08-26 CN CN201180041332.9A patent/CN103068804B/zh not_active Expired - Fee Related
- 2011-08-26 SI SI201130427T patent/SI2609083T1/sl unknown
- 2011-08-26 DK DK11754833T patent/DK2609083T3/da active
- 2011-08-26 CA CA2809341A patent/CA2809341A1/en not_active Abandoned
- 2011-08-26 RS RS20150337A patent/RS54007B1/en unknown
- 2011-08-26 TW TW100130608A patent/TWI522349B/zh not_active IP Right Cessation
- 2011-08-26 US US13/218,512 patent/US8653101B2/en not_active Expired - Fee Related
- 2011-08-26 RU RU2013113300/04A patent/RU2595894C2/ru not_active IP Right Cessation
- 2011-08-26 AU AU2011295405A patent/AU2011295405B2/en not_active Ceased
- 2011-08-26 AR ARP110103117A patent/AR082732A1/es unknown
- 2011-08-26 ES ES11754833.9T patent/ES2537628T3/es active Active
- 2011-08-26 BR BR112013004562A patent/BR112013004562A2/pt not_active IP Right Cessation
- 2011-08-26 WO PCT/EP2011/004277 patent/WO2012025236A1/en active Application Filing
- 2011-08-26 MX MX2013002118A patent/MX342119B/es active IP Right Grant
- 2011-08-26 KR KR1020137007675A patent/KR20130100300A/ko not_active Application Discontinuation
- 2011-08-26 PL PL11754833T patent/PL2609083T3/pl unknown
- 2011-08-26 EP EP11754833.9A patent/EP2609083B1/en not_active Not-in-force
- 2011-08-26 PT PT117548339T patent/PT2609083E/pt unknown
- 2011-08-26 JP JP2013525186A patent/JP5837933B2/ja not_active Expired - Fee Related
- 2011-08-26 PE PE2013000264A patent/PE20131379A1/es not_active Application Discontinuation
-
2012
- 2012-12-25 IL IL223885A patent/IL223885A/en active IP Right Grant
-
2013
- 2013-02-15 CO CO13031095A patent/CO6700824A2/es unknown
- 2013-02-21 EC ECSP13012453 patent/ECSP13012453A/es unknown
- 2013-02-22 CL CL2013000520A patent/CL2013000520A1/es unknown
- 2013-03-26 ZA ZA2013/02266A patent/ZA201302266B/en unknown
- 2013-11-13 HK HK13112725.2A patent/HK1185347A1/xx not_active IP Right Cessation
- 2013-11-26 US US14/089,842 patent/US9073862B2/en not_active Expired - Fee Related
-
2015
- 2015-04-29 CY CY20151100390T patent/CY1116234T1/el unknown
- 2015-05-18 HR HRP20150526TT patent/HRP20150526T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL225762A0 (en) | 6- amino-nicotinamides are converted as 2/3 kcnq modulators | |
ZA201107444B (en) | Substituted 2-mercaptoquinoline-3-carboxamides as kcnq2/3 modulators | |
AP3607A (en) | Substituted imidazopyridazines | |
HK1166061A1 (en) | Substituted nicotinamides as kcnq2/3 modulators kcnq2/3 | |
HK1171452A1 (en) | Substituted pyrrolidine-2-carboxamides -2- | |
HK1185347A1 (en) | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators kcnq2/3 2---3- | |
ZA201107443B (en) | Substituted 2-mercapto-3-aminopyridines as kcnq2/3 modulators | |
IL214944A0 (en) | Substituted 3-amino-2-mercaptoquinolines as kcnq2/3 modulators | |
HK1188782A1 (en) | Substituted sodium-1h-pyrazole-5-olate 1h--5- | |
ZA201208013B (en) | " selp-standing comtainer " | |
HK1185346A1 (en) | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators kcnq2/3 2-- 2---3- | |
GB201018890D0 (en) | Corcost 2222 | |
GB201018356D0 (en) | Corcost 1111 | |
GB201017776D0 (en) | Yota 201010 | |
GB201015872D0 (en) | Joint-saver 2 | |
GB201008294D0 (en) | Ecomodule 600 | |
GB201008318D0 (en) | Tidemill 1 | |
GB201003793D0 (en) | Georobic 2 | |
GB201003790D0 (en) | Georobic 1 | |
GB201019720D0 (en) | Corcost- T 1 T | |
GB201018463D0 (en) | B'doosh | |
GB201010529D0 (en) | "Tapease" | |
GB201005408D0 (en) | "Speedlight" | |
AU2010904361A0 (en) | Biotower 4 | |
AU2010903100A0 (en) | Pinsafe 1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20190824 |